Chemical Constituents of Artemisia frigida

Chemistry of Natural Compounds -     

New Eudesmane and Eremophilane Derivatives from Laggera Alata

From the aerial part of Laggera alata,a novel erenophilanoid(1)as well as two new eudesmanoids(2-3)were isolated.Their structures were elucidated by 2D-NMR technique and Xray diffraction studies.The cytotoxic activities of these sesquiterpenes were also investigated.     

Four New Eudesmane Sesquiterpenoid Lactones from Chloranthus serratus

Four new eudesmane sesquiterpenoids endowed with an α,β‐unsaturated γ‐lactone five‐membered ring, serralactones A–D ( 1 – 4 , resp.), along with seven known sesquiterpenoids, were isolated from the whole plant Chloranthus serratus. Their structures and relative configurations were established on the basis of extensive spectroscopic analyses.     

Artselenoide, a New Dimeric Guaianolide from Artemisia selengensis

Inaprelindnary.ommunication',wehavereportedonanewguaianolideartseleninisolatedfromArtemisiaselengensisTurcz(Compositae).Inthepresentpaperwedescribethestructureelucidationofartselenoide1obtainedasanewdimericguaianolidefromthesamepart.1wasobtainedascolorlesspowders,mpl85-l86D,[a]." l25(cO.l,MeOH).TheIRspectrumexhibitedabsorptionbandsduetohydroxyl(3435cm-'),Ylactone(l764cm-')anddoublebond(l648,l635,l456cm-')groups.Themolecularformu1aCstheooof1wasdeducedfromthedataofESIMS(Inlz5l9[M Na] ,53…     

Structural Elucidation and HPLC Analysis of Six Flavone Glycosides from Artemisia frigida Willd.

An investigation of the EtOAc-soluble fraction from the aerial parts of Artemisia frigida Willd.(A. frigida) led to the isolation of three new flavonoid glycosides together with three known compounds. Their structures were elucidated by spectral experiments. At the same time, high-performance liquid chromatographic(HPLC) method was used for the simultaneous determination of the six flavonoid glycosides from the aerial parts of A. frigida. The separation by gradient elution was performed on a Hypersil ODS-2 column(250 mm×4.6 mm, 5 μm) at 30 ℃ with acetonitrile and water as the mobile phase, and monitored by absorbance at 276 nm. The parameters of linearity, precision, accuracy and specificity of the method were evaluated. The recovery of the method is 96.50%―98.01%, and linearity(r>0.9992) was obtained for all the flavonoid glycosides. A high degree of specificity as well as repeatability and reproducibility(relative standard deviation values less than 2.0%) were also achieved. This assay was applied to the determination of six flavonoid glycosides in ten samples. The results indicate that the developed assay method was rapid, accurate, reliable and could be readily utilized as a quantitative analysis method for A. frigida.     

冷蒿挥发油化学成分的分离和鉴定

采用水蒸气蒸馏法提取了冷蒿挥发油,气相色谱-质谱联用结合计算机检索对其化学成分进行了分析和鉴定,共分离出106个峰,确定了101种化合物,它们主要是二甲基-甲撑基环庚(17.67%)、3,3,6-三甲基-1,5-庚二烯醇-2(16.40%)、3,3,6-三甲基-1,4-庚二烯醇-6(8.55%)、桉树脑(5.57%)、3,7-二甲-基2,6-辛二烯醇-1(3.85%)、神圣亚麻三烯(3.73%)、1-甲基-3-异丙基苯(3.26%)、桥环[2,2,1]萜烯(2.91%)、樟脑(2.26%)、香叶烯(2.20%),以上10种化合物占挥发油总量的66.40%。     

New Sesquiterpenoids from Artemisia anomala

One new guaianolide, anomalactone A ( 1 ), and one new norcadinane sesquiterpene, anomallenodiol ( 2 ), along with two germacranolides, anomalactones B and C ( 3 and 4 , resp.), were isolated from the aerial part of Artemisia anomala S. Moore . Their structures were determined on the basis of extensive spectroscopic analyses.     

Structural Elucidation of a New Glycoside from Artemisia sieversiana

Chemistry of Natural Compounds - A new glycoside, named artesieverosid (1), was isolated from Artemisia sieversiana Ehrh. The structure of 1 was elucidated by spectroscopic methods, including UV,...     

Eudesmane sesquiterpenoids from the Asteraceae family

This review covers the structures and biological activities of eudesmane-type sesquiterpenoids from the plants of the Asteraceae family. Biosynthetic studies or chemical syntheses leading to the revision of structures or stereochemistries have also been included, and 593 references are cited.     

牛尾蒿中—新倍半萜结构的确定

牛尾蒿中—新倍半萜结构的确定李瑜，杨立，师彦平（兰州大学应用有机化学国家重点实验室，兰州，７３００００）关键词牛尾蒿，倍半萜，牛尾蒿酮牛尾蒿（ＡｒｔｅｍｉｓｉａＳｕｂｄｉｇｉｔａｔａ）是菊科蒿属的一种多年生草本植物，广布于华北、东北、西北和西南等地区...     

Cadinane and Eudesmane Sesquiterpenoids from Chloranthus henryi

Chemical investigation of the leaves and stems of Chloranthus henryi resulted in the isolation and characterization of the three new cadinane‐type sesquiterpenes 1 – 3 and of the new eudesmane‐type sesquiterpene 4 , together with three known compounds. Among the new compounds, the two cadinane‐type sesquiterpenes 1 and 2 possess an unusual aromatic ring B in their molecule. These structures were established on the basis of spectroscopic evidence. In addition, antitumor activities of the isolates were also evaluated.     

Two New Phenolic Compounds from Artemisia iwayomogi

Two new phenolic compounds, (Z)‐5′‐hydroxyjasmone 5′‐O‐{6″‐O‐[(E)‐caffeoyl]‐β‐D ‐glucopyranoside} ( 1 ) and quercetin‐7‐O‐β‐D ‐glucuronide methyl ester ( 2 ), along with ten known phenolic compounds, 3 – 12 , were isolated from the aerial parts of Artemisia iwayomogi. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR, and HR‐ESI‐TOF‐MS techniques. The inhibitory effects of compounds 1 – 12 on the LPS‐stimulated production of IL‐12 p40, IL‐6, and TNF‐α in bone marrow‐derived dendritic cells were evaluated.     

Eudesmane sesquiterpenes from the aquatic fungus Beltrania rhombica

From the ethyl acetate extract of the culture broth of Beltrania rhombica, two new eudesmane sesquiterpenes, named rhombidiol (1) and rhombitriol (2), were isolated and characterized along with five enantiomers of known sesquiterpenes: (-)-beta-eudesmol, (-)-pterocarpol, (-)-chrysanthemol, (-)-longilobol and (-)-5beta-hydroxy-beta-eudesmol. Their structures were determined by analysis of 1D and 2D NMR data and comparison of spectral data and physical data with those previously reported.     

Bioactive Eudesmane sesquiterpenes from Artabotrys hongkongensis Hance

Abstract

A new naturally occurring trinoreudesmane sesquiterpene, artahongkongol A (1), together with seven known eudesmane sesquiterpenes (2?8), was isolated from the stems and leaves of Artabotrys hongkongensis Hance. Among them, 1 is a rare trinoreudesmane sesquiterpene containing 12 carbon atoms on the carbon skeleton. All known compounds (2?8) were isolated from the genus Artabotrys for the first time. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1?8 showed significant inhibitory effects against various human cancer cell lines with IC₅₀ values ranging from 0.57 to 15.68?μM.     

A New Thiophen Acetylene from Artemisia Absinthium

The investigation of the dried roots of A. absinthium afforded two known lignans of tetrahydrofuran skeleton, sesamin and yangambin, one known coumarin, 6‐methoxy‐7,8‐methylenedioxy coumarin and a new thiophen acetylene. The structures were elucidated by spectroscopic methods.