共查询到20条相似文献,搜索用时 15 毫秒
1.
Weina Jiang Wei Zhou Raymie Othman Hajime Uchida Ryuichi Watanabe Toshiyuki Suzuki 《Natural product research》2018,32(1):97-104
A new malyngamide (1) was isolated along with seven known compounds (2–8) from the marine cyanobacterium Moorea producens collected in Hawaii. Compound 1 represented the first reported malyngamide with a hydroxy moiety at C-7 of the characteristic fatty acid portion of the compound. Compound 1 showed cytotoxicity against L1210 cell line at an IC50 value of 2.9 mM and lethal toxicity against the shrimp Palaemon paucidens at a LD100 value of 33.3 mg/kg. The bioactivity of compound 1 was approximately 10–100 times weaker than those of isomalyngamides A and B (3, 4). These results indicated that the methoxy group at C-7 of the fatty acid section confers a degree of bioactivity in malyngamides. 相似文献
2.
Diaa T.A. Youssef Lamiaa A. Shaala Gamal A. Mohamed Sabrin R.M. Ibrahim Zainy M. Banjar Jihan M. Badr 《Natural product research》2015,29(8):703-709
Chemical investigation of the organic extract of a Red Sea strain of the cyanobacterium Moorea producens has afforded 2,3-seco-2,3-dioxo-lyngbyatoxin A (1). Five known compounds including lyngbyatoxin A (2), majusculamides A and B (3 and 4), aplysiatoxin (5) and debromoaplysiatoxin (6) were also isolated. Their structures were elucidated by using HR-FAB-MS, 1D and 2D NMR analyses. The compounds were evaluated for antiproliferative activity against HeLa cancer cells. Lyngbyatoxin A (2) showed potent activity, with an IC50 of 9.2 nM, while 5 and 6 displayed modest activity with IC50 values of 13.3 and 3.03 μM, respectively. In contrast, compounds 1, 3 and 4 were inactive, with IC50 values greater than 50 μM. The lack of cytotoxicity for 2,3-seco-2,3-dioxo-lyngbyatoxin A (1) demonstrates that the indole moiety in lyngbyatoxin (2) is essential for its cytotoxicity, and suggests that detoxification of 2 may be carried out by biological oxidation of the indole moiety to yield 1. 相似文献
3.
Li Zhang Jing Shi Cheng Li Liu Lang Xiang Shi Ying Ma Wei Li Rui Hua Jiao Ren Xiang Tan Hui Ming Ge 《Tetrahedron letters》2018,59(51):4517-4520
Three new borrelidin-type macrolactones, designated as borrelidins J?L (4–6), together with borrelidin A (1), borrelidin E (2), and 12-desnitrile-12-carboxyl-borrelidin (3) were isolated from a plant endophytic Streptomyces sp. NA06554. Their structures were determined by extensive spectroscopic analysis including HRESIMS, 1D and 2D NMR data. The antibacterial activities for compounds 1–6 were examined. Borrelidins A (1) and L (6) showed potent and moderate antibacterial activity against Micrococcus luteus, respectively, whereas other derivatives (2–5) are almost inactive, which allows us to propose a plausible structure-activity relationship. 相似文献
4.
Mariko Kitajima Minako Anbe Noriyuki Kogure Sumphan Wongseripipatana Hiromitsu Takayama 《Tetrahedron》2014
Seven new indole alkaloids (aspidofractinine type 1–3, kopsine type 5, strychnos type 6, and vincamine type 7, 8) were isolated from Kopsia jasminiflora (Apocynaceae) collected in Thailand. 5-Oxokopsinic acid (4) was isolated from nature for the first time. The structures of the new alkaloids were determined by spectroscopic analyses and chemical transformation of a known alkaloid. 5,6-Secokopsinine (1) possesses a dialdehyde function that is formed by oxidative cleavage of the C-5–C-6 bond of kopsinine (9). New vincamine-type alkaloid 8 showed potent inhibitory activity toward human cancer cell lines (A549, HT29, HCT116). 相似文献
5.
Dong-Hua Cao Shang-Gao Liao Lin Yang Xiao-Nian Li Bin Wu Ping Zhang Juan Guo Chun-Fen Xiao Hua-Bin Hu You-Kai Xu 《Tetrahedron letters》2017,58(33):3283-3286
Trichiliasinenoids A–C (1–3), three new limonoids with an unprecedented C-29-C-7 connecting carbon skeleton formed by migration of C-7 from C-6 to C-29 of a mexicanolide-type limonoid precursor were isolated from the leaves and twigs of Trichilia sinensis. Their structures were assigned by spectroscopic analysis, and the absolute configurations were determined by X-ray crystallography (1) and ECD calculation (2 and 3). A possible biosynthetic pathway of 1 was also proposed. Compound 2 exhibited moderate cytotoxicity against HL-60 cells and weak cytotoxicity against SMMC-7721cells. 相似文献
6.
线叶紫菀中一个单萜酸的化学结构王明安,陈耀祖(北京农业大学应用化学系,北京,100094)(兰州大学化学系)关键词线叶紫菀,单萜,结构分析线叶紫菀(AsterfarreriW.W.SmithetJ.F.Jeffery)系菊科紫菀属多年生草本植物,用于... 相似文献
7.
Margaret Mwihaki Ng’ang’a Hidayat Hussain Sumesh Chhabra Caroline Langat-Thoruwa Ahmed AI-Harrasi Karsten Krohn Ivan Robert Green 《中国化学快报》2012,23(5):576-578
Two new naphthalene derivatives named eucleanal A and B(1 and 2) were isolated from Euclea divinorum.The structures of the new compounds were elucidated by detailed spectroscopic analysis such as 1H,13C NMR,COSY,HMQC,HMBC and HREIMS mass spectrometry. 相似文献
8.
Five new polyketides, biselides A (1), B (2), C (3), D (4), and E (5), were isolated from the Okinawan ascidian Didemnidae sp. Their structures were determined by spectroscopic analysis. Biselides A (1), B (2), and C (3) showed cytotoxicity against human cancer cells NCI-H460 and MDA-MB-231. 相似文献
9.
Zhen-Xing Zou Gui-Shan Tan Guo-Gang Zhang Xia Yu Ping-Sheng Xu Kang-Ping Xu 《中国化学快报》2017,28(5):931-934
75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A(1) and B(2),together with ten known compounds(3-12) were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC_(50) values of 0.82 μmol/L and 1.32 μmol/L,respectively. 相似文献
10.
朝鲜淫羊藿中一种黄酮醇甙的化学结构 总被引:2,自引:0,他引:2
朝鲜淫羊藿中一种黄酮醇甙的化学结构李文魁,肖培根,廖矛川,张如意(中国协和医科大学药用植物研究所,北京,100094)(北京医科大学药学院)关键词朝鲜淫羊藿,黄酮醇甙,结构分析前文[1]中我们报道了从朝鲜淫羊藿(EpimediumkoreanumNa... 相似文献
11.
Zhongbin Cheng Dong Liu Nicole J. de Voogd Peter Proksch Wenhan Lin 《Helvetica chimica acta》2016,99(8):588-596
Chemical examination of a marine sponge Xestospongia sp. resulted in the isolation of 20 sterol derivatives ( 1 – 20 ), including eight new sterols namely aragusterols J – L ( 1 – 3 ), (5α,7α,12β,22E)‐7,12,18‐trihydroxystigmast‐22‐en‐3‐one ( 4 ), (5α,7α,12β,24R)‐ and (5α,7α,12β,24S)‐7,12,20‐trihydroxystigmastan‐3‐one ( 5 / 6 ), and (5α,7α,12β,22E,24R)‐ and (5α,7α,12β,22E,24S)‐7,12,20‐trihydroxyergost‐22‐en‐3‐one ( 7 / 8 ). The structures of new compounds were determined through extensive spectroscopic analyses and chemical conversion. The sterol diversity was mainly characterized by the presence of a cyclopropane unit at side chain, while compound 4 with 18‐hydroxymethyl group was found in stigmasterol family for the first time. Cytotoxic test revealed the inhibitory effects of compounds 1 , 4 , and 17 against human leukemia cell line K562 with IC50 values of 18.3, 24.1, and 34.3 μm , respectively. 相似文献
12.
Two new norsesterterpenoid cyclic peroxides, trunculins X and Y, were isolated from an Okinawan sponge Sigmosceptrella sp. Their structures were determined by spectroscopic analyses on intact molecules and derivatives and also by crystallographic study. The compounds showed cytotoxicity in a range of IC50 0.32–20 μM against three cell lines. 相似文献
13.
《Tetrahedron letters》2019,60(34):150952
Cytochalasins D1 (1) and C1 (2) were isolated from the liquid fermentation of fungus Xylaria cf. curta. Their structures and absolute configurations were determined by comprehensive experimental spectroscopic methods as well as ECD and GIAO 13C NMR calculation. They possess a unique eleven-membered macrocycle with an oxygen bridge. Cytochalasins D1 and C1 showed moderate cytotoxicity against human leukemia cell lines HL-60 with IC50 value of 12.7 and 22.3 μM, respectively. 相似文献
14.
Yi-Bing Wu Xia Qing Chang-Hong Huo Hui-Min Yan Qing-Wen Shi Françoise Sauriol Yu-Cheng Gu Hiromasa Kiyota 《Tetrahedron》2014
Four novel tetranortriterpenoids, xylomexicanins E–H (1–4), were isolated from the seeds of the Chinese mangrove, Xylocarpus granatum. Among them, xylomexicanin E (1) represents the first example of limonoid with azaspiro skeleton between B (pyrrolidine) and C rings, whose biosynthetic pathways were proposed. The structures were elucidated on the basis of one- and two-dimensional NMR (including 1H, 13C NMR, DEPT, 1H–1H COSY, HSQC, HMBC, and NOESY) and confirmed by high-resolution mass spectrometry. Compound 2, the second example of a limonoid with a C-9–C-30 linkage, showed moderate activity against the A549 and RERF cell line with IC50 value of 18.83 and 15.83 μM, 相似文献
15.
Seven new prenylated indole diketopiperazine alkaloids, including compound 1, 3 spirotryprostatins C-E (2-4), 2 derivatives of fumitremorgin B (5 and 6), and 13-oxoverruculogen (7), have been isolated from the holothurian-derived fungus Aspergillus fumigatus, along with 12 known ones (8-19). The structures of the new compounds were determined on the basis of extensive spectroscopic data and amino acid analysis. All new compounds were evaluated for their cytotoxic activities on MOLT-4, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods. 相似文献
16.
Mariko Kitajima 《Tetrahedron》2010,66(32):5987-4813
Six new humantenine-type (1-6) and two new gelsemine-type (7, 8) oxindole alkaloids and one new indole alkaloid (9) were isolated from the leaves and branches of Gelsemium rankinii. The structures of the new alkaloids were determined by spectroscopic analyses. Among them, 6-hydroxyhumantenine (5) is the first example of a Gelsemium alkaloid with an oxygen function at C-6 position, and is a plausible biogenetic precursor of gelsemine-type alkaloids. 相似文献
17.
Kazuaki KatakawaHiroko Mito Noriyuki KogureMariko Kitajima Sumphan WongseripipatanaMunehisa Arisawa Hiromitsu Takayama 《Tetrahedron》2011,67(35):6561-6567
Ten new fawcettimine-related alkaloids, i.e., lycopoclavamines, lycoposquarrosamine-A, and other hydroxylated fawcettimine derivatives, were isolated from three species of Lycopodium (Lycopodium clavatum, Lycopodium serratum, and Lycopodium squarrosum). The structures of the new alkaloids were elucidated by spectroscopic methods and chemical correlation. 相似文献
18.
Ingrid Bernhardi Thomas Drews Konrad Seppelt 《Angewandte Chemie (International ed. in English)》1999,38(15):2232-2233
Strongly bent at the nitrogen atom (130.7°), the OCNCO+ ion (see structure) is the closest relative to carbon suboxide OCCCO. According to calculations the linear OCNCO+ ion is only a few kJ mol−1 higher in energy. 相似文献
19.
Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388). 相似文献
20.
David C. Green Ulrich Englich Karin Ruhlandt‐Senge 《Angewandte Chemie (International ed. in English)》1999,38(3):354-357
An unprecedented ligand bending mode is displayed by the acetylide ligands in the first structurally characterized σ‐bound organometallic strontium and barium complexes [M([18]crown‐6)(CCSiPh3)2] (M=Sr, Ba). Furthermore, the observed decrease of the angle at the sp‐hybridized C atom on descending Group 2 (see structures depicted) affords new information that will lead to a better understanding of the bonding in alkaline earth metal compounds. 相似文献