缬沙坦联合氨氯地平治疗社区老年原发性高血压合并糖尿病的临床效果及安全性

目的探究在治疗老年性原发性高血压合并糖尿病患者中采用缬沙坦联合氨氯地平治疗的效果以及术后安全性,评估其临床意义,为临床治疗做出指导。方法以天津市滨海新区杭州道街社区卫生服务中心2013年5月—2014年6月间收诊的80例原发性高血压合并糖尿病老年患者的临床资料作为研究对象,按治疗方式不同将患者分成氨氯地平合并缬沙坦组40例(实验组)和单纯缬沙坦组40例(对照组)。测定分析两组患者治疗后情况,包括患者血压水平变化、空腹血糖、饭后2 h血糖以及胰岛素等指标,记录治疗情况。结果治疗后实验组血压水平下降的程度优于对照组(P0.05)。实验组空腹血糖等指标对比对照组均具有显著优势(P0.05)。结论联合氨氯地平缬沙坦治疗高血压合并糖尿病患者在血压下降水平、血糖前后变化水平等方面明显优于单纯使用缬沙坦治疗,不良反应发生率低,值得临床推广使用。     

门诊儿童微量元素现状分析

为调查门诊儿童微量元素现状及相关疾病的发病率，检测了248例门诊儿童血锌、钙、铁、铜、铅值，并分析了相关疾病患病率。结果表明，本地区门诊儿童锌缺乏率76．2％，钙缺乏率71．37％，铜缺乏率19．29％，铅中毒率39．19％，全血铁测定缺铁比例87．92％。提示门诊儿童存在微量元素失衡现象，应采取适当措施予以纠正。     

硒酸脂多糖治疗原发性肝癌临床疗效观察

硒酸脂多糖具有硒和多糖两者特殊作用，它治疗原发性肝癌有肯定的疗效。     

原发性高血压病与血清钙,镁关系的探讨

对１０７例住院的原发性高血压病患者和８１例健康人分别进行血清钙、镁的测定，并作对比，结果表明，原发性高血压病患者常量元素钙、镁较健康人有明显下降，钙、镁比例下降、它们之间有显著差异（Ｐ〈０．０１），此可能对高血压病的防治有一定的价值。     

针刺加密波电针治疗原发性坐骨神经痛50例

用针刺加密波电针加频谱照射治疗原发性坐骨神经痛５０例，取得满意效果。     

2340例门诊患儿发铅的分析

为了解儿科门诊常见病的发病与有害金属元素铅的关系,对深圳市龙岗区2340例门诊患儿的发铅水平进行了测定分析。结果表明,儿科常见疾病与体内铅含量具有密切关系。还显示,铅高儿童的锌与钙普遍缺乏,可能为铅蓄积的重要促发因素,值得重视。     

个体化孕期营养管理对胎儿体质量和产后出血的影响分析

目的研究分析个体化孕期营养管理对胎儿体质量和产后出血的影响。方法研究对象选择吉安市妇幼保健院2015年12月—2016年7月进行定期产检的146例孕妇,将其随机分成研究组和对照组,每组73例。对照组孕妇给予常规体检以及注意事项讲述;实验组孕妇则在对照组基础上给予个体化孕期营养管理。结果研究组2 500~3 500 g新生儿体质量明显的高于对照组,数据差异显著具有统计学意义(P0.05);研究组剖宫产率、产后出血率、巨大儿发生率分别为20.55%、3.27%、2.74%,对照组分别为36.98%、16.44%、19.18%,数据差异显著具有统计学意义(P0.05)。研究组孕妇蛋白质、钙、铁等指标摄入量以及RDA均明显高于对照组,数据差异显著具有统计学意义(P0.05)。结论个体化孕期营养管理能够有效地将胎儿体质量控制在正常范围之内,同时还能降低孕产妇产后出血情况,临床效果显著,值得推广使用。     

门诊输液室感染危险因素分析及管理对策

目的分析门诊输液室感染危险因素,总结其管理对策。方法回顾性分析2014年6月—2015年6月间湖北省孝感市中心医院门诊输液室接受输液治疗患者临床资料,筛选发生门诊输液室感染病例,分析其发生感染的危险因素,总结降低门诊输液感染发生率的管理对策。结果本组感染率为11.37%,其中呼吸道感染175例(57.00%),消化系统感染80例(26.06%),呼吸道并消化系统感染50例(16.29%),其他2例(0.65%);年龄、治疗时间、医护人员手卫生情况是影响门诊输液室感染发生率的危险因素。结论年龄、输液时间、环境因素均与门诊输液室感染发生相关,为降低医院感染发生率,必须严格贯彻管理制度,重视对医护人员培训,加强对患者的健康教育,重视输液室环境的维护。     

探讨妊娠糖尿病运用个体化营养膳食的影响

目的了解妊娠期糖尿病专业治疗中行个体化营养膳食疗法对其妊娠结局以及血糖控制水平产生的影响。方法选择130例因妊娠期糖尿病进入江西省萍乡市人民医院的患者,以膳食疗法的差异分组:62例Ⅰ组施以常规膳食疗法,68例Ⅱ组则施以个体化营养膳食疗法,再对两组病例血糖值及其妊娠结局专业统计、观察。结果施以两种膳食疗法后,62例Ⅰ组FPG值(5.60±0.90)mmol/L,68例Ⅱ组(4.47±0.49)mmol/L,(P<0.05);同时Ⅱ组2h PG值及其妊娠结局等都优于Ⅰ组,(P<0.05)。结论对于患有糖尿病的妊娠期患者,通过施以个体化营养膳食疗法,可实现对妊娠结局的充分改善,值得推荐应用。     

血液中某些必需微量元素与高血压的关系探讨

为探讨人全血中微量元素与高血压的关系,用电感耦合等离子体质谱仪测定了47例高血压患者和3 2例健康对照者全血中钒(V)、铬(Cr)、锰(Mn)、钴(Co)、铜(Cu)、锌(Zn)、钼(Mo)、锶(Sr)八种必需微量元素的含量。结果表明,高血压组患者全血中除锰元素外,其余微量元素均显著低于对照组(P <0 0 5 )。提示这些必需微量元素可能在高血压的发生和发展中起着一定的作用     

Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment

Onychomycosis is a disease that affects many adults, whose treatment includes both oral and topical therapies with low cure rates. The topical therapy is less effective but causes fewer side effects. This is why the development of an effective, easy to apply formulation for topical treatment is of high importance. We have used a nanotechnological approach to formulate Pickering emulsions (PEs) with well-defined properties to achieve site-specific delivery for antifungal drug combination of tioconazole and Melaleuca alternifolia essential oil. Silica nanoparticles with tailored size and partially hydrophobic surface have been synthesized and used for the stabilization of PEs. In vitro diffusion studies have been performed to evaluate the drug delivery properties of PEs. Ethanolic solution (ES) and conventional emulsions (CE) have been used as reference drug formulations. The examination of the antifungal effect of PEs has been performed on Candida albicans and Trichophyton rubrum as main pathogens. In vitro microbiological experimental results suggest that PEs are better candidates for onychomycosis topical treatment than CE or ES of the examined drugs. The used drugs have shown a significant synergistic effect, and the combination with an effective drug delivery system can result in a promising drug form for the topical treatment of onychomycosis.     

Individualized Differences Scaling,the Analysis of Independent Sets of Measurements: An Application in Environmental Analytical Chemistry

Abstract

The environmental effects of coal mining on the chemical composition of Trout Creek in Colorado are investigated using Individualized Differences Scaling and Canonical Correlation Analysis. Individualized Differences Scaling shows superiority over Canonical Correlation in the analysis of several matrices of measurements when the hypothesis of commonality of chemistry between each matrix cannot be justified a priori.     

粉苞苣挥发油化学成分的GC-MS测定分析

利用气相色谱 质谱联用技术对粉苞苣的挥发油成分进行分析测定.从这种植物挥发油的45个峰中鉴定出27个化合物,所鉴定的组分占挥发油色谱总峰面积的77.25%.     

130名哈萨克族牧民血清铁、血红蛋白含量与高血压关系的分析

为探讨乌鲁木齐南山130名哈萨克族牧民血清铁及血红蛋白含量与原发性高血压的关系,给哈萨克族原发性高血压的病因学研究提供科学依据,对这些牧民进行了血压测定和血清铁、血红蛋白含量分析。结果表明,130名哈萨克族牧民高血压检出率为53.3%;高血压组血清铁水平明显高于正常组(P=0.000);高血压组血红蛋白含量也明显高于正常组(P=0.004);进一步分析表明,高血压组男性和女性血清铁水平明显高于正常组男性和女性(P0.01和P0.001);血红蛋白含量高血压组女性较正常血压组女性高,差异有统计学意义(P0.05),而男性两组差异不明显。提示哈萨克族高血压患者血清铁和血红蛋白的含量与高血压的发生可能有关。     

The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors

Cardiovascular diseases (CVDs) are a global health burden that greatly impact patient quality of life and account for a huge number of deaths worldwide. Despite current therapies, several side effects have been reported that compromise patient adherence; thus, affecting therapeutic benefits. In this context, plant metabolites, namely volatile extracts and compounds, have emerged as promising therapeutic agents. Indeed, these compounds, in addition to having beneficial bioactivities, are generally more amenable and present less side effects, allowing better patient tolerance. The present review is an updated compilation of the studies carried out in the last 20 years on the beneficial potential of essential oils, and their compounds, against major risk factors of CVDs. Overall, these metabolites show beneficial potential through a direct effect on these risk factors, namely hypertension, dyslipidemia and diabetes, or by acting on related targets, or exerting general cellular protection. In general, monoterpenic compounds are the most studied regarding hypotensive and anti-dyslipidemic/antidiabetic properties, whereas phenylpropanoids are very effective at avoiding platelet aggregation. Despite the number of studies performed, clinical trials are sparse and several aspects related to essential oil’s features, namely volatility and chemical variability, need to be considered in order to guarantee their efficacy in a clinical setting.     

十种常用口服抗生素在医院门诊的使用情况--广州市第六人民医院门诊统计

统计了广州市第六人民医院十种口服抗生素的使用情况，提出了使用抗生素应注意的问题。     

自然分材教学法在有机化学实验教学中的实施

针对高职高专有机化学实验课程,以乙酸乙酯的制备为例,提出“自学指导→感情调节→重讲基础→强化训练→总结反思→因人作业”的6步自然分材教学环节。教学实践表明,学生的自主学习能力和团队合作意识得到显著提升,获得了良好的教学效果。     

Molecules Present in Plant Essential Oils for Prevention and Treatment of Colorectal Cancer (CRC)

Essential oils (EOs) are a complex mixture of hydrophobic and volatile compounds synthesized from aromatic plants, commonly present in the human diet. In recent years, many in vitro studies have suggested possible anticancer properties of single EO compounds, on colorectal cancer (CRC) cells. However, the majority of these studies did not compare the effects of these compounds on normal and cancer colon cells. By using NCM-460, a normal human mucosal epithelial cell line, Caco-2, a human colon epithelial adenocarcinoma cell line, and SW-620, colon cancer cells derived from lymph node metastatic site, we identified cinnamaldehyde, derived from cinnamon EO and eugenol, derived from bud clove EO, as compounds with a specific anticancer action selectively targeting the transformed colonic cells. Both cinnamaldehyde (75 µM) and eugenol (800 µM), after 72 h of treatment, were capable to induce apoptosis, necrosis and a cell cycle slowdown in Caco-2 and in SW-620, but not in NCM-460 cells. If associated with a targeted delivery to the colon, these two compounds could prove effective in the prevention or treatment of CRC.