共查询到20条相似文献,搜索用时 15 毫秒
1.
A short, practical, and efficient preparation of 2-(indol-3-yl)pyridine derivatives via a one-pot procedure of 3-cyanoacetylindole, chalcones, and ammonium acetate under microwave irradiation was described. All these compounds were obtained in good yield, and their structures were confirmed by 1H NMR, infrared, and elementary analysis. 相似文献
2.
微波辐射下2,7,7-三甲基-3-乙氧羰基-4-(3-硝基苯基) -5-氧代-1,4,5,6,7,8-六氢喹啉的合成和晶体结构 总被引:2,自引:0,他引:2
标题化合物C21H24N2O5是由间硝基苯甲醛、达咪酮、乙酰乙酸乙酯、醋酸铵在微波辐射下干反应而得。结构通过单晶X-射线衍射法确定,其晶体属斜方晶系,空间群 Pbcn, a =17.953(3), b =15.206(4), c =14.299(3), V =3904.(2)3, Mr =384.42, Z =8, Dc =1.308g/cm3 , m(MoKa) =0.094mm-1, F(000)=1632。晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R=0.0493, wR=0.1078。X-射线分析结果表明,吡啶环为船式构象,与之稠合的六元环为信封式构象。 相似文献
3.
1INTRODUCTIONThepyrazolo[3,4-b]pyridineclassofcompoundspossessmanybiologicalandpharmacologicalactivi-ties[1],suchasactiveanti-concretionmedicaments[2]aswellasactiveanti-gramnegativeandpositivebacteriaagents[3].Thereforethesynthesesofsuchcompoundshavearousedgreatattentionofalargenumberofchemists.Themostimportantsyntheticrouteisthecondensationreaction[4~11]ofamino-pyrazoleandα,β-unsaturatedcompounds.Theorganicreactionundermicrowaveirradia-tionhastheadvantagesoffastreactionspeed,shorttime… 相似文献
4.
5.
微波作用下3-取代-(1H)-嘧啶[1,2-a]喹啉-1-酮的一步合成法 总被引:1,自引:0,他引:1
5-(双甲硫基亚甲基 ) -2 ,2 -二甲基 -1 ,3 -二环己 -1 ,4-二酮 (1 ) [1] 既具有丙二酸亚异丙酯的环状结构 ,又具有乙烯基硫代缩酮的结构特征 .它是一种多功能的合成试剂 ,其最重要性质是可与多种亲核试剂发生加成反应 ,继而消除甲硫基 ,从而可以转变成一系列有用的合成中间体 (2 ) [2~ 5] .若亲核试剂具有两个亲核部位 Nu1及 Nu2 ,则 Nu1反应后 ,Nu2可进一步与丙二酸亚异丙酯的羰基进行分子内的亲核加成 ,从而形成环状化合物 (3 ) ,这一模式已在多种杂环化合物合成中获得应用[6~ 8] .Me SMe SOOMe OOMe + Nu1-Nu Me SNu1Nu … 相似文献
6.
标题化合物C14H15ClN2O3是由2-氯苯甲醛、乙酰乙酸乙酯、尿素在TsOH作用下用微波辐射反应得到, 结构通过单晶X-射线衍射法确定, 其晶体属三斜晶系, 空间群P, Mr = 294.73, a = 7.688(1), b = 9.106 (2), c = 11.412(2) ? = 102.963(3), = 105.957(2), g = 102.484(2), V = 714.9(2) ?, Z = 2, Dc = 1.369 g/cm3, = 0.276 mm-1, F(000) = 308, 最终的偏离因子为R = 0.0845, wR = 0.2092。在分子结构中嘧啶环为船式结构, 平面1(苯环)与平面2 ((C(8)C(9) C(10)N(2))之间的两面角为 91.57啊? 相似文献
7.
8.
Seref Demirayak Ahmet C. Karaburun Ismail Kayagil Umit Uçucu Rana Beis 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):1841-1848
In this study, some 2-[2-(benzazole-2-thioxy)acetylamino]-3-ethoxycarbonylthiophene and 2-[2-(benzazole-1-yl)acetylamino]-3-ethoxycarbonylthiophene compounds were obtained by the reaction of 2-chloroacetylamino-3-ethoxycarbonylthiophene derivatives and a suitable benzazole-2-thione or benzimidazole derivatives. Analgesic activities of the compounds were tested by using tail-flick and tail-immersion methods. It is reported that some of the compounds showed remarkable analgesic activities. 相似文献
9.
10.
11.
TU Shu-Jiang② FANG Fang JIANG Hong ZHU Song-Lei LI Tuan-Jie ZHANG Xiao-Jing SHI Da-Qing 《结构化学》2004,23(5):494-497
1 INTRODUCTION Since Biginelli firstly reported the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in 1893, this com- pound has been found to emerge as calcium channel blockers, antihypersive agents and a-antagonists[1]. Consequently, this Biginelli reacti… 相似文献
12.
13.
6-氟-4-(N-芳基)胺基喹唑啉类化合物的微波合成及生物活性研究 总被引:3,自引:0,他引:3
经2-氨基-5-氟苯甲酸与甲酰胺闭环、氯化反应, 合成了6-氟-4-氯喹唑啉, 然后在微波辐射下与芳香胺反应, 合成了6个新的6-氟-4-(N-芳基)胺基喹唑啉类化合物. 新化合物经1H NMR, IR及元素分析证明其结构. 体外抑瘤试验证明化合物对前列腺癌细胞(PC3)、人胃癌细胞(BGC823)、人乳腺癌细胞(BCap-37)均无抑制活性. 经ERK的抗磷酸化活性免疫印迹试验证明化合物对小鼠成纤维细胞(NIH3T3)无抑制活性. 相似文献
14.
15.
采用5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮和醛进行缩合反应,合成了二[4-羟基-5,6-二氢-6-烷基(芳基)-2H-吡喃-2-酮-3-]烃.其结构经1HNMR和元素分析证实.对反应条件(反应温度、反应时间)进行了探讨.生物活性初步测定表明,该类化合物具有一定的杀菌和抗烟草花叶病毒的活性. 相似文献
16.
The reaction of (E)-4-arylbut-3-en-2-ones with [(hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment with thioureas, thioamide, and thiobenzamide has offered a one-pot synthesis of 2-substituted 4-styrylthiazoles. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. 相似文献
17.
T. Lipin'ska 《Chemistry of Heterocyclic Compounds》2001,37(2):231-236
The nucleophilic substitution of hydrogen in 3-methylthio-1,2,4-triazine by the carbanions of nitrobutane and 4-nitrobut-1-ene gave oximes, the selective fission of which using sodium dithionite gave ketones in the case of compounds with a saturated carbon chain. Ketones in Diels-Alder reaction with 1-pyrrolidinocyclohex-1-ene gave 3-acyl-1-methylthio-5,6,7,8-tetrahydroisoquinolines. Phenylhydrazones of the compounds obtained underwent Fischer reaction under usual conditions and also when using microwave irradiation on a solid support. The final 3-(3-ethylindol-2-yl)-5,6,7,8-tetrahydroisoquinoline was obtained via reductive desulfuration using Raney nickel in ethanol. 相似文献
18.
19.
A green and efficient method for direct preparation of 3-cyanopyridine from aromatic aldehydes is reported. A series of novel 4-aryl-2-amino-6-(naphthalene-1-yl)-3-cyanopyridine derivates were successfully prepared by one-pot synthesis of three-component domino reactions including aromatic aldehydes, 1-acetylnaphthalene, and dicyanomethane in the presence of ammonium acetate in a solution of ethanol under microwave irradiation. This synthetic method for these compounds possesses many advantages including greater yield and shorter reaction times compared with traditional methods. The structures of these compounds were confirmed by means of high-resolution mass spectrometry, 1H NMR, 13C NMR, and infrared. Moreover, the results of their fluorescent spectra showed that these compounds have good fluorescence intensity excited by the visible light wavelength of 416 nm. 相似文献
20.
<正>The crystal structure of the title compound (C16H17NO5) has been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group C2/c with a = 18.520(2), b = 7.8910(1), c = 21.728(3) A, β = 104.77(1)°, V= 3070.4(7) A3, Mr= 303.31, Z = 8, Dc= 1.312 g/cm3, λ = 0.71073 A,μ(MoKα) = 0.098 mm-1 and F(000) = 1280. The structure was refined to R = 0.0486 and wR = 0.1287. There exist intermolecular hydrogen bonds in the crystal. 相似文献