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番荔枝内酯————明日抗癌之星 总被引:8,自引:3,他引:8
本文介绍一类近年来被发现于番荔枝科(Annonaceae)植物中的强抗肿瘤活性化合物----番荔枝内酯(annonaceousacetogenin) , 从这类化合物的结构特点, 生理活性, 生源假说, 化学合成等几个方面综述了在该领域的氧基状况 . 相似文献
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The structure of rogioldiol A ((?)- 1 ), isolated from the red seaweed Laurencia microcladia, was determined. Employing the exciton-coupling technique for rogioldiol A p-bromobenzoate ( 2 ), the absolute configuration at C(9) of (?)- 1 was assigned, and, together with extensive NMR experiments, the absolute configuration at C(10) and preferred conformations of (?)- 1 were determined. The absolute configuration of the hetero-substituted cyclohexane ring was deduced in analogy from the X-ray structure of 4 , a derivative of the aldehyde 3 , which was isolated from the same seaweed and is believed to be a degradation product of (?)- 1 . 相似文献
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利用柱层析法(硅胶,C18)从日香桂根的乙酸乙酯提取物中分离出8个单体化合物[女贞苷(1),连翘苷(2),(+)-羟基松脂醇-1-O-β-D-葡萄糖(3),(+) 环橄榄树脂素(4), 2α,3β-二羟基乌苏-12-烯-28酸(5),对羟基苯乙醇(6),(-) 橄榄脂素(7)和橄榄树脂素-4-O-β-D-葡萄糖苷(8)],其结构经1H NMR和13C NMR确证。5为首次在木犀科植物中发现,4为首次在木犀属植物中发现,2, 3, 7和8为首次在日香桂植物中发现。 相似文献
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Three new 19-membered macrolides, amphidinolides T2 (2), T3 (3), and T4 (4), structurally related to amphidinolide T1 (1) have been isolated from two strains of marine dinoflagellates of the genus Amphidinium. The structures of 2-4 were elucidated on the basis of spectroscopic data. The absolute configurations at C-7, C-8, and C-10 of 1-4 were determined by comparison of NMR data of their C-1-C-12 segments with those of synthetic model compounds for the tetrahydrofuran portion. The biosynthetic origins of amphidinolide T1 (1) were investigated on the basis of 13C NMR data of a 13C enriched sample obtained by feeding experiments with [1-(13)C], [2-(13)C], and [1,2-(13)C2] sodium acetates and 13C-labeled sodium bicarbonate in the cultures of the dinoflagellate. These incorporation patterns suggested that amphidinolide T1 (1) was generated from four successive polyketide chains, an isolated C1 unit formed from C-2 of acetates, and three unusual C2 units derived only from C-2 of acetates. Furthermore, it is noted that five oxygenated carbons of C-1, C-7, C-12, C-13, and C-18 were not derived from the C-1 carbonyl, but from the C-2 methyl of acetates. 相似文献
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Das Niranjan Deb Prashanta Kumar Ali Eunus S. Das Manash C. Sarkar Biswatrish Mishra Siddhartha Kumar 《Chemistry of Natural Compounds》2022,58(1):21-26
Chemistry of Natural Compounds - A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was... 相似文献
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Liu Xia Yang Yi-Xuan Gao Xin Liu Qian Zhang Xiao-Na Niu Xiao-Feng Zhang Hui 《Chemistry of Natural Compounds》2021,57(6):1035-1037
Chemistry of Natural Compounds - A new sesquiterpene, 1β-hydroxy-4(5),7(8),11(12)-triene-6,9-dione-7,8-furanoeudesmane (1), was isolated from the root extract of Chloranthus multistachys C.... 相似文献
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The 1H and 13C NMR spectra of methyl (-)-zanzibarate (1), an ent-labdanic diterpene isolated from the epicarp of Hymenaea courbaril var. altissima (Leguminosaea, Cesalpinoideae, Detariae), was fully assigned by COSY experiments, 13C/1H shift correlation diagrams and NOE experiments. 相似文献
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The complete assignments of all the (1)H and (13)C NMR signals of three sesquiterpene lactones, 4-oxo-5(6),11-eudesmadiene-8,12-olide (1), 4-oxo-11-eudesmaene-8,12-olide (2) and (1(10)E)-5beta-Hydroxygermacra-1(10),4(15),11-trien-8, 12-olide (3), were carried out by various 2D NMR experiments. Compounds 1-3 were isolated from the roots of Inula helenium for the first time. Among them, 1 was identified as a new nor-sesquiterpene lactone, and 2 was isolated from a natural source for the first time. The (13)C-NMR data of compound 3 was also reported for the first time. 相似文献
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Su JH Dai CF Huang HH Wu YC Sung PJ Hsu CH Sheu JH 《Chemical & pharmaceutical bulletin》2007,55(4):594-597
Two new sesquiterpenoidal natural products chabrolidiones A and B (1 and 2), two C(18) terpenoid-related carboxylic acids, ketochabrolic acid (3) and isoketochabrolic acid (4), and one naphthoquinone derivative chabrolonaphthoquinone C (5), along with two known compounds (+)-aristolone (6) and teuhetenone A (7) were isolated from a Formosan soft coral Nephthea chabrolii. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of related metabolites. Metabolite 1 has been synthesized previously, but was isolated for the first time from natural sources. Cytotoxic activity of metabolites 1-3 and 5-7 against a limited panel of cancer cell lines is also described. 相似文献
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Alali FQ Tawaha K El-Elimat T Qasaymeh R Li C Burgess J Nakanishi Y Kroll DJ Wani MC Oberlies NH 《Natural product research》2006,20(6):558-566
As a part of our continuing investigation of Jordanian Colchicum species, the biologically active components of Colchicum hierosolymitanum Feinbr and Colchicum tunicatum Feinbr (Colchicaceae) were pursued. The brine shrimp lethality test (BSLT) was used to direct the fractionation and isolation of active components. Five and four known colchicinoids were isolated and characterized from C. tunicatum and C. hierosolymitanum, respectively. The known colchicinoids, reported for the first time from these two species are: (-)-colchicine (I), 3-demethyl-(-)-colchicine (II), (-)-cornigerine (III), beta-lumicolchicine (IV), and (-)-androbiphenyline (V) from C. tunicatum, and (-)-colchicine (I), 2-demethyl-(-)-colchicine (VI), (-)-cornigerine (III), and beta-lumicolchicine (IV) from C. hierosolymitanum. The chemical structures of the isolated compounds have been elucidated using a series of spectroscopic and spectrometric techniques principally; 1D-NMR (1H and 13C) and low resolution EI-MS and APCIMS. All pure compounds were evaluated for cytotoxicity against three human cancer cell lines; MCF-7 human breast carcinoma, NCI-H460 human large cell lung carcinoma, and SF-268 human astrocytoma. (-)-Colchicine (I) and (-)-cornigerine (III) were found to be the most bioactive of the identified compounds with EC50 values in the range of 0.016-0.097 microM. 相似文献
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A new cyclic peptide, prepatellamide A (1), along with three known cyclic peptides (2)-(4), was isolated from the ascidian Lissodinum patella. The structure of prepatellamide A was determined from one- and two-dimensional H and 13C NMR spectra. The known cyclic peptides were identified as patellamides A (2), B (3) and C (4). 相似文献