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1.
利用3-(2-吡啶基)-1,2,4-三唑配体(HL)和不同的金属盐设计合成了5个配合物[Co(HL) 2(H 2O) 2](NO 3) 2( 1)、[Cu 2(L) 2(NO 3) 2(H 2O) 4] ( 2)、[Cu 2(L) 2(AcO) 2(H 2O) 2]·6H 2O ( 3)、[Cu 2(L) 2(HL) 2(ClO 4) 2]·2CH 3CN ( 4)和[Cd 2(L) 2(HL) 2(NO 3) 2]·2H 2O ( 5),并通过X射线单晶衍射、红外、元素分析、X射线粉末衍射和热重对配合物结构进行了表征。测试结果表明配合物 1具有单核结构,并且可以通过氢键的相互作用形成二维超分子结构。配合物 2~ 5为双核结构。配合物 2和 5可以通过氢键的相互作用形成二维超分子结构。配合物 3通过氢键的相互作用形成三维超分子结构。研究了配合物中HL配体的配位模式。此外,研究了配体HL和配合物 1和 5的固态荧光性质及荧光寿命。 相似文献
2.
Abstract A series of condensation polymer intermediates, which included several new compositions, was prepared from 5-t-butyl-m-xylene (I) so that the effect of the bulky t-butyl group on polymer properties could be determined. Compound (I) was oxidized with nitric acid to obtain 5-t-butyl-isophthalic acid (II), which was converted successively to the diacid chloride, the diamide, the dinitrile, and finally to 5-t-butyl-m-xylene-α,α′-diamine (VI); the overall yield was 80%. The dimethyl ester of (II) was prepared and converted to 5-t-butyl-m-xylene-α,α′-diol (VIII), a new composition, in 79.5% overall yield; the diphenyl ester was also prepared. The sodium salt of (II) was catalytically reduced to obtain 5-t-butyl-1,3-cyclohexanedicarboxylic acid (IIa) in 95% yield. (IIa) was converted successively to the diacid chloride, the diamide, the dinitrile, and finally to 5-t-butyl-1,3-cyclohexanebis(methylamine) (VIa), a new composition; the overall yield was 37%. (IIa) was also converted to the dimethyl ester and finally to 5-t-butyl-1,3-cyclohexanedimethanol (VIIIa), a new composition; the overall yield was 64%. Condensation polymers were prepared from the intermediates (II), (IIa), (VI), (VIa), (VIII), and (VIIIa). These polymers had higher glass transition temperatures (T g) than corresponding polymers containing no t-butyl groups. This general effect of the t-butyl group to increase the T g value of the polymer was noted in all polymers prepared, regardless of whether the intermediate carrying the t-butyl group was a diacid, a diol, or a diamine, or whether the polymer was a polyamide, a polyester, or a polyurethane. 相似文献
3.
AbstractThe methanolic extract of Callyspongia samarensis (MCS) significantly inhibited β-secretase 1 (IC 50 99.82?µg/mL) in a dose-dependent manner and demonstrated a noncompetitive type of inhibition. Furthermore, it exhibited the highest AMPK activation (EC 50 14.47?μg/mL) as compared with the standard, Aspirin (EC 50 >100?μg/mL). HPLC/ESI-MS analysis of MCS extract revealed 15 peaks, in which nine peaks demonstrated similar fragmentation pattern with the known compounds in literature and in database library: 5-aminopentanoic acid (1), 4-aminobutanoic acid (3), Luotonin A (4), (E)-3-(1H-imidazol-5-yl) prop-2-enoic acid (8), Galactosphingosine (10), D-sphingosine (11), 5,7,4′-trihydroxy-3′,5′-dimethoxyflavone (12), hydroxydihydrovolide (13), and 3,5-dibromo-4-methoxyphenylpyruvic acid (14); and 6 peaks are not identified (2, 5–7, 9, and 15). Acute oral toxicity test of MCS extract revealed that it is nontoxic, with an LD 50 of >2000?mg/kg. Assessment of BBB permeability of MCS extract showed that compound 15 was able to cross the BBB making it a suitable candidate for developing CNS drugs. 相似文献
4.
AbstractTwo new coruleoellagic acid derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid (1); 3′,4,4′,5,5′-pentamethylcoruleoellagic acid (2) and a new friedelane-type triterpene derivative rinol (5), were isolated from leaves and trunk bark of Rinorea oblongifolia (Violaceae) along with seven known compounds including 3,3′,4,4′,5′-pentamethylcoruleoellagic acid (3), hexamethylcoruleoellagic acid (4), 28-hydroxyfriedelin (6), friedelin (7), friedelan-3-ol (8), scopoletin (9) and β-sitosterol-3- O-β-D-glucopyranoside (10). Their structures were elucidated by means of spectroscopic methods including IR, 1D and 2D NMR in conjunction with mass spectrometry. Crude extracts of leaves and trunk bark as well as compounds 1–4 were evaluated for their antibacterial activities against 7 pathogenic bacterial strains ( Streptococcus pneumoniae ATCC49619, Staphylococcus aureus ATCC 43300, Klepsiella pneumoniae ATCC 700603, Haemophilus influenza ATCC 49247, Escherichia coli ATCC 25922, Pseudomonas aeruginosa HM601, Staphylococcus aureus BAA 977). Compound (3) displayed noteworthy activity against Haemophilus influenza with MIC value of 9.38?µg/mL. 相似文献
5.
Cyclocondensation of 2-cyanomethyl-4-thiazolidinone (1) with tetracyanoethylene (2) furnished pyrano[2,3-d]thiazole derivative (4) . Benzo[e]pyrano[2,3-d]thiazole derivative (6) was obtained by cyclization of compound (1) with salicylaldehyde. In a similar manner, condensation of compound (1) with 2-hydroxy-1-naphthaldehyde in refluxing ethanol yielded naphtho[e]pyrano[2,3-d]thiazole derivative (7) . Interaction of compound (9) with benzylidenemalononitriles (10) (1 : 1 molar ratio) at reflux temperature in ethanol in the presence of piperidine afforded thiazolo[3,2-a]pyridines (12a-c) . Treatment of compound (12a) with hydrazines furnished pyrazolo[3′,4′:4,5] thiazolo[3,2-a]pyridines (14a,b) . The reaction of compound (1) with benzyli-denecyanoacetate (16) yielded 5-hydroxythiazolo[3,2-a]pyridine derivative (21) . Cyclization of bis(thiazolinone) (23) with benzylidenemalononitriles (10) produced bis(thiazolopyridine) derivatives (25a,b) . 相似文献
6.
Chloroform extract from the leaves of Turraea vogelii Hook f. ex Benth demonstrated cytotoxic activity against a chronic myelogenous leukemia cell, K-562 with IC 50 of 14.27 μg/mL, while chloroform, ethyl acetate and methanol extracts from the stem of the plant inhibited K-562 cells growth with IC 50 of 19.50, 24.10 and 85.40 μg/mL respectively. Bioactive chloroform extract of Turraea vogelii leaves affords two triterpenoids: oleana-12,15,20-trien-3β-ol (1), and oleana-11,13-dien-3β,16α,28-triol (2), with six fatty esters, ethyl hexaeicos-5-enoate (3), 3-hydroxy-1,2,3-propanetriyltris(tetadecanoate) (4), 1,2,3-propanetriyl(7Z,7′Z,7′′Z)tris(-7-hexadecenoate) (5), 1,2,3-propanetriyl(5Z,5′Z,5′′Z)tris(-5-hexadecenoate) (6), 1,2,3-propanetriyltris(octadecanoate) (7), and 2β-hydroxymethyl tetraeicosanoate (8). Tetradecane ( 9), four fatty acids: hexadecanoic acid ( 10), tetradecanoic acid ( 11), (Z)-9-eicosenoic acid (12), and ethyl tetradec-7-enoate (13) were isolated from chloroform extract of Turraea vogelii stem. 1,2,3-propanetriyltris(heptadecanoate) (14), (Z)-9-octadecenoic acid (15) and (Z)-7-tetradecenoic acid (16) were isolated from ethyl acetate extract while (Z)-5-pentadecenoic acid (17) was obtained from methanol extract of the plant stem. Compounds 1, 2, 5, 6, 11, 12, 15, 16 and 17 exhibited pronounced antiproliferative activity against K-562 cell lines. 相似文献
7.
利用3-(2-吡啶基)-1,2,4-三唑配体(HL)和不同的金属盐设计合成了5个配合物[Co(HL) 2(H 2O) 2](NO 3) 2( 1)、[Cu 2(L) 2(NO 3) 2(H 2O) 4]( 2)、[Cu 2(L) 2(AcO) 2(H 2O) 2]·6H 2O( 3)、[Cu 2(L) 2(HL) 2(ClO 4) 2]·2CH 3CN( 4)和[Cd 2(L) 2(HL) 2(NO 3) 2]·2H 2O( 5),并通过X射线单晶衍射、红外、元素分析、X射线粉末衍射和热重对配合物结构进行了表征。测试结果表明配合物 1具有单核结构,并且可以通过氢键的相互作用形成二维超分子结构。配合物 2~ 5为双核结构。配合物 2和 5可以通过氢键的相互作用形成二维超分子结构。配合物 3通过氢键的相互作用形成三维超分子结构。研究了配合物中HL配体的配位模式。此外,研究了配体HL和配合物 2和 5的固态荧光性质及荧光寿命。 相似文献
8.
The mononuclear six metal(II) complexes ([Co(mef) 2(3-pic) 2(CH 3OH) 2] ( 1), [Ni(mef) 2(3-pic) 2(CH 3OH) 2] ( 2), [Cu(mef) 2(3-pic) 2] ( 3), [Co(mef) 2(4-pic) 2] ( 4), [Ni(mef) 2(4-pic) 2] ( 5), and [Cu(mef) 2(4-pic) 2] ( 6) with mefenamic acid and picoline ligands were synthesized, characterized, and their carbonic anhydrase inhibitory activities were evaluated. The six complexes were characterized by elemental analysis, FT-IR spectroscopy, and thermal analyses. The crystal structures of 1, 3, and 6 were determined by X-ray crystallography. The complexes have octahedral geometry. In 1, the mefenamato ligand behaved as monodentate whereas in 3 and 6, the mefenamato ligand acted as a bidentate ligand. Complexes 3 and 6 consist of the mefenamate and 4-picoline ligands. In 1, unlike the other complexes, methanol acted as a ligand and was involved in the coordination. Carbonic anhydrase I and II isoenzymes were purified from human erythrocytes. The in vitro effects of mefenamic acid, 3-picoline, 4-picoline, and the six metal(II) complexes on these isoenzymes were evaluated. 相似文献
9.
Reaction of 2-methylchromone (2) with phenylhydrazine provides 3-methyl-5-( o-hydroxyphenyl)-1-phenylpyrazole (6) as a major product. In contrast under similar conditions, heterocyclylhydrazines (8a-c) yield exclusively 5-ethyl-3-(o-hydroxyphenyl)-1-heterocyclylpyrazoles (9a-c). The structural assignments are based on an unambiguous synthesis and an analysis of NMR ( 1H & 13C) spectral data. 相似文献
10.
A convenient preparation of t-butyl methylthiomethyl ether (2) and its conversion to t-butyl chloromethyl ether (1) are described. Methylthiomethanol (4), which was previously unknown, was isolated as a by-product from the preparation of (2): it is a stable distillable liquid. 相似文献
11.
The reaction of the complex Re 2(CO) 4(NO) 2Cl 4 (1) with NaSCMe 3 (2) (in THF or MeCN, 65–80°C, 24 h) was studied at different ratios of the reagents (from 1∶2 to 1∶6). At the reagent ratio
of 1∶2, the binuclear complex Re 2(CO) 4(NO) 2Cl 2(μ-SCMe 3) 2 ( 3) was obtained as a mixture of syn and anti isomers ( 3a and 3b, respectively) containing Re 2S 2 fragments with different structures (the butterfly-like structure in 3a and the planar fragment in 3b). When the initials were taken in ratios from 1∶4 to 1∶6, two compounds were isolated: the binuclear complex Re 2(CO) 4(NO) 2(μ-SCMe 3) 2(μ-S) 4 (cocrystallized as a mixture of syn and anti isomers, 4a and 4b, respectively) and the triangular cluster Re 3(CO) 3(NO) 3(μ-SCMe 3((μ 3-S)(μ 3-Cl) ( 5). Apparently, complex 4 is formed in the course of isolation as a result of elimination of SR 2 from the unstable tetrathiolate dimer Re 2(CO) 4(NO) 2(SCMe 3) 2(μ-SCMe 3) 2 ( 6). Cluster 5 is the product of the reaction between compounds 3 and 4. Products of interaction of compound 6 with silica gel upon column chromatography of the reaction mixture were studied. Four complexes containing hydroxy and oxo
bridging groups, (CO) 2(NO)Re(μ-SCMe 3) 2(μ-OH)Re(SCMe 3)(CO)(NO) ( 7), (CO) 3(NO) 3RE 3(μ-SCMe 3) 3(μ 3-SCME 3)(μ 3-O) ( 8), [(CO) 2(NO) 2Re 2(SCMe 3) 2(μ-SCMe 3) 2(μ-OH)][Na(THF)(Et 2O)] ( 9), and [(CO) 2(NO) 2Re 2(SCMe 3) 2(μ-SCMe 3) 2(μ-OH)] 2−[Na(H 2O) 6][H 5O 2] ( 10), were isolated. The structures of complexes 3, 4, 5, 7, 8, 9, and 10 were established by X-ray diffraction study.
Translated from Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1030–1044, May, 1998. 相似文献
12.
AbstractPhytochemical study was conducted on the leaves of Globimetula braunii which is a hemi parasitic plant belonging to the family Loranthaceae. Extraction was carried out using cold extraction method with increasing polarity of solvents i.e n-hexane, CH 2Cl 2 and MeOH. The components were separated by chromatographic technique and the structures of the compounds were elucidated by extensive spectroscopic analyses including MS, FTIR, 1D and 2D NMR, HRMS and chemical methods. Six new pentacyclic triterpenoid esters named as globrauneine A (1), globrauneine B (2), globrauneine C (3), globrauneine D (4), globrauneine E (5), and globrauneine F (6), together with six known compounds (7 – 12) were successfully isolated from the leaves of G. braunii growing on Piliostigma thonningii. These results depict a substantial support to the chemotaxonomy of the genus Globimetula. 相似文献
13.
AbstractThree NO +-ruthenium(II) complexes were prepared by using cis-[RuCl 2(DMSO) 4] as precursor, P, and the compounds benzohydroxamic acid (BHA), 1′, anti-diphenylglyoxime (H 2dpg), 2′, and dimethylglyoxime (H 2dmg), 3′, as sources of NO moiety. The three complexes [RuCl 2(DMSO) 3(NO)] +(BA) ?, 1, [RuCl 2(DMSO) 3(NO)] +(Hdpg) ?, 2, and [RuCl 2(DMSO) 3(NO)] +(Hdmg) ?, 3, were characterized by (FT-IR, NMR, UV-Vis) spectroscopy, thermogravimetry, and microanalysis. From FT-IR spectral data, two modes of coordination of DMSO to Ru atom through both S and O atoms were detected for 1 and 2. For 3, only S coordination was reported. Computational studies on the [RuCl 2(DMSO) 3(NO)] + cationic parts, 1″, 2″ and 3″, of the investigated complexes 1, 2 and 3 were carried out by DFT. The molecular geometry and mode of attachment of Ru(II) with DMSO were performed with the B3LYP/LANL2DZ level of theory and basis set. Theoretical to the experimental agreement was achieved for analysis of IR data of the investigated complexes. Additional information about binding between the ruthenium atom and the DMSO ligand has been obtained by NBO analysis. 相似文献
14.
The present authors have given an exact theory of the exchange-correlation potential V xc ( r) in terms of (i) the exact ground-state electron density n( r) and (ii) the idempotent Dirac density matrix γ( r,? r′) generated by the DFT one-body potential V( r), having n( r) as its diagonal element. Here, we display two approximate consequences: (a) a form of V xc ( r) generated by the semiempirically fine-tuned HF density of Cordero et al. (N.A. Cordero, N.H. March, and J.A. Alonso, Phys. Rev. A 75, 052502 (2007)) and (b) the exchange-only potential V x ( r) determined solely by the HF ground state density for the Be atom. 相似文献
15.
The reaction of Cd(NO3)2 · 4H2O and Eu(NO3)3 · 6H2O or Tb(NO3)3 · 6H2O with potassium 3,5-di-tert-butylbenzoate (Kbzo) and N-donor ligands (1,10-phenanthroline (phen), 2,4-lutidine (2,4-lut), 3,4-lutidine (3,4-lut), phenanthridine (phtd), 2,3-cyclododecenopyridine (cdpy), acridine (acr)) afforded heterometallic LnCd2 complexes: [EuCd2(bzo)7(EtOH)2(phen)] (2), [LnCd2(bzo)7(2,4-lut)4] (Ln = Eu (3), Tb (4)), [EuCd2(bzo)7(H2O)2(2,4-lut)2] · MeCN (5), [EuCd2(NO3)(bzo)6(EtOH)2(2,4-lut)2] (6), [EuCd2(bzo)7(H2O)(EtOH)(3,4-lut)2] · 5EtOH (7), 3[EuCd2(bzo)7(H2O)2(phtd)2] · 4phtd (8), [EuCd2(bzo)7(EtOH)3(cdpy)] (9), 2[EuCd2-(bzo)2(EtOH)4] · acr (10). The structures of complexes 2, 3, and 5–10 were determined by single-crystal X-ray diffraction. The isostructurality of complexes 3 and 4 was confirmed by powder X-ray diffraction. The structure of the trinuclear {Ln2Cd} metal core is stable and independent of the type of peripheral ligands coordinated to cadmium atoms. Photoluminescent properties of compounds 3 and 4 were studied. 相似文献
16.
One new isoquinoline alkaloid named berberidione (1) along with four new source alkaloids berberine (2), palmatine (3), jatrorrhizine (4) and chondrofoline (5) and three new source non-alkaloids syringic acid (6), β-sitosterol (7) and stigmasterol (8) was isolated and characterised from different fractions of Berberis jaeschkeana Schneid var. jaeschkeana. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells. 相似文献
17.
The synthesis, characterization and thermal analysis of the novel cyclometallated compounds [Pd 2(dmba) 2Cl 2( μ-bpe)] ( 1), [Pd 2(dmba) 2(N 3) 2( μ-bpe)] ( 2), [Pd 2(dmba) 2(NCO) 2( μ-bpe)] ( 3), [Pd 2(dmba) 2(SCN) 2( μ-bpe)] ( 4), [Pd 2(dmba) 2(NO 3) 2( μ-bpe)] ( 5) (bpe= trans-1,2-bis(4-pyridyl)ethylene; dmba=N,N-dimethylbenzylamine) are described. The thermal stability of [Pd 2(dmba) 2X 2( μ-bpe)] complexes varies in the sequence 1> 4> 3> 2> 5. The final residues of the thermal decompositions were characterized as metallic palladium by X-ray powder diffraction. 相似文献
18.
A new alkylated coumarin derivative, hexapetarin ( 1) along with three other xanthones, trapezifolixanthone ( 2), cudraxanthone G ( 3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone ( 4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin ( 1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone ( 4) gave very good activity. 相似文献
19.
The title indolecarboxylate (1) is synthesized as a potential intermediate for the preparation of the central and right parts of CC-1065 (2). 相似文献
20.
In this study, {[Cu 2(µ-HCO 2) 4](µ-Mepyrz)} n ( 1), [Cu 2(µ-HCO 2) 4(Mepyrz) 2] ( 2), {[Cu 2(µ-AcO) 4](µ-Mepyrz)} n ( 3), [Cu 2(µ-AcO) 4(Mepyrz) 2] ( 4), [Cu 2(µ-AcO) 4(2,3-Me 2pyrz) 2] ( 5), [Cu 2(µ-AcO) 4(2,6-Me 2pyrz) 2] ( 6), and {[Cu 2(µ-AcO) 4](µ-2,5-Me 2pyrz)} n ( 7) have been synthesized and characterized by chemical analysis and electronic spectroscopy. Compounds 2, 4, 5, and 6, characterized by single-crystal X-ray diffraction, are composed of molecular dimers based on a paddle-wheel motif with two coppers, four syn–syn carboxylates, and two ligands coordinated to copper in the axial positions. In 7, chains of [Cu 2(µ-AcO) 4] dimers with 2,5-Me 2pyrz as bridging ligands are formed. Magnetic properties and electron paramagnetic resonance results of the compounds are also described. 相似文献
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