THE USE OF MALONONITRILE IN THE SYNTHESIS OF NOVEL α-AMINO NITRILES

Continuing earlier studies designed to obtain compounds of pharmaceutical interest, we used acetyl acetone (1, R=CH₃) and ethyl acetoacetate (1, R=OEt) for the preparation of some novel α-amino nitriles (3, 6 and 7). The structures of the new ring systems have been confirmed by IR, NMR and mass spectral data.     

A NOVEL APPROACH FOR THE PREPARATION OF MEDIUM-SIZE LACTAMS

ＡＮＯＶＥＬＡＰＰＲＯＡＣＨＦＯＲＴＨＥＰＲＥＰＡＲＡＴＩＯＮＯＦＭＥＤＩＵＭ－ＳＩＺＥＬＡＣＴＡＭＳ￥ＹｕｎＸｉｎＢｏ；ＤｏｎｇＬｕＢＡＩ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＭａｔｅｒｉａＭｅｄｉｃａ，ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉｅｎ...     

STUDIES ON THE SYNTHESIS OF NOVEL ISONUCLEOSIDE FROM D-GLUCOSE

ＳＴＵＤＩＥＳＯＮＴＨＥＳＹＮＴＨＥＳＩＳＯＦＮＯＶＥＬＩＳＯＮＵＣＬＥＯＳＩＤＥＦＲＯＭＤ－ＧＬＵＣＯＳＥ￥ＨｏｎｇＷｕＹＵ；ＬｉｎｇＴａｉＭＡ；ＬｉＨｅＺＨＡＨＧ（ＳｃｈｏｏｌｏｆＰｈａｒｍａｃｅｕｔｉｃａｌＳｃｉｅｎｃｅｓＢｅｉｊｉｎｇＭｅｄｉ...     

THE SYNTHESIS OF A NOVEL HETEROPOLYCOMPOUND BY HYDROTHERMAL METHOD

ＴＨＥＳＹＮＴＨＥＳＩＳＯＦＡＮＯＶＥＬＨＥＴＥＲＯＰＯＬＹＣＯＭＰＯＵＮＤＢＹＨＹＤＲＯＴＨＥＲＭＡＬＭＥＴＨＯＤ￥ＪｉａＮｉｎｇＸＵ；ＧｕｏＹｕＹＡＮＧａｎｄＪｉＱｉｎｇＸＵ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＪｉｌｉｎＵｎｉｖｅｒｓｉ...     

THE REGIOSELECTIVE SYNTHESIS OF NOVEL PHENYLSULFONES BEARING ISOPRENE UNITS

The facile and regioselective synthesis of some novel phenylsulfones bearing isoprene units were accomplished by using the corresponding terpenoid compounds as the starting material through ene-chlorination and phenylsulfonyl group substritution steps. The yields are excellent and the experimental conditions are very mild.     

SYNTHESIS OF THE NOVEL CHIRAL POLYMERS WITH MULTIDENTATE LIGAND AND RESOLUTION OF DL-AMINO ACIDS

A new way for synthesizing styrenic type of chiral resins grafting to multidentate ligand has been found. The synthetic scheme is proved to be practical by means of elemental anaysis, IR spectra and metal adsorbility. The resolving power of the new chiral ligand resins coordinated with copper (Ⅱ) as stationary phases has been discussed based on HPLC, and some points of view about the compositions of mobil phase and mechanism of resolution are presented.     

THE CRYSTAL STRUCTURE OF A NOVEL INCLUSION COMPOUND——TETRAKIS

The title compound crystallizes in the space group C_5~4 with unit cell constants a=17.900 (5)A, b=18.466 (7)A, c=15.483 (4)A, β=92.78 (2)°and contains four formulaunits of MoFeS_(10)Cl_4N_4C_(34)H_(54). Intensities of 3499 independent reflections are collected withdiffractometer using MoKa radiation. The y coordinates of the Mo atoms are derived fromthe Patterson function. The parameters of the other atoms are found from successive Fourierand difference syntheses. The block-diagonal least-squares refinement for all atoms gives a final discrepancy factorR = 0.054. The result of structure analysis shows that this inclusion compound consists of threekinds of structural units and the oppositely charged complex ions [Mo(S_2CN(Et)_2)_4]~ and[FeCl_4]~- form a very interesting ionic host framework with infinite tunnels extending alongC direction and containing guest disulfide molecules PhCH_2SSCH_2Ph.     

THE IMMOBILIZATION OF AMINOACYLASE AND THE RESOLUTION OF D,L-PHENYLALANINE

A polymer with suitable physical characters and matched functional groups was synthesized,and used as a supporter to immobilize aminoacylase. The results showed that this supporterhad high immobilizing capacity and high selectivity for aminoacylase. Immobilized amino-acylase had high specific activity. In this paper, we determine the physical and chemicalcharacters of aminoacylase for resolution of D,L--phenylalanine, including its optimum tem-perature, pH, ion concentration, activated ion, substrate concentration, thermal stability anddenaturation. The immobilized aminoacylase was used to resolve the D,L-phenylalaninecontinuously. Thc resolved products was separated and purified with ion-exchange resins. L-phenylalanine solution was concentrated by vacuum evaporation and its hydrochloride wasformed. Checking of final product with polarimeter showed high yield and purity.     

SYNTHESIS OF NOVEL TRLACETAL OXA-CAGECOMPOUNDS

ＳＹＮＴＨＥＳＩＳＯＦＮＯＶＥＬＴＲＬＡＣＥＴＡＬＯＸＡ－ＣＡＧＥＣＯＭＰＯＵＮＤＳＨｓｉｅｎＪｅｎＷＵ；Ｃｈｕｎｇ．ＹｉＷＵａｎｄＣｈｕ；．ＣｈａｎｇＬＩＮ（ＤｅｐａｒｔｍｅｎｔｏｆＡｐｐｌｉｅｄＣｈｅｍｉｓｔｒｙ，ＣｈｉａｏＴｕｎｇＵｎｉｖｅｒｓ...     

CN(R,S)METHOD FOR THE ASYMMETRIC SYNTHESIS OF ALKALOIDS

The alkaloids constitute a large groupof plant and animal substances in the struc-ture of Which the pyrrolidine and the pi-peridine rings are an integral feature.The     

SYNTHESIS OF NOVEL SOLUBLE AROMATIC POLYPYROMELLITIMIDE CONTAINING ORDERED 1,2,4-TRIAZINE IN THE MAIN CHAIN

A new heat-resistant, soluble polymer, poly(phenyl-1,2,4-triazine imide), has been prepared via a two-step methodof polycondensation of N,N'-bis(4-benzil)pyromellitimide and terephthalamidrazone in cresol, followed by curing at highertemperature. The rigid 1,2,4-triazine group increases the solubility of the polyimide so that the polymer is soluble in cresol,N-methyl-2-pyrrolidone (NMP), trifluoroacetic acid and concentrated sulfuric acid, etc. Thermogravimetric analysis (TGA)indicates that this novel polyimide has good thermal stability with a high decomposition temperature of 447℃ in air and of423℃ in N_2. It has a tensile strength of 107.4 MPa with an elongation at break of around 7.6%.     

IS THE“DEGREE OF AGGREGATION”A FUNCTION OF THE AVERAGE AGGREGATE NUMBER,OR OF THE NUMBER OF AGGREGATES,OR BOTH?

Measurement of the average aggregate number of coaggregates(N_co)and evaluationOf the number of coaggregates([CoAg])in the region of increasing degree of aggregationshows that only N_co increases linearly with the concentration of the target moleculesCE-In and BL-ol.     

A NOVEL METHOD OF SECONDARY SYNTHESIS OF FeY ZEOLITE

ＡＮＯＶＥＬＭＥＴＨＯＤＯＦＳＥＣＯＮＤＡＲＹＳＹＮＴＨＥＳＩＳＯＦＦｅＹＺＥＯＬＩＴＥ￥ＡｉＭｉｎＺＨＡＮＧ；ＳｈｕＬｉｎＢＡＯ；ＱｉｎＨｕａＸＵ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＮａｎｊｉｎｇＵｎｉｖｅｒｓｉｔｙ，Ｎａｎｊｉｎｇ，２１...     

CHEMISTRY OF THE PERFLUORO AND POLYFLUORO ORGANIC COMPOUNDS——THE RELATIVE EASE OF FORMATION OF TWO PERFLUOROALKYL R ADICALS

The relative rates of formation of perfluoro iso-propyl radicals (i—C_3F_7,5(i)) and perfluoro n-propyl radicals (n—G_3F_7, 5(n)) are reported. The relative rate constants of β-scission and of bromine abstraction by perfluoro-(α-alkoxyethyl)radicals(RFOCFCF_3:R_F=i—C_3F_7, 3(i); R_F=C_3F_, 3(n)), designated as kr(i) and k,(n), were measured at 7 temperatures in the range of 50—80℃, thence the ratio of the relative rate constants of formation of perfluoro iso-propyl radicals (5(i) and perfluoro n-propyl radicals (5(n)), K_β(i):K_β(n), were obtained. These ratios range from 540—680 at 50℃ to 400—590 at 80℃, much larger than those of the corresponding hydrocarbon radicals. Finally, the differences of activation-free-energy differences between 3(i) and 3 (n), △G~≠(i—n), together with the corresponding enthalpy and entropy terms, △H~≠(i—n), △S~≠(i- n), were calculated. These kinetic parameters indicate that the much higher rate of formation of the perfluoro iso-propyl radicals is caused     

THE DEVELOPMENT OF THE THEORY OF MOLECULAR STRUCTURE AND THE NATURE OF THE CHEMICAL BOND

THE development of the theory of molecular structure and thenature of the chemical bond are discussed.Particular atten-tion is given to the theory of hybrid bond orbitals.     

THE STUDY OF THE SYNTHESES OF THE DERIVATIVES OF POLYPHENYLENE AND THEIR CONDUCTIVITY

ＴＨＥＳＴＵＤＹＯＦＴＨＥＳＹＮＴＨＥＳＥＳＯＦＴＨＥＤＥＲＩＶＡＴＩＶＥＳＯＦＰＯＬＹＰＨＥＮＹＬＥＮＥＡＮＤＴＨＥＩＲＣＯＮＤＵＣＴＩＶＩＴＹ￥ＹｉｎＫｕｉＬｌ；ＱｉｎｇＺｉＬＩＵ；ＳａｎＨＵＡＮＧ；ＴｉｅＦｅｎｇＷＥＮ；ＳｈａｎｇＹｏｕＺＨＯＵ...     

SOME NOVEL Au-Ag SUPRACLUSTERS: THE SYNTHESES AND CHAR- ACTERIZATION OF 25-ATOM,37-ATOM,AND 38-ATOM CLUSTERS

<正> The reduction of mixtures of mononuclear Au(I)and Ag(I) phosphine halide complexes with sodium,boronhydride in different solvents gave rise to two types of 25-atom clusters,and 37-atom and 38-atom clusters. These clusters were formed by vertex-sharing of Au-centered icosahedral cluster units (Au7Ag6). The nuclearity of these clusters is given by (13n-e) , where n is the number of the cluster units and e is the edges of the polyhedron formed by centers of the icosahedral cluster units . The structures of these novel 25-atom,37-atom and 38-atom clusters can be described as two icosahedra sharing one vertex (2×13-1 = 25)or three icosahedra sharing three vertices in a triangle(3×13-3 = 36)plus capping atom(s).     

A NOVEL REDUCTIVE TETRAALLYLATION OF PYRIDINE

ＡＮＯＶＥＬＲＥＤＵＣＴＩＶＥＴＥＴＲＡＡＬＬＹＬＡＴＩＯＮＯＦＰＹＲＩＤＩＮＥ￥ＸｉａｎＭｏｕＺＥＮＧ；ＪｉａＱｉａｎｇ；ＣＡＩａｎｄＹｉＪｉａｎＧＵ（ＤａｌｉａｎｉｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＰｈｙｓｉｃｓ，ＡｃａｄｅｍｉａＳｉｎｉｃａ１...     

NOVEL ADDITION REACTION OFHGeCl＿3 TO IMINE AND THE STABILITY OF THE CORRESPONDING PRODUCTS AND THEIR DERIVATIVES

ＮＯＶＥＬ　ＡＤＤＩＴＩＯＮ　ＲＥＡＣＴＩＯＮ　ＯＦＨＧｅＣｌ＿３　ＴＯ　ＩＭＩＮＥ　ＡＮＤ　ＴＨＥ　ＳＴＡＢＩＬＩＴＹ　ＯＦ　ＴＨＥ　ＣＯＲＲＥＳＰＯＮＤＩＮＧ　ＰＲＯＤＵＣＴＳ　ＡＮＤ　ＴＨＥＩＲ　ＤＥＲＩＶＡＴＩＶＥＳＬｉＪｕａｎＭＡＯ；Ｒｕｙ...