共查询到20条相似文献,搜索用时 15 毫秒
1.
Mohammad Bakherad Hossein Nasr-Isfahani Ali Keivanloo Nesa Doostmohammadi 《Tetrahedron letters》2008,49(23):3819-3822
The reaction of 2-amino-1-(2-propynyl)pyridinium bromide with various iodobenzenes, catalyzed by Pd-Cu, leads to the formation of 2-benzylimidazo[1,2-a]pyridines. 相似文献
2.
Majid M. Heravi Ali Kivanloo Mehdi Bakavoli Bernhard Neumüller 《Tetrahedron letters》2005,46(10):1607-1610
The reaction of 3-mercaptopropargyl-1,2,4-triazoles with various iodobenzenes catalyzed by Pd-Cu leads to the regioselective formation of 6-benzylthiazolo[3,2-b]1,2,4-triazoles 4. The structure of 4d was confirmed by X-ray analysis. 相似文献
3.
The reaction of 2-amino-3-(2-propynyl)thiazolium bromide with various iodobenzenes, catalyzed by Pd/Cu, in the presence of sodium lauryl sulfate as surfactant and cesium carbonate as base, in water, leads to the formation of 6-substituted imidazo[2,1-b]thiazoles. 相似文献
4.
Mohammad Bakherad Ali Keivanloo Hossein Nasr-Isfahani Mersad Raeissi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1422-1427
Abstract The reaction of 4,5-diphenyl-2-propargylmercaptoimidazole with various aryl iodides catalyzed by Pd-Cu in the presence of triethylamine as base in dimethyl formamide (DMF) leads to the formation of 3-aryl-substituted imidazo[2,1-b]thiazoles. 相似文献
5.
The reaction of 2-imino-3-(2-propynyl)-1,3-benzothiazole with various iodobenzenes in the presence of a palladium catalyst leads to the production of 2-benzylimidazo[2,1-b][1,3]benzothiazoles. 相似文献
6.
7.
The reaction of 2-aminothiazoles with ethyl acetoacetate in acetic or polyphosphoric acid gave a series of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives which were nitrated with a mixture of nitric and sulfuric acid to 6-nitro-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-ones, and the latter were reduced to the corresponding amines. 相似文献
8.
Dong Han Kim Richard A. Fieber Arthur A. Santilli Stanley C. Bell 《Journal of heterocyclic chemistry》1974,11(5):703-706
Treatment of N-(2-hydroxyphenyl)anthranilic acid with acetic anhydride, under refluxing conditions provided a simple method for the synthesis of 5H-henzoxazolo[3,2-a] quinolin-5-one (IVa), a heretofore unreported ring system. When propionic anhydride was used in the above reaction, 6-methyl-5H-benzoxazolo[3,2-a]quinolin-5-one (Va) was obtained. Other examples prepared in this fashion were IVb, IVc and Vb. Treatment of IVa with methoxyethylamine afforded 1,2-dihydro-1-(2-hydroxyphenyl)-2-(methoxyethylimino)-4-quinolinol (VII). A possible mechanism for the cyclization reaction is discussed. 相似文献
9.
V. N. Britsun A. N. Esipenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2006,42(3):396-402
We have studied the reaction of 2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4-one and 2-aryl-2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4-ones
with amines, alkylating reagents, and hydrogen peroxide. We have shown that the presence of an aryl substituent at the 2 position
of [1,3-thiazino[3,2-a]benzimidazol-4-ones has a substantial effect on the direction of the reactions.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 445–452, March, 2006. 相似文献
10.
Russian Journal of Organic Chemistry - An efficient synthetic approach to new fluorine-containing [1,3,4]thiadiazolo[3,2-a]quinazolin-5-ones has been developed on the basis of intramolecular... 相似文献
11.
2-Hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one 2a and 7-hydroxy-5H-thiazolo[3,2-a]pyrimidin-5-one 2b, were obtained in high yields under mild conditions from the cyclization reactions of bis-(2,4,6-trichlorophenyl) malonate and 2-aminobenzothiazole or 2-aminothiazole, respectively. A new class of compounds, 2,3-dihydro-4H-benzo[4,5]thiazolo[3,2-a]furo[2,3-d]pyrimidin-4-ones and 6,7-dihydro-5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-ones, were synthesized via the microwave assisted radical addition of compounds 2a and 2b to various alkenes using manganese(III) acetate. A preliminary acetylcholine esterase (AchE) inhibition test of compound 4e showed excellent (92%) inhibitory potential, comparable with the standard drug Donapezil®. 相似文献
12.
Mohammad Bakherad Ali KeivanlooZahra Kalantar Saeideh Jajarmi 《Tetrahedron letters》2011,52(2):228-230
An efficient synthesis of 2-benzylimidazo[1,2-a]pyrimidines in water is accomplished via Pd/C-catalyzed reaction of 2-imino-1-(2-propynyl)pyrimidine with various aryl iodides in the presence of K2CO3 as the base. 相似文献
13.
Dong Han Kim 《Journal of heterocyclic chemistry》1981,18(4):801-802
5H-Benzothiazolo[3,2-a]quinazolin-5-ones (Va-d) were synthesized by thermal cyclization of N-(2-benzothiazolyl)-2-fluorobenzamides (IVa-d) which were obtained by allowing 2-fluorobenzoyl chloride to react with 2-aminobenzothiazoles. 相似文献
14.
A. Mobinikhaledi N. Foroughifar J. Alipour Safari T. Mosleh 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):2329-2335
3-Oxo-2-[(Z)-1-phenylmethylidene]-5H-[1,3]thiazolo[3,2-a] pyrimidine derivatives 2a–f were synthesized by the reaction of an appropriate 3,4-dihydro-2(H)-pyrimidone 1 , chloroacetic acid, sodium acetate and benzaldehyde. Reaction of 1 with acetic anhydride under heating afforded only 3-N-acetylated 3,4-dihydro-2(H)-pyrimidines 3a–f . The yields of the products after recrystallization from ethanol were of the order of 60–92 %. IR, 1 H NMR spectroscopy, and elemental analysis were used for the identification of these compounds. 相似文献
15.
The reaction of 2-mercaptobenzimidazole, 5-ethoxy-2-mercaptobenzimidazole, and 2-mercaptoimidazoline with cinnamoyl chloride, its derivatives, and heteroanalogs was studied. Convenient methods were found for the synthesis of 2-aryl-2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4-ones and 7-aryl-2,3,6,7-tetrahydro-5H-imidazo[2,1-b]-1,3-thiazin-5-ones. 相似文献
16.
Dong Han Kim 《Journal of heterocyclic chemistry》1981,18(2):287-291
5H-Benzoxazolo[3,2-a]quinazolin-5-ones (Xa-d) were synthesized in excellent yields from N-(2-hydroxyphenyl)anthranilic acids (Ia-d) and cyanogen bromide. The synthesis was based on the mechanistic consideration of the reactions of salicylic acid with cyanogen bromide previously reported in the literature. A versatile alternative route to these novel heterocyclic compounds was through thermal cyclization of N-(2-benzoxazolyl)-2-fluorobenzamides (XIII) obtained by reacting 2-fluorobenzoyl chloride with 2-aminobenzoxazoles. The reaction of Xb with ethanol in the presence of potassium hydroxide gave an ethoxyquinazolinone (XVII). Similarly, the alkaline hydrolysis of Xb afforded an quinazolindione (XVIII). 相似文献
17.
M. V. Karpov A. V. Eremin A. I. Fisher A. N. Belyaev M. D. Stadnichuk 《Russian Journal of General Chemistry》2011,81(1):128-131
Reaction of N-tert-butyl-1-aza-1,3-enynes with symmetrically substituted 2-mercaptobenzimidazoles in water-alcohol solutions afford 4H-[1,3]thiazino[3,2-a]benzimidazol-4-ols. The structure of compounds obtained was proved by the 1H and 13C NMR spectroscopy and X-ray diffraction data. 相似文献
18.
A novel route for the synthesis of thiazolo[3,2-a]pyrimidin-7-ones and pyrido[1,2-a]pyrimidin-2-ones from acetylated 2aminothiazoles and 2-aminopyridines under Vilsmeier conditions has been developed.The plausible mechanism has also been proposed. 相似文献
19.
New 2-substituted pyrazolo[5,1-b][1,3]oxazoles are synthesized through the Sonogashira coupling reaction of 2-iodomethyl-6-methylpyrazolo[5,1-b][1,3]oxazole with terminal alkynes in the presence of a palladium catalyst. This process is carried out in the absence of any copper salt, and provides an eco-friendly and efficient method for the synthesis of the products in water in good-to-high yields. Some of the compounds synthesized were screened for their in vitro anti-oxidant activity using the DPPH (2,2-diphenyl-2-picrylhydrazyl) assays. 相似文献
20.
In a one-pot synthesis, 1′-methyl-2,3″-dioxo-5″-aryl-1,2,5a″,7″,8″,9a″-hexahydro-5″H,6″H-dispiro[indole-3,2′-pyrrolidine-3′,2″-pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine]-4′-carboxylic acid methyl ester was prepared via the sequential reaction of 4-aryl-octahydro-pyrano[2,3-d]pyrimidine-2-thione, dimethyl acetylenedicarboxylate (DMAD), and a mixture of isatin and sarcosine. All the novel spiro compounds, in moderate yields, were characterized thoroughly by infrared, NMR, mass spectromentry, and elemental analysis together with x-ray crystallographic analysis. 相似文献