Two New Dihydroflavanoids from Patrinia villosa Juss

Patrinia villosa Juss is a famous traditional Chinese medicine and often used in folkmedicine as anti-virus and anti-bacteria agent1,2. However, there is little research aboutits chemical study through a literature search. In order to find bioactive princ…     

Two New Dihydroflavanoids from Patrinia vittosa Juss (II)

Two new dihydroflavonoids named villosin A and villosin B were obtained from the traditional Chinese medicinal herb Patrinia villosa Juss. Their structures were elucidated as (2S)-5, 2', 6'-trihydroxy-2", 2"-dimethylpyrano [5", 6": 6, 7]flavanone 1 and (2S, 3"S)-5, 2', 6'-trihydroxy-3"-γ, γ-dimethylallyl-2", 2"-dimethyl-3", 4"-dihydropyrano [5", 6": 6, 7] flavanone 2 by spectroscopic methods including UV, IR, HR-TOF- MS, 1D NMR and 2D NMR techniques.     

Two New Antibacterial Iridoids from Patrinia rupestris

Patrinia rupestris has long been used as Chinese folk medicine for treatment of enteritis, appendicitis and hepatitis1. The chemical studies of this plant have not been reported till now, and iridoid containing chlorine has not been isolated from Patrinia…     

植物墓头回中总皂甙的提取与含量测定

墓头回系败酱科败酱属植物，有异叶败酱patrinia heterophylla Bge和糙叶败酱patrinia scabra Bge。分布于陕西、河南、河北、山西等地。根及全草入药用。其中含挥发油、黄酮、皂甙、萜类等多种化学成分，临床上用于治疗急性阑尾炎初起，瘰疬等症。有效成分主要是以齐墩果酸苷元和常春藤苷元组成的三萜皂甙，其总皂苷具有抗肿瘤等作用。目前对齐墩果酸苷含量的测定已有报道。本文建立用比色法测定墓头回中总皂甙含量的方法，并对5种不同产地墓头回植物不同部位中总皂甙的含量进行了测定。     

Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link

As a traditional Chinese medicine, Patrinia scabiosifolia Link has been used to treat various inflammatory-related diseases, and recent studies have shown that it possesses potent anti-inflammatory activity. Therefore, phytochemical investigation on whole plants of P. scabiosifolia were carried out, which led to the isolation of two new iridoid glucosides, patriniscabiosides A (1) and B (2), together with six known compounds (3–8). The structural elucidation of all compounds was performed by HRESIMS and extensive spectroscopic analyses including IR, 1D, 2D NMR, and electronic circular dichroism (ECD). All the isolated compounds were tested for their anti-inflammatory activity using the NF-κB-Dependent Reporter Gene Expression Assay, and compound 3 displayed anti-inflammatory activity through the inhibition of the NF-κB pathway, with an inhibitory rate of 73.44% at a concentration of 10 μM.     

Chemical Constituents from the Roots of Patrinia Rupestris

Phytochemical investigation of the roots of Patrinia rupestris afforded a new triterpenoid patrirupin A ( 1 ) and a new iridoid patrirupin B ( 2 ), as well as three known triterpenoids: 3‐oxo‐olean‐12‐en‐28‐oic acid ( 3 ), ursolic acid ( 4 ), α‐amyrin ( 5 ), three known iridoids: isovaltratum ( 6 ), 11‐ethoxyviburtinal ( 7 ), homobaldrinal ( 8 ), five known steroids: ergosterol ( 9 ), ergost‐6,22‐diene‐3β,5α,8α‐triol ( 10 ), 6‐hydroxenone ( 11 ), β‐sitosterol ( 12 ), daucosterol ( 13 ), and two known flavones: 1‐hydroxy‐5‐methoxy xanthen‐9‐one ( 14 ), 3′,4′,5,7‐tetrahydroxyflavanone ( 15 ). The new compounds were characterized by means of spectroscopic methods including UV, IR, 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature.     

Two new iridoids from roots of Patrinia scabra Bunge

Two new iridoids 1,3-dimethyloxy-7-hydroxymethyl-4-(3-methyl-butyryloxymethyl)-1-hydrocyclopenta-4,7-diene[c]pyran-6-one (1) and 1,3-dimethyloxy-7-hydroxymethyl-4-methyloxymethyl-1-hydrocyclopenta-4,7-diene[c]pyran-6-one (2) were isolated from the roots of Patrinia scabra Bunge. The structure elucidation of the isolated compounds was based primarily on HRESIMS, EIMS, IR, UV, 1D- and 2D-NMR analyses, including COSY, HMQC, HMBC and NOESY correlations, as well as X-ray crystallographic analysis.     

A New Azafluorenone Alkaloid from Alphonsea monogrma

ThegenusAIPhonsea(Annonaceae)comprisesaboutthirtyspeciesgrowingintropicalorsubtropicalareainAsia,ofwhichsixspecieswerefoundinChina.AIPhonseamonogrma.distributedinthesouthernareaofChina,isanevergreentree.Nopreviouschemicalinvestigationhasbeenreportedonthisspecies.UPtonow,onlythreespeciesofthisgenushavebeenstudiedchemically,theymainlycontainedalkaloids,furanicdiacetylenesandlignans'-'.AseriesofonychineandoxoaporphinealkaloidswereisolatedfromthestemandbranchofAIPhonseamonogyma.Thepresentpap…     

A new Dendrobine-Type Alkaloid from Dendrobium nobile

A new dendrobine-type alkaloid has been isolated from stems of Dendrobium nobile lindl.Its structure has been identified on the basis of spectroscopic method.     

A New Indole Alkaloid from Limonia Crenulata

Limonia crenulata Roxb. (Rutaceae), a small tree widely distributed in dry warm regions of southeastern Asia, has been reported to have antiepileptic, purgative and sudorific effects and is used for colic trouble and cardialgia1. Various parts of this plant have been employed in indigenous medicine. Our investigation on its stems led to the isolation of one new alkaloid, crenulatine 1, together with three known ones, 4-methoxy-6- hydroxy-1-methyl-2-quinolone2, N-benzoyltyramine methyl ether2,…     

A New Nitro Alkaloid from Corydalis saxicola Bunting

A new nitro tetrahydronprotoberberins alkaloid, 1-nitro-apocavidine was isolated from Corydalis saxicola Bunting. The structure was established by spectroscopic methods.     

A New Benzylisoquinoline Alkaloid from Sabia parviflora

A new benzylisoquinoline alkaloid,1,2,3,4-tetrahydro-5-hydroxyl-8-methoxyl-2-methyl-4′-methoxyl-benzylisoquinoline,was isolated from the arial parts of Sabia parviflora. Its structure was established on the basis of spectral analysis.     

反相制备液相色谱分离白花败酱草异戊烯基黄酮

用半制备型反相高效液相色谱(RPLC)对白花败酱草氯仿萃取物进行了分离制备。色谱柱为YWGC18(200 mm×10.0 mm i.d.,10μm),流动相为乙腈∶水∶乙酸(55∶45∶1,V/V),检测波长280 nm,流速4.0mL/m in,进样750μL(样品液浓度30 g/L)。在此条件下一次分离得到5个单体化合物,经理化反应和光谱分析分别鉴定为bolusanthol B(1),(2S)-5,7,2,′6-t′etrahydroxy-6-lavandu lylated flavanone(2),(2S)-5,2,′6-′trihydroxy-2,″2-″d im ethylpyrano[5,″6″∶6,7]flavanone(3),orotin in(4)和orotin in-5-m ethyl ether(5)。其中2和3为新化合物,1、4和5为首次从败酱属植物中分离得到。     

A New Binary Carbazole Alkaloid from Murraya koenigii

A new binary carbazole alkaloid,8,8″-biskoenigine (1), along with its monomer, koenigine,was isolated from the dried leaves of Murraya koenigii collected in Xishuangbanna, Yunnan province. The structure of 1 was established spectroscopic methods.     

A New Quinolizidine Alkaloid from Boehmeria siamensis

Boehmeria siamensis Craib is distributed in China, Vietnam, Laos and Thailand1. The whole plants of B. siamensis were used in folk medicine2,3. Previous studies on the plants of this genus led to the isolation of different compounds such as alkaloids, flavones, lignans, triterpenoids and its glycosides4-9. Some antimicrobial alkaloids were obtained from B. cylindrical4. In the investigation of the whole plant of B. siamensis, a new alkaloid, 3-(4-hydroxyphenyl)-4-(3-methoxy -4-hydroxypheny…     

Three new secoiridoid glycosides from the rhizomes and roots of Gentiana scabra and their anti-inflammatory activities

Three new (1–3) and 17 known (4–20) iridoid and secoiridoid glycosides were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their chemical structures were elucidated from 1D and 2D NMR, IR absorption, and HR-ESI-MS spectra, as well as comparisons of these data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 6, 10 and 20 exhibited significant inhibitory effects on LPS-induced IL-12 p40 and IL-6 production with IC₅₀ values of 1.62–14.29 μM. Compound 10 also showed a strong inhibitory effect on the LPS-stimulated production of TNF-α with an IC₅₀ value of 10.45 μM.     

Peduncin, A New Indole Alkaloid from Pueraria peduncualris

Pueraria peduncularis (Grah. ex Benth.) Benth. is a plant of Leguminosae which grows in the southwest of China. Different from other plants of Pueraria, it could not be used as a medicine due to its toxicity1. In order to use the Pueraria plants safer, we studied the constituents of P. peduncularis. Previous phytochemical studies of an n-BuOH extract afforded three triterpenoid saponins2-3. The continuing investigation on CHCl3 extract led to the isolation of a new indole alkaloid. …     

Huperzine V, A New Lycopodium Alkaloid from Huperzia serrata

Huperzine V, a new Lycopodium alkaloid, was isolated from the whole plant of Huperzia serrata, and the absolute stereochemistry was determined by X-ray crystallographic analysis.     

A New Alkaloid from Sinomenium acutum

Sinomenium acutum is widely used in East and South Asia for the treatment of many diseases, especially rheumatoid arthritis （RA）. The chemical research on Sinomenium acutum led to the isolation of a new alkaloid compound （1）. On the basis of chemical evidences and spectral analysis, 1 was identified as N-（1, 7-dimethoxylphenanthren-2-yl）acetamide.