共查询到20条相似文献,搜索用时 15 毫秒
1.
Vijay V. Dabholkar Faisal Y. Ansari 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):298-305
Ultrasound accelerated synthesis of 2,3-(substituted)benzo-1,4-thiazino[5,6-b]-4H-9H-7- methyl-10-oxoquinolines (4), 7-substituted-2,2-dimethyl-2,3-dihydro-1H,10H-phenothiazin- 4-one (5), 4-substituted-3,9, 10-trihydro-11-oxo-quinolino[2,3-b]-1,3,4-thiadiazino[2,3-d]- 1,2,4-triazole (6), and 7,7-dimethyl-7,8-dihydro-3H,5H,6H-1,2,4-triazolo[3,4-b][1,3,4] benzothiadiazin-9-one (7) from carbostyril and dimedone using sulfur powder and iodine as a catalyst in THF is reported. The structures of the compounds have been elucidated on the basis of spectral and elemental analysis. 相似文献
2.
Spiro [3H-indole-3,2′-[4H] pyrido [3,2-e]-1,3-thiazine]-2,4′ (1H) diones, a class of previously unknown compound which does not form under conventional conditions, can be prepared by treatment of ‘in situ’ generated 3-indolylimine derivatives with 2-mercaptonicotinic acid under microwave irradiation in absence of any solvent or solid support in 85-92% yields in 3-8 min. The facile one pot reaction is generalized for a variety of ketones and amines to give pure pyrido [3,2-e] thiazine derivatives, which do not require further purification processes. 相似文献
3.
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5.
ZrCl4/TMSCl as an Efficient Catalyst for Synthesis of 4,6‐Substituted 2‐Alkylthio‐6H‐1,3‐thiazines
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4,6‐Substituted‐2‐alkylthio‐6H‐1,3‐thiazines were synthesized by the reaction of S‐alkyl dithiocarbamates and α, β‐unsaturated ketones in the presence of ZrCl4/TMSCl. The procedure is simple and efficient and gives good to high yields of products. 相似文献
6.
The one-electron oxidation of toluidine blue by specific oxidising radicals such as Cl
2
−
, Tl(II), N3, Br
2
−
etc. has been studied by employing the pulse radiolysis technique. The Br
2
−
radical was found to be less efficient in oxidising toluidine blue as compared to Cl
2
−
., Tl+2 and N3. The semioxidised species exhibited only onepK
a indicating the presence of two conjugate acid-base forms whose spectral and kinetic features were evaluated. Reaction of
OH radicals with the dye gave rise to a transient species which exhibited spectral and kinetic features different from that
of the semioxidised species indicating that the mode of reaction of OH is different. 相似文献
7.
L. Yu. Chumakova A. M. Demchenko A. N. Krasovsky T. V. Dolishnyak M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2003,39(8):1002-1012
3-Ethoxycarbonyl-2-(N-R-thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophenes were obtained by the reaction of 2-amino-3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzo[b]thiophene with isothiocyanates and of 3-ethoxycarbonyl-2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene with primary and secondary amines. The cyclization paths of the products leading to derivatives of thieno[2,3-d]pyrimidine and thieno[2,3-d]-1,3-thiazine were studied. The corresponding S-substituted derivatives were obtained by the alkylation of 3-R-2-thioxo-3,4,5,6,7,8-hexahydrobenzo[b]thieno[2,3-d]pyrimidin-4-ones. 相似文献
8.
Samvel N. Sirakanyan Athina Geronikaki Viktor G. Kartsev Elmira K. Hakobyan Anush A. Hovakimyan 《合成通讯》2019,49(10):1262-1276
Taking into account previously obtained biological results on some polyheterocyclic compounds (containing different heteroatoms) and in particular on several 8-amino-5-isopropyl-2,2-dimethyl-10-(methylthio)-1,4-dihydro-2H-pyrano[4’’,3’’:4’,5’]pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidines Ia-v we have carried out the synthesis of twentyone 8-amino-5-isobutyl-2,2-dimethyl-10-(methylthio)-1,4-dihydro-2H-pyrano[4’’,3’’:4’,5’]pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidines 6. Therefore we have slightly modified the structure of the previously studied I introducing at C-5 an isobutyl group instead of the previously examined isopropyl ones in order to see if this variation (changing a little the lipophilicity) will affect the biological activity. Furthermore thieno[3,2-d]pyrimidine-8-thione 7 and their S-alkylated 8 were synthesized. Finally by alkylation of 5-isobutyl-2,2-dimethyl-10-thioxo-1,4,10,11-tetrahydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one 3 with alkyl dichlorides (bifunctional reagents) we realized the cyclization of a thiazole or thiazine ring on the [b] side of the pyrimidine ring with formation of the new condensed pentaheterocyclic systems: pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-8-one 11 and pyrano[4''',3''':4'',5'']pyrido[3'',2'':4',5']thieno[3',2':4,5]pyrimido[2,1-b][1,3]thiazin-8-one 12. It was found that some of the synthesized compounds showed interesting antimicrobial activity (by agar diffusion method) against some gram-positive and gram-negative bacilli strains. 相似文献
9.
10.
Utilization of 2‐Chloronicotinonitrile in the Syntheses of Novel Fused Bicyclic and Polynuclear Heterocycles of Anticipated Antitumor Activity
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Wafaa S. Hamama Mohamed A. Waly Ibrahim I. El‐Hawary Hanafi H. Zoorob 《Journal of heterocyclic chemistry》2016,53(3):953-957
Some of synthetic bicyclic and polynuclear heterocyclic compounds based on pyridine scaffold were tested as in vitro antitumor agents, and these compounds found to exhibit interesting activities. Fused heterocycles containing sulfur such as thienopyridine, pyridothiazine, and some related fused heterocycles as new ring systems were achieved. Bicyclic thienopyridine 6 and pyrido[3,2‐e][1,3]thiazin‐4(3H)‐one 7 exhibited good antitumor activities compared with 5‐fluorouracil. 相似文献
11.
Sheng-Rong Liao Yong Tang Liang Xu Xue-Feng Zhou Jun-Feng Wang Bin Yang Yong-Hong Liu 《Tetrahedron》2017,73(1):98-107
An unexpected ring-contraction from benzo[b]pyrazino[1,2-d][1,4]thiazine-1,4-diones (6) to benzo[4,5]thiazolo[3,2-a]pyrazine-1,4-diones (7) has been developed. The preliminary mechanistic studies showed the transformation contained two independent steps: the first step is the formation of a Michael adduct upon the addition of the protic solvent, in the presence of base, to the C-2-C-3 double bond of compound 6, and the second step is a ring-contraction induced by oxygen via the migration of sulfur atom from C-2 to C-3 position. And its scope is also studied. 相似文献
12.
Hossein F. Dastjerdi Manijeh Nematpour Elham Rezaee Mehdi Jahani Sayyed A. Tabatabai 《中国化学会会志》2019,66(11):1537-1541
A one‐pot synthesis of functionalized benzo thiazine derivatives via a Cu‐catalyzed, multicomponent reaction of isocyanides, aniline, and heterocumulenes in acetonitrile at room temperature was developed. Transition metal‐catalyzed activation of C‐H bonds under mild copper‐catalytic reaction conditions, using simple and available starting materials, also obtaining a pure product with high yield without applying column chromatography are the major advantages of the applied method among the other ones used for this purpose. The structures are confirmed spectroscopically (1H‐ and 13C‐NMR, IR, and EI‐MS) and through elemental analyses. 相似文献
13.
In this article, we showed the synthesis of new polycyclic aromatic compounds, such as thienotriazolopyrimidinones, N-(thienotriazolopyrimidine) acetamide, 2-mercapto-thienotriazolo-pyrimidinones, 2-(((thieno-triazolopyrimidine) methyl) thio) thieno-triazolopyrimidines, thieno-pyrimidotriazolo-thiazines, pyrrolo-triazolo-thienopyrimidines, thienopyrimido-triazolopyrrolo-quinoxalines, thienopyrimido-triazolo-pyrrolo-oxathiino-quinoxalinones, 1,4-oxathiino-pyrrolo- triazolothienopyrimidinones, imidazopyrrolotriazolothienopyrimidines and 1,2,4-triazoloimidazo- pyrrolotriazolothienopyrimidindiones, based on the starting material 2,3-diamino-6-benzoyl-5- methylthieno[2,3-d]pyrimidin-4(3H)-one (3). The chemical structures were confirmed using many spectroscopic ways (IR, 1H, 13C, −NMR and MS) and elemental analyses. A series of thiazine, imidazole, pyrrole, thienotriazolopyrimidine derivatives were synthesized and evaluated for their antiproliferative activity against four human cancer cell lines, i.e., CNE2 (nasopharyngeal), KB (oral), MCF-7 (breast) and MGC-803 (gastric) carcinoma cells. The compounds 20, 19, 17, 16 and 11 showed significant cytotoxicity against types of human cancer cell lines. 相似文献
14.
Synthesis of 2,5‐Disubstituted Derivatives of Pyrano[2,3‐d][1,3]thiazines via the Interaction of 2‐Substituted 4‐Hydroxy‐6H‐1,3‐thiazine‐6‐ones with Aldehydes
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Roman V. Shutov Marina V. Sopova Alexander V. Krylov Andry N. Kaluzhskikh Boris А. Ivin 《Journal of heterocyclic chemistry》2015,52(6):1618-1624
A new and efficient route for the synthesis of derivatives of the poorly investigated pyrano[2,3‐d][1,3]thiazine heterocyclic system is disclosed. These compounds were prepared via annulation of 2‐aryl‐4‐hydroxy‐6H‐1,3‐thiazine‐6‐ones with aliphatic and aromatic aldehydes in the presence of pyridine. The method is general and versatile, and the interaction is independent on the nature of the aldehyde, the only exceptions being formaldehyde and salicylaldehydes. 相似文献
15.
Ibrahim Ali M. Radini 《Phosphorus, sulfur, and silicon and the related elements》2016,191(6):844-856
This review article presents the available synthetic routes for the preparation of different types of imidazothiazines. Imidazothiazines dealt with are classified into five types based on the position of linkage between imidazole and thiazine rings. The importance of the latter compounds in pharmacology is also discussed. The main purpose of this review is to present a survey of literature on imidazothiazines and provide useful and up-to-date data to organic and medicinal chemist, since such compounds have not been reviewed before. 相似文献
16.
The reaction of 2-(diphenylmethylene)thietan-3-one (2) with 1,2,4,5-tetrazines (3a-c) in KOH/MeOH/THF gives 4H-pyrazolo[5,1-c]thiazines (7a-c). This novel condensation reaction proceeds via the intermediacy of an 8-(diphenylmethylene)-2H-1,4,5-thiadiazocin-7(8H)-one (5), which undergoes a multi-step rearrangement including a rare anti-Michael addition. 相似文献
17.
The absorption spectra of several thiazine dyes such as thionine, azure A, azure B, azure C and methylene blue in aqueous solution of Triton X-100 show that dyes as electron acceptors form 11 charge-transfer (CT) or electron-donor-acceptor (EDA) complexes with Triton X-100, which acts as an electron donor. From the thermodynamic and spectrophotometric properties of these complexes, the abilities of dyes to accept an electron are in the order: azure C > thionine > azure A > azure B > methylene blue. The photogalvanic effect in the aqueous solution dye-surfactant has been studied. Generation of photovoltage supports a CT or EDA interaction between thiazine dyes and Triton X-100. There is a good correlation among the photophysical (photovoltage), spectral and thermodynamic properties of these complexes. 相似文献
18.
Joung Heo 《Journal of Coordination Chemistry》2017,70(23):3837-3858
The reaction of [ZnCl2] with N-cyclopentyl-1-(quinolin-2-yl)methanimine (LA), N-cyclohexyl-1-(quinolin-2-yl)methanimine (LB), N-cyclohexyl-1-(pyridin-2-yl)methanimine (LC), 2,6-diethyl-N-(pyridin-2-ylmethylene)aniline (LD), N-cyclopentyl-1-(pyridin-2-yl)methanimine (LE), and N-phenyl-(pyridin-2-yl)methanimine (LF) in ethanol produced the bidentate [(NN′)ZnCl2] complexes, [LAZnCl2], [LBZnCl2], [LCZnCl2], [LDZnCl2], [LEZnCl2] and [LFZnCl2], respectively. The molecular structures revealed that the zinc in [LnZnCl2] (Ln = LA ? LD) showed a distorted tetrahedral geometry involving two nitrogens of N,N’-bidentate ligands and two chloride ligands. Most of these initiators were effective for polymerization of methyl methacrylate (MMA) and polymerization of rac-lactide (rac-LA). [LCZnCl2] (with N-cyclohexyl substituted at imine-pyridine moiety) exhibited the highest catalytic activity for MMA polymerization in the presence of modified methylaluminoxane (MMAO) with an activity of 3.33 × 104 g PMMA/mol·Zn·h at 60 °C, giving moderate syndiotactic poly methyl methacrylate (PMMA) with high molecular weight (9.62 × 105 g/mol). The dimethyl derivatives [LnZnMe2] (Ln = LA ? LF), generated in situ, polymerized rac-LA with moderate activity and yielded a polylactide (PLA) with good number-average molecular weights and narrower polydispersity indices (PDIs). [LAZnMe2] effectively initiates the ring-opening polymerization (ROP) of rac-LA to attain heterotactic PLA (Pr = 0.91). 相似文献
19.
A new 9,10-dihydrophenanthrene,1,5-dihydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthrene (1) was isolated and identified from the whole plants of Dendrobium moniliforme, as well as 24 known compounds including hircinol (2), (2R*,3S*)-3-hydroxymethyl-9-methoxy-2-(4′-hydroxy-3′,5′-dimethoxyphenyl)-2,3,6,7-tetrahydro-phenanthro[4,3-b]furan-5,11-diol (3), diospyrosin (4), aloifol I (5), moscatilin (6), 3,4′-dihydroxy-3′,4,5-trimethoxybibenzyl (7), gigantol (8), 3,3′-dihydroxy-4,5-dimethoxybibenzyl (9), longicornuol A (10), N-trans-cinnamoyltyramine (11), paprazine (12), N-trans-feruloyl 3′-O-methyldopamine (13), moupinamide (14), dihydroconiferyl dihydro-p-coumarate (15), dihydrosinapyl dihydro-p-coumarate (16), 3-isopropyl-5-acetoxycyclohexene-2-one-1 (17), p-hydroxybenzaldehyde (18), vanillin (19), p-hydroxyphenylpropionic acid (20), vanillic acid (21), protocatechuic acid (22), (+)-syringaresinol (23), β-sitosterol (24) and daucosterol (25). Compounds 3, 4, 13, 16, 17 and 20 were isolated from the Dendrobium genus for the first time, and compounds 2, 5, 7, 9–12, 14, 15, 18, 21 and 22 were originally obtained from D. moniliforme. 相似文献
20.
Mei Jin Wei Zhou Chunshi Jin Zhe Jiang Shengbao Diao 《Natural product research》2019,33(16):2422-2425
Twenty-seven compounds including nine triterpenoids (1–9), eight sterols (10–17), two ribonucleotides (18, 19), four phenols (20–23), three glycosides (24–26), and one furan (27) were isolated from the fruiting bodies of Trametes versicolor (L.) Lloyd. This study is the first confirmation of the presence of the 11 compounds (3, 5, 6, 8, 18, 20, 21, 23–25, and 27) isolated from the Polyporaceae family, with six of these (2 and 12–16) from the genus Trametes. Compounds 3, 4, 10, 11, 16 and 17 were found to significantly inhibit the production of NO, TNF-α and IL-6 in a dose-dependent manner. 相似文献