重离子治癌终端的束流强度及剂量监测系统

 为实现重离子肿瘤治疗临床实验中对照射束流状态的实时监测,研制了束流强度及剂量监测系统,包括积分电离室、后续电流频率转换电路及LabVIEW数据获取处理三部分。利用闪烁体探测器和标准剂量计测试了系统的线性响应和得到剂量的准确性,结果表明：系统在束流临床照射流强范围内的线性响应好于90%,其实时反馈的临床照射剂量偏差小于5%。同时束流强度及剂量监测系统与安全控制系统相结合,保证束流照射状态满足临床照射的安全要求。     

Analysis of phantom centering positioning on image noise and radiation dose in axial scan type of brain CT

ABSTRACT

This study examined the dose and image quality according to the position change of a human phantom in a CT scan. This study used an MDCT 128 Slice CT Scanner instrument. An axial scan was performed with a 16 cm CTDI phantom of a human phantom, and the dose was measured using a pencil chamber meter. The phantom was scanned 10 cm above and below the isocenter and 15 cm above the right and left. The position of the phantom is indicated by C-0 in the isocenter position, S-10 in the upper 10 cm, I-10 in the lower 10 cm, R-15 in the right 15 cm, and L-15 in the left 15 cm. The test was performed 30 times using the brain CT protocol to calculate the dose and the dose width product (DWP). The acquired images were analyzed using the ImageJ program. Statistical analysis was performed using SPSS with one-way ANOVA (p < .05). The mean DWP values of the CT scanner were C-0 31.97 mGy·cm, S-10 24.52 mGy·cm, I-10 24.28 mGy· cm, R-15 17.95 mGy·cm, and L15 17.6 mGy·cm. Compared to the isocenter (C-0), the DLP values measured at each site were 23.3% for S-10, 24% for I-10, 43.8% for R-15, and 44.9% for L15. A significant difference in the one-way ANOVA statistical process was observed (p>0.05). C-0 was measured to be 7.42 HU, S-10 7.87 HU, I-10 8.4 HU, R-15 117 HU, and L-15 13.6 HU for evaluating the image quality. Compared to C-0, S-10 was 5.39%, I-10 was 13.2%, R-15 was 57.6%, and L-15 was 83.2%. The PSNR for S-10, I-10, R-15, and L-15 was 17.37, 17.5, 16.62, and 16.37 dB, respectively. A good quality image can be obtained by positioning the subject precisely in the isocenter in the axial scan, if possible, because the irradiated dose to the subject is low, which can lead to an increase in noise in image reconstruction.     

重离子治癌终端的束流强度及剂量监测系统

为实现重离子肿瘤治疗临床实验中对照射束流状态的实时监测,研制了束流强度及剂量监测系统,包括积分电离室、后续电流频率转换电路及LabVIEW数据获取处理三部分。利用闪烁体探测器和标准剂量计测试了系统的线性响应和得到剂量的准确性,结果表明：系统在束流临床照射流强范围内的线性响应好于90%,其实时反馈的临床照射剂量偏差小于5%。同时束流强度及剂量监测系统与安全控制系统相结合,保证束流照射状态满足临床照射的安全要求。     

Experimental measurement of radiation dose in a dedicated breast CT system

Radiation dose is an important performance indicator of a dedicated breast CT (DBCT). In this paper, the method of putting thermoluminescent dosimeters (TLD) into a breast shaped PMMA phantom to study the dose distribution in breasts was improved by using smaller TLDs and a new half-ellipsoid PMMA phantom. Then the weighted CT dose index (CTDI_w) was introduced to average glandular assessment in DBCT for the first time and two measurement modes were proposed for different sizes of breasts. The dose deviations caused by using cylindrical phantoms were simulated using the Monte Carlo method and a set of correction factors were calculated. The results of the confirmatory measurement with a cylindrical phantom (11 cm/8 cm) show that CTDI_w gives a relatively conservative overestimate of the average glandular dose comparing to the results of Monte Carlo simulation and TLDs measurement. But with better practicability and stability, the CTDI_w is suitable for dose evaluations in daily clinical practice. Both of the TLDs and CTDI_w measurements demonstrate that the radiation dose of our DBCT system is lower than conventional two-view mammography.     

Evaluation of the radiation dose to a phantom for various X-ray exposure factors performed using the dose area product in digital radiography

The aim of this study is to measure the dose area product (DAP) in digital radiography by using a DAP meter to determine the X-ray exposure. Pediatric X-ray examinations can be obtained for any radiographic examinations using the selected radiographic examination parameters (kVp and mAs), the DAP information recorded. The best peak signal-to-noise ratio (PSNR) at a fixed tube voltage of 70 kVp was obtained at tube currents of 20 and 32 mA, whereas the best PSNR at a fixed tube current of 25 mA was obtained at a tube voltage of 73 kVp. The fixed tube voltage of 70 kVp and the fixed tube current of 25 mA could help to obtain the best image quality and depict the spatial resolution of an anthropomorphic torso phantom radiographic examination. The normalized data over the DAP were provided to determine the patient dose from radiography.     

NMOS器件不同剂量率γ射线辐射响应的理论预估

介绍了利用线性响应理论预估CC4007-NMOS器件在剂量率01，23，44和91rad(Si)/s下的辐射损伤情况，理论预估值和试验结果符合得比较好.利用线性响应理论预估了CC4007-NMOS器件从低剂量率到高剂量率环境下的辐射损伤及25℃长时间退火情况，结果表明，在相同偏压下，高剂量率辐照加室温退火所引起的阈值电压漂移量在误差容许的范围内等于低剂量率辐照的漂移量，两者总的时间相同.利用线性响应理论预估CC4007-NMOS器件在不同剂量率辐照下的失效剂量.     

X射线辐射剂量率的模拟计算与实验测量

利用C语言对钨反射式X射线管出射的X射线光谱公式编制计算机程序,对模拟计算得到的光谱的形状与理论及实验结果进行比较,对模拟计算结果的正确性加以验证.     

Scatter radiation dose at the height of the operator's eye in interventional cardiology

This paper presents the first experimental result for scatter dose at the height of the operator's eye measured for a Polymethyl methacrylate (PMMA) phantom simulating an adult patient in an interventional laboratory at Belo Horizonte, Brazil. Values for scattered radiation doses at the height of the operator's eye are reported for procedures performed with and without a ceiling-suspended screen. Correlations between scatter radiation doses and different angiographic projections, phantom entrance dose and kerma area product, were obtained.Experimental measurements were made in an angiography X-ray system equipped with flat-panel detector. A cine and three fluoroscopy modes: low, medium and high dose were available. Scattered radiation doses were measured at three angiographic projections: anterior-posterior (AP), left anterior oblique 90° and left anterior oblique 45° with cranial 30° (spider) angulations. The detector measuring scatter radiation was positioned at the usual distance of the cardiologist's eye and the detector measuring phantom entrance dose was positioned at the bottom of the PMMA phantom.The phantom entrance dose for fluoroscopy low, medium, high and cine were 15, 29, 36 ± 4 and 184 ± 18 mGy/min, respectively to AP projection. A good linear correlation exists between phantom entrance doses rate and scatter dose rate to AP projection. There is a good linear correlation between the kerma-area product and scatter dose at the height of the operator's eye, coefficient of determination R² were 0.9728 and 0.9913 with and without ceiling-suspended screen. An experimental correlation factor of 0.1 and 3.5 μSv/Gy*cm2 has been found for the AP projection with and without ceiling-suspended screen, respectively. Scatter dose at the eyes cardiologist position depends on the C-arm angulation an increase of the scatter radiation dose by a factor of 5 was found.The highest dose rate in the lens was 19.74 ± 1.97 mSv/h without ceiling-suspended screen in cine mode for “spider” projection. For lateral projection in cine mode, the ceiling-suspended screen reduced dose by a factor 0.01. Interventional operator may therefore easily exceed the lens dose limit if ceiling-suspended screen is not used.     

Total dose radiation effects on SOI NMOS transistors with different layouts

Partially-depleted Silicon-On-Insulator Negative Channel Metal Oxide Semiconductor (SOI NMOS) transistors with different layouts are fabricated on radiation hard Separation by IMplanted OXygen (SIMOX) substrate and tested using 10keV X-ray radiation sources. The radiation performance is characterized by transistor threshold voltage shift and transistor leakage currents as a function of the total dose up to 2.0×10⁶ rad(Si). The results show that the total dose radiation effects on NMOS devices are very sensitive to their layout structures.     

Total dose radiation effects on SOI NMOS transistors with different layouts

Partially-depleted Silicon-On-Insulator Negative Channel Metal Oxide Semiconductor (SOI NMOS)transistors with different layouts are fabricated on radiation hard Separation by IMplanted OXygen (SIMOX)substrate and tested using 10 keV X-ray radiation sources.The radiation performance is characterized by transistor threshold voltage shift and transistor leakage currents as a function of the total dose up to 2.0×106 rad(Si).The results show that the total dose radiation effects on NMOS devices are very sensitive to their layout structures.     

The kinetics of radiation defect accumulation in oxide crystals

The problem of radiation defect accumulation modeling is considered. The analysis is carried out for models describing basic processes and phenomena taking place during crystal irradiation, namely the genetic defects of recharging and recombination, displacement defect formation and ionization, as well as the limitation of these processes by recombination and complex formation.     

Total dose radiation response of modified commercial silicon-on-insulator materials with nitrogen implanted buried oxide

Nitrogen ions of various doses are implanted into the buried oxide(BOX) of commercial silicon-on-insulator(SOI) materials,and subsequent annealings are carried out at various temperatures.The total dose radiation responses of the nitrogen-implanted SOI wafers are characterized by the high frequency capacitance-voltage(C-V) technique after irradiation using a Co-60 source.It is found that there exist relatively complex relationships between the radiation hardness of the nitrogen implanted BOX and the nitrogen implantation dose at different irradiation doses.The experimental results also suggest that a lower dose nitrogen implantation and a higher post-implantation annealing temperature are suitable for improving the radiation hardness of SOI wafer.Based on the measured C-V data,secondary ion mass spectrometry(SIMS),and Fourier transform infrared(FTIR) spectroscopy,the total dose responses of the nitrogen-implanted SOI wafers are discussed.     

吸入性氚化粒子在人体肺部组织中吸收剂量的研究

涉氚核设施在检修及退役时,其产生的氚化粒子容易被工作人员误吸入,并在呼吸系统的不同部位停留,部分尺寸较小的粒子可能在肺泡间质区(AI 区) 停留超过1 年的时间。氚粒子通过 衰变释放电子,在释放电子的同时以及释放的电子与周围原子相互作用还会分别产生出内、外轫致辐射,这些都会对人体肺部组织造成辐射损伤。本文采用蒙特卡罗程序PENELOPE 对多种氚化粒子在人体肺部组织中的吸收剂量进行了模拟计算,特别是讨论了氚 衰变的内轫致辐射的贡献。研究发现,电子辐射对人体肺泡产生的吸收剂量大于外、内轫致辐射,但后两者作用距离较长,对人体造成的影响重要;电子辐射吸收剂量随着粒子尺寸的增大以及金属原子序数的增大而减小;外轫致辐射吸收剂量随着粒子尺寸的增大而减小,随着金属原子序数的增大而增大;内轫致辐射吸收剂量随着粒子尺寸的增大以及金属原子序数的增大而减小。Some tritium relevant nuclear facilities, such as Tokamak, can produce tritiated particles. There is the possibility for the staffs to inhale the tritiated particles by accident in the process of maintenance or decommission of these facilities. Tritium decays to 3He, during which the beta electron and the internal bremsstrahlung are released. Meanwhile, the released electrons will interact with the surrounding atoms, and the external bremsstrahlung will be generated. All the electrons, internal bremsstrahlung and external bremsstrahlung will deposit the radiation energies to lung tissues and generate the radiation damage. In this paper we studied the radiation doses by inhaled tritiated particles in lung tissues by Monte Carlo code PENELOPE, in particular, internal bremsstrahlung contribution was included. Our results demonstrated that (1) the dose caused by electron radiation is far higher than those of external and internal bremsstrahlung, which however shall not be negligible due to their long-distance effects; (2) the dose caused by electron radiation decreases as the particle size and metal atomic number Z increase; (3) the dose caused by external bremsstrahlung decreases as the particle size increases, but increases as the metal Z increases; (4) the dose caused by internal bremsstrahlung decreases as the particle size and metal Z increase.     

双极电压比较器电离辐射损伤及剂量率效应分析

为了对双极电压比较器在电离辐射环境下的损伤变化特征及其剂量率效应进行研究,选择一组器件,在不同偏置条件下进行60Coγ高低剂量率的辐照和退火试验.结果表明:电压比较器的电源电流、偏置电流及失调电压等多个关键参数都有不同程度的蜕变;偏置条件对于电压比较器的辐射响应有很大影响;此外,不同公司生产的同种型号电路表现出不同的剂量率效应;通过对测试结果分析,系统地讨论了各参数变化的原因,并结合电离损伤退火特性,探讨了各剂量率效应形成的机理.研究结果对工程应用考核提供了参考,而且为设计抗辐射加固器件提供了依据.     

X射线管辐射剂量分布的理论分析与实验测量

简述了反射式X射线管与透射式X射线管的结构.理论分析了透射式X射线管不具有足跟效应.实验测量表明:在所研究的范围内透射式X射线管辐射剂量分布情况明显好于反射式X射线管的辐射剂量分布.     

Influence of thyroid volume reduction on absorbed dose in 131I therapy studied by using Geant4 Monte Carlo simulation

A simulation study has been performed to quantify the effect of volume reduction on the thyroid absorbed dose per decay and to investigate the variation of energy deposition per decay due to β- and γ-activity of 131I with volume/mass of thyroid, for water, ICRP- and ICRU-soft tissue taken as thyroid material. A Monte Carlo model of the thyroid, in the Geant4 radiation transport simulation toolkit was constructed to compute the β- and γ-absorbed dose in the simulated thyroid phantom for various values of its volume. The effect of the size and shape of the thyroid on energy deposition per decay has also been studied by using spherical, ellipsoidal and cylindrical models for the thyroid and varying its volume in 1-25 cm3 range. The relative differences of Geant4 results for different models with each other and MCNP results lie well below 1.870%. The maximum relative difference among the Geant4 estimated results for water with ICRP and ICRU soft tissues is not more than 0.225%. S-values for ellipsoidal, spherical and cylindrical thyroid models were estimated and the relative difference with published results lies within 3.095%. The absorbed fraction values for beta particles show a good agreement with published values within 2.105% deviation. The Geant4 based simulation results of absorbed fractions for gammas again show a good agreement with the corresponding MCNP and EGS4 results （±6.667%） but have 29.032% higher values than that of MIRD calculated values. Consistent with previous studies, the reduction of the thyroid volume is found to have a substantial effect on the absorbed dose. Geant4 simulations confirm dose dependence on the volume/mass of thyroid in agreement with MCNP and EGS4 computed values but are substantially different from MIRD8 data. Therefore, inclusion of size/mass dependence is indicated for 131I radiotherapy of the thyroid.     

燃烧:一个不息的话题--同步辐射单光子电离技术在燃烧研究中的应用

燃烧应用于工业、农业、交通运输、国防等各个领域，提供了当今社会极大部分的能量需求。100多万年前人类就开始利用燃烧，人类研究燃烧已经有150多年的历史。本文介绍了将同步辐射真空紫外单光子电离技术结合分子束取样，应用于燃烧研究中，可以探测到燃烧中的各种中间物，包括稳定的和不稳定的产物。通过扫描光子能量，测量产物的光电离效率谱，可以区分其同分异构体，因此，利用这种新的诊断技术，在150年后的今天，我们仍然可以在火焰中发现很多新的燃烧中间体，为发展燃烧动力学模型提供精确的实验数据。最后，展望该方法在其它学科中的可能应用。     

高剂量率单次快脉冲辐射参量测量

记述了“强光一号”高剂量率脉冲辐射装置在状态调试过程中对其出射波形和辐射剂量进行监测的基本情况，实际监测的结果与设计方监测的结果进行了比对，双方的剂量监测值基本一致，偏差在20％以内；双方的波形形状十分相似，但测量得到的波形半宽度却相差10～20ns，最后对双方束流监测产生的差异进行了定性分析。     

浮栅ROM集成电路空间低剂量率辐射失效时间预估

利用60Coγ射线开展了浮栅ROM集成电路（AT29C256）总剂量辐照实验， 研究了集成 电路功耗电流和出错数在不同剂量率下的辐射响应；按照定义的失效标准和外推实验技术， 探索了集成电路参数失效与功能失效时间随辐射剂量率的变化关系；根据失效时间与辐射剂 量率的函数关系，预估了浮栅ROM集成电路AT29C256(9911)和AT29C256(9939)空间低剂量率辐射失效时间. 关键词： 低剂量率 辐射损伤 失效时间 总剂量     

Neutron dose measurement in carbon ion radiation therapy at HIRFL (IMP)

For radiation protection purposes, the neutron dose in carbon ion radiation therapy at the HIRFL (Heavy Ion Research Facility in Lanzhou) was investigated. The neutron dose from primary 12C ions with a specific energy of 100 MeV/u delivered from SSC was roughly measured with a standard Anderson-Broun rem-meter using a polyethylene target at various distances. The result shows that a maximum neutron dose contribution of 19 mSv in a typically surface tumor treatment was obtained, which is less than 1% of the planed heavy ion dose and is in reasonable agreement with other reports. Also the γ-ray dose was measured in this experiment using a thermo luminescent detector.