共查询到18条相似文献,搜索用时 62 毫秒
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以3-羟甲基色酮为原料,在4-二甲氨基吡啶催化下与(Boc)2O反应生成中间体A;A与靛红和脯氨酸生成的1,3-偶极子发生[3+2]环加成反应,合成了8个未见文献报道的多环吡咯并双螺环色满酮氧化吲哚类化合物(3a^3h),收率50%~67%,dr值4/1~2/1,其结构经^1H NMR,^13C NMR和HR-MS(ESI-TOF)表征。确定了化合物3a(CCDC:1973858)和3g(CCDC:1973859)的相对构型。结果表明:该类化合物含有连续5个立体中心,包括两个螺环季碳中心。 相似文献
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以取代的3-羧酸活化色酮、靛红与消旋脯氨酸为原料,乙腈为溶剂,依次经1,3-偶极子[3+2]环加成和脱羧反应,合成了8个新型的二氢色原酮拼接多环吡咯螺环氧化吲哚类化合物 (3a~3h),产率68%~87%, dr值15/1~20/1,其结构经1H NMR, 13C NMR和HR-MS(ESI-TOF)表征。采用MTT法研究了3a~3h对人白血病细胞(K562)的体外抑制活性。结果表明:化合物3d,3f, 3g对K562具有一定的抑制活性(IC50=46.3~69.4 μmol·L-1)。 相似文献
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以色酮-氧化吲哚合成子与3-烯基苯并呋喃酮为原料,在催化剂1,8-二氮杂二环十一碳-7-烯作用下,在二氯甲烷中发生Michael/Michael加成关环反应,合成了6个未见文献报道的螺环六氢山酮素-氧化吲哚-苯并呋喃酮类拼接物(3a^3f),产率75%~87%,dr值3/1~5/1,其结构经1H NMR,13C NMR和HR-MS(ESI-TOF)表征。采用MTT法研究了3a^3f对人白血病细胞(K562)的体外抗增殖活性。结果表明:化合物3c,3e和3f对K562增殖有一定的抑制活性。 相似文献
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以3-异硫氰基氧化吲哚与3-丙二腈缩合的3-烯氧化吲哚为原料,乙腈为溶剂,在无催化剂存在的条件下于室温发生[3+2]环加成反应,合成了6个新型的螺环吡咯酮双氧化吲哚类化合物(3a~3f),产率91%~95%,dr 17/1~>20/1,其结构经1H NMR, 13C NMR和HR-MS(ESI-TOF)表征。采用MTT法研究了3a~3f对人白血病细胞(K562)的体外抗肿瘤活性。结果表明:化合物3c对K562具有明显的抑制活性(IC50为36.3 μM),与阳性对照药顺铂接近。 相似文献
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Shuo Sun Danna Chen Hai Guo Yinghui Liu Prof. Dr. Xia Liu Prof. Dr. Wenjin Yan Prof. Dr. Jinqi Huang 《European journal of organic chemistry》2023,26(31):e202300586
Here described an acid-controlled regional diverse synthesized process of CF3-containing ketoimines by the condensation of benzo[b]thiophene-2,3-dione and 2,2,2-trifluoroethlamine. The imines obtained at either the 2-position or 3-position can be further used as substrates in asymmetric organocatalyzed [3+2]-cycloaddition reactions, leading to a library of regiodiverse bispiro-compounds with 85–96 % yield and 65–99 % ee. 相似文献
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M. V. Badiger V. S. Kadam A. K. Lele P. P. Wadgaonkar D. Hourdet 《Macromolecular Symposia》2006,241(1):9-13
We report on the synthesis and characterization of a novel hydrophobically modified end-capped poly(ethylene oxide)s. The end-capping agent of this polymer was designed and synthesised from a renewable resource material namely, gallic acid (i.e. 3,4,5-trihydroxybenzoic acid), the byproduct of tannin industry. The hydroxyl groups at 3, 4 and 5 positions of gallic acid provide an opportunity for varying the hydrophobicity of the compound. The hydrophobic end-capping compound, 3,4,5-tridodecyloxy bezoylazide was prepared from gallic acid and PEGs with different chain lengths (of number average molecular weights, 10000 and 35000 g/mol) were end-capped using 3,4,5-tridodecyloxybenzoyl azide. The quantitative analysis of end-capping in the polymers was demonstrated by 1H-NMR spectroscopy and the rheological studies were carried out in the surfactant solutions. 相似文献