共查询到20条相似文献,搜索用时 15 毫秒
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Juan‐José Cid Dr. Miguel García‐Iglesias Jun‐Ho Yum Dr. Amparo Forneli Josep Albero Eugenia Martínez‐Ferrero Dr. Purificación Vázquez Prof. Michael Grätzel Prof. Mohammad K. Nazeeruddin Prof. Emilio Palomares Prof. Tomás Torres Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(20):5130-5137
Let it shine! The impact of the anchoring group on photovoltaic performance by a series of phthalocyanine sensitisers (see figure) has been demonstrated.
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取代锌酞菁的合成及光物理性质 总被引:14,自引:0,他引:14
取代锌酞菁的合成及光物理性质张先付,许慧君(中国科学院感光化学研究所,北京,100101)关键词取代酞菁,合成,光物理性质,电荷转移癌症的光动力疗法及其机制是目前光医学、光生物学及光化学的前沿课题[1]。临床应用的光疗药物──血卟啉有一些难以克服的致... 相似文献
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A new class of metal phthalocyanines(MPcs) containing four 8-quinolinol(8-QH) derivative moieties were successfully synthesized and characterized by mass spectroscopy, IR, UV-Vis and element analysis, the results of which were consistent with the proposed structures. All of them can dissolve in common organic solvents, such as dichloromethane, chloroform, and acetone. The effect of metal ion on the absorption of Q band was studied with UV-Vis spectra. The fluorescent properties for those complexes were also investigated. 相似文献
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以非经典叶酸拮抗剂2,4-二氨基-6-(4-甲基苯基)乙基吡啶并[3,2-d]嘧啶(wm-5b)及其侧链简化产物2,4-二氨基吡啶并[3,2-d]嘧啶为先导化合物, 选取具有抗肿瘤活性的基团, 通过微波法高效合成了2-位或4-位取代吡啶并嘧啶类非经典叶酸拮抗剂, 研究了2-位及4-位取代基对抗肿瘤活性的影响, 为非经典叶酸拮抗剂的设计合成提供了更多的理论依据. 目标化合物的结构均经核磁共振波谱(NMR)和质谱(MS)确证. 生物活性测定结果表明, 所有目标化合物均具有抗肿瘤活性, 其中, 6-(4-甲基苯基)乙基-4-氨基-2-(3-氯-4-氟苯基)氨基吡啶并[3,2-d]嘧啶(6b)对HL-60细胞的IC50=(4.09±0.48) μmol/L, 对A549细胞的IC50=(17.99±7.20) μmol/L, 而对HCT116细胞的IC50=(14.52±4.74) μmol/L; 部分目标化合物具有二氢叶酸还原酶抑制活性. 此外, 对部分目标化合物和先导物进行了二氢叶酸还原酶晶体结构的分子对接, 对活性结果和构效关系从分子水平上进行解释. 相似文献
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酞菁配合物的结构与其光动力抗癌活性 总被引:9,自引:0,他引:9
光动力治疗是一种正在发展中的治疗癌症的新方法.主要是利用抗癌光敏剂可优先在 肿瘤组织中富集的特性和随后在适当波长的光照下所引发的光敏化反应来杀死癌肿瘤.自198 5年以来,酞菁配合物作为抗癌光敏剂的研究越来越引人注目. 此文在总结51篇参考文献的 基础上,提出了酞菁配合物的结构与其光动力抗癌活性的某些相关性,着重讨论了中心离子 、环取代基、轴向配体对光动力活性和相关物化性质的影响.得出的一个主要的结论是两亲 性酞菁是极具潜力的光敏剂. 相似文献
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Kupriyan D. G. Anikin V. F. Merz A. Pantsenker L. D. 《Russian Journal of Organic Chemistry》2004,40(5):699-704
The synthetic route to 4-substituted bisnaphthalimides consisting in reaction of 4-halonaphthalic anhydrides with a,w-diaminoalkanes followed by halogen substitution with dialkylamino group is more promising than imidating coupling of 4-dialkylaminonaphthalic anhydrides for it opens wider synthetic opportunities and ensures better yields of target products. Dihalosubstituted bis-naphthalimides can be prepared by N-alkylation of the corresponding naphthalimides with polymethylene dibromides under conditions of phase-transfer catalysis in the presence of tetraalkylammonium salts. 相似文献
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Mastaneh Safarnejad Shad Sandra Claes Eline Goffin Tom Van Loy Dominique Schols Steven De Jonghe Wim Dehaen 《Molecules (Basel, Switzerland)》2021,26(20)
An expansion of the structure–activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines, bearing a tetrahydroquinoline or a 3-methylpyridinyl moiety as head group. All compounds were investigated for CXCR4 affinity and antagonism in competition binding and calcium mobilization assays, respectively. In addition, the anti-HIV activity of all analogues was determined. All compounds showed excellent activity, with compound 24c being the most promising one, since it displayed consistently low nanomolar activity in the various assays. 相似文献
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Compounds containing 1,2,3-thiodiazole ring were reported to posses fungicidal1, herbicidal2 and growth regulation properties3. For example, N-phenyl-N'-1,2,3-thiadizazol-5-yl-urea (Thidiazuron, Dropp) has been used as a cotton defoliant4, herbicide and was also found to exhibit cytokinin-like activity in bioassay systems. The compound was more effective than Zeatin5 and 6-BA6. Because the synthesis of 1,2,3-thiodiazole ring is difficult,compounds containing 1,2,3-thiadiazole ring are relatively seldom reported. Herein, we report the synthesis of a novel series of α-substituted-1,2,3-thiadiazole-4-acetic acid derivatives. 相似文献
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L. Leite D. Jansone M. Fleisher H. Kazhoka J. Popelis N. Veretennikova I. Shestakova I. Domracheva E. Lukevics 《Chemistry of Heterocyclic Compounds》2004,40(6):715-724
The respective 4-(arylvinyl)lactones and compounds of the Michael adduct type were synthesized by the condensation of substituted benzaldehydes with 3-cyano-4,6,6-trimethyl-5,6-dihydro-2-pyranone in the presence of catalytic amounts of sodium hydroxide. It was shown by the semiempirical AM1 method that the indicated products can be formed through one and the same intermediate compound. Some of the synthesized phenylvinyl-5,6-dihydro-2-pyranones have a cytotoxic effect, and this corresponds to the prognosis of the OREX expert system. 相似文献
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