共查询到17条相似文献,搜索用时 62 毫秒
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通过对23个羟基蒽醌衍生物的质子核磁共振研究, 观察了不同取代类型羟基的化学位移范围;讨论了酚羟基乙酰化对芳环质子的化学位移影响, 为羟基取代位置的确定及芳环质子谱线归属提供了某种判据.此外, 还用HMO 法探讨了各类取代羟基的氢键强度及羰基迫位仅有一个羟基的内氢键强度与给予原子电荷密度的关系.本文报道一系列新型冠醚N,N'-双取代-1,7-二氧杂-12-冠-4(1~6), N,N' -双取代-1, 7-二氮杂-15冠-5(7~10) 及N,N'-双取代-1,10-二氮杂-18-冠-6(11~14)的质谱. 借助联动扫描和去焦技术对它们的开裂机理作了详细探讨. 相似文献
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CHEN Wen-Sen South China Institute of Botany Chinese Academy of sciences Guangzhou Guangdong ChinaYAO Zhu-Jun ZHANG Yi-Bin XU Yong-Zhen WU Yu-LinState Key Laboratory of Bio-organic & Natural Products Chemistry Shanghai Instutute of Organic Chemistry Chinese Academy of Sciences Fenglin Lu Shanghai China 《中国化学》1995,13(3):263-266
Atemoyacin A, a new annonaceous acetogenin was isolated from the alcoholic extract of the seeds of Annona atemoya Hort (Annonaceae). Its structure and relative configuration were elucidated on the basis of the spectral analysis. 相似文献
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Alexandra G. Durn M. Teresa Gutirrez Francisco J. R. Mejías Jos M. G. Molinillo Francisco A. Macías 《Molecules (Basel, Switzerland)》2021,26(10)
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill. 相似文献
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Shi Sun Jingchun Liu Xiuxiu Sun Wenjun Zhu Fei Yang Lisa Felczak Q. Ping Dou Kequan Zhou 《Tetrahedron letters》2017,58(19):1895-1899
Five bioactive Annonaceous acetogenins, including three new compounds, annonamuricins A (1), B (2), and C (3), one registered but no spectral data reported compounds, annonamuricin D (4), and one known compound annonacin (5) were isolated from Graviola fruit (Annona muricata) and further determined through bioassay-guided fractionation. All five compounds are C35 Anonnonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated using spectral methods as well as chemical modification after isolation via chromatographic techniques and HPLC purification. These acetogenins demonstrated potent anti-proliferative activities against human prostate cancer PC-3 cells. 相似文献
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Tian‐Jye Hsieh Yang‐Chang Wu Su‐Ching Chen Ching‐Shan Huang Chung‐Yi Chen 《中国化学会会志》2004,51(4):869-876
A new kaurane diterpenoid, annoglabasin G (16α‐hydro‐19‐acetoxy‐ent‐kauran‐17‐al) ( 1 ), along with 27 compounds including 18 kaurane diterpenoids, 16β‐hydro‐ent‐kauran‐17‐oic acid ( 2 ), 16α‐hydro‐ent‐kauran‐17‐oic acid ( 3 ), 19‐nor‐ent‐kauran‐4α‐ol‐17‐oic acid ( 4 ), 16α‐hydro‐19‐ol‐ent‐kauran‐17‐oic acid ( 5 ), ent‐kaur‐16‐en‐19‐oic acid ( 6 ), 16α‐hydroxy‐ent‐kauran‐19‐oic acid ( 7 ), 16α,17‐dihydroxy‐ent‐kauran‐19‐oic acid ( 8 ), 16β,17‐dihydroxy‐ent‐kauran‐19‐oic acid ( 9 ), 16α‐hydro‐ent‐kauran‐17,19‐dioic acid ( 10 ), 16β‐hydroxy‐17‐acetoxy‐ent‐kauran‐19‐oic acid ( 11 ), 16β‐hydro‐17‐hydroxy‐ent‐kauran‐19‐al ( 12 ), 16α‐hydro‐17‐hydroxy‐ent‐kauran‐19‐al ( 13 ), 16β,17‐dihydroxy‐ent‐kauran‐19‐al ( 14 ), 16α‐hydro‐19‐al‐ent‐kauran‐17‐oic acid ( 15 ), 16α‐hydro‐17‐acetoxy‐ent‐kauran‐19‐al ( 16 ), 16α‐hydro‐19‐acetoxy‐ent‐kauran‐17‐oic acid ( 17 ), ent‐kaur‐15‐en‐19‐oic acid ( 18 ) and ent‐kaur‐15‐en‐17‐ol‐19‐oic acid ( 19 ); four acetogenins, annomontacin ( 20 ), annonacin ( 21 ), isoannonacinone ( 22 ) and squamocin ( 23 ); four steroids, β‐sitosterol ( 24 ), stigmasterol ( 25 ), β‐sitosteryl‐D‐glucoside ( 26 ) and stigmasteryl‐D‐glucoside ( 27 ) and one oxoaporphine, liriodenine ( 28 ), were isolated from the fresh fruits of Annona glabra. These compounds were characterized and identified by physical and spectral evidence. 相似文献
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Althoughourresearchrevealedthatnarumicin-IIanddesacetyluvaricinwerethetwomajorbioactivebis-THFringacetogeninsintherootsofUvariacalamistralaHance,twonewbis-THFringannonaceousacetogeninswithmild-activitiesnamedcalamistrinsF(l)andG(2)hadalsobeenisolated.TheacetogeninsweretraceconstituentsintheplantandstructurallyhadthecharacteristicsofOH-flankedTHFringfromC-l8toC-25andathirdOHgroupatC-5.lwasisolatedaswaxysolid.TheFABMSoflgave[MH1 peakatm/:623,which,combiningwithelementalanaIysis,sugge… 相似文献
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Thirty-five compounds including twenty-one alkaloids, lysicamine ( 1 ), liriodenine ( 2 ), atherospermidine ( 3 ), oxoxylopine ( 4 ), oxoanolobine ( 5 ), oxoglaucine ( 6 ), (-)-anonaine ( 7 ), (-)-asimilobine ( 8 ), (-)-xylopine ( 9 ), (-)-anolobine ( 10 ), (-)-norisocorydine ( 11 ), (+)-laurotetanine ( 12 ), (+)-isocorydine ( 13 ), (-)-N-methylasimilobine ( 14 ), (+)-N-methyllaurotetanine ( 15 ), (-)-norushinsunine ( 16 ), (-)-ushinsunine ( 17 ), (-)-N-formylanonaine ( 18 ), (+)-stepharine ( 19 ), (+)-orentaline ( 20 ), and (-)-kikemanine ( 21 ); four kauranes, ent-kaur-16-en-19-oic acid ( 22 ), 16β-hydroxy-17-acetoxy-ent-kauran-19-al ( 23 ), 17-acetoxy-16β-ent-kauran-19-oic acid ( 24 ), and 16β-hydroxy-17-acetoxy-ent-kauran-19-oic acid ( 25 ); two amides, N-trans-femloyltyramine ( 26 ), and N-trans-caffeoyltyramine ( 27 ); one purine, adenosine ( 28 ); one lactam amide, squamolone ( 29 ); and six steroids, β-sitosterol ( 30 ), stigmasterol ( 31 ), β-sitostenone ( 32 ), stigmasta-4,22-dien-3-one ( 33 ), 6β-hydroxy-β-sitosterone ( 34 ), and 6β-hydroxystigmasterone ( 35 ) are isolated from the stems of Annona cherimola. These compounds were characterized and identified by physical and spectral evidence. Among them, (-)-norisocorydine (11) was elucidated as a new enantiomer with a levorotary configuration, which is isolated for the first time. 相似文献