Chemical Constituents from the Root Bark of Formosan Zanthoxylum Ailanthoides

Two new N‐isobutylamides, hydroxy lanyuamide I ( 1 ) and hydroxy lanyuamide II ( 2 ), together with one hundred and ten known compounds, have been isolated from the root bark of Formosan Zanthoxylum ailanthoides. These known compounds include twenty coumarins, twenty‐one benzo[c]phenanthridines, ten quinoline derivatives, one aporphine, one purine, seven amides, twelve benzenoids, one lactone, four flavonoids, nine lignans, eight steroids, two chlorophylls, eleven terpenoids and three other compounds, which were determined by means of spectral analyses.     

Chemical Constituents from the Root Wood of Zanthoxylum Integrifoliolum

Two new phenylpropanoids, integrifoliolin ( 1 ) and integrifoliodiol ( 2 ), together with 23 known compounds, have been isolated from the root wood of Zanthoxylum integrifoliolum. The structures of these compounds were determined by means of spectral analyses. The reported anti‐HIV constituents of decarine and γ‐fagarine were also isolated from the root wood of this plant.     

Chemical Constituents from the Root and Aerial Parts of Rosa taiwanensis

The root and aerial parts of Rosa taiwanensis Nakai contain the chemical constituents phenols, unsaturated acids, loliolide, abscisic acid, flavones, sterols, lupeol, betulin, betulinic acid, oleanolic acid and ursolic acid derivatives. Among them, 2α,3α-dihydroxyurs-12,19-dien-28-oic acid and its C-3 epimer are new compounds.     

Secoiridoid Glucosides and Anti-Inflammatory Constituents from the Stem Bark of Fraxinus chinensis

Qin Pi (Fraxinus chinensis Roxb.) is commercially used in healthcare products for the improvement of intestinal function and gouty arthritis in many countries. Three new secoiridoid glucosides, (8E)-4′′-O-methylligstroside (1), (8E)-4′′-O-methyldemethylligstroside (2), and 3′′,4′′-di-O-methyl-demethyloleuropein (3), have been isolated from the stem bark of Fraxinus chinensis, together with 23 known compounds (4–26). The structures of the new compounds were established by spectroscopic analyses (1D, 2D NMR, IR, UV, and HRESIMS). Among the isolated compounds, (8E)-4′′-O-methylligstroside (1), (8E)-4′′-O-methyldemethylligstroside (2), 3′′,4′′-di-O-methyldemethyloleuropein (3), oleuropein (6), aesculetin (9), isoscopoletin (11), aesculetin dimethyl ester (12), fraxetin (14), tyrosol (21), 4-hydroxyphenethyl acetate (22), and (+)-pinoresinol (24) exhibited inhibition (IC₅₀ ≤ 7.65 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leuckyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 9, 11, 14, 21, and 22 inhibited fMLP/CB-induced elastase release with IC₅₀ ≤ 3.23 μg/mL. In addition, compounds 2, 9, 11, 14, and 21 showed potent inhibition with IC₅₀ values ≤ 27.11 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation. The well-known proinflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6), were also inhibited by compounds 1, 9, and 14. Compounds 1, 9, and 14 displayed an anti-inflammatory effect against NO, TNF-α, and IL-6 through the inhibition of activation of MAPKs and IκBα in LPS-activated macrophages. In addition, compounds 1, 9, and 14 stimulated anti-inflammatory M2 phenotype by elevating the expression of arginase 1 and Krüppel-like factor 4 (KLF4). The above results suggested that compounds 1, 9, and 14 could be considered as potential compounds for further development of NO production-targeted anti-inflammatory agents.     

Diversity of Chemical Constituents from Saxifraga Montana H.

A thorough phytochemical investigation of the whole plant of Saxifraga montana H. afforded a new glucoside, methyl 6″‐O‐(E)‐p‐hydroxycinnamoxyl‐glucosyringate ( 1 ), and seventeen known natural products, 3‐methyl‐6‐methoxy‐3,4‐dihydroisocoumarin‐8‐O‐β‐D‐glucospyranoside ( 2 ), gallic acid ( 3 ), glucosyringic acid ( 4 ), daphnoretin ( 5 ), chamaejasmoside ( 6 ), myricetin ( 7 ), quercetin ( 8 ), quercetin‐3‐O‐β‐D‐galactopyranoside ( 9 ), quercetin‐3‐O‐α‐L‐arabinoside ( 10 ), quercetin‐3‐O‐β‐D‐glucospyranoside ( 11 ), rutin ( 12 ), quercetin‐3‐O‐β‐D‐glucopyranosyl (6‐1) glucopyranoside ( 13 ), ursolic acid ( 14 ), 5,28‐stigmastadien‐3β‐ol ( 15 ), β‐sitosterol ( 16 ), β‐daucosterin ( 17 ), 6′‐palmitoxyl‐β‐daucosterin ( 18 ). On the basis of various spectroscopic methods, especially intensive 2D‐NMR (COSY, HMQC and HMBC), FAB‐MS and HR‐ESI‐MS techniques, their structures were elucidated.     

Cytotoxic Constituents from the Stem Bark of Zanthoxylum Pistaciiflorum

Two new esters, methyl 4‐(prenyloxy)dihydrocinnamate and methyl 4‐(geranyloxy)dihydrocinnamate, together with fourteen known compounds have been isolated from the stem bark of Zanthoxylum pistaciiflorum. The structures of two new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited effective cytotoxicities against P‐388 and HT‐29 cell lines in vitro.     

Chemical Constituents from the Root of Antidesma Pentandrum var. Barbatum

Investigation of the root extract of Antidesma pentandrum var. barbatum led to the isolation of seven new compounds, antidesmol ( 1 ), antidesmanins E ( 2 ) and F ( 3 ), antidesnone ( 4 ), antidesnol ( 5 ), barbatumols A ( 6 ) and B ( 7 ), together with 14 known compounds including sodium aristolochate‐I ( 10 ) and aristolochic acid‐I methyl ester ( 11 ).     

Chemical Constituents from the Roots of Neolitsea hiiranensis

One triterpenoid, taraxerone ( 1 ); four germacrane-type sesquiterpene lactones, linderane ( 2 ), linderalactone ( 6 ), pseudoneolinderane ( 7 ), (+)-linderadine ( 8 ); one sesquiterpene dilactone, pseudoneoliacine ( 10 ); three elemane-type sesquiterpenes, isolinderalactone ( 3 ), compound 4 and sericealactone ( 9 ); one eudesmane type sesquiterpene, cryptomeridol ( 11 ); one glucoside, β-sitosterol-β-D-glucoside ( 12 ) along with β-sitosterol (5) were isolated from the roots of Neolitsea hiiranensis. The structures of these compounds were identified on the basis of spectral properties.     

中药鬼灯擎根精油成分的研究

鬼灯擎(Roodgersia aesculifolia,Batal):又名慕荷,系虎耳草科(Saxifagacede)鬼灯擎属,主要分布于甘肃、陕西、四川、河南等省,而甘肃天水、陇南山区资源十分丰富。民间常用于治疗湿热下痢、久泻、白浊、崩带、金疮等疾病。经我们对该植物根部化学成分的研宄和有效部位的药理试验证明,对耶尔森菌、金黄色葡萄球菌等十种病菌和单纯泡疹病毒及     

Chemical Constituents from the Leaves of Ligustrum robustum and Their Bioactivities

The leaves of Ligustrum robustum have been consumed as Ku-Ding-Cha for clearing heat and removing toxins, and they have been used as a folk medicine for curing hypertension, diabetes, and obesity in China. The phytochemical research on the leaves of L. robustum led to the isolation and identification of two new hexenol glycosides, two new butenol glycosides, and five new sugar esters, named ligurobustosides X (1a), X₁ (1b), Y (2a), and Y₁ (2b) and ligurobustates A (3a), B (3b), C (4b), D (5a), and E (5b), along with seven known compounds (4a and 6–10). Compounds 1–10 were tested for their inhibitory effects on fatty acid synthase (FAS), α-glucosidase, and α-amylase, as well as their antioxidant activities. Compound 2 showed strong FAS inhibitory activity (IC₅₀ 4.10 ± 0.12 μM) close to that of the positive control orlistat (IC₅₀ 4.46 ± 0.13 μM); compounds 7 and 9 revealed moderate α-glucosidase inhibitory activities; compounds 1–10 showed moderate α-amylase inhibitory activities; and compounds 1 and 10 displayed stronger 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) ammonium salt (ABTS) radical scavenging effects (IC₅₀ 3.41 ± 0.08~5.65 ± 0.19 μM) than the positive control l-(+)-ascorbic acid (IC₅₀ 10.06 ± 0.19 μM). This study provides a theoretical foundation for the leaves of L. robustum as a functional tea to prevent diabetes and its complications.     

川桂皮挥发油的化学组成

采用GC－MS技术分析了川桂（Cinnamomum wilsonii）皮挥发油的化学组成，共确定了其中42种化学成分与相对含量，占总组分相对含量的94．14％，其中有40种为萜类或其衍生物；研究结果显示，川桂皮油的主要成分为桉油素（11．02％），1（10），4－杜松二烯（10．21％），乙酸异龙脑酯（6．30％），杜松醇（5．53％），桉叶油醇（5．34％）等，与该植物叶和同属药用植物肉桂皮挥发油的主要组成均差别较大。     

A Study of the Constituents of the Bark of Chamaecyparis Formosensis Matsum

Sixteen compounds were isolated from the bark of Chamaecyparis formosensis Matsum. These compounds include four categories: (a) long-chain alcohols, acids and esters, (b) sterols and their glucosides, (c) o-methoxyphenol and related compounds, (d) diterpenes of abietane, pimarane, secoabietane and totarane.     

Chemical Constituents from Fruits and Stem Bark of Celtis australis L.

Four triterpenoids named (9β,31R)‐9,25‐cyclo‐30‐propylhopan‐31‐ol ( 1 ), (3β)‐3‐hydroxy‐30‐propylhopan‐31‐one ( 2 ), (3β)‐oleanan‐3‐ol ( 3 ), and (3β,9β)‐9,25‐cycloolean‐12‐en‐3‐yl β‐D ‐glucofuranoside ( 4 ), a steroid named (3β,9β,14β)‐14‐hydroxy‐9,19‐cyclocholan‐3‐yl β‐D ‐glucopyranoside ( 5 ), and an anthraquinone named 6‐hydroxy‐5,7,8‐trimethoxy‐9,10‐dioxo‐9,10‐dihydroanthracen‐2‐yl acetate ( 6 ) have been isolated from the fruits and bark of Celtis australis (Ulmaceae), along with apigenin, quercetin, and its glucoside. Their structures were elucidated by means of chemical and spectral analysis including COSY, NOESY, and HMBC experiments.     

Flavones and Cytotoxic Constituents from the Stem Bark of Muntingia Calabura

Two new flavones, 8‐hydroxy‐7,3′,4′,5′‐tetramethoxyflavone and 8,4′‐dihydroxy‐7,3′,5′‐trimethoxyflavone, together with thirteen known compounds have been isolated from the stem bark of Muntingia calabura. The structures of two new compounds were determined through spectral analyses. Among the isolates, 8‐hydroxy‐7,3′,4′,5′‐tetramethoxyflavone, 8,4′‐dihydroxy‐7,3′,5′‐trimethoxyflavone, and 3‐hydroxy‐1‐(3,5‐dimethoxy‐4‐hydroxyphenyl)propan‐1‐one exhibited effective cytotoxicities (ED₅₀ values = 3.56, 3.71, and 3.27 μg/mL, respectively) against the P‐388 cell line in vitro.     

复方板蓝根颗粒化学成分的质谱研究

利用电喷雾多级串联质谱(ESI-MSn)和傅里叶变换离子回旋共振质谱(FT-ICR-MS)技术,对复方板蓝根颗粒经溶剂萃取后的95%(体积分数)醇提和水提部位的化学成分进行了系统研究,鉴定出多种氨基酸成分、糖及其衍生物、有机酸、氨基酸和单糖的梅拉德反应初级产物以及含硫化合物表告依春.该方法灵敏快速,适宜于中药提取物的化学成分分析.     

气相色谱-质谱法与化学计量学分辨法分析当归须挥发油中化学成分

本文借助化学计量学分辨方法,建立了用气相色谱-质谱(GC-MS)联用法分析当归须挥发油成分的方法.对重叠色谱峰采用直观推导式演进特征投影算法进行分辨,从而获得每一组分的纯色谱和质谱,依靠每一组分纯质谱在NIST质谱库进行相似性检索而定性分析,用总体积积分法进行定量分析.在当归须挥发油中共分辨出86个色谱峰,通过质谱库检...     

鬼灯擎化学成份的分离和鉴定

从鬼灯擎根中分离出十种化合物,其中除鬼灯擎素(Ⅰ)已有文献报道外,其余9种化合物为首次从该植物中分得,而7-甲氧基鬼灯擎素(Ⅱ)和2,6-二羟基苯乙酸甲酯(Ⅳ)为新化合物。