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Abstract Thiazolidin-4-ones are known to exhibit diverse biological activities such as antimicrobial, anticancer, antidiarrheal, anticonvulsant, antidiabetic, antihistaminic, and antifungal activities. In the present investigation, a series of 2-haloacetamides was prepared by reacting chloroacetyl chloride with amines in dry benzene under reflux conditions. The formed 2-haloacetamides reacted with potassium thiocyanate in refluxing dry acetone to afford new 2-iminothiazolidin-4-ones. The 5-arylidene-2-imino-3 (napthalen-2yl)-thiazolidin-4-ones were prepared by condensing 2-iminothiazolidin-4-ones with substituted benzaldehydes. All the products were characterized by infrared, mass, and 1H and 13C NMR techniques. 相似文献
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S. Ebrahimi A. Mobinikhaldei H. Eibagi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2279-2285
Abstract Without a catalyst and under solvent-free conditions, 2,3-disubstituted-1,3-thiazolidin-4-one 5a–j derivatives were synthesized efficiently via the three-component reaction of aryl hydrazide, aromatic aldehyde, and mercaptoacetic acid. All the newly synthesized compounds were confirmed by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. GRAPHICAL ABSTRACT 相似文献
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新型3-萘基-1,3-噻唑烷-4-酮衍生物的微波促进合成及其抗菌活性研究 总被引:2,自引:1,他引:2
利用微波促进的多组分一锅法, 在封管条件下, 以萘胺、芳醛和巯基乙酸为原料, 4-二甲氨基吡啶(DMAP)/N,N’-二环已基碳二亚胺(DCC)为催化剂, 合成了系列新的噻唑烷酮衍生物, 该反应具有时间短、操作简便等优点. 目标化合物通过IR, NMR, MS和元素分析等方法确定结构. 初步测试了化合物对丁香假单胞杆菌黄瓜角斑病菌致病变种、番茄灰霉病菌和黄瓜白粉病菌抑制活性, 结果表明: 部分化合物对黄瓜白粉病菌有显著抑制作用, 但对前两种植物病菌抑制效果不明显. 相似文献
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Bao Xiang Hu Zhen Lu Shen Jun Lu Xin Quan Hu Wei Min Mo Nan Sun 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):523-535
The synthesis of some new functionalized thiazolidin-4-one derivatives has been described. The N-substituted-thiosemicarbazides 3a-3i were obtained though the reaction of alkylamines 2a–2i , carbon disulfide, and hydrazine hydrate. The condensation reaction between 3a–3i and 4-amino-2-methanesulfanylpyrimidine-5-carboxaldehyde 1 afforded the thiosemicarbazones 4a–4i . The corresponding thiazolidin-4-ones 5a–5i were prepared by cyclization of 4a–4i with ethyl bromoacetate. The structures of the final products were confirmed by IR, 1 H NMR, 13 C NMR, and HRMS. 相似文献
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P. Manivel Ashok Sharma T. Maiyalagan M. R. Rajeswari F. Nawaz Khan 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):387-393
A series of 1H-isochromen-1-one derivatives and their thio analogues were synthesized by thionation using Lawesson's reagent for evaluation of their cytotoxic effect on cancer cells. The effect of these derivatives was tested on the growth of human epidermoid carcinoma A431 cell line by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] colorimetric assay. MTT assay revealed that these new compounds are potent inhibitors of cell growth. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
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A. V. Vasilyev N. P. Solov'eva N. Ya. Podhaluzina A. Yu. Tolmachev V. F. Traven 《Chemistry of Heterocyclic Compounds》2003,39(4):534-538
Fries rearrangement of 7-acetoxy-4-methylquinolin-2-one and subsequent condensation of the 6-acetyl-7-hydroxy-4-methylquinolin-2-one obtained with -chloro ketones gives a series of furo[3,2-g]quinolin-7-ones. 相似文献
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为改善二唑及三唑类化合物的生物活性, 设计合成了一系列多氟烷基乙基取代的1,3,4-噁二唑-2-硫酮6a~6l及1,2,4-三唑-5-硫酮类化合物9a~9l. 1H NMR, 19F NMR, IR和MS谱以及元素分析表征了它们的结构; 实验结果与Materials Studio 3.0中的Dmol3计算模块理论计算表明了唑环上的NH较之CONH中的NH更易进行烷基化反应. 相似文献
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T. E. Glotova T. N. Komarova A. S. Nakhmanovich V. A. Lopyrev 《Russian Chemical Bulletin》2000,49(11):1917-1918
The reaction of thiourea with l-acyl-2-bromoacetylenes in AcOH in the presence of BF3·Et2O affords 2-amino-4-phenyl(2-thienyl)-1,3-thiazine-6-thiones in high yields.
Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya. No. 11, pp. 1947–1949, November, 2000. 相似文献
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N—烃氧丙酰基四氢噻唑—2—硫酮的合成 总被引:1,自引:0,他引:1
在三聚氯氰存在下由烃氧丙酸与四氢噻唑-2-硫酮反应得到N-烃氧丙酰四氢噻哇-2-硫酮(2a-i),由2a,c-h与格氏试剂反应得到烃氧乙基苯基酮(3a,c-h).产物2a-i未见报道. 相似文献
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某些有机锗化物,例如β-羧乙基锗倍半氧化物及其衍生物能诱发干扰素,对癌症有一定疗效,日本专利报道丙酰胺基锗倍半氧化物及其衍生物也具有抗癌活性[2,3],白明章等曾合成丙酰芳胺基锗倍半氧化物[4]。 相似文献
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Methods for the synthesis of 1,3-dithiole-2-thiones, based on [4+2] cycloaddition of the 1,3-dithiole-2,4,5-trithione oligomer
to various unsaturated acyclic, carbocyclic, and heterocyclic compounds, are reviewed. Methods for the production of substituted
tetrathiafulvalenes, which can be regarded as derivatives of bis(ethylenedithio)tetrathiafulvalene, from 1,3-dithiole-2-thiones
synthesized by this method are described.
Dedicated to the memory of Professor O. Neilands.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 483–502, April, 2006. 相似文献
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Tarlok S. Lobana 《Journal of Chemical Sciences》2000,112(3):323-329
The interaction of heterocyclic thiones/thiosemicarbazones with metals has been the subject of several investigations as these
ligands contain chemically active groups,-N(H)-C(=S)-↔ -N=C(-SH)-,and are useful model compounds for sulphur-containing analogues
of purine and pyrimidine bases. Heterocylic-2-thiones bind to metals in several ways and lead to the formation of monomeric
or polymeric complexes. For example, the simplest prototype of heterocylic-2-thiones, namely, pyridine-2-thione has several
ways of binding, notably, terminal S-bonding and S-bridging (in neutral form), while in anionic form the modes are terminal
S-bonding, S-bridging, N,S-chelation, N,S-bridging, N,S-chelation-cum-S-bridging and N,S-bridging-cum-S-bridging. Similarly,
thiosemicarbazones bind to metals as S-bonded unidentates or N,S-chelates. In this paper, the chemistry of pyridine-2-thione,
its N-oxide, 2-(benzylthio)pyridine-1-oxide thione with metals like iron(II), ruthenium(II), nickel(II), palladium(II), platinum(II),
copper(I), copper(II), silver(I) and mercury(II) is briefly described. As regards thiosemicarbazones, focus is only on two
compounds, namely organomercury(II) and organothallium(III). A variety of new molecules, well characterised by NMR and X-ray
crystallography, is introduced. 相似文献
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