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1.
I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov O. I. Naboka 《Chemistry of Heterocyclic Compounds》2008,44(2):178-183
A large series of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides has been prepared as potential diuretic agents.
The effect of all of the synthesized compounds on the urinary function of the kidney has been investigated. The appearance
of a “structure — diuretic activity” relationship is discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 239–245, February, 2008. 相似文献
2.
《Journal of Coordination Chemistry》2012,65(5):747-765
Continued exploration of the coordination behavior of derivatives of 2-benzophenone-based ligands with metal alkoxides ([M(OR)4]) was undertaken from the reaction of 2-(2-hydroxy-4-methoxybenzoyl)benzoic acid (H2-OBzA) with a series of Group 4 precursors. The products of these reactions were identified as: [(OR)2Ti(μ-(c,c-OBzA))]2 (OR?=?OCHMe2 (OPri; 1 ?2tol); OCMe3 (OBut; 2 ?THF); OCH2CMe3 (ONep; 3)), [[(OPri)3Ti(μ-OPri)Ti(OPri)2]2(μ-(μc,μ-OBzA))2]2 (4), [(ONep)3Zr(μ-ONep)2Zr(ONep)2]2(μ-(c,μ-OBzA)2) (5 ?tol), [(py)(OBut)3Zr]2(μ-(c,c-OBzA)) (6), [(OBut)2Hf(μ-OBut)]2(μ-(c,η1-OBzA)) (7) where ‘c’?=?chelating or η2; ‘μ’?=?bridging or η1,η1(O,O’); and μc?=?bridging chelating or η1,η1(O,O’); η2?:?η1. The metal centers for each of these compounds adopt a pseudo-octahedral geometry employing the OBzA ligand in numerous binding modes. The different functional oxygens (carboxylate, hydroxyl, and carbonyl) were employed in a variety of coordination modes for 1–7. The complexity of these OBzA-modified compounds is driven by a combination of the coordination behavior of the OBzA moieties, the size of the metal cation, and the pendant chain of the OR ligand. Solution NMR indicates a complex structure exists in solution that was considered to be consistent with the solid-state structure. 相似文献
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I. V. Ukrainets S. G. Taran P. A. Bezuglyi O. A. Evtifeeva 《Chemistry of Heterocyclic Compounds》1993,29(9):1041-1043
The thermolysis of ethyl 2-ethoxycarbonylmalonanilate in boiling diphenyl oxide gave the 2-ethoxycarbonylanilide of 1H-2-oxo-4-hydroxyquinoline-3-carboxylic acid, which is also formed from the N,N-di-2-ethoxycarbonylaniline of malonic acid in the conditions of the Dieckmann reaction. The mechanism of the chemical conversions indicated is presented and discussed.For Communication 16, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1219–1222, September, 1993. 相似文献
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Ismael Valois-EscamillaAlejandro Alvarez-Hernandez Luis Felipe Rangel-RamosOscar Rodolfo Suárez-Castillo Francisco Ayala-MataGerardo Zepeda-Vallejo 《Tetrahedron letters》2011,52(29):3726-3728
The synthesis of 6-bromo-2-arylindoles starting from readily available 2-iodobenzoic acid is presented. Regioselective bromination of the latter was followed by Curtius rearrangement and trapping of the isocyanate with benzyl alcohol led to the benzyl carbamate of 2-iodo-5-bromoaniline. Chemoselective Sonogashira coupling of this compound with arylacetylenes followed by TBAF induced 5-endo-dig cyclization gave the desired bromo indoles. The method allows selective introduction of a bromine atom at the indole C-6 position. 相似文献
6.
Summary The succinic acid used for the biosynthesis of the tropane alkaloids is probably included in their molecule as a whole, and forms the fragment of the alkaloid molecule consisting of carbon atoms 1, 7, 6, and 5.Khimiya Prirodnykh Soedinenii, Vol. 3, No. 6, pp. 395–397, 1967 相似文献
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Manohar Mantipally Rambabu Gundla Madhusudhana Reddy Gangireddy Viswanathan Vijayan Velmurugan Devadasan 《Tetrahedron letters》2018,59(52):4616-4619
A novel method for the synthesis of 2-imino-2H-benzo[h]chromenes via the sequential addition of N-chlorosuccinimide and triethylamine to 2-amino-4H-benzo[h]chromenes has been established. This reaction protocol represents an efficient synthetic strategy to form iminochromene derivatives under mild reaction conditions, which utilizes readily accessible aminochromenes as starting materials and tolerates a wide range of substrates. 相似文献
9.
I. V. Ukrainets M. Amer P. A. Bezuglyi O. V. Gorokhova L. V. Sidorenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2002,38(5):571-575
The synthesis, antitubercular, anti-HIV, and antitumor activity of the 4-(adamant-1-yl)thiazolyl-2-amides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids have been studied. An efficient method for purifying the 4-hydroxy-2-oxoquinoline derivatives from their metal salts is proposed. 相似文献
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The reaction of N-R-substituted amides of 2-carboxymalonanilic acid with the equimolar amount of o-phenylenediamine was studied under conditions of thermolysis. It was established that the main products of this reaction are the corresponding amides of benzimidazolyl-2-acetic acid and 1H-2-oxo-3-(benzimidazolyl-2)-4-hydroxyquinoline. Mechanisms of the indicated chemical conversions are discussed. The data on the study of the anticonvulsive activity of the compounds synthesized are presented.For Communication 15, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1105–1108, August, 1993. 相似文献
11.
I. V. Ukrainets S. G. Taran N. V. Likhanova Nidal Amin Jaradat O. V. Shishkin 《Chemistry of Heterocyclic Compounds》2000,36(1):57-61
S-(–)-1-phenylethylamide of 6-bromo-4-hydroxy-1-isoamyl-2-oxo-3-quinolinecarboxylic acid was synthesized. X-ray diffraction investigation of this product was carried out to determine its absolute configuration.For communication 38, see ref. [1].National Pharmaceutical Academy of Ukraine, 310002 Kharkov, Ukraine Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 64–69, January, 2000. 相似文献
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I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov V. N. Kravchenko 《Chemistry of Heterocyclic Compounds》2008,44(1):64-72
The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents
leads to the formation of a significant amount of colored side products, consequently it was proposed the reaction be carried
out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride
with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the
urine-excreting function of the kidney.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 78–87, January, 2008. 相似文献
15.
I. V. Ukrainets P. A. Bezuglyi V. I. Treskach A. V. Turov 《Chemistry of Heterocyclic Compounds》1992,28(5):538-540
A comparison of several methods of preparation of N-R-substituted 4-hydroxy-2-quinolone-3-carboxylic acid amides showed that intramolecular cyclization of 2-carbalkoxymalonanilic acid ethyl esters with simultaneous amidation is the most rational method.See [1] for Communication 3.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 640–642, May, 1992. 相似文献
16.
A nitric acid method for the preparation of cellulose from miscanthus is considered. The method consists in successive treatment of the raw material with nitric acid and sodium hydroxide and affords cellulose with properties suitable for the synthesis of cellulose nitrates. The data on the nitrogen weight fraction, the viscosity, and the solubility of cellulose nitrates from miscanthus in the alcohol-ether medium are given. The miscanthus cellulose was nitrated using an industrial sulfuric-nitric acid mixture to yield cellulose nitrate samples with characteristics close to those of colloxylin.
相似文献17.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova N. A. Jaradat 《Chemistry of Heterocyclic Compounds》2006,42(4):475-487
Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic acids have been studied. Results
of investigations on the antitubercular and antiinflammatory activity of the obtained compounds are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 542–555, April, 2006. 相似文献
18.
Trideep Rajale Shikha SharmaDaniel A. Stroud Daniel K. Unruh Emily MiaouKimberly Lai David M. Birney 《Tetrahedron letters》2014
An efficient Pd-catalyzed Suzuki cross-coupling reaction of sterically crowded 4-chlorocoumarin derivatives with air- and moisture-stable potassium organotrifluoroborates is developed. This methodology has been used to generate a series of novel alkyl, aryl, and vinyl substituted coumarin derivatives in good to excellent yields. The twisted conformation of the vinyl groups in the X-ray crystal structures of (2-oxo-4-vinyl-2H-chromen-3-yl)methyl acetate (2) and (2-oxo-4-vinyl-2H-chromen-3-yl)methyl 2,2,2-trichloroacetimidate (3), along with the atropisomerism of 3-(hydroxymethyl)-4-(2-methoxyphenyl)-2H-chromen-2-one (1d), are evidence of the steric crowding in these adducts. 相似文献
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Viktor O. Iaroshenko Friedrich ErbenSatenik Mkrtchyan Ani Hakobyan Marcelo Vilches-HerreraSergii Dudkin Alina Bunescu Alexander VillingerVyacheslav Ya. Sosnovskikh Peter Langer 《Tetrahedron》2011,67(41):7946-7955
4-Chloro-3-(trifluoroacetyl)- and 4-chloro-3-(methoxalyl)coumarins react with electron-rich aminoheterocycles, dimethyl 1,3-acetonedicarboxylate, hydrazines, alkyl thioglycolates, and methyl sarcosinate to give a variety of 3,4-heteroannulated coumarins. The starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride. An NMR study and X-ray crystallographic analysis are reported. 相似文献