共查询到20条相似文献,搜索用时 15 毫秒
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Shi Fei Sheng~a Hui Xia Zheng~b Jiang Liu~a Zheng Bao Zhao~ 《中国化学快报》2008,19(4):419-422
To explore the better prodrug of 4-aminosalicylic acid(4-ASA)with higher activity and less side effects against the inflammatory bowel disease.4-ASA,after a succession of synthesis process,was conjugated with various carder molecules to get seven azo derivatives of 4-ASA.All compounds were characterized by FT-IR,^1H NMR,^13C NMR spectras in detail.New derivatives of 4-ASA were definituded. 相似文献
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ZhengBaoZHAO JingGUO YuanGuiWEI TongDaLIANG 《中国化学快报》2005,16(7):889-892
To search for a better prodrug of 4-aminosalicylic acid that is expected to deliver stably parent drug to colon against the inflammatory bowel disease, a novel 4-aminosalicylic acid derivative was designed and synthesized from 4-aminosalicylic acid. 4-Aminosalicylglycine was prepared from 4-aminosalicylic acid by protecting amino and hydroxyl groups with benzyloxycarbonyl and acetyl, respectively, then the carboxylic acid was converted to acyl chloride which was treated with glycine. After removing the protection groups, 4-aminosalicylglycine wasobtained. All the compounds were characterized by FT-IR, ^1H-NMR, ^13C-NMR spectra. In vivo experiment on rats suggested that the curative effect of 4-aminosalicylglycine was more effective than that of 4-aminosalicylic acid. 相似文献
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11-Deoxyglycyrrhetinic acid (DGA) (2) was produced by Clemmensen reduction of the C-11 carbonyl of 18β-glycyrrhetic acid (GA) (1). Four derivatives of GA and DGA (3a–3d) were synthesized. Their structures were elucidated using spectral data (IR, mass, 1H, 13C NMR).
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 153–155, March–April, 2008. 相似文献
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苯氧乙酸类化合物的合成研究 总被引:2,自引:0,他引:2
二苯醚型苯氧基乙(丙)酸类除草剂是一类用于禾本科杂草的除草剂,具有选择性强,内吸迅速,对环境危害小和使用安全等优点,被广泛应用于农林业生产。为了寻找更高效、低毒和低残留的除草剂,本文以相应结构的取代羟基二苯醚为骨架,以氯代乙酸乙酯为原料,经亲核取代反应制得此类化合物。在反应过程中为提高产率,加入了相转移催化剂;由于羟基二苯醚类化合物在空气中容易被氧化,在反应过程中采用氮气保护,得到了较纯产物,产率较高。共合成了苯氧基苯氧基乙酸乙酯类化合物5个,目标物的合成路线如下: 相似文献
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A series of thiourea derivatives have been synthesized. Their structures were confirmed by MS and 1H NMR. Several compounds showed potent activities as antagonists of CCR4 receptor. 相似文献
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Yu. N. Bubnov A. Yu. Zykov I. V. Zhun A. V. Ignatenko 《Russian Chemical Bulletin》1996,45(11):2598-2601
An original method was developed for the synthesis of functional derivatives of triallylmethane (CH2=CH-CH2)3C-X (X = OH, NH2, or SCOPh) based on reactions of triallylborane with the corresponding derivatives of carbonic acid (ethylene carbonate, diethylcyanamide, and 0,S-dimethyidithio carbonate) at 110–120 °C.Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 11, pp 2739–2742, November, 1996. 相似文献
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The basicities and nucleophilicities along with prototautomerism of biologically active oxazolidin-4-one and its thio and azo analogs were investigated by semi-empirical methods. The oxo and thion protonation were found to be easier than that of azo protonation for 4-oxo and 4-thion derivatives whereas amino protonation was found to be easier than imino and azo protonation in 4-imino derivative. The preferred tautomeric form for 4-oxo and 4-thion derivatives were found to be the keto and thion forms, respectively, whereas the amino form was found to be preferred in 4-imino derivatives. An acceptable correlation between gas phase proton affinities and aqueous phase acidity constants as well as the correlation between nucleophilicity and acidity constants was observed. 相似文献
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N. I. Baram Kh. L. Ziyaev A. I. Ismailov D. Ziyamov Yu. S. Mangutova 《Chemistry of Natural Compounds》2000,36(2):185-188
New azo derivatives of gossypol are described. Their physicochemical properties are reported. The presence of hydroxyazo- and quinonhydrazo-tautomers is proposed.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (99871) 162 70 71. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 145–148, March–April, 2000. 相似文献
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<正>A series of new 4-substituted benzoxazolone derivatives were synthesized according to a convenient method,their anti-inflammatory and analgesic activities in vivo were evaluated.All of them were new compounds,the structures of all the synthesized compounds were confirmed by ~1H NMR,~(13)C NMR,ESI-MS and HR-MS.Most of the compounds exhibited anti-inflammatory activity. 相似文献
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Enayat O'llah Moradi-e-Rufchahi 《中国化学快报》2010,21(5):542-546
<正>In this study,6-chloro-4-hydroxy-2-quinolone and 6-flouro-4-hydroxy-2-quinolone were synthesized from corresponding dianilides.These compounds were coupled with some diazotized aromatic amines to give the corresponding azo disperse dyes.The structures of the quinolone derivatives and new azo dyes were confirmed by UV-vis,FT-IR,~1H NMR and elemental analysis. 相似文献
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Ytterbium perfluorooctanoate [Yb(PFO)3] has been proved to be an efficient catalyst for Doebner reaction of pyruvic acid, aldehydes and amines under mild conditions in water to afford quinoline-4-caboxylic acid derivatives with three component one-pot method in good yields. The process is operationally simple and environmentally benign and the catalyst has readily been recycled for several times with consistent activity. Furthermore, a plausible mechanism for this transformation is also presented. 相似文献
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Dominik Rejman 《Tetrahedron》2007,63(5):1243-1253
The work deals with the synthesis of hydroxypyrrolidine analogs of nucleosides. Starting from the optically pure l- or d-tartaric acid, we improved the synthesis of enantiomeric trans-3,4-dihydroxypyrrolidines and elaborated a procedure for the synthesis of all possible diastereoisomers of 3-hydroxy-4-pyrrolidinyl derivatives of both purine and pyrimidine nucleobases. The prepared compounds were tested for cytostatic and antiviral properties but no significant activity was found. 相似文献
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Yue Mei Jia Xiao Mei Liang Xue Qin.Fang Jing Ping Wu Dao Quan Wang Chang Hui Rui Xian Lin Fan Hai Yan Zhao Yun Xia Wang 《中国化学快报》2007,18(8):895-898
Six new 4"-benzyloxyimino-4"-deoxyavermectin B la derivatives were synthesized from avermectin Bla by the selective protection of C-5-hydroxy group, oxidation of C-4"-hydroxy group, and deprotection followed by reaction with O-substituted hydroxylamine hydrochlorides. Their structures were confirmed by IR, 1H NMR, 13C NMR and MS. Insecticidal activities of the derivatives against Phopalosiphum pseudobrassicae, Spodoptera exigua and Pluteua xylosteua were evaluated. 相似文献
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Rui Qing Xian Shu Tao Ma~* Bo Jiao School of Pharmacy Shandong University Jinan China 《中国化学快报》2008,19(4):409-411
In order to develop new antibiotics effective against resistant bacteria,a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11,C-12 and C-4" positions.Their structures were confirmed by MS,IR,^1H NMR or ^13C NMR. 相似文献
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Arnaud de la ReberdièreFabien Lachaud Françoise ChuburuCyril Cadiou Gilles Lemercier 《Tetrahedron letters》2012,53(45):6115-6118
The synthesis and characterization of a new family of ester protected N-substituted [1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (H3DO3A) derivatives containing a pendant thioctic acid (α lipoic acid, LA) are reported. These compounds (DO3AtBu-NLA, DO3AtBu-NMeNLA, and DO3AtBu-NEtNLA) are suitable for the functionalization of gold surfaces with rare-earth complexes. 相似文献