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绿色化学与有机合成及有机合成中的原子经济性 总被引:28,自引:0,他引:28
本文概述了有机合成和绿色化学的关系, 并介绍了原子经济性的概念及其在有机合成中的重要性。对21 世纪的化学发展提出了希望。 相似文献
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微波在有机合成化学中的应用及进展 总被引:31,自引:4,他引:27
简述了微波有机合成的机理和特点,介绍了近年来微波辐射技术在有机合成中的应用,展望了微波促进有机合成化学的发展方向。参考文献30篇。 相似文献
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Click Chemistry, a modular, rapid, and one of the most reliable tool for the regioselective 1,2,3-triazole forming [3+2] reaction of organic azide and terimal alkyne is widely explored in various emerging domains of research ranging from chemical biology to catalysis and medicinal chemistry to material science. This regioselective reaction from a diverse range of azido-alkyne scaffolds has been well performed in both intermolecular as well as intramolecular fashions. In comparison to the intermolecular metal (Cu/Ru/Ni) variant of ‘Click Chemistry’, the intramolecular click tool is little addressed. The intramolecular click chemistry is exemplified as a mordern tool of cyclization which involves metal-catalyzed (CuAAC/RuAAC) cyclization, organo-catalyzed cyclization, and thermal-induced topochemical reaction. Thus, we report herein the recent approaches on intramolecular azide-alkyne cycloaddition ‘Click Chemistry‘ with their wide-spread emerging applications in the developement of a diverse range of molecules including fused-heterocycles, well-defined peptidomemics, and macrocyclic architectures of various notable features. 相似文献
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Entesar A. Hassan Salem E. Zayed 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):300-323
Abstract Organic dithiocarbamates have received great attention due to their interesting chemistry and wide utility as radical precursors and intermediates in organic synthesis. They also have found many of applications, that is, in agriculture and medicine. They are in use as pesticides, as well as in the rubber industries as vulcanization accelerators; and as antioxidants. Because they exhibit strong metal-binding capacity, they can act as in inhibitors of enzymes and have a profound effect on biological systems. Moreover, they have found application in the treatment of cancer and HIV. 相似文献
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The review summarizes published data on the application of N-halocuccinimides in organic synthesis and in natural compounds chemistry. Halogenation, imidation, oxidation, and other reactions are discussed. 相似文献
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以乙酰乙酸乙酯和5-氨基-1H-1,2,4-三氮唑-3-羧酸甲酯为原料,经过系列官能团转化和环合,制备出带有多种衍生化基团(如酰肼)的生物碱essramycin 类似物。实验涉及加热回流、真空脱溶、抽滤和TLC检测等基础操作,可以锻炼学生在有机化合物合成、纯化及结构鉴定等方面的操作技能。实验要求学生独立查阅文献,熟练掌握ChemDraw和MestReC等软件的使用,可以提升学生分析问题并解决问题的能力。实验以提高本科生综合素质为宗旨,适用于学生综合有机化学实验。 相似文献
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HU Jin ZHANG Han-Hui CAO Yan-Ning ZHANG Chun-Gang ZHANG Shuai CHEN Yi-Ping SUN Rui-Qing 《结构化学》2009,28(8):939-946
Two novel transition metal phosphonate compounds, [Co(H2BDPP)(phen)]n 1 (BDPP = p-O3PCH2(C6H4)CH2PO3, phen = 1,10-phenanthroline) and [Pb3(BCP)2]n 2 (BCP = OOC(C6H4)CH2PO3), have been synthesized and structurally determined by X-ray single-crystal diffraction. Compound 1 crystallizes in the monoclinic system, space group C2/c with a = 21.169(4), b = 12.001(2), c = 7.6211(15)A, β = 98.03(3)°, V= 1917.2(6)A^3, C20H18N2O6P2Co, Mr = 505.22, Z = 8, De= 1.737 g/cm^3, p = 1.107 mm^-1, F(000) = 1020, the final R= 0.0450 and wR = 0.1306 for 2072 observed reflections (I 〉 2σ(I). Compound 2 crystallizes in the monoclinic system, space group C2/c with a = 4.7167(9), b = 18.753(2), c = 22.781(3)A, β = 91.07(3)°, V= 2014.7(14)A^, C8H6O5PPb1.5, Mr = 523.88, Z = 8, Dc = 3.454 g/cm^3, p = 25.222 mm^-1, F(000) = 1856, the final R = 0.0441 and wR = 0.1906 for 2259 observed reflections (I 〉 2σ(I). In compound 1, the 1D chain running along the c axis is bridged by four ligands (trans- HO3PCH2C6H4CH2PO3H) in four different directions to extend the structure into a three- dimensional network. In compound 2, the Pb(II) displays 4- and 5-coordination modes. There is a one-dimensional P-O-Pb band along the a axis formed by PO3 groups and Pb(II) cations. These bands are joined by μ2-O of -COO to yield two-dimensional inorganic P-O-Pb layers which are pillared by the OOCC6HaCH2PO3 ligands to form a three-dimensional network. Moreover, compound 2 displays a strong emission band attributed to the ligand-centered (LC) transition. 相似文献
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