A theoretical model of oscillatory blood flow in arteries

Wave propagation within a thick-walled, compressible, viscoelastic tube containing a polar fluid is studied as a model of oscillatory blood flow in arteries. Describing blood rheology using polar fluid theory allows one to take into account dissipative effects arising from hydrodynamic interactions between red cells. The phase velocity ratio, transmission per wavelength and hydraulic fluid impedance are determined as a function of the frequency parameter for various specified values of fluid and tube parameters. Hydrodynamic interactions between red cells are found to reduce significantly the transmission per wavelength. Futher, it is found that the marked increase in fluid resistance with increasing frequency which is observed experimentally is due, in part, to the dissipative effects of cell-cell interactions.     

Mathematical modeling of pulsatile flow of non-Newtonian fluid in stenosed arteries

The pulsatile flow of blood through mild stenosed artery is studied. The effects of pulsatility, stenosis and non-Newtonian behavior of blood, treating the blood as Herschel–Bulkley fluid, are simultaneously considered. A perturbation method is used to analyze the flow. The expressions for the shear stress, velocity, flow rate, wall shear stress, longitudinal impedance and the plug core radius have been obtained. The variations of these flow quantities with different parameters of the fluid have been analyzed. It is found that, the plug core radius, pressure drop and wall shear stress increase with the increase of yield stress or the stenosis height. The velocity and the wall shear stress increase considerably with the increase in the amplitude of the pressure drop. It is clear that for a given value of stenosis height and for the increasing values of the stenosis shape parameter from 3 to 6, there is a sharp increase in the impedance of the flow and also the plots are skewed to the right-hand side. It is observed that the estimates of the increase in the longitudinal impedance increase with the increase of the axial distance or with the increase of the stenosis height. The present study also brings out the effects of asymmetric of the stenosis on the flow quantities.     

Dynamic response of pulsatile flow of blood in a stenosed tapered artery

The aim of this paper is to throw some light on the rheological study of pulsatile blood flow in a stenosed tapered arterial segment. Arterial wall is considered to be rigid and flexible separately for improving the similarity to the in vivo situation. The streaming blood is considered to be Newtonian. The governing nonlinear equations of motion are sought using the well‐known stream function‐vorticity method and are solved numerically by finite difference technique. Important rheological parameters, such as axial velocity component, wall shear stress, and flow separation region are estimated in the neighborhood of the stenosis. Effects of stenosis height, vessel tapering, and wall flexibility on the blood flow are investigated properly and are explained in detail through their graphical representations.     

The effects of post-stenotic dilatations on the flow of a blood analogue through stenosed coronary arteries

Previous work on the resistance to flow ratio and wall shear ratio of non-Newtonian blood flow through arteries containing aneurisms and stenoses has considered only Power Law and Casson models of fluid behaviour. Here a Bingham fluid is used to model blood. Flow through both constrictions and dilatations is considered. The effects of both a single diseased portion and pairs of abnormal wall segments in close proximity to each other are investigated. Comparison is made with earlier studies. Particular attention is paid to the effects of a post-stenotic dilatation as the ameorlation of the increase in resistance to flow ratio caused by such a situation is clinically relevant.     

A 3D non-Newtonian fluid-structure interaction model for blood flow in arteries

The mathematical modelling and numerical simulation of the human cardiovascular system is playing nowadays an important role in the comprehension of the genesis and development of cardiovascular diseases. In this paper we deal with two problems of 3D modelling and simulation in this field, which are very often neglected in the literature. On the one hand blood flow in arteries is characterized by travelling pressure waves due to the interaction of blood with the vessel wall. On the other hand, blood exhibits non-Newtonian properties, like shear-thinning, viscoelasticity and thixotropy. The present work is concerned with the coupling of a generalized Newtonian fluid, accounting for the shear-thinning behaviour of blood, with an elastic structure describing the vessel wall, to capture the pulse wave due to the interaction between blood and the vessel wall. We provide an energy estimate for the coupling and compare the numerical results with those obtained with an equivalent fluid-structure interaction model using a Newtonian fluid.     

Unsteady response of non-Newtonian blood flow through a stenosed artery in magnetic field

Current theoretical investigation of atherosclerotic arteries deals with mathematical models that represent non-Newtonian flow of blood through a stenosed artery in the presence of a transverse magnetic field. Here, the rheology of the flowing blood is characterised by a generalised Power law model. The distensibility of an arterial wall has been accounted for based on local fluid mechanics. A radial coordinate transformation is initiated to map cosine geometry of the stenosis into a rectangular grid. An appropriate finite difference scheme has been adopted to solve the unsteady non-Newtonian momentum equations in cylindrical coordinate system. Exploiting suitably prescribed conditions based on the assumption of an axial symmetry under laminar flow condition rendered the problem effectively to two dimensions. An extensive quantitative analysis has been performed based on numerical computations in order to estimate the effects of Hartmann number (M$M$), Power law index (n$n$), generalised Reynolds number (R_eG)$\left(R{e}_G\right)$, severity of the stenosis (δ)$\left(\delta \right)$ on various parameters such as flow velocity, flux and wall shear stress by means of their graphical representations so as to validate the applicability of the proposed mathematical model. The present results agree with some of the existing findings in the literature.     

A non-Newtonian fluid flow model for blood flow through a catheterized artery—Steady flow

In this paper the effects catheterization and non-Newtonian nature of blood in small arteries of diameter less than 100 μm, on velocity, flow resistance and wall shear stress are analyzed mathematically by modeling blood as a Herschel–Bulkley fluid with parameters n and θ and the artery and catheter by coaxial rigid circular cylinders. The influence of the catheter radius and the yield stress of the fluid on the yield plane locations, velocity distributions, flow rate, wall shear stress and frictional resistance are investigated assuming the flow to be steady. It is shown that the velocity decreases as the yield stress increases for given values of other parameters. The frictional resistance as well as the wall shear stress increases with increasing yield stress, whereas the frictional resistance increases and the wall shear stress decreases with increasing catheter radius ratio k (catheter radius to vessel radius). For the range of catheter radius ratio 0.3–0.6, in smaller arteries where blood is modeled by Herschel–Bulkley fluid with yield stress θ = 0.1, the resistance increases by a factor 3.98–21.12 for n = 0.95 and by a factor 4.35–25.09 for n = 1.05. When θ = 0.3, these factors are 7.47–124.6 when n = 0.95 and 8.97–247.76 when n = 1.05.     

Pulsatile flow of Herschel–Bulkley fluid through catheterized arteries – A mathematical model

The pulsatile flow of blood through catheterized artery has been studied in this paper by modeling blood as Herschel–Bulkley fluid and the catheter and artery as rigid coaxial circular cylinders. The Herschel–Bulkley fluid has two parameters, the yield stress θ and the power index n. Perturbation method is used to solve the resulting quasi-steady nonlinear coupled implicit system of differential equations. The effects of catheterization and non-Newtonian nature of blood on yield plane locations, velocity, flow rate, wall shear stress and longitudinal impedance of the artery are discussed. The existence of two yield plane locations is investigated and their dependence on yield stress θ, amplitude A, and time t are analyzed. The width of the plug core region increases with increasing value of yield stress at any time. The velocity and flow rate decrease, whereas wall shear stress and longitudinal impedance increase for increasing value of yield stress with other parameters held fixed. On the other hand, the velocity, flow rate and wall shear stress decrease but resistance to flow increases as the catheter radius ratio (ratio of catheter radius to vessel radius) increases with other parameters fixed. The results for power law fluid, Newtonian fluid and Bingham fluid are obtained as special cases from this model.     

A one dimensional model of blood flow through a curvilinear artery

We present a one-dimensional model describing the blood flow through a moderately curved and elastic blood vessel. We use an existing two dimensional model of the vessel wall along with Navier−Stokes equations to model the flow through the channel while taking factors, namely, surrounding muscle tissue and presence of external forces other than gravity into account. Our model is obtained via a dimension reduction procedure based on the assumption of thinness of the vessel relative to its length. Results of numerical simulations are presented to highlight the influence of different factors on the blood flow.     

Numerical simulation of Casson fluid flow through differently shaped arterial stenoses

The present investigation deals with a mathematical model of blood flow through an asymmetric (about its narrowest point) arterial constriction obtained from casting of a mildly stenosed artery. The flowing blood is represented as the suspension of all red cells (erythrocytes) in plasma assumed to be Casson fluid, while the arterial wall is considered to be rigid having differently shaped stenoses in its lumen arising from various types of abnormal growth or plaque formation. The governing equations of motion accompanied by the appropriate choice of the boundary conditions are solved numerically by Marker and Cell method in order to compute the physiologically significant quantities with desired degree of accuracy. The necessary checking for numerical stability has been incorporated in the algorithm for better precision of the results computed. The quantitative analyses have been carried out finally with the inclusion of the respective profiles of the flow field over the entire arterial segment as well. The key factors such as the wall shear stress, the pressure drop and the velocity profiles are exhibited graphically and examined thoroughly for qualitative insight into blood flow phenomena through arterial stenosis.     

Two-fluid and population balance models for subcooled boiling flow

Population balance equations combined with a three-dimensional two-fluid model are employed to predict subcooled boiling flow at low pressure in a vertical annular channel. The MUSIG (MUltiple-SIze-Group) model implemented in the computer code CFX4.4 is further developed to accommodate the wall nucleation at the heated wall and condensation in the subcooled boiling regime. Comparison of model predictions against local measurements is made for the void fraction, bubble Sauter mean diameter and gas and liquid velocities covering a range of different mass and heat fluxes and inlet subcooling temperatures. Additional comparison using empirical relationships for the active nucelation site density and local bubble diameter is also investigated. Good agreement is achieved with the local radial void fraction, bubble Sauter diameter and liquid velocity profiles against measurements. However, significant weakness of the model is evidenced in the prediction of the vapour velocity. Work is in progress to circumvent the deficiency through the consideration of additional momentum equations or developing an algebraic slip model to account for bubble separation.     

A numerical model for gas-particle flow through an orifice

The two-dimensional steady flow of a gas-particle mixture through an orifice is numerically modeled using the particle-source-in-cell approach. The results show the extent of the recirculation zone behind the orifice and the effect of particles on the gas velocity and pressure distributions. The predicted pressure drop across the orifice agrees favorably with experimental results.     

Numerical computation of pulsatile flow through a locally constricted channel

This paper deals with the numerical solution of a pulsatile laminar flow through a locally constricted channel. A finite difference technique has been employed to solve the governing equations. The effects of the flow parameters such as Reynolds number, flow pulsation in terms of Strouhal number, constriction height and length on the flow behaviour have been studied. It is found that the peak value of the wall shear stress has significantly changed with the variation of Reynolds numbers and constriction heights. It is also noted that the Strouhal number and constriction length have little effect on the peak value of the wall shear stress. The flow computation reveals that the peak value of the wall shear stress at maximum flow rate time in pulsatile flow situation is much larger than that due to steady flow. The constriction and the flow pulsation produce flow disturbances at the vicinity of the constriction of the channel in the downstream direction.     

A micropolar fluid model of blood flow through a tapered artery with a stenosis

A nonlinear two‐dimensional micropolar fluid model for blood flow in a tapered artery with a single stenosis is considered. This model takes into account blood rheology in which blood consists of microelements suspended in plasma. The classical Navier–Stokes theory is inadequate to describe the microrotations or particles' spin of such suspension in a viscous medium. The governing equations involving unsteady nonlinear partial differential equations are solved using a finite difference scheme. A quantitative analysis performed through numerical computation shows that the axial velocity profile and the flow rate decrease and the wall shear stress increases once the artery is narrower in the presence of the polar effect. Furthermore, the taper angle certainly bears the potential to influence the velocity and the flow characteristics to considerable extent. Copyright © 2010 John Wiley & Sons, Ltd.     

Power law fluid model for blood flow through a tapered artery with a stenosis

In the present paper, blood flow through a tapered artery with a stenosis is analyzed, assuming the flow is steady and blood is treated as non-Newtonian power law fluid model. Exact solution has been evaluated for velocity, resistance impedance, wall shear stress and shearing stress at the stenosis throat. The graphical results of different types of tapered arteries (i.e. converging tapering, diverging tapering, non-tapered artery) have been examined for different parameters of interest. Some special cases of the problem are also presented.     

A general theoretical model for the magnetohydrodynamic flow of micropolar magnetic fluids. Application to Stokes flow

Many practical applications, which have an inherent interest of physical and mathematical nature, involve the hydrodynamic flow in the presence of a magnetic field. Magnetic fluids comprise a novel class of engineering materials, where the coexistence of liquid and magnetic properties provides us with the opportunity to solve problems with high mathematical and technical complexity. Here, our purpose is to examine the micropolar magnetohydrodynamic flow of magnetic fluids by considering a colloidal suspension of ferromagnetic material (usually non‐conductive) in a carrier magnetic liquid, which is in general electrically conductive. In this case, the ferromagnetic particles behave as rigid magnetic dipoles. Thus, the application of an external magnetic field, apart from the creation of an induced magnetic field of minor significance, will prevent the rotation of each particle, increasing the effective viscosity of the fluid and will cause the appearance of an additional magnetic pressure. Despite the fact that the general consideration consists of rigid particles of arbitrary shape, the assumption of spherical geometry is a very good approximation as a consequence of their small size. Our goal is to develop a general three‐dimensional theoretical model that conforms to physical reality and at the same time permits the analytical investigation of the partial differential equations, which govern the micropolar hydrodynamic flow in such magnetic liquids. Furthermore, in the aim of establishing the consistency of our proposed model with the principles of both ferrohydrodynamics and magnetohydrodynamics, we take into account both magnetization and electrical conductivity of the fluid, respectively. Under this consideration, we perform an analytical treatment of these equations in order to obtain the three‐dimensional effective viscosity and total pressure in terms of the velocity field, the total (applied and induced) magnetic field and the hydrodynamic and magnetic properties of the fluid, independently of the geometry of the flow. Moreover, we demonstrate the usefulness of our analytical approach by assuming a degenerate case of the aforementioned method, which is based on the reduction of the partial differential equations to a simpler shape that is similar to Stokes flow for the creeping motion of magnetic fluids. In view of this aim, we use the potential representation theory to construct a new complete and unique differential representation of magnetic Stokes flow, valid for non‐axisymmetric geometries, which provides the velocity and total pressure fields in terms of easy‐to‐find potentials, via an analytical fashion. Copyright © 2009 John Wiley & Sons, Ltd.     

Application of Adomian's approximation to blood flow through arteries in the presence of a magnetic field

The present investigation deals with the application of Adomian's decomposition method to blood flow through a constricted artery in the presence of an external transverse magnetic field which is applied uniformly. The blood flowing through the tube is assumed to be Newtonian in character. The expressions for the two-term approximation to the solution of stream function, axial velocity component and wall shear stress are obtained in this analysis. The numerical solutions of the wall shear stress for different values of Reynold number and Hartmann number are shown graphically. The solution of this theoretical result for a particular Hartmann number is compared with the integral method solution of Morgan and Young [17].     

Performance modeling and analysis of blood flow in elastic arteries

The effect of magnetic field has been examined on rheological models of blood. One. of them is the Power Law model and the other is the generalized Maxwell model. It is noticed that the magnetic field has a significant effect on the flow phenomena. The investigation shows that the model considered here is capable of taking into account the rheological properties affecting the blood flow and hemodynamic features, which may be important for medical doctors to predict diseases for individuals on the basis of the pattern of flow for an elastic artery in the presence of a transverses magnetic field. The effects of a magnetic field have been used to control the flow, which may be useful in certain hypertension cases, etc.     

A numerical simulation of unsteady blood flow through multi-irregular arterial stenoses

An unsteady mathematical model to study the characteristics of blood flowing through an arterial segment in the presence of a couple of stenoses with surface irregularities is developed. The flow is treated to be axisymmetric, with an outline of the stenoses obtained from a three dimensional casting of a mildly stenosed artery [1], so that the flow effectively becomes two-dimensional. The governing equations of motion accompanied by appropriate choice of boundary and initial conditions are solved numerically by MAC (Marker and Cell) method in cylindrical polar coordinate system in staggered grids and checked numerical stability with desired degree of accuracy. The pressure-Poisson equation has been solved by successive-over-relaxation (SOR) method and the pressure–velocity correction formulae have been derived. The flexibility of the arterial wall has also been accounted for in the present investigation. Further, in-depth study in the flow pattern reveals that the separation Reynolds number for the multi-irregular stenoses is lower than those for cosine-shaped stenoses and a long single irregular stenosis. The present results predict the excess pressure drop across the cosine stenoses than the irregular ones and show quite consistency with several existing results in the literature which substantiate sufficiently to validate the applicability of the model under consideration.     

Effects of variable viscosity on pulsatile flow of blood in a tapered stenotic flexible artery

The objective of the present study is to investigate the effects of variable viscosity on incompressible laminar pulsatile flow of blood through an overlapping doubly constricted tapered artery. To mimic the realistic situation, wall of the artery is taken to be flexible, and physiologically relevant pulsatile flow is introduced. The governing equations of blood flow are made dimensionless. A coordinate transformation is used to make the overlapping doubly constricted wall geometry of tube to a straight tube. Taking advantage of the Stream function–Vorticity formulation, the system of partial differential equations is then solved numerically by finite difference approximations. Effects of Reynolds number, Strouhal number, degree of contraction, tapering angle, and viscosity parameters are presented graphically and analyzed. The results show that formation of stenosis and tapering disturb the flow field significantly, and degree of stenosis is more important in influencing blood flow compared with tapering.