共查询到20条相似文献,搜索用时 15 毫秒
1.
P. Giori A. C. Veronese T. Poli C. B. Vicentini M. Manfrini M. Guarneri 《Journal of heterocyclic chemistry》1986,23(2):585-588
The reaction of pyrazolo[4,3-c][1,2,5]oxadiazin-3(5H)-ones 1 with carbanions prepared in situ from compounds containing an activated methylene group afforded pyrazolo[3,4-b]pyrazines 4–13 in good yields. The possible reaction mechanism is proposed and discussed. 相似文献
2.
Braulio Insuasty Ricaurte Rodriguez Jairo Quiroga Roberto Martinez Enrique Angeles 《Journal of heterocyclic chemistry》1997,34(4):1131-1133
The acid catalyzed condensation of 4,5-diaminopyrazoles and chalcones gave the hitherto unknown 1-benzyl-2,4,6-triphenyl-2,3-dihydropyrazolo[3,4-b][1,4]diazepines derivatives. The structure of all products was supported by ir, 1H and 13C-nmr and mass spectra. 相似文献
3.
A synthesis of 4-N-oxides and of 3-hydroxy derivatives of 1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-ones and of 2,3-dihydro-1H-benzofuro[3,2-e][1,4]diazepines is described. Condensation of 2-acetyl- and 2-benzoyl-3-ethoxycarbonylaminobenzofurans with acrylonitrile gave derivatives of 1,2-dihydro- and of 1,2,3,4-tetrahydrobenzofuro[3,2-b]pyridine. 相似文献
4.
The condensation of 1-acyl-2-(morpholin-4-yl)cycloalkenes with 3-amino-1-phenyl-1H-pyrazol-5(4H)-ones gave the corresponding 2,3,6,7,8,9-hexahydropyrazolo[3,4-c]isoquinoline and 3,6,7,8,9,10-hexahydrocyclohepta[ d]pyrazolo[3,4-b]pyridine derivatives. Alkylation of 2,3,6,7,8,9-hexahydropyrazolo[3,4-c]-isoquinolines with alkyl halides occurred at the nitrogen atom in the 3-position. The structure of 7-methyl-2,5-diphenyl-2,3,6,7,8,9-hexahydro-1H-pyrazolo[3,4-c]isoquinolin-1-one was proved by X-ray analysis. 相似文献
5.
Y. C. Tong 《Journal of heterocyclic chemistry》1975,12(3):451-453
1,2,5-Thiadiazolo[3,4-b]pyrazine and its derivatives were prepared. Nucleophilic displacements of halogen atoms on the nucleus were reported. 相似文献
6.
Michael D. Thompson 《Journal of heterocyclic chemistry》1986,23(5):1545-1549
The reaction conditions for the preparation of 7H,8H-1,3-dimethyl-2,4,6,9-tetraoxopyrimidino[4,5-b][1,4]-diazocine ( 9 ), 1,3-dimethy 1–2,4,6,11-tetraoxobenzo[f]pyrimidino[4,5-b][1,4]diazocine ( 10 ), 7H,8H-1,3-dimethyl-2,4,6,10-tetraoxopyrimidino[4,5-b][1,4]diazonine ( 16 ), and 7H,8H-6,9-dioxopyridino[2,3-b][1,4]diazocine ( 19 ) were determined. The mechanism of the formation of these compounds was established. The scope of these reactions was found to be general for eight and nine ring formation from 2,3-diamino-N-heterocycles. 相似文献
7.
Several new pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-e][1,4]diazepine, pyrazolo[3,4-d][1,2,3]triazine and pyrolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives were prepared by the reaction of the corresponding 5-amino-pyrazole-4-carbonitrile derivative with different organic reagents under different reaction conditions. Using IR, 1H NMR, and mass spectra we have characterized all new compounds. 相似文献
8.
The synthesis and characterization of a number of 3-aryl-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines and 3-aryl-6H-isoxazolo[5,4-d]pyrazolo[3,4–6]pyridines from common precursors, 5-benzoyl-4-chloro-1H-pyrazolo-[3,4-b]pyridines, has been described. The structures were determined by unambiguous chemical synthesis and by isolation and 13C nmr analysis of some key, isolated, intermediates. The ability of these compounds to displace [3H]flunitrazepam from CNS binding sites was also observed. 相似文献
9.
A method was developed for the synthesis of 5,6-dichlorofurazano[3,4-b]pyrazine (a compound with easily removed leaving groups). The optimum conditions for their substitution by various nucleophiles were determined.For Communication 2, see [1].Latvian Institute of Organic Synthesis, Riga. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1402–1416, October, 1997. 相似文献
10.
A series of novel 6-functionalized-5-amino-3-methyl-1-phenyl-1H-furo[3,2-e]pyrazolo[3,4-b]pyrazines (4a–c) was synthesized by the reaction of 3-methyl-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (2) with α-halocarbonyl compounds such as: diethyl 2-bromomalonate, phenacyl bromide and chloroacetone. Cyclocondensation of the amino benzoyl 4b with diethyl malonate yielded the oxopyridine carboxylate derivative 5. Also, the starting intermediate amino ester compound 4a was allowed to react with ethanol amine to afford the hydroxyethyl caboxamide derivative 6. Furthermore, hydrazinolysis of the amino ester 4a afforded the corresponding amino carbohydrazide 7 which was used as a versatile precursor for synthesis of other heterocyclic compounds attached or fused to the furopyrazolopyrazine moiety. The chemical structures of the newly synthesized compounds were confirmed on the basis of elemental and spectral analyses containing FT-IR, 1H NMR, 13C NMR, and mass spectrometry hoping these molecules should allow us to investigate their pharmacological activities in the future study. 相似文献
11.
12.
Lothar Hennig Mario Alva-Astudillo Reinhard Meusinger Gerhard Mann 《Monatshefte für Chemie / Chemical Monthly》1993,124(8-9):893-898
Summary Donor substituted arylidene aminopyrazoles1a–c and CH-acidic 1,3-dicarbonyl compounds2a–e give in ethanol in an addition/cyclization reaction pyrazolo[3,4-c]isoquinolines4a–i and pyrazolo[3,4-b]pyridine derivatives5a,b, respectively. Using ethyl cyanoacetate as CH-acidic component, cinnamate6 and the cyano substituted pyrazolo[3,4-b]pyridine7 are formed.
Synthese von Pyrazolo[3,4-c]isochinolin- und Pyrazolo[3,4-b]pyridin-Derivaten aus Azomethinen und CH-aciden Verbindungen
Zusammenfassung Die Reaktion der donorsubstituierten Aryliden-aminopyrazole1a–c mit den CH-aciden 1,3-Dicarbonylverbindungen2a–e führt in einer Additions/Cyclisierungsreaktion zu den Pyrazolo[3,4-c]isochinolin-4a–i bzw. Pyrazolo[3,4-b]pyridin-Derivaten5a,b. Verwendet man Cyanessigester als CH-acide Komponente, werden der Zimtsäureester6 und das cyanosubstituierte Pyrazolo[3,4-b]pyridin7 gebildet.相似文献
13.
Ho Sik Kim Yoshihisa Kurasawa Chiemi Yoshii Minako Masuyama Atsushi Takada Yoshihisa Okamoto 《Journal of heterocyclic chemistry》1990,27(4):1111-1114
The pyridazino[3,4-b]quinoxalines 6a,b and pyrazolo[3,4-b]quinoxaline hydrochloride 9 were synthesized by the 1,3-dipolar cycloaddition reaction of 6-chloro-2-(1-methylhydrazino)quinoxaline 4-oxide 5 with dimethyl or diethyl acetylenedicarboxylate and 2-chloroacrylonitrile, respectively. The reaction mechanisms were postulated for the formation of 6a,b and 9 . 相似文献
14.
I. B. Starchenkov V. G. Andrianov A. F. Mishnev 《Chemistry of Heterocyclic Compounds》1998,34(9):1081-1085
The reduction of 1,2,3-triazolo[4,5-e]furazano[3,4-b]pyrazine 6-oxide was investigated. By means of data from x-ray crystallographic analysis it was shown that there is a relation between the aromaticity and the structure of the obtained triazoles.For communication 5, see [1].Latvian Institute of Organic Synthesis, Riga LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1259–1264, September, 1998. 相似文献
15.
By the action of thionyl chloride on 3(5)-R-4-phenacylpyrazole-5(3)-carboxylic acid ( 3c,d ), 3-R-5-phenylpyrano[3,4-c]pyrazole-7-(1H)ones ( 4c,d ) were obtained. When 4c,d were treated with hydrazine hydrate followed by refluxing in ethanol containing acetic acid, 4,7-dihydro-3-R-5-phenylpyrazolo[3,4-d][1,2]-diazepin-8-(1H)ones ( 6c,d ) were formed. Compounds 6c,d , in turn, were refluxed in ethanol saturated with hydrochloric acid to yield 6-amino-1,6-dihydro-3-R-5-phenyl-7H-pyrazolo[3,4-c]pyridin-7-ones ( 7c,d ). Compounds 7c,d could be obtained directly from 5c,d. The starting materials 3c,d were prepared by hydrolysis of the oxime of 3(5)-R-4-phenacyl-5(3)carboalcoxypyrazoles ( 1a,b ). Structural assignments rested on correct elemental analysis, molecular weights determined by mass spectrometry, and spectroscopic evidence. 相似文献
16.
The synthesis and the optical and electrochemical properties of thiophene end capped oligo(2,3-alkylthieno[3,4- b]pyrazine)s are presented. The optical absorption rapidly shifts to lower energies with increasing chain length, caused in almost equal amounts by a rise of the HOMO and a lowering of the LUMO levels. The optical band gap of the polymer is estimated to be 1.13 +/- 0.07 eV. Extrapolated redox potentials indicate that the polymer is a small band gap p-type material. 相似文献
17.
É. I. Ivanov 《Chemistry of Heterocyclic Compounds》1998,34(6):723-726
Starting from benzocrown substituted 4(5)-aminoimidazole-5(4)-carboxamides we have, for the first time, prepared benzocrown imidazo[4,5-e]-and-[5,4-e][1,4]diazepines-cyclic homologs of the corresponding xanthines.A. V. Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Odessa 270080. Translated from Khimiya Geterotsiklicheskikh Soedinenii No. 6, pp 828–831, June, 1998. 相似文献
18.
Joseph Raker Yi Wang Anthony D. Pechulis James C. Haber Michael A. Lynch Stacey L. Spring 《Journal of heterocyclic chemistry》2012,49(1):221-226
The synthesis and in vitro biological evaluation of two novel benzodiazepine derivatives are described. The compounds were synthesized divergently from the key amino alcohol 5 , which was realized using the unusual Weinreb‐enamino ketone 10 . J. Heterocyclic Chem., (2012). 相似文献
19.
V. G. Andrianov I. B. Starchenkov A. F. Mishnev 《Chemistry of Heterocyclic Compounds》1997,33(8):977-981
The corresponding 7-substituted furazano[3,4-b]tetrazolo[1,2-d]pyrazines were obtained by nucleophilic substitution of the azido group in 7-azidofurazano[3,4-b]tetrazolo[1,2-d]pyrazine. It was shown that these compounds exist in the tetrazole form in the crystalline state; in solutions, a tautomeric equilibrium is observed between the azide and tetrazole forms. Further reaction with nucleophiles leads to the production of 5,6-disubstituted furazano[3,4-b]pyrazines.For Communication 1, see [2].Latvian Institute of Organic Synthesis. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1120–1124, August, 1997. 相似文献
20.
G. Kh. Khisamutdinov V. L. Korolev T. N. Parkhomenko V. M. Sharonova E. S. Artem'eva I. Sh. Abdrakhmanov S. P. Smirnov B. I. Ugrak 《Russian Chemical Bulletin》1993,42(10):1700-1702
New methods for the synthesis of 1,2,4-triazolo[4,3-d]-1,2,4-triazolo[3,4-f]furazano[3,4-b]pyrazines with functional substituents of various types are proposed and some properties of these compounds are studied.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1776–1778, October, 1993. 相似文献