一个肿瘤生长自由边界问题的研究

本文研究一个描述肿瘤生长的自由边界问题.这个自由边界问题是对Byrne和Chaplain相应肿瘤生长模型的一个改进,研究了该问题解当t→∞时的渐近状况,证明了未血管化的肿瘤体积不会无限制地增大,它或者趋于消失,或者趋于一个休眠态,依营养物浓度的大小和抑制物浓度的大小而定.     

一个肿瘤生长自由边界问题的研究

本文研究一个描述肿瘤生长的自由边界问题.这个自由边界问题是对Byrne和Chaplain相应肿瘤生长模型的一个改进,研究了该问题解当t→∞时的渐近状况,证明了未血管化的肿瘤体积不会无限制地增大,它或者趋于消失,或者趋于一个休眠态,依营养物浓度的大小和抑制物浓度的大小而定.     

一类周期自由边界问题解的渐近性态

本文证明了化学反应扩散过程中的一类周期自由边界问题古典解的存在唯一性，并且讨论了潜热L→0时周期Stefan问题古典解的渐近性态及误差估计．     

一个药物作用肿瘤生长自由边界问题整体解的存在唯一性

该文研究一个描述药物作用下肿瘤生长的数学模型,这个肿瘤模型是对Jackson模型的一个改进,其数学形式是由一个二阶非线性抛物型方程与两个一阶非线性偏微分方程组耦合而成的自由边界问题.通过运用抛物型方程的L~P理论与一阶偏微分方程的特征方法,并利用Banach不动点定理,证明了该问题存在唯一的整体经典解.     

肿瘤生长的自由边界问题

本文介绍肿瘤生长的自由边界问题这一新兴研究方向的研究内容和进展状况.文章首先介绍肿瘤生长的数学建模历史、最新进展和一些重要的肿瘤生长模型,这些模型的数学形式是偏微分方程的自由边界问题.之后介绍近几年人们对这些自由边界问题所做严谨数学理论分析获得的一些主要成果,并简单介绍了证明这些成果用到的数学理论和方法.     

一个肿瘤生长自由边界问题解的整体存在性和唯一性

该文研究一个反应扩散方程组的自由边界问题,它来源于描述抑制物作用下无坏死核肿瘤生长的数学模型.作者运用抛物型方程的L_p理论和压缩映照原理,证明了这个问题局部解的存在唯一性,然后用延拓方法得到了整体解的存在唯一性.     

一个关于肿瘤治疗的自由边界问题的数学分析

§1Introduction Avarietyofpartialdifferentialequationmodelsfortumorgrowthortherapyhave beendevelopedinthelastthreedecades[see2,3,16-18,21-26].Mostofthosemodelsare informoffreeboundaryproblems,andareverydiversified.Rigorousmathematical analysisofsuchfreeboundaryproblemshasdrawngreatinterest,andmanyinteresting resultshavebeenestablished[4-15].Inthispaperwedealwithamathematicalmodeldescribingtumorchemotherapy.In thismodelthetumorisviewedasdenselypacked,radially-symmetricsphereofradiusR(t)contain…     

高阶微分方程解的渐近性态

对高阶微分方程x~(n)+F(t,x,…,x~(n-1)=0及x~(n)+H_n(t,x~(n-1)+…+H_1(t,x)=f(t),本文得到了有解(?)x~(n-1)存在且不为零的的定理1、1＇,从而把文[1]、[2]、[3]在二阶微分方程的结果完善地推广到一般高阶微分方程。另外本文还得到了上面微分方程有解逼近方程 x~(n)=0的解的定理2,2＇。本文的推论证明本文定理1、1＇的条件是必要的.     

一种肿瘤生长自由边界问题整体解的存在唯一性

研究了一种肿瘤生长模型中自由边界问题,该肿瘤生长模型异于其它此类模型之处就在于采用了新的方式来描述繁衍细胞和休眠细胞的运动．运用抛物型方程的Lp理论和不动点原理,证明了该模型存在唯一的整体解．     

线性时滞微分方程解的渐近性态

本文用一个简单的方法证明了一类一阶线性时滞微分方程解的有界性帮必有非振动解，分析了振动解的性质。这个方法也被用来讨论一阶时滞方程组和中立型微分方程，所得结果均较简明。     

Analysis of a Free Boundary Problem Modeling Tumor Growth

In this paper, we study a free boundary problem arising from the modeling of tumor growth. The problem comprises two unknown functions： R = R（t）, the radius of the tumor, and u = u（r, t）, the concentration of nutrient in the tumor. The function u satisfies a nonlinear reaction diffusion equation in the region 0 〈 r 〈 R（t）, t 〉 0, and the function R satisfies a nonlinear integrodifferential equation containing u. Under some general conditions, we establish global existence of transient solutions, unique existence of a stationary solution, and convergence of transient solutions toward the stationary solution as t →∞.     

Global Existence for a Parabolic-hyperbolic Free Boundary Problem Modelling Tumor Growth

In this paper we study a free boundary problem modelling tumor growth, proposed by A. Friedman in 2004. This free boundary problem involves a nonlinear second-order parabolic equation describing the diffusion of nutrient in the tumor, and three nonlinear first-order hyperbolic equations describing the evolution of proliferative cells, quiescent cells and dead cells, respectively. By applying Lp theory of parabolic equations, the characteristic theory of hyperbolic equations, and the Banach fixed point theorem, we prove that this problem has a unique global classical solution.     

Asymptotic Behaviour of Solutions of a Multidimensional Moving Boundary Problem Modeling Tumor Growth

We study a moving boundary problem modeling the growth of multicellular spheroids or in vitro tumors. This model consists of two elliptic equations describing the concentration of a nutrient and the distribution of the internal pressure in the tumor's body, respectively. The driving mechanism of the evolution of the tumor surface is governed by Darcy's law. Finally surface tension effects on the moving boundary are taken into account which are considered to counterbalance the internal pressure. To put our analysis on a solid basis, we first state a local well-posedness result for general initial data. However, the main purpose of our study is the investigation of the asymptotic behaviour of solutions as time goes to infinity. As a result of a centre manifold analysis, we prove that if the initial domain is sufficiently close to a Euclidean ball in the C ^m+μ-norm with m ≥ 3 and μ ∈ (0,1), then the solution exists globally and the corresponding domains converge exponentially fast to some (possibly shifted) ball, provided the surface tension coefficient γ is larger than a positive threshold value γ_*. In the case 0 < γ < γ_* the radially symmetric equilibrium is unstable.     

Asymptotic Behavior of Solutions to a Class of Semilinear Parabolic Equations with Boundary Degeneracy

This paper concerns the asymptotic behavior of solutions to one-dimensional semilinear parabolic equations with boundary degeneracy both in bounded and unbounded intervals. For the problem in a bounded interval, it is shown that there exist both nontrivial global solutions for small initial data and blowing-up solutions for large one if the degeneracy is not strong. Whereas in the case that the degeneracy is strong enough, the nontrivial solution must blow up in a finite time. For the problem in an unbounded interval, blowing-up theorems of Fujita type are established. It is shown that the critical Fujita exponent depends on the degeneracy of the equation and the asymptotic behavior of the diffusion coefficient at infinity, and it may be equal to one or infinity. Furthermore, the critical case is proved to belong to the blowing-up case.     

Analysis of a Free Boundary Problem Modeling Multi- Layer Tumor Growth in Presence of Inhibitor

In this paper we study well-posedness and asymptotic behavior of solution of a free boundary problem modeling the growth of multi-layer tumors under the action of an external inhibitor. We first prove that this problem is locally well-posed in little Holder spaces. Next we investigate asymptotic behavior of the solution. By making delicate analysis of spectrum of the linearization of the stationary free boundary problem and using the linearized stability theorem, we prove that if the surface tension coefficient γ is larger than γ^＊ 〉 0 the fiat stationary solution is asymptotically stable provided that the constant c representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficient small.     

一类Sturm-Liouville问题特征的渐近分析

考虑[0,1]上带第三类边界条件的S-L问题特征值的渐近表示.利用已有的渐近性结果及Fr啨chet导数技术,对特征值进行了精细的分析,清楚地给出了边界条件中的常数(h,H)对特征值的影响.本文的工作对S-L问题的一类反谱问题及相关微分方程反问题的唯一性结果有着重要的应用,也为专著[4,6]中的某些关键结果提供了一个简化的证明途径.     

Blowup and Asymptotic Behavior of a Free Boundary Problem with a Nonlinear Memory

In this paper, we investigate a reaction-diffusion equation $u_t-du_{xx}=au+\int_{0}^{t}u^p(x,\tau){\rm d}\tau+k(x)$ with double free boundaries. We study blowup phenomena in finite time and asymptotic behavior of time-global solutions. Our results show if $\int_{-h_0}^{h_0}k(x)\psi_1 {\rm d}x$ is large enough, then the blowup occurs. Meanwhile we also prove when $T^*<+\infty$, the solution must blow up in finite time. On the other hand, we prove that the solution decays at an exponential rate and the two free boundaries converge to a finite limit provided the initial datum is small sufficiently.     

Global Existence and Asymptotic Behavior of Solutions to a Free Boundary Problem for the 1D Viscous Radiative and Reactive Gas

In this paper, we study a free boundary problem for the 1D viscous radiative and reactive gas. We prove that for any large initial data, the problem admits a unique global generalized solution. Meanwhile, we obtain the time-asymptotic behavior of the global solutions. Our results improve and generalize the previous work.