共查询到20条相似文献,搜索用时 515 毫秒
1.
6-(Perfluoroalkyl)salicylates were prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with 3-ethoxy-1-(perfluoroalkyl)prop-2-en-1-ones. 相似文献
2.
D. N. Bazhin Yu. S. Kudyakova Ya. V. Burgart V. I. Saloutin 《Russian Chemical Bulletin》2018,67(3):497-499
Lithium 4,4-dimethoxy-1-(perfluoroalkyl)pentane-1,3-dionates react with BF3?Et2O to give 2-methoxy-2-methyl-5-(perfluoroalkyl)furan-3(2H)-ones in high yields. 相似文献
3.
The synthesis of substituted 2-(trifluoromethyl)- and 2-(perfluoroalkyl)-2-hydroxy-2H-chromenes 2a-o was achieved in good yields by intramolecular cyclization of 3-(perfluoroalkyl)-3-phenoxypropenals 1 in the presence of aluminum chloride. Then a Lewis acid mediated nucleophilic reaction with silyl enol ethers 3 proceeded with complete regiospecificity to afford 4-functional 2-(trifluoromethyl)- and 2-(perfluoroalkyl)-4H-chromenes 4a-p with high yields. 相似文献
4.
Bis 1,2-(perfluoroalkyl) iodoethenes 4 were prepared by thermal addition of 1-iodo perfluoroalcanes 2 on perfluoroalkylethynes 3. Their duplication in the presence of copper gives in good yields 1,2,3,4-tetrakis(perfluoroalkyl) 1,3-butadienes 1, designed to serve as inert oxygen carriers for biological uses. 相似文献
5.
D. N. Bazhin T. I. Gorbunova A. Ya. Zapevalov V. I. Saloutin 《Russian Chemical Bulletin》2008,57(11):2324-2327
On treatment with sodium alkoxides in the corresponding alcohols, [2-iodo-3-(perfluoroalkyl)propyl]glycidyl ethers are converted
into 3-alkoxy-1-[3-(perfluoroalkyl)prop-2-enyloxy]-propan-2-ols in 56–78% yields, while its reaction with 2,2,2-trifluoroethanol
and phenol under phase transfer conditions (NaOH, CH2Cl2-H2O, Bu4N+I−, 35–40 °C) gives 3-alkoxy1-[2-iodo-3-(perfluoroalkyl)propoxy]propan-2-ols (yields 45–72%). 相似文献
6.
Teruo Umemoto Yuriko Kuriu Shin-chi Nakayama Osamu Miyano 《Tetrahedron letters》1982,23(14):1471-1474
RfI(Ph)OSO2CF3 or RfI(Ph)OSO3H smoothly reacted with various trimethylsilyl enol ethers under mild conditions to give α-(perfluoroalkyl) carbonyl and γ=(perfluoroalkyl)-α,β-unsaturated carbonyl compounds in high yields. 相似文献
7.
D. N. Bazhin T. I. Gorbunova A. Ya. Zapevalov V. I. Saloutin 《Russian Journal of Organic Chemistry》2009,45(4):491-495
Epoxy(perfluoroalkyl)alkenes were synthesized in one step by reaction of perfluoroalkyl iodides with 2-(allyloxymethyl)oxirane and 2-(oct-7-en-1-yl)oxirane in the presence of sodium dithionite and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under mild conditions. 相似文献
8.
Teruo Umemoto Yuriko Kuriu Hideo Shuyama Osamu Miyano Shin-Ichi Nakayama 《Journal of fluorine chemistry》1982,20(5):695-698
(Perfluoroalkyl)aryliodonium halides [2] and -tetra- fluoroborates [3] were previously synthesized. We now wish to report the synthesis of several kinds of (perfluoroalkyl)aryliodonium sulfonates which are important as electrophilic perfluoroalkylating agents [4]. 相似文献
9.
Lyudmila V. Saloutina Aleksandr Ya. Zapevalov Victor I. Saloutin Mikhail I. Kodess Valentina E. Kirichenko Marina G. Pervova Oleg N. Chupakhin 《Journal of fluorine chemistry》2005,126(6):976-983
The reactions of oxides of internal trans-, cis-perfluoroolefins with o-phenylenediamine and 2-aminophenol in dioxane gave 2,3-bis(perfluoroalkyl)quinoxalines and 2,3-bis(perfluoroalkyl)-2H-1,4-benzoxazin-2-ols respectively in yields of 23-67%. When N,N-dimethylacetamide was used as a solvent an anionic isomerization of the oxides into ketones, which further yielded 2-(perfluoroalkyl)benzimidazoles in the case of o-phenylenediamine and 2-hydroxy-N-perfluoroalkanoylanilines in the case of 2-aminophenol, became the main path of these reactions. Unusual cyclization resulting in 2-pentafluoroethyl-2-pentafluoropropanoylbenzoxazolidine occurs on interaction between dodecafluoro-3,4-epoxyhexane and 2-aminophenol in N,N-dimethylacetamide. 相似文献
10.
1-二茂铁基-3-(4-烷氧基-3-溴苯基)-1,3-丙二酮的合成及其结构表征 总被引:1,自引:0,他引:1
由乙酰基二茂铁(1)与4-长链烷氧基-3-溴苯甲酸甲酯(2)通过酮酯缩合反应, 合成了1-二茂铁基-3-(4-烷氧基-3-溴苯基)-1,3-丙二酮(3). 标题化合物3为首次合成, 具有复杂的共振结构.通过元素分析、红外光谱、核磁共振氢谱对其结构进行了表征. 用X射线单晶衍射法测定了1-二茂铁基-3-(4-十二烷氧基-3-溴苯基)-1,3-丙二酮(3c)的结构, 结果表明: 晶体属于三斜晶系, P-1空间群, a=0.8677(5) nm, b=0.8791(5) nm, c=2.1444(11) nm, α=101.489(9)°, β=94.784(10)°, γ=102.522(9)°, V=1.5511(14) nm3, Dc=1.273 g8226;cm-3, μ=1.801 mm-1, F(000)=618, Z=2, R1=0.0597, wR2=0.1386. 相似文献
11.
Reactions of 3-methyl-6-[4-(4-hydroxyphenyl)-1-piperazinyl]-2(3H)-benzoxazolone, 3-methyl-6-[4-(4-hydroxy-phenyl)-1-piperazinyl]-2(3H)-benzothiazolone and 1,3-dimethyl-5-[4-(4-hydroxyphenyl)-1-piperazinyl]-2(3H)-benzimidazolone with cis-{[2-(2,4-dichlorophenyl) -2-(1H-imidazol-1-ylmethyl)]-1,3-dioxolan-4-yl}methyl meth-anesulfonate in the presence of sodium hydride furnish the title compounds. 相似文献
12.
1 INTRODUCTIONInrecentyears ,triazolo[3,4, b] 1 ,3,4 thiadiazolederivativeshavebeenat tractingmuchattentionfromchemistsandpharmacologistsbecausetheyshowbroadspectraofbiologicalactivities,suchasinsecticidal[1 ] ,antifungal[2 ] ,herbicidal[3] ,an tibacterial[4] ,hypotensiv… 相似文献
13.
Bhovi K. Venkatesh Yadav D. Bodke S. A. Biradar 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1926-1931
A protocol for the synthesis of 3-[4-(1-benzofuran-2-yl)-1,3-thiazol-2-yl]-2-(4-aryl)-1,3-thiazolidin-4-one derivatives (5a–e) has been developed from 1-(1-benzofuran-2-yl)-2-bromoethanone (2),which served as a key intermediate for the synthesis of the title compounds. The reaction of compound 2 with thiourea furnished 4-(1-benzofuran-2-yl)-1,3-thiazol-2-amine 3, which upon further reaction with various aromatic aldehydes, gave Schiff bases 4a–e. These Schiff bases, when treated with thioacetic acid in the presence of catalytic amount of anhydrous ZnCl2, yielded thiazolidinone derivatives 5a–e. All the newly synthesized compounds have been characterized by analytical and spectral data and screened for their antimicrobial and analgesic activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
14.
The first example of nucleophilic substitution with perfluoroalkyl Grignard reagents on the sp3 carbon centre is described. Thus, a series of organometals RF-MgBr, prepared from perfluorinated alkyl iodides RF-I with RF = C4F9, C6F13, C8F17, C10F21 and C12F25, reacted with 1,3,2-dioxathiolane-2,2-dioxide to afford the corresponding 2-(perfluoroalkyl)ethyl magnesium sulfates, which were isolated after metathesis to the corresponding potassium salts. In the model reaction, perfluorohexylmagnesium iodide was reacted with methyl triflate yielding polyfluorinated alkane. The attempts to extend the reaction to 1,3,2-dioxathiane-2,2-dioxide were unsuccessful due to its inferior reactivity and only reduced polyfluoroalkane and the product of coupling were detected in the reaction mixture. Polyfluorinated sulfates are easily hydrolyzed with hydrochloric or triflic acid to the corresponding alcohols, which is an alternative to standard transformation of perfluoroalkyl iodides to 2-(perfluoroalkyl)ethanols. Quantum-chemical calculations of the PES of the reaction with both sulfur-containing heterocycles found that the failure of the reaction with 1,3,2-dioxathiane-2,2-dioxide is caused by higher activation energy of the process. 相似文献
15.
A. A. Shchipalkin M. L. Petrov V. A. Kuznetsov 《Russian Journal of Organic Chemistry》2011,47(12):1878-1881
Treatment of 4-(1-adamantyl)-1,2,3-thiadiazole with potassium tert-butoxide generated potassium 2-(1-adamantyl)ethynethiolate which reacted with aromatic carboxylic acid chlorides to give
unstable S-[2-(1-adamantyl)ethynyl] arenecarbothioates whose acid hydrolysis afforded S-[2-(1-adamantyl)-2-oxoethyl] arenecarbothioates. The latter reacted with ammonium acetate in acetic acid yielding 4-(1-adamantyl)-2-aryl-1,3-thiadiazoles.
Reactions of 4-(1-adamantyl)-2-(4-chloro-3-nitrophenyl)-1,3-thiadiazole with cyclic secondary amines gave the corresponding
products of nucleophilic replacement of the chlorine atom in the aromatic ring. 相似文献
16.
Yun Gen LIU Shao Bai LI* National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 《中国化学快报》2001,(12)
Natural diarylheptanoids have significant bioactivities. Some of them are potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase) and 5-lipoxygenase (LT synthetase)1-2. Compound 1 was firstly isolated from Alnus rubra bark3. So far its synthesis has not been reported yet. Herein, we report the synthesis of compound 1. Meantime, compound 24 was also obtianed as an intermediate. Compound 7 and 16 were converted to compound 10 and 18 respectively, because compound 1… 相似文献
17.
V.Ya Sosnovskikh D.V SevenardB.I Usachev G.-V Röschenthaler 《Tetrahedron letters》2003,44(10):2097-2099
Reactions of 2-perfluoroalkylchromones with (perfluoroalkyl)trimethylsilanes proceed as a 1,4-nucleophilic perfluoroalkylation to give 2,2-bis(perfluoroalkyl)chroman-4-ones in high yields after acid hydrolysis. Oxidation of 2,2-bis(trifluoromethyl)-6-methylchroman-4-one with K2S2O8 leads to fluorinated analogs of natural lactarochromal and the corresponding acid. 相似文献
18.
LnCl3(cat.)/Zn system has been found to cause hydroperfluoro-alkylation of α,β - unsaturated esters with perfluoroalkyl iodides in high yields as compared with the reaction with Zn alone. 相似文献
19.
Russian Journal of General Chemistry - A novel synthetic approach to (E)-1-{[1-(3-chlorophenyl)-3-[(4-methoxyphenyl-1H-pyrazol-4-yl)- methylene]hydrazono}-3-phenylthiazolidin-4-one starting from... 相似文献
20.
V. V. Il'in O. V. Slavinskaya Yu. A. Strelenko A. V. Ignatenko V. A. Ponomarenko 《Russian Chemical Bulletin》1991,40(11):2177-2180
Previously unknown 1,4-dichloro-1,4-bis(perfluoroalkyl)-1,3-diazatetra-1,3-Dienes have been prepared and shown to be mixtures of isomers of Z and E configurations. The structures have been identified and a quantitative estimate made of the ratio of Z and E isomers using13C,19F, and15N NMR spectroscopy. 相似文献