Synthesis of Cationic Cholesterol Derivatives with Fragments of Aliphatic Nitrogen-Containing Bases

Cationic cholesterol derivatives were synthesized, in which fragments of aliphatic amines (2-di-methylaminoethanol, N,N-dimethylethylenediamine, and N,N,N',N'-tetramethylethylenediamine) are attached to the cholesterol backbone either directly or through a spacer ester or carbamate moiety. The products may be used as efficient agents for liposome-mediated transfection.     

Synthesis of New Water-Soluble Cholesterol Derivatives

L-Proline has been used as an organocatalyst for an efficient synthesis of 1,8-dioxo-octahydroxanthenes by treatment of aldehydes (aromatic, heteroaromatic, and aliphatic) with 5,5-dimethyl-1,3-cyclohexanedione. Three new compounds have been prepared.     

含偶氮苯基团的阳离子表面活性剂的合成

以对硝基苯酚为原料,经偶氮,Williamson醚化和季铵化反应合成了一种疏水基中间含偶氮苯基团的阳离子表面活性剂,其结构经1H NMR,IR和元素分析表征.     

Cationic Amphiphiles of Methylphosphonates and Cholesterol Phosphocholines and Their Homo Derivatives

A method of synthesis of (PO) and (PN)-choline cholesteryl methylphosphonates and their homo derivatives of the cationic type is developed. These compounds were obtained by the Arbuzov reaction between bromomethane and cyclic cholesteryl phosphorous esters and amidoesters and subsequent aminolysis of the intermediate bromoalkyl phosphonates. Alkylation of trimethylamine with cholesteryl ethanediyl and propanediyl phosphates gives cholesterol phosphocholines and their homo derivatives.     

含酰胺基Gemini阳离子表面活性剂的合成

含酰胺基Gemini阳离子表面活性剂的合成     

含芳香基的乙二胺四乙酸酰胺衍生物的合成

乙二胺四乙酸二酐(1)与氨基芳香酸(2)进行酰化反应,合成了3种新型含芳香基的乙二胺四乙酸酰胺衍生物,其结构经UV,1H NMR,IR和元素分析表征。探讨了反应条件对收率的影响,在最佳反应条件[110mmol,n(1)∶n(2)=1∶2,pH 3~4时,于40℃反应12 h]下,收率高于75%。     

Cationic Xylan Derivatives with High Degree of Functionalization

Xylan from birch wood was characterized regarding both the supramolecular structure (X-ray, CP/MAS ¹³C-NMR) and the sugar composition. The reaction of the birch wood xylan with 2,3-epoxypropyltrimethylammonium chloride in 1,2-dimethoxyethane as slurry medium yields water-soluble, cationic 2-hydroxypropyltrimethylammonium xylan derivatives with high degree of substitution (DS). The DS values up to 1.6 can be controlled by adjusting the molar ratio in a one step synthesis. The structure of the cationic xylan derivatives was confirmed by means of DEPT(135) NMR spectroscopy. Film forming properties of cationic xylan derivatives were investigated with SEM measurements.     

Synthesis and Photoinitiated Cationic Polymerization of Epoxidized Castor Oil and Its Derivatives

ABSTRACT

In this communication we describe the synthesis of epoxidized castor oil (ECO) as an interesting and inexpensive biorenewable monomer by an efficient and low cost epoxidation process. Also described are studies of the photoinitiated cationic polymerization of ECO using diaryliodonium salt photoinitiators. The influence of the structure and the concentration of the photoinitiator on the polymerization are reported. The ability of photosensitizers to accelerate the photopolymerization was also studied. Studies comparing the photopolymerization behavior of ECO with other commercially available epoxidized linseed and soybean oils and with other types of synthetic epoxy monomers were conducted. The excellent reactivity of ECO can be ascribed to the presence of both epoxy and hydroxyl groups in the molecule which permits this material to polymerize mainly by an activated monomer mechanism.

     

氰基修饰的新型寡聚噻吩衍生物的合成

以2,3,4,5-四碘代噻吩为起始原料,利用Suzuki偶联反应来构筑分子骨架,合成了3个氰基和烷基修饰的新型寡聚噻吩衍生物,其结构经1H NMR,13C NMR,EI-MS和元素分析表征。     

胆汁酸及其丁二酸衍生物的快速原子轰击质谱

本文研究游离胆汁酸及其丁二酸衍生物的快速原子轰击(FAB)质谱.用甘油或硫甘醇作样品的基质,具有不同的灵敏度增强效应。FAB负离子质谱,获得[M-n]^-典型离子簇,[M-1]^-作为最强离子是每一个样品的基峰.     

Synthesis of Cholesterol Derivative with Amino Acid as Hydrophilic Group and the Vesicles Prepared Therefrom

Cholesterolisoneofthemainconstituentsofmembranelipidsandhasbeenconsideredtogovernthemembranefluidityandpermeabilityofsolutes'.Inthecourseofstudyonliposomesconstructedbyphospholipidsasmodelbiomembraneordrugdeliverysystem,itwasalsofoundthatthestabilityofliposomeswasenhancedbyincorporationofcholesterolintothelipidbilayerZ".Allthesepropertiesofcholesterolinmembranechemistryarecausedbyitsuniquesmicture,inwhichtherigidandflatsteroidalringshowsgoodcompatibilitywithlipid.DuetotheeXtraordinaryfijnctio…     

Cationic Hypericin Derivatives as Novel Agents with Photobactericidal Activity: Synthesis and Photodynamic Inactivation of Propionibacterium acnes

The present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. Uncharged hypericin derivatives with ω , ω '-attached C₂-linkers leading to a pyridyl or a 4-dimethylaminophenyl residue were prepared and subsequently quaternized by means of iodomethane. Photobactericidal activity was assessed using Propionibacterium acnes . The quaternary N , N , N -trimethyl-anilinium derivative displayed a pronounced photodynamic inactivation of the bacteria at low incubation concentrations (<100 n m ) and a short incubation time (1 h) after illumination with yellow light (590 nm, 20 J cm⁻²), whereas the photobactericidal efficacy of the N -methyl-pyridinium derivative was negligible under identical experimental conditions.     

Synthesis and Photovoltaic Properties of Ester Group Functionalized Polythiophene Derivatives

To increase the open circuit voltage (V_OC) of polymer solar cells (PSCs) based on polythiophene, two new ester group functionalized polythiophene derivatives, PCTDT and PCTBDT, were designed and synthesized via alternating copolymerization of thiophene‐3‐carboxylate (CT) with the 2,2′‐bithiophene (DT) and benzodithiophene (BDT) units, respectively. The resulting copolymers exhibited broad and strong absorptions in the visible region, which was similar to that of the commonly used poly(3‐hexylthiophene) (P3HT). Through cyclic voltammetry measurements, it was found that both copolymers showed lower HOMO energy levels (−5.27 eV for PCTDT and −5.36 eV for PCTBDT) than that of P3HT (−5.03 eV), indicating that the HOMO energy level could be efficiently reduced by introducing the ester group into the polymer side chain. Photovoltaic properties of the copolymers blended with [6,6]‐phenyl‐C₆₁‐butyric acid methyl ester (PCBM) as electron acceptor were investigated. The obtained two devices possessed both relatively large short circuit current (I_SC) and higher V_OC than that of P3HT:PCBM blend. For PCTBDT:PCBM blend, a power conversion efficiency (PCE) up to 2.32%, an I_SC of 6.94 mA · cm⁻², and a V_OC of 0.80 V were observed while PCTDT:PCBM system demonstrated a PCE of 1.75% with a V_OC of 0.68 V.

     

异戊烯基取代的黄烷酮衍生物的合成及杀菌活性

异戊烯基溴;异戊烯基取代的黄烷酮衍生物的合成及杀菌活性     

对羟基苯甲醛磷酸酯席夫碱衍生物的合成及其抗抑郁活性

以对羟基苯甲醛为起始原料,经醚化和酯化反应制得中间体4-（2-羟乙氧基）苯甲醛磷酸二甲酯（2）; 2分别与伯胺经缩合反应合成了4个对羟基苯甲醛磷酸酯席夫碱衍生物（4a~4d）,其结构经¹H NMR, ¹³C NMR, IR和ESI-MS确证。采用应急模型对4a~4d进行抗抑郁活性研究。初步结果表明： 2和4-（2-羟乙氧基）苯甲醛磷酸二甲酯甲氧基胺席夫碱（4d）表现出较好的抗抑郁活性,2的活性优于丙咪嗪,4d的活性与丙咪嗪接近。     

含羟基芳基或氨基芳基的磷酰胺酯衍生物的合成

采用均相反应的方法合成了6个含羟基芳基或氨基芳基的磷酰胺酯衍生物:[(ClCH_2CH_2)_2NP(O)(OPh)(XArY)](X:O,NH;Y:m或p-OH或NH_2).用元素分析、红外光谱、氢核磁共振谱及质谱证实了它们的组成及结构.     

Antimicrobial Activity of Gemini Surfactants with Ether Group in the Spacer Part

Due to their large possibility of the structure modification, alkylammonium gemini surfactants are a rapidly growing class of compounds. They exhibit significant surface, aggregation and antimicrobial properties. Due to the fact that, in order to achieve the desired utility effect, the minimal concentration of compounds are used, they are in line with the principle of greenolution (green evolution) in chemistry. In this study, we present innovative synthesis of the homologous series of gemini surfactants modified at the spacer by the ether group, i.e., 3-oxa-1,5-pentane-bis(N-alkyl-N,N-dimethylammonium bromides). The critical micelle concentrations were determined. The minimal inhibitory concentrations of the synthesized compounds were determined against bacteria Escherichia coli ATCC 10536 and Staphylococcus aureus ATCC 6538; yeast Candida albicans ATCC 10231; and molds Aspergillus niger ATCC 16401 and Penicillium chrysogenum ATCC 60739. We also investigated the relationship between antimicrobial activity and alkyl chain length or the nature of the spacer. The obtained results indicate that the synthesized compounds are effective microbicides with a broad spectrum of biocidal activity.     

Synthesis,Properties, and Application of Cationic Reactive Disperse Dyes Containing Quaternary Group

A series of cationic reactive disperse dyes containing quaternary group were synthesized. The dyeing behavior of these dyes on wool was studied. The results show that cationic reactive disperse dyes containing quaternary group is available to form covalent bond with nucleophiles in the wool even under acidic condition. The fastness on wool was excellent.