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1.
Javad Azizian Ali A. Mohammadi M. Kohshari Ali R. Karimi Mohammad R. Mohammadizadeh 《Journal of heterocyclic chemistry》2007,44(2):455-458
In the context of our high‐throughput organic synthesis program, we have studied the reactivity of special β‐keto esters toward the Biginelli reaction. We have found that a diethyl‐3‐oxoglutarate reacts with one molecule of urea and one molecule of aldehyde under solvent‐free conditions to give a new family of 3,4‐dihydropyrimidin‐2(1H)‐ones in good yields. 相似文献
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Vellaisamy Sridharan Pandi Dhanalakshmi Shanmugam Muthusubramanian 《Journal of heterocyclic chemistry》2007,44(2):491-493
A one‐pot synthesis of some new 2,8‐disubstituted 3H‐phenoxazin‐3‐ones from 4‐substituted‐2‐aminophenols through a selective oxidative condensation by lead tetraacetate in acetic acid is described. 相似文献
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Venkatapuram Padmavathi Konda Mahesh Pinnu Thriveni Tippireddy Venkata Ramana Reddy 《Journal of heterocyclic chemistry》2007,44(5):1165-1169
A new class of 1,2,3‐selena/thiadiazoles and 2H‐diazaphospholes were synthesized by exploiting α‐ketomethylene group in phenacylsulfonylacetic acid methyl ester. 相似文献
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A simple synthesis of several methyl 2‐oxo‐2,3‐dihydrobenzo[b]oxepine‐4‐carboxylates from Baylis‐Hillman adducts of O‐benzyl protected 2‐hydroxybenzadehydes has been described through the acetylation, cyanation, debenzylation, as well as acid assisted Pinner cyclization. 相似文献
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P. Haranath V. Sreedhar Kumar C. Suresh Reddy C. Naga Raju C. Devendranath Reddy 《Journal of heterocyclic chemistry》2007,44(2):369-373
Substituted benzoxazaphosphorin 2‐yl ureas were synthesized by reacting 2‐(4‐fluoro‐phenylamino)‐methylphenol (4) with different carbamidophosphoric acid dichlorides (3) in the presence of triethylamine in dry toluene at 45‐50 °C and characterized by spectral data. These compounds were found to possess good antimicrobial activity. 相似文献
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Abbas Shafiee Mohammad Z. Kassaee Ahamad R. Bekhradnia 《Journal of heterocyclic chemistry》2007,44(2):471-474
The synthesis of a series of novel 3,4‐diaryl‐1H‐pyrroles and related arylalkenes from p‐bromo thiophenol, tosylmethyl isocyanide and commercially available materials is reported. Arylalkenes having electron‐withdrawing substituents gave higher yield of 3,4‐diaryl‐1H‐pyrroles. 相似文献
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Changsheng Yao Song Lei Cuihua Wang Chenxia Yu Shujiang Tu 《Journal of heterocyclic chemistry》2008,45(6):1609-1613
The solvent‐free synthesis of 5‐methyl‐7‐aryl‐4,7‐dihydrotetrazolo[1,5‐a]pyrimidine‐6‐carboxylic esters was performed and effectively catalyzed by sulfamic acid. Compared with conventional methods, this protocol features mild reaction conditions and high yields. Furthermore, it is solvent‐free and thus eco‐friendly. 相似文献
8.
Anna D. Photiadou Christos I. Stathakis John K. Gallos 《Journal of heterocyclic chemistry》2008,45(4):1251-1253
Reduction of the Michael addition products of anions of nitro compounds to dimethyl maleate led to the spontaneous formation of the respective 2‐alkyl‐5‐oxopyrrolidine‐3‐carboxylic acid methyl esters. Conventional hydrolysis of the later gave the desired compounds. 相似文献
9.
The carbodiimides 5 , obtained from reactions of iminophosphorane 4 with aromatic isocyanates, reacted with amines, phenols or ROH to give 2‐substituted 5,6,7,8‐tetrahydropyrido[4′,3′:4,5]thieno[2,3‐d]‐pyrimidin‐4(3H)‐one 7 in the presence of catalytic amount of sodium alkoxide or solid potassium carbonate in satisfactory yields. 相似文献
10.
Venkatapuram Padmavathi Thunga Radhalakshmi Gali Sudhakar Reddy Adivireddy Padmaja 《Journal of heterocyclic chemistry》2008,45(6):1579-1582
New and novel sulfone linked bis heterocycles_ bis pyrroles and pyrrolyl pyrazolines are prepared from 1‐arylsulfonyl‐2‐styrylsulfonylethenes by 1,3‐dipolar cycloaddition methodology. 相似文献
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A series of new unsymmetrical 3‐phenyl‐6‐benzyl‐1,2,4,5‐tetrazine derivatives 10a‐i were synthesized and characterized by IR, NMR, MS, and element analysis. The structures of 4a, 10c, 10d and 10h were analyzed by X‐ray crystallography, which had intermolecular C‐H‐N, C‐H‐Cl, C‐H‐II and II‐II interactions. 相似文献
13.
Osman M. E. El‐Dusouqui Nouria A. Al‐Awadi Mohamed H. Elnagdi Mervat M. Abdelkhalik 《Journal of heterocyclic chemistry》2008,45(6):1751-1753
1,2,3‐Triazolylpropanone was prepared and coupled with aryldiazonium salts yielding the corresponding arylhydrazones. Gas‐phase pyrolysis of the hydrazono derivative produced N‐arylamino‐2‐acetylimidazole as well as 2‐acetylimidazole. The latter is the product of further pyrolysis of the former. 相似文献
14.
Davood Azarifar Hassan Ghasemnejad Bosra Mahmood Tajbaksh 《Journal of heterocyclic chemistry》2007,44(2):467-469
1,3‐Dibromo‐5,5‐dimethylhydantoin (DBH) has been found to efficiently promote the conversion of various 3‐arylsydnones to their 4‐acetyl congeners in the presence of acetic anhydride under neutral conditions in satisfactory yields. 相似文献
15.
Suzan Ibrahim Aziz Hany Fakhry Anwar Mohamed Hilmy Elnagdi Daisy Hanna Fleita 《Journal of heterocyclic chemistry》2007,44(3):725-729
Efficient route to 5‐acyl‐2‐substituted‐1,2,3‐triazol‐4‐amines via reaction of 3‐oxo‐2‐(arylhydrazono)‐pentanenitrile with hydroxylamine hydrochloride is reported. X‐ray crystal structure has been made to confirm the structure of reaction products. 相似文献
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Abdelmalek Bouraiou Abdelmadjid Debache Salah Rhouati Ali Belfaitah Bertrand Carboni 《Journal of heterocyclic chemistry》2008,45(2):329-333
Some new polysubstituted 3‐pyrrolidinylquinolinyl derivatives were prepared by 1,3 dipolar cycloadditions of an azomethine ylide, generated in situ from benzylideneimine of methylglycinate and triethylamine in the presence of LiBr, to quinolyl α,β‐unsaturated esters 相似文献
19.
Chhanda Mukhopadhyay Arup Datta Bimal K. Banik 《Journal of heterocyclic chemistry》2007,44(4):979-981
We report here domestic microwave‐induced perchloric acid‐catalyzed solvent‐free synthesis of various 4‐aryl‐3,4‐dihydropyrimidones for the first time. In all the cases the yields are excellent and the mechanism follows a simple Biginelli condensation to produce the dihydropyrimidones in a few seconds. This procedure has been successfully employed to synthesize the mitotic kinesin EG5 inhibitor Monastrol (Figure I). 相似文献
20.
Jingping Liu Hong Song Lanlan Zhang Hongyan Xu Xiaojun Zhao 《Macromolecular bioscience》2010,10(10):1164-1170
The promising potential of a RAD‐16 self‐assembly‐peptide hydrogel as a scaffold for tissue‐engineered cartilage was investigated. Within 3 weeks of in vitro culture, chondrocytes within the hydrogel produced a high amount of GAG and type‐II collagen, which are the components of cartilage‐specific extracellular matrix (ECM). With the culture time increased, toluidine‐blue staining for GAG and immuno‐histochemistry staining for type‐II collagen of the chondrocytes‐hydrogel composites became more intense. Analysis of the gene expression of the ECM molecules also confirmed the chondrocytes in the peptide hydrogel maintained their phenotype within 3 weeks of in vitro culture.