共查询到20条相似文献,搜索用时 15 毫秒
1.
A naked-eye turn-on fluorescent Fe3+ probe (RQ6) was developed by linking a new conjugated quinoline fluorescent group to the rhodamine platform. The probe can detect Fe3+ with high selectivity over other metal ions. Bioimaging studies indicated that RQ6 was cell permeable and suitable for detecting Fe3+ in the living cells by confocal microscopy. 相似文献
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A. Yu. Mironenko M.V. Tutov A.K. Chepak P.A. Zadorozhny S. Yu. Bratskaya 《Tetrahedron》2019,75(11):1492-1496
In this work, we design and synthesize the novel probe RC through introduction the 1-aza-4,13-dithia-15-crown-5 ring into the structure of rhodamine 6G hydrazide, where the N atom of crown ring is responsible for quenching of rhodamine fluorescence. The compound obtained behaves as multifunctional cation sensor providing selective fluorescent response to Au3+ and selective colorimetric response to Cu2+ ions in aqueous acetonitrile (1/1, v/v) at pH 7.0. The use of 10?5?M RC solution allowed reliable determination of target cations in the presence of a wide range of environmentally relevant ions with detection limits of 2?×?10?6?M and 5?×?10?7?M for gold and copper, respectively. 相似文献
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A new fluorescent ‘‘on–off' chemosensor for Hg2+initiated by a derivative of rhodamine B was designed and synthesized. Compound 1 exhibited high sensitivity and selectivity for Hg2+over other commonly coexistent metal ions in aqueous media. Upon the addition of Hg2+, the spirocyclic ring of probe is opened and a significant enhancement of visible color and fluorescence in the range of 500–600 nm is observed. The colorimetric and fluorescent response to Hg2+can be conveniently detected by the naked eye, which provides a facile method for visual detection of Hg2+. From the molecular structure and spectral results of 1, an irreversible, hydrolysis, desulfurization reaction mechanism is proposed. 相似文献
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Siyue Ma Linyang Li Mengyao She Yan Mo Shengyong Zhang Ping Liu Jianli Li 《中国化学快报》2017,28(10):2014-2018
Rhodamine-based fluorescent probe is widely used in chemical analysis, environmental analysis and life sciences area due to their excellent optical properties. Based on the thiophilic property of Hg~(2+), using C = S structural motif as the core segment, our group have designed and synthesized three novel probes containing cinnamyl aldehyde with different substituents, exhibiting high selectivity and excellent sensitivity. The structure-property relationships of these probes have been investigated that the optical change caused by electron withdrawing effect and heavy atom effect. Furthermore, these Hg~(2+) probes could be applied in living mice imaging, which provide a promising tool for quantitative mercury(Ⅱ) ion imaging in living organism. 相似文献
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Three novel rhodamine-based Hg~(2+) fluorescent sensors were designed and synthesized. The sensors could work in semi-aqueous solutions with nearly neutral p H and showed high selectivity and sensitivity to Hg~(2+) with remarkable fluorescence enhancement. For these three sensors, the linear working range broadened(0–80, 0–100 and 0–140 μmol/L, respectively) and the sensitivity increased(7.7, 15.5 and 17.6 folds of the fluorescence enhancement and 512, 66.2 and 37.6 ppb of the detection limit) with the rising of the thiourea-unit numbers. Furthermore the sensors exhibited excellent interference immunity to multiple environmentally and biologically relevant metal ions. Pond and tap water assay showed good practicability of the sensors. The number of the bound Hg~(2+) equaling to that of the thiourea units and the irreversible recognition process implied a new interaction way between Hg~(2+) and the sensor. 相似文献
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Qiu-Juan Ma Xiao-Bing Zhang Xu-Hua Zhao Guo-Jiang Mao Ru-Qin Yu 《Analytica chimica acta》2010,663(1):85-1197
A fluorescent probe 1 for Hg2+ based on a rhodamine-coumarin conjugate was designed and synthesized. Probe 1 exhibits high sensitivity and selectivity for sensing Hg2+, and about a 24-fold increase in fluorescence emission intensity is observed upon binding excess Hg2+ in 50% water/ethanol buffered at pH 7.24. The fluorescence response to Hg2+ is attributed to the 1:1 complex formation between probe 1 and Hg2+, which has been utilized as the basis for the selective detection of Hg2+. Besides, probe 1 was also found to show a reversible dual chromo- and fluorogenic response toward Hg2+ likely due to the chelation-induced ring opening of rhodamine spirolactam. The analytical performance characteristics of the proposed Hg2+-sensitive probe were investigated. The linear response range covers a concentration range of Hg2+ from 8.0 × 10−8 to 1.0 × 10−5 mol L−1 and the detection limit is 4.0 × 10−8 mol L−1. The determination of Hg2+ in both tap and river water samples displays satisfactory results. 相似文献
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Triphenylmethane (TPM) dyes normally render rather weak fluorescence due to easy vibrational deexcitation. However, when they stack onto the two external G-quartets of a G-quadruplex (especially intramolecular G-quadruplex), such vibrations will be restricted, resulting in greatly enhanced fluorescence intensities. Thus, TPM dyes may be developed as sensitive G-quadruplex fluorescent probes. Here, fluorescence spectra and energy transfer spectra of five TPM dyes in the presence of G-quadruplexes, single- or double-stranded DNAs were compared. The results show that the fluorescence spectra of four TPM dyes can be used to discriminate intramolecular G-quadruplexes from intermolecular G-quadruplexes, single- and double-stranded DNAs. The energy transfer fluorescence spectra and energy transfer fluorescence titration can be used to distinguish G-quadruplexes (including intramolecular and intermolecular G-quadruplexes) from single- and double-stranded DNAs. Positive charges and substituent size in TPM dyes may be two important factors in influencing the binding stability of the dyes and G-quadruplexes. 相似文献
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《Arabian Journal of Chemistry》2022,15(7):103929
The detection of acetylcholinesterase (AChE) activity is of great significance for studying the physiological functions of AChE and clinical diagnosis of pesticide poisoning. Herein, a small-molecule fluorescent probe BDFA was rationally designed and readily synthesized via a one-step reaction, which enables qualitative and quantitative detection of AChE. BDFA emits a slight fluorescence in an aqueous medium, while the fluorescence is significantly enhanced under the catalysis of AChE. Mechanism studies reveal that BDFA eliminates the N, N-dimethyl carbamate protective group in the presence of AChE and then spontaneously undergoes intramolecular cyclization conversion to generate an intense fluorescent product. Based on the above mechanism, BDFA exhibits a sensitive, selective, rapid and stable “turn-on” fluorescence response to AChE, without interference from pH, ions, thiols, amino acids and other enzymes. The fluorescence intensity of BDFA at 525 nm has a linear relationship with the AChE concentration in the range of 0.0045–1.0 U/mL, and the detection limit is 4.5 mU/mL. Moreover, BDFA is suitable for rapidly diagnosing AChE activity in blood samples, thus providing an efficient and convenient tool for diagnosing organophosphorus and carbamate pesticide poisoning. Compared with the reported AChE fluorescent probes, BDFA exhibits apparent advantages including simple synthesis, low detection limit and fast response speed. 相似文献
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Hye Gun Ryu Subhankar Singha Yong Woong Jun Ye Jin Reo Kyo Han Ahn 《Tetrahedron letters》2018,59(1):49-53
Hydrogen sulfide (H2S) is an endogenous gasotransmitter and plays intriguing biological roles. To study the biological role of H2S, efficient fluorescent probes are in great demand. For imaging of H2S in deep-tissue, a two-photon probe that emits in the red wavelength region is of choice to avoid the autofluorescence from intrinsic biomolecules. Here, we disclose such a probe, which, developed based on an acetyl benzocoumarin fluorophore, can be excited at 900?nm under two-photon excitation and emit in the red region. The probe shows high reactivity, selectivity, and sensitivity in in vitro assays. Two-photon microscopic imaging of H2S in HeLa cells aided by the probe demonstrates that it is potentially useful to study H2S level changes in cells and tissues influenced by external stimuli. 相似文献
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A new colorimetric and fluorescent sensor for the highly acidic pH was developed from rhodamine B, 1-(2-aminoethyl)piperazine, and 4-chloro-7-nitro-2,1,3-benzoxadiazole. The sensor could be synthesized in one pot with an 82.5% yield, and for the first time N,N-diisopropylethylamine was found to be crucial for the rhodamine spirolactam formation. The sensor responded to pH rapidly, visibly, reversibly, highly selectively, and sensitively. From pH 7.77 to 2.03, the absorption and fluorescence intensity of the sensor increased by 285 and 50.3 folds, respectively. The pKa value based on the fluorescence titration was 2.87. Fluorescent imaging of living cells treated with the sensor in different pH media indicated that the sensor could provide intracellular pH information. 相似文献
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A squaraine based fluorescent probe for mercury ion via coordination induced deaggregation signaling
Due to the high affinity between dithiocarbamate(DTC) and Hg2+,a fluorescent probe based on squaraine chromophore with DTC side arm for Hg2+via coordination induced deaggregation signaling has been designed and synthesized.Squaraine has a high tendency to aggregate in aqueous solution,and such self-aggregation usually results in a dramatic absorption spectral broadening with fluorescence emission quenching.The combination of the DTC side arm of the probe with Hg2+induces steric hindrance,leading to the deaggregation of the dye complex,companying with a fluorescence emission restoration.In EtOH–H2O(20:80,v/v) solution,this ‘‘turn on' fluorescent probe has high selectivity and sensitivity toward Hg2+over other metal ions,and the limit of detection for Hg2+was estimated as2.19 ? 10à8mol/L by 3s/k. 相似文献
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Ying Xia Xiaoyu Liu Dan Wang Zechen Wang Qiang Liu Haibo Yu Mingyan Zhang Youtao Song 《中国化学快报》2018,29(10):1517-1520
A colorimetric, fluorometric and mitochondrion-targetable probe (Rh-ClO) based on rhodamine B fluorophore and thiophene-2-carbohydrazide has been unveiled and successfully utilized for ClO- detection in water samples and HeLa cells. 相似文献
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Cuicui Jiang Mian Wang Yanxiu Wang Xiuneng Tang Yamin Zhang Hui Zhang Lin Ma Jianyi Wang 《Tetrahedron letters》2017,58(26):2560-2565
Two low cytotoxic fluorescence probes Rb1 and Rb2 detecting Fe3+ were synthesized and evaluated. Rb1 and Rb2 exhibited an excellent selectivity to Fe3+, which was not disturbed by Ag+, Li+, K+, Na+, NH4+, Fe2+, Pb2+, Ba2+, Cd2+, Ni2+, Co2+, Mn2+, Zn2+, Mg2+, Hg2+, Ca2+, Cu2+, Ce3+, AcO?, Br?, Cl?, HPO42?, HSO3?, I?, NO3?, S2O32?, SO32? and SO42? ions. The detection limits were 1.87 × 10?7 M for Rb1 and 5.60 × 10?7 M for Rb2, respectively. 1:1 stoichiometry and 1:2 stoichiometry were the most likely recognition mode of Rb1 or Rb2 towards Fe3+, and the corresponding OFF–ON fluorescence mechanisms of Rb1 and Rb2 were proposed. 相似文献
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A simple,water-soluble,Fe3+-selective fluorescent probe,derived from rhodamine B,was synthesized and characterized.The probe exhibits a fluorescence response toward Fe3+ with acceptable sensitivity and selectivity and even facilitates visual or naked-eye detection of Fe3+.The experiment results show that the response of the probe to Fe3+ is pH-independent over a wide range of 4.0-10.0.In addition,fluorescence microscopic imaging experiments have proven that the probe is cell permeable and can be used for monitoring intracellular Fe3+ in living cells. 相似文献
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Li Ling Hao Jun Fen Li Pei Hua Lin Rui Feng Dong Du Xin Li Shao Min Shuang Chuan Dong 《中国化学快报》2010,21(1):9-12
<正>A novel carbazole-based compound 5,3,6-bis[(N-ethylcarbazole-3-yl)-propene-1-keto]-N-ethylcarbazole has been designed, synthesized and characterized.The absorption and fluorescence spectra in solvents of different polarities prove that the compound has a distinct intramolecular charge transfer character.Compound 5 can be used as a new class of fluorescent probe or biosensor due to its sensitivity to the local microenvironment such as solvent polarity. 相似文献