共查询到19条相似文献,搜索用时 125 毫秒
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3-芳基咪唑并[1,2-a]吡啶骨架广泛存在于药物结构中,在药物学方面具有重要的地位及在材料化学、有机化学等方面也具有潜在的应用价值.在含水介质中,利用醋酸钯催化咪唑并[1,2-a]吡啶及其衍生物与芳基/杂芳基氯代物的碳氢芳基化反应,简便、高效地合成系列3-芳基咪唑并[1,2-a]吡啶类化合物,并以较好至优秀的收率获得芳基化产品.该方法采用廉价易得的芳基/杂芳基氯代物和咪唑并[1,2-a]吡啶类化合物为偶联反应的底物,且底物的范围能够拓展至缺电子、富电子的芳基氯代物和杂芳基氯代物及多种基团取代的咪唑并[1,2-a]吡啶类化合物. 相似文献
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咪唑并[1,2-a]吡啶化合物是由五元和六元稠和的氮杂环化合物,在多种天然产物中被发现,表现出广泛的药理学活性,具有重要的研究意义和广阔的医药应用前景,因此有关于此类化合物的多样性的合成策略被不断报道.近年来,绿色化学是当代化学的热门方向之一,科学家们对绿色合成越来越重视,不断开发出各种绿色合成方案,其中一锅"多组分"反应、微波反应和固相合成这几种绿色、高效的合成方法一直是研究热点,就从这三类绿色合成的方法对咪唑[1,2-a]吡啶类化合物近几年绿色合成的研究进展加以概括总结. 相似文献
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Direct thionation of imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines results in the formation of their 2-thioxo derivatives, usually in high yield. The thione structure of the imidazopyridines obtained has been confirmed from their IR spectra in the solid state and in solution. The general nature of the thionation of imidazole, benzimidazole, imidazo[4,5-b]pyridine, imidazo[4,5-c]pyridine, and purine has been noted as one of the distinctive chemical properties of compounds in this series of nitrogen heterocycles.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 799–804, June, 1988. 相似文献
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It is shown that when N-methyl (or benzyl) derivatives of imidazo[4,5-b]pyridine and N-methyl-substituted derivatives of imidazo[4,5-c]pyridine are heated with alkalis, the imidazole ring is always hydroxylated to give the corresponding 2-imidazolones.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1252–1254, September, 1976. 相似文献
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V. A. Anisimova N. I. Avdyunina A. F. Pozharskii A. M. Simonov L. N. Talanova 《Chemistry of Heterocyclic Compounds》1980,16(4):409-417
The interaction of condensed nitrogen-containing bridge systems with chloral has been studied and the high sensitivity of the reaction to the -excess of the initial heteroaromatic system has been established. It has been shown that chloral is a convenient formylating agent for systems with a moderate -excess —imidazo[l,2-a]imidazole, 9H-imidazo[1,2-a]benzimidazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]naphtho[2,3-d]imidazole. Heterocycles with a high -excess (indolizine, pyrrolo[1,2-a]benzimidazole) form cyanine dyes under the action of chloral. Systems with a lowered -excess (1H-imidazo[1,2-a]benzimidazole, imidazo[1,2-a]quinoline, imidazo[2,1-a]isoquinoline, imidazo[1,2-a]perimidine, imidazo[5,1-b]benzoxazole, imidazo[1,2-a]benzothiazole, and imidazo[1,2-a]pyrimidine) do not react with chloral in a neutral medium. However, in a number of cases their foraylation can be carried out in an acid medium.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 528–537, April, 1980. 相似文献
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Methods for the preparation of aza and deaza analogs of purine nucleosides, viz., nucleosides of imidazo[4,5-d]-v-triazines, imidazo[4,5-b]pyridines, and imidazo[4,5-c]pyridines, and their properties are described. References to the synthesis of nucleosides of imidazo[4,5-d]pyridazines, imidazo[4,5-c]pyridazines, and imidazo[4,5-b]pyrazines are also given.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 147–161, February, 1981. 相似文献
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V. A. Anisimova T. B. Korochina N. I. Avdyunina A. M. Simonov 《Chemistry of Heterocyclic Compounds》1986,22(3):275-282
Methods for the synthesis of imidazo[1,2-a]benzimidazole haloketone derivatives have been investigated. It has been found that -bromoketone derivatives of this heterocycle can be prepared either by bromination of 3-acylimidazo[1,2-a]benz-imidazoles with bromine in glacial acetic acid or by acylation of 3-unsubstituted imidazo[1,2-a]benzimidazoles with haloanhydride derivatives of -bromoalkanoic acids. Treatment of imidazo[1,2-a]benzimidazoles with 3-chloropropionyl chloride results in the formation of imidazo[1,2-a]benzimidazolyl-3-propionyl chloride and bis(imidazo[1,2-a]benzimidazolyl)propan-3-one derivatives as side products. Reaction of 2-phenylimidazo[1,2-a]benzimidazoles with 3-bromopropionic acid in polyphosphoric acid gives benzocyclohepten[5,6:4,5]imidazo[1,2-a]benzimidazole derivatives.For Communication 20, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 339–345, March, 1986. 相似文献
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Baeza A Mendiola J Burgos C Alvarez-Builla J Vaquero JJ 《The Journal of organic chemistry》2005,70(12):4879-4882
An efficient synthesis of substituted azolopyrimidines such as pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidines, pyrimido[1,6-a]indoles, benzo[4,5]imidazo-[1,2-c]pyrimidines, an imidazo[1,2-c]pyrimidine, and pyrazolo[1,5-c]pyrimidines is described. The method involves the reaction of N-protected bromomethylazoles and tosylmethyl isocyanide (TosMIC) derivatives in nonanhydrous media. The study of the reaction conditions shows that the method is only successful under phase-transfer conditions (CH2Cl2/30% aq NaOH) using benzyltriethylammonium chloride as a catalyst. 相似文献
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A. F. Vlasenko B. E. Mandrichenko G. K. Rogul'chenko R. S. Sinyak I. A. Mazur P. M. Kochergin 《Chemistry of Heterocyclic Compounds》1976,12(6):696-698
Methods were developed for the synthesis of dihydro and tetrahydro derivatives of imidazo-[1,2-a]- and imidazo[1,2-c]pyrimidine and imidazo[2,1-b]-5-quinazolone from 2-amino- and 4-aminopyrimidines, 2-amino-4-quinazolones, and -haloethanols or 1,2-dihaloethanes. Dihydroimidazo[1,2-c]quinazoline, which was also obtained by cyclization of 4-(-hydroxyethylamino)-quinazoline, was synthesized by reaction of 4-chloroquinazoline with -haloethylamines.See [1] for communication LXXXV.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 834–836, June, 1976. 相似文献
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Elina A. S. Musatova I. S. Tsyrul'nikova L. G. 《Chemistry of Heterocyclic Compounds》1972,8(9):1144-1148
The N-oxides and N,N-dioxides of methyl derivatives of imidazo[4,5-b]quinoxaline and imidazo[4,5-b]pyrazine were synthesized. The higher reactivity of the 2-methyl group in the N-oxides of 2-methylimidazo[4,5-b]quinoxaline as compared with the corresponding unoxidized derivatives was demonstrated.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1266–1270, September, 1972. 相似文献