共查询到20条相似文献,搜索用时 15 毫秒
1.
Ernesto Fattorusso Orazio Taglialatela-Scafati M. Janib Achmad Giorgio Bavestrello 《Tetrahedron》2008,64(14):3141-3146
Four novel xenicane diterpenoids, xenimanadins A-D (1-4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids. 相似文献
2.
Gupta P Sharma U Schulz TC Sherrer ES McLean AB Robins AJ West LM 《Organic letters》2011,13(15):3920-3923
Three new briarane diterpenoids, briareolate esters L-N (1-3), have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1) was found to contain a "spring-loaded" (E,Z)-dieneone Michael acceptor group that can form a reversible covalent bond to model sulfur-based nucleophiles. 相似文献
3.
Jian-Fan Sun Hui Huang Xing-Yun ChaiXian-Wen Yang Li MengCai-Guo Huang Xue-Feng ZhouBin Yang Jing HuXian-Qiang Chen Hui LeiLishu Wang Yonghong Liu 《Tetrahedron》2011,67(6):1245-1250
Five new briarane type diterpenoids, dichotellides A−E (1−5), were isolated from the South China Sea gorgonian Dichotella gemmacea together with four known analogues (6−9). Compounds 1−5 represent the first examples of iodine-containing briarane type diterpenoids from nature. The structures of these diterpenoids were elucidated by spectroscopic analysis, including 1D, 2D-NMR, and HRESIMS, and the absolute configuration of 1 was further confirmed by single crystal X-ray diffraction analysis. All the isolates were evaluated for cytotoxicity activity against four human tumor cell lines, and only 3 exhibited marginal activity against SW1990 (human pancreatic cancer). 相似文献
4.
Yoshikawa K Kokudo N Tanaka M Nakano T Shibata H Aragaki N Higuchi T Hashimoto T 《Chemical & pharmaceutical bulletin》2008,56(1):89-92
From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). 相似文献
5.
Five new natural labdane-type diterpenoids (5-9), designated leoheteronins A-E, together with four known diterpenoids (1-4), two phytosterols as a mixture of beta-sitosterol and stigmasterol, and the flavone genkwanin (10) were isolated from the aerial parts of Leonurus heterophyllus SW. (Lamiaceae) collected in northern Vietnam. Compound 1 was isolated for the first time from a Leonurus species, and 10 is considered to be a chemotaxonomic marker of the Leonurus genus. Their structures were determined using spectroscopic analyses. 相似文献
6.
Castanolide (1) and epi-castanolide (2), two novel diterpenoids possessing a unique seco-norabietane skeleton, were isolated from Salviacastanea Diels f. pubescens Stib. Their structures and relative stereochemistry were elucidated by extensive NMR analysis and confirmed by single-crystal X-ray diffraction study. A possible biosynthetic pathway of these two compounds was also proposed. 相似文献
7.
Two novel diterpenoids were isolated from the bulbs of Fritillaria anhuiensis S. C. Chen and S. E. Yin. Compound 1 was the first diterpenoid containing a sulfonyl group isolated from nature. Compound 2 was a novel kaurane-type diterpenoid. Their structures were determined by extensive spectroscopic analysis (IR, MS, NMR, and X-ray diffraction). Compound 1 significantly attenuated nitric oxide (NO) production of a macrophage cell line of Raw 264.7 cells stimulated with IFN-γ. 相似文献
8.
Study of the secretion from a scale insect (Ceroplastes ceriferus) diterpenoids and sesterterpenoids
Structures of four new minor sesterterpenoids 1–3,18 and three new diterpenoids 12–14 isolated from the secretion of Ceroplastes ceriferus are described. All four sesterterpenoids are 14-membered monocyclic compounds; one of them has been chemically correlated with cericeroic acid1 of proven absolute stereochemistry. The “cyclic wax” was a complex mixture of esters consisting of fatty acids (C10-C32) and unusual cyclic alcohols (diterpenoids and sesterterpenoids) 相似文献
9.
Ono M Yamasaki T Konoshita M Ikeda T Okawa M Kinjo J Yoshimitsu H Nohara T 《Chemical & pharmaceutical bulletin》2008,56(11):1621-1624
Two new halimane-type diterpenoids, viteagnusins A and B, and three new labdane-type diterpenoids, viteagnusins C, D, and E, were isolated from the fruit of Vitex agnus-castus L. (Chasteberry, Verbenaceae) along with two known diterpenoids. Their chemical structures were determined on the basis of spectroscopic data. 相似文献
10.
Nagashima F Kondoh M Uematsu T Nishiyama A Saito S Sato M Asakawa Y 《Chemical & pharmaceutical bulletin》2002,50(6):808-813
Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis. 相似文献
11.
Hong-Shun Gu Shuang-Gang Ma Yu-Huan Li Ya-Dan Wang Yun-Bao Liu Li Li Yong Li Jing Qu Hai-Ning Lv Xiao-Guang Chen Jian-Dong Jiang Shi-Shan Yu 《Tetrahedron》2014
Nine new prenylbisabolane diterpenoids, claoxylones A–I (1–9), were isolated from the branches and leaves of Claoxylon polot. This is the first example of prenylbisabolane diterpenoids with furan and tetrahydrofuran rings. Their structures and relative configurations were established by spectroscopic and conformational analysis, and the absolute configurations were determined by single-crystal X-ray diffraction and electronic circular dichroism (ECD) analysis. Compounds 1–9 exhibited antiviral activity against Coxsackie B3 virus, with IC50 values of 6.0–33.3 μM. 相似文献
12.
Three highly oxidized casbane-type diterpenoids with unique α,β-unsaturated γ-lactones, named Hookerianolides A (1), B (2), and C (3), were isolated from the methylene chloride extracts of Mallotus Hookerianus. Their structures were elucidated based on NMR spectroscopic data and chemical conversions. The stereochemistry was confirmed by combination of ROESY correlations and CD analyses. 相似文献
13.
A minor diterpenoid with a novel carbon skeleton,secoeuphoractin(1),was isolated from an ethanol extract of the roots of Euphorbia micractina.Its structure including the absolute configuration was determined by extensive spectroscopic studies,especially by 2D NMR and CD data analysis,in combination with a plausible biosynthetic pathway associated with co-occurring diverse diterpenoids.This compound showed activity against HIV-1 replication with an IC_(50) value of 1.76 ± 0.61 μmol/L. 相似文献
14.
Bruno M Rosselli S Maggio A Piozzi F Scaglioni L Arnold NA Simmonds MS 《Chemical & pharmaceutical bulletin》2004,52(12):1497-1500
Two new neoclerodane diterpenoids, 6-deacetyl-teucrolivin A (5) and 8beta-hydroxy-teucrolivin B (6), were isolated from the aerial parts of Teucrium orientale, along with four already known neoclerodane diterpenoids, teucrolivin A (1), teucrolivin B (2), teucrolivin C (3) and teucrolivin H (4), previously isolated from Teucrium oliverianum. Their structures were elucidated on the basis of spectroscopic evidence and chemical transformations. Compounds 1-3 were assayed for antifeedant activity against Spodoptera littoralis, S. frugiperda and Heliocoverpa armigera. Teucrolivin A was the most potent of the three compounds tested. 相似文献
15.
Bruce M. Howard William Fenical Stephen E. Donovan Jon Clardy 《Tetrahedron letters》1982,23(38):3847-3850
Neoirieone, a dibrominated diterpenoid of a new skeletal class, related to the irieol diterpenoids, has been isolated from Laurencia cf. irieii. The structure of neoirieone was elucidated by x-ray crystallographic analysis of its corresponding reduction product, neoirieol (. 相似文献
16.
Two new icetexane diterpenoids from Salvia przewalskii 总被引:3,自引:0,他引:3
Xu G Peng LY Zhao Y Li XL Tu L Zhao QS Sun HD 《Chemical & pharmaceutical bulletin》2005,53(12):1575-1576
Two new icetexane diterpenoids, przewalskin C, D (1, 2), together with sixteen known diterpenoids, were isolated from Salvia przewalskii. Eight of known ones (compounds 3, 12-18) were reported firstly from this plant. To the best of our knowledge, it's the first report of icetexane diterpenoids from this plant. The identification and structural elucidation of these compounds were based on 1D- and 2D-NMR spectral data analysis. 相似文献
17.
Three new diterpenoids with jatrophane‐type skeleton, sororianolides A–C ( 1 – 3 , resp.), were isolated from Euphorbia sororia. The identification and structure elucidation of these compounds were based on 1D‐ and 2D‐NMR‐spectral data analysis. It was the first time to isolate diterpenoids in this species. 相似文献
18.
Daphnane diterpenoids are mainly distributed in Thymelaeaceae and Euphorbiaceae and have various bioactivities. About 100 daphnane diterpenoids have been isolated from natural plants. In this review, we systematically summarize the 13C‐NMR data of daphnane diterpenoids isolated from natural plants over the past several decades and briefly discussed their biological activities and basic structural–activity relationship. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
19.
Atisane‐type diterpenoids are the principal constituent of tetracyclic C20‐diterpenoids, widely isolated from the plant kingdom with varying degrees of structural complexity and pharmacological activity. The tetracarbocyclic system with the unique bicyclo[2.2.2]octane skeleton of this natural product family has generated interest within the synthetic community. Divergent total synthesis is an effective tactic to synthesize several atisane‐type diterpenoids using structural interconversion from a common intermediate. This account summarizes the divergent total synthesis of atisane‐type diterpenoids. 相似文献
20.
Nagashima F Kasai W Kondoh M Fujii M Watanabe Y Braggins JE Asakawa Y 《Chemical & pharmaceutical bulletin》2003,51(10):1189-1192
Two new ent-kaurene-type and a new rearranged ent-kaurene-type diterpenoids possessing cytotoxicity against a human leukemia cell line have been isolated from the New Zealand liverwort Jungermannia species, together with previously known ent-kaurene-type diterpenoids. Their structures were established based on extensive NMR techniques. 相似文献