共查询到20条相似文献,搜索用时 78 毫秒
1.
An easy, one-pot transformation of Baylis-Hillman adducts into carbamates of unsaturated β-amino acids, for example, 2-(aryl(methoxycarbonylamino)methyl)acrylic acid methyl esters 7 and 2-(methoxycarbonyl aminomethyl)-3-arylacrylic acid methyl esters 8 via reaction with the Burgess reagent is described. 相似文献
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Hoo Sook Kim 《Tetrahedron letters》2009,50(26):3154-9061
Modified Baylis-Hillman adducts having 2-bromoaniline moiety at the primary position underwent Pd-mediated reductive Heck type cyclization to produce dihydroindole derivatives. The same starting materials can also be used for the synthesis of indole derivatives under slightly different conditions via the concomitant δ-carbon elimination and decarboxylation process. 相似文献
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An original two-step process for the synthesis of [1,4]oxazepin-2-ones starting from Baylis-Hillman (BH) adducts is reported. The protocol involves a nucleophilic substitution of the acetates of BH adducts with renewable natural α-amino esters followed by base-catalyzed intramolecular Michael addition. These sequential reactions are operationally simple, performed under ambient conditions, and give 81-93% yields of the target [1,4]oxazepin-2-ones. Thus, the present invention opens up a new aspect for the synthetic utility of BH adducts. 相似文献
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The highly α-regioselective N-nucleophilic substitution of B-H adducts bearing five (1a-f) or six-membered ring (5a-e) moieties with aromatic amines (2a-e) was developed under the catalysis of In(OTf)3 (10 mol%). During the reaction the allylic rearrangement from γ-product to α-product occurred, resulting in thermodynamically stable α-product predominately. 相似文献
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Sonia Khamri 《Tetrahedron》2009,65(25):4890-1471
Nucleophilic substitution of vinyl β-iodo Baylis-Hillman acetates using 1,4-diazabicyclo[2.2.2] octane (DABCO) and then KCN, provides a stereoselective method for the synthesis of the corresponding β-cyano Baylis-Hillman acetates in high yields. 相似文献
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Natália Aparecida Liberto Sarah de Paiva Silva Ângelo de Fátima Sergio Antonio Fernandes 《Tetrahedron》2013
A simple, green and efficient protocol was developed using β-cyclodextrin as a solid catalyst for the solvent-free synthesis of various Biginelli adducts. The advantages of our protocol included the following: (i) a metal-free methodology; (ii) high yields; (iii) simple and efficient work-up procedures; (iv) improved results under solvent-free conditions. β-cyclodextrin-catalyzed the Biginelli reactions for various aldehydes, demonstrating that it is an efficient and eco-friendly catalyst for the preparation of heterocyclic compounds. 相似文献
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Hong-Wen Hu Xu-Dong Wei Cun Li Hong-Zhe Sun Yi-Ming Yao Zhong-Yuan Zhou Kai-Bei Yu 《中国化学》1992,10(3):278-284
The reaction of m-chlorobenzaldoxime dehydrodimer with styrene gives two 1:1 adducts.The main product 7 is a bisnitrone. The minor product 8 has been shown by X-ray diffraction anal-ysis to possess the structure: ArCH(N=O)CH_2CH (Ph)O--N=CHAr. The two C=N bonds areall in Z configuration. The structure of the adducts from benzaldoxime dehydrodimer and styrene isalso assigned. 相似文献
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A. Yu. Alekseeva D. L. Mikhailov I. N. Bardasov O. V. Ershov O. E. Nasakin A. N. Lyshchikov 《Russian Journal of Organic Chemistry》2014,50(2):244-250
Reaction of arylmethylidene derivatives of malononitrile dimer with 1,3-cyclohexanediones in anhydrous methanol in the presence of sodium methylate as catalyst affords 4-amino-5-aryl-2-methoxy-6-oxo-5,6,7,8,9,10-hexahydrobenzo[b][1,8]naphthyridine-3-carbonitrile. In the presence of strong electron-donor substituents in the benzene ring the reaction takes another route resulting in 4-amino-2-aryl-6-methoxypyridine-3,5-dicarbonitriles. 相似文献
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V. A. Kuznetsov M. G. Pervova Yu. G. Yatluk 《Russian Journal of Applied Chemistry》2013,86(2):176-181
Oxidation of cyclohexanone to ?-caprolactone with stable industrially manufactured hydrogen peroxide derivatives: adduct with urea (urea hydrogen peroxide), sodium perborate, sodium percarbonate (Persol), magnesium monoperphthalate (Dismozon) was studied. Oxidation with urea hydrogen peroxide is the most efficient in hexafluoroisopropanol in the case of preliminary removal of urea in the form of an oxalate. Oxidation with sodium perborate and percarbonate provides high yields in trifluoroacetic acid. The lowest cost process consists in interaction with sodium monoperphthalate (Persol and phthalic anhydride) in an aqueous medium. 相似文献
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Jian LI Yun Kui LIU Yong Min ZHANG 《中国化学快报》2006,17(7):877-879
Benzotriazole derivatives are a class of useful intermediates in organic synthesis because of the easy introduction and elimination of the auxiliary benzotriazole. The syntheses and application of benzotriazole derivatives have been much developed, especi… 相似文献
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Sung Hwan Kim 《Tetrahedron letters》2009,50(15):1696-3242
We developed an efficient synthetic method of diallylated δ-valerolactam and γ-butyrolactam derivatives via an indium-mediated successive double Barbier type allylations starting from the Baylis-Hillman adducts. 相似文献
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Marie G. Kissane Scott A. Frank Gregory A. RenerChristopher P. Ley Charles A. AltPaul A. Stroud Radhe K. VaidSathish K. Boini Laura A. McKeeJeffrey T. Vicenzi Gregory A. Stephenson 《Tetrahedron letters》2013
The identification and development of an aldehyde–bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the extension of the scope of this study to include an investigation into the solid state properties of a range of sodium and potassium bisulfite adducts of commonly encountered aldehydes is discussed. 相似文献
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O. Yu. Doronina Yu. A. Khalilova B. T. Sharipov L. V. Spirikhin F. A. Valeev 《Russian Journal of Organic Chemistry》2012,48(11):1419-1423
A two-step Michael transformation was developed: an aldol condensation of levoglucosenone with 1,3-dicarbonyl compounds containing an ??-methylketo fragment resulting in the products of ??1,3-cyclohexafusion?? of levoglucosenone. Based on this procedure spiro derivatives were obtained using ????-methylketo-substituted cyclic ketones, among them macrocyclic compounds. 相似文献
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LI Ji-Sheng DONG Guo-Xiao FENG Jun JI Gai-JiaoInstitute of Chemistry Chinese Academy of Sciences Beijing China 《中国化学》1995,13(6):525-531
Fullerene C60 reacted with p-azidostyrene derivatives in refluxing chlorobenzene,yielding monoadducts 2a and 2d as well as diadduct 2c with aziridine structure at 6/6-ring junctions.Experimental results showed that the addition of the second azide to the monoadduct was regioselective.The diadduct,of Cs symmetry in C60 moiety,was unstable by opening to be 1,6-imido[10]annulene structure. 相似文献
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