生物无机化学的新台阶

作为生命化学的重要组成部分,生物无机化学开始进入成熟发展阶段。这首先表现在它所研究的覆盖面迅速扩展。除了在金属蛋白和金属酶方面由铁、铜、锌、钴……等扩大到诸如镍酶、钒酶、锰酶、钼酶、钨酶……等以外,还从金属蛋白扩大到以非金属元素为活性元素的蛋白,如硒     

中国生物无机化学的发展战略--2003年中国科学院化学部关于生物无机化学发展战略讨论会纪要

在过去的10年中,生物无机化学取得了令人瞩目的成就和发展。首先,研究队伍不断壮大。从美国主要高校的情况来看,生物无机化学工作者在化学学科中占据非常重要的地位;生物无机化学已经成为近年来新兴的化学生物学的重要组成部分。其次,各国政府及基金组织连续在生物无机化学的研     

我国生物无机化学的发展

叙述了生物无机在我国的发展。着重从金属离子及其配合物与生物大分子的作用、药物中的金属及抗癌活性配合物的作用机理、稀土元素生物无机化学、金属离子与细胞的作用、金属蛋白与金属酶、生物矿化、环境生物无机化学等七个方面综述了我国已取得的进展和成绩。     

我国稀土生物无机化学研究进展

我国稀土生物无机化学研究的特点是紧密结合稀土在农用及药物中应用所提出急需回答的问题, 经过长期的工作, 已在稀土的跨细胞膜运转, 稀土进入动物体内后的物种分布, 稀土与细胞膜的作用, 稀土对血红蛋白结构与载氧功能的作用, 稀土对骨细胞及骨结构的影响以及稀土在大鼠肝脏中的积累等方面取得了满意的结果. 从而可以为今后开展稀土元素在农用及药用中危险性评价的基础数据, 同时亦将促进稀土细胞化学的发展.     

我国固体无机化学的研究进展

综合介绍了建国５０年来，尤其是近２０年来我国固体化学研究领域所取得的进展，阐述了该领域在合成方法上的更新以及不断向信息、能源、环保等应用领域提供的各种新材料。     

生物无机化学与农业

金属离子在生物体系中的作用已引起农业科技工作者的重视,应用生物无机化学原理可在分子水平上进行研究工作。本文介绍生物无机化学在农业上、特别是在土壤化学、植物营养、动物营养、农业环境保护和能源方面的应用。     

模块化生物无机化学教学模式的构建与实践

围绕提高学生专业能力这一核心需求，结合课堂教学实践，遵循“前沿导读+专题研讨+项目实训”的专业课程模块化理念，以“结构-性质-活性关系”为线索，对生物无机化学教学内容进行模块化处理与再加工。在实际教学中将问题导向学习和案例教学相结合。实践表明，绝大部分学生认为模块化教学模式更有利于对理论知识的认识，且参加项目实训的积极性很高。     

Prion疾病与生物无机化学

介绍了除病菌、病毒以外的第三种病原体－－病蛋白Ｐｒｉｏｎ。这种病原蛋白的本质是正常蛋白的异常折叠,因此又被称为蛋白分子的“构象病”。还介绍了这种病蛋白的可能致病机理。铜离子对这种病蛋白生成的重要作用,充分显示了生物无机化学这门新兴学科的重要性和前沿性。     

EXAFS谱在生物无机化学中的应用

本文综述了EXAFS 谱在生物无机化学中的应用研究的最新进展, 详细探讨了EXAFS 谱研究金属离子与生物分子相互作用的基本方法及所得的主要信息, 并展望了国内外该领域的研究前景。     

欢迎订阅《无机化学学报》

《无机化学学报》是由中国化学会主办、南京大学化学化工学院和配位化学研究所承办的我国无机化学基础性学术期刊，面向国内外发行。设有综述、研究快报、论文和研究简报等栏目，报道我国无机化学领域的基础研究和应用基础研究的创新研究成果，内容涉及固体无机化学、配位化学、无机材料化学、生物无机化学、     

Silicateins—A Novel Paradigm in Bioinorganic Chemistry: Enzymatic Synthesis of Inorganic Polymeric Silica

The inorganic matrix of the siliceous skeletal elements of sponges, that is, spicules, is formed of amorphous biosilica. Until a decade ago, it remained unclear how the hard biosilica monoliths of the spicules are formed in sponges that live in a silica‐poor (<50 μM ) aquatic environment. The following two discoveries caused a paradigm shift and allowed an elucidation of the processes underlying spicule formation; first the discovery that in the spicules only one major protein, silicatein, exists and second, that this protein displays a bio‐catalytical, enzymatic function. These findings caused a paradigm shift, since silicatein is the first enzyme that catalyzes the formation of an inorganic polymer from an inorganic monomeric substrate. In the present review the successive steps, following the synthesis of the silicatein product, biosilica, and resulting in the formation of the hard monolithic spicules is given. The new insight is assumed to open new horizons in the field of biotechnology and also in biomedicine.     

The Bioinorganic Chemistry of Vanadium

Vanadium is a trace element that plays an important, perhaps essential and general role in the regulation of enzymatic phosphorylations. Several forms of life, including the fly agaric toadstool (Amanita muscaria) and certain sea squirts (ascidians), are able to concentrate vanadium. In other organisms vanadium is part of the active site of some enzymes. Well-studied examples are the nitrogen-fixing bacterium Azotobacter and various seaweeds that use vanadate-dependent peroxidases to synthesize halogenated organic compounds. Despite its importance as a “biometal” both in primitive, prokaryotic organisms (Azotobacter) and in the highly organized ascidians, which represent an early stage in the evolution of vertebrates, the bioinorganic chemistry of vanadium is still in its infancy. Just as young, but undergoing explosive development, is the chemistry of model compounds for vanadium-containing biomolecules, a domain of the bioinorganic coordination chemist, who almost daily discovers compounds with new and surprising structural features. This article reviews this fascinating area of bioinorganic chemistry.     

无机化学课程中融入思想政治教育的途径与策略*

为落实“立德树人”人才培养目标,在无机化学课程教学中有效实施思想政治教育,将辩证唯物主义世界观、爱国主义、科学精神与社会责任、优秀传统文化等思想政治教育内容有机地融入到无机化学教学中,保障无机化学专业课程教学与思想政治教育同向同行。教学实践中挖掘梳理了无机化学课程中蕴含的思想政治教育素材,凝练出了无机化学课程中融入思想政治教育的6种途径和教学中实施思想政治教育的渗透性、适度性、情感性和匹配性等4个策略。     

Biologically inspired 3Fe4S cluster as structural mimics of FeMoco M-cluster

A 3Fe4S cluster related to M-cluster of Mo-nitrogenase is reported. [K(THF)₅][Fe₃(μ-bdt)₂(μ-PPh₂)(CO)₅] ( 1 ) is synthesized from photo-assisted structural rearrangement of [K(THF)₂][(μ,κ²-bdt)Fe₂(μ-PPh₂)(CO)₅] under visible light irradiation. The molecular structure of 1 consists of a Fe₃ core bearing one dithiolate bridge and the second dithiolate group capping onto the metallic plane. The structural motif of 1 is analogous to that of Mo-participated 3Fe4S unit in M-cluster of Mo-nitrogenase, with the similar Fe-Fe and Fe-S bond distances. Upon protonation in 193 K, a Fe-hydride species ( 1H ) is generated and characterized to possess the bridging hydride group (δ = −12.57 ppm) by ¹H-NMR spectroscopy and DFT calculation. In CH₃CN solution, complex 1 exhibits a reversible reduction and oxidation process at $E_{1/2}^{\mathrm{red}}$ = −1.94 V and $E_{1/2}^{\mathrm{ox}}$ = −0.18 V, respectively, at 273 K. The reduction behavior of 1 in CH₂Cl₂ solution at 243 K displays a slight modification in the presence of trifluoroacetic acid, revealing a moderate anodic potential shift (~50 mV). The current amplitude of the reduction wave is linearly increased with the increasement of acid added, indicative of the catalytic event.     

中国高校化学化工专业无机化学教材建设历史回顾与展望

20世纪50年代以前,中国高校无机化学教科书主要采用译著或国外原版教材。在20世纪60年代,我国无机化学教材建设工作进入了一个短暂繁荣期。现在高校广泛使用的无机化学教材源于我国在1977-1990年间编写的4部教材。2000年之后,虽然无机化学教材品种数明显增多,但精品较少。未来的无机化学教材编写应当考虑基础无机化学与中级无机化学内容的分工与衔接,以及加强教材与信息技术的融合。     

Design of Bioinorganic Materials at the Interface of Coordination and Biosupramolecular Chemistry

Protein assemblies have recently become known as potential molecular scaffolds for applications in materials science and bio‐nanotechnology. Efforts to design protein assemblies for construction of protein‐based hybrid materials with metal ions, metal complexes, nanomaterials and proteins now represent a growing field with a common aim of providing novel functions and mimicking natural functions. However, the important roles of protein assemblies in coordination and biosupramolecular chemistry have not been systematically investigated and characterized. In this personal account, we focus on our recent progress in rational design of protein assemblies using bioinorganic chemistry for (1) exploration of unnatural reactions, (2) construction of functional protein architectures, and (3) in vivo applications.     

中学绿色化学教育实施策略探讨

本文探讨了中学绿色化学教育实施的基本策略 :以确立可持续发展为化学教育的道德规诫和价值准则而更新观念 ,以融合多元文化价值、贯彻源头战略、体现原子经济性、寓能力培养于知识体系之中而整合内容 ,以开展绿色实验、运用现代媒体而创新手段等。