Synthesis of cyano-2,3-dihydropyrrolo[1,2-<Emphasis Type="Italic">f</Emphasis>]phenanthridine derivatives via a domino-Knoevenagel-cyclization

Abstract  

In a new multicomponent reaction phenanthridine reacts with isocyanides and malonitrile in the presence of benzaldehyde derivatives to produce 2-aryl-3-(alkyl- or arylimino)-2,3-dihydropyrrolo[1,2-f]phenanthridine-1,1(12b H)-dicarbonitrile in a simple, mild, and efficient protocol in excellent yields.     

Synthesis of silver and lithium sub-micro- and nanoparticles coated with derivatives of <Emphasis Type="Italic">p</Emphasis>-<Emphasis Type="Italic">tert</Emphasis>-butyl thiacalix[4]arenes

The effect of solvent nature and temperature on the formation of 3D-dimensional SAM (self-assembled monolayers on nanoparticles) based on synthetically available stereoisomers of p-tert-butyl thiacalix[4]arenes tetrasubstituted at the lower rim by pyrrolidide and octylamide groups (cone, partial cone, and 1,3-alternate) with lithium and silver nanoparticles were determined by dynamic light-scattering and transmission electron microscopy. It was found that the variation of the temperature of the system and the nature of the solvent leads to the formation discrete or extended particles (CH₂Cl₂) (98–110 nm), nanostructures (CH₃CN) (120–295 nm) or three-dimensional SAM (DMF) (1–13 nm; 46–622 nm).     

Synthesis of 1<Emphasis Type="Italic">H</Emphasis>-imidazo[1,2-<Emphasis Type="Italic">b</Emphasis>]-1,2,4-triazol-6-amines via multicomponent reaction

A simple and effective method for the synthesis of bioactive imidazo[1,2,4]triazole analogues has been developed utilizing the MCR technique, which involved the reaction of aminotriazoles, isocyanides and aldehydes. The products were characterized by ¹H, ¹³C NMR spectroscopy, MS and elemental analysis. Interestingly, compounds 19d, 21a, 21b and 21h displayed good cytotoxic activities at 10⁻⁴ M concentration in the inhibition of tumor cell growth as evaluated by the MTT method.     

An efficient and facile synthesis of new tetracyclic fused pyrazolo[4,3-<Emphasis Type="Italic">c</Emphasis>][1,2,4]triazino[4,5-<Emphasis Type="Italic">a</Emphasis>]quinolin-4(5<Emphasis Type="Italic">H</Emphasis>)-ones

Reaction of amidrazones 1a–1i with (1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)propanedinitrile (2) in ethyl acetate solution in one-step reaction led to the formation of unprecedented pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones 3a–3g along with pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-12b-oles 3h–3m in moderate to excellent yields. These novel heterocycles were formed via a Michael addition reaction followed by intramolecular cyclization via a dearomatization process.     

A new one-pot three-component synthesis of 2,4-diamino-5<Emphasis Type="Italic">H</Emphasis>-chromeno[2,3-<Emphasis Type="Italic">b</Emphasis>]pyridine-3-carbonitrile derivatives

In this study, a three-component one-pot synthesis of new 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles derived from 2-amino-1,1,3-tricyanopropene, salicylic aldehydes and secondary cyclic amines is reported. The reaction is conducted in ethanol at ambient temperature in good-to-excellent yields.     

<Emphasis Type="Italic">V</Emphasis>-<Emphasis Type="Italic">A</Emphasis> sum rules with <Emphasis Type="Italic">D</Emphasis> = 10 operators

The difference of vector and axial-vector charged current correlators is analyzed by means of QCD sum rules. The contribution of 10-dimensional 4-quark condensates is calculated and its value is estimated within the framework of the factorization hypothesis. It is compared to the result obtained from an operator fit of Borel sum rules in the complex q ²-plane, calculated from experimental data on hadronic -decays. This fit gives accurate values of the light quark condensate and the quark-gluon mixed condensate. The size of the high-order operators and the convergence of the operator series are discussed.Received: 10 May 2004, Revised: 7 September 2004, Published online: 18 November 2004     

Electrical and optical properties of pulse plated CdS<Subscript><Emphasis Type="BoldItalic">x</Emphasis></Subscript>Te<Subscript>1-<Emphasis Type="BoldItalic">x</Emphasis></Subscript> films

Thin films of CdS_xTe_1-x were deposited by the pulse electrodeposition technique using cadmium sulfate, sodium thiosulfate, and tellurium dioxide on titanium and conducting glass substrates. Structural studies indicated the formation of polycrystalline films possessing hexagonal structure. The resistivity varies from 53 Ω cm to 8 Ω cm as the stochiometric coefficient “x” value decreases from 1 to 0. The carrier concentration increases with CdTe concentration. It is observed that as the post-heat treatment temperature increases, the photosensitivity also increases. It is observed that a post-heat treatment temperature of 550 °C results in high photosensitivity as well as low light resistance. The optical constants, refractive index (n) and extinction coefficient (k) were evaluated from the transmission spectra of the films of different composition.     

Interplay between grand unification and supersymmetry in <Emphasis Type="BoldItalic">SU</Emphasis>(5) and <Emphasis Type="BoldItalic">E</Emphasis> <Subscript> <Emphasis Type="Bold">6</Emphasis> </Subscript>

Some aspects of minimal supersymmetric renormalizable grand unified theories are reviewed here. These include some constraints on the model parameters from the Higgs and light fermion masses in SU(5), and the issues of symmetry breaking, doublet–triplet splitting and fermion masses in E₆.     

Sneutrino production at <Emphasis Type="Italic">e</Emphasis><Superscript> + </Superscript><Emphasis Type="Italic">e</Emphasis><Superscript>-</Superscript> linear colliders: addendum to slepton production

Complementing the preceding study of charged scalar leptons, the sector of the neutral scalar leptons, sneutrinos, is investigated in a high-precision analysis for future e ⁺ e ^- linear colliders. The theoretical predictions for the cross-sections are calculated at the thresholds for non-zero widths and in the continuum including higher-order corrections at the one-loop level. Methods for measuring the sneutrino masses and the electron-sneutrino-gaugino Yukawa couplings are presented, addressing theoretical problems specific for the sneutrino channels.Received: 10 September 2004, Revised: 11 October 2004, Published online: 3 March 2005     

Single and double spin asymmetries in the elastic <Emphasis Type="Italic">e</Emphasis>-<Emphasis Type="Italic">d</Emphasis> scattering and their dependence on the deuteron wave function

Single and double spin asymmetries in the elastic electron-deuteron (e-d ) scattering were investigated. The tensor-deuteron asymmetries T_2i(i = 0, 1, 2) and the beam-vector-deuteron asymmetries T ^e _1i(i = 0, 1) were calculated and compared with the available experimental data. The sensitivity of the results for these spin asymmetries to the deuteron wave function has been investigated. The predicted asymmetries were found to be agree with one another and with experiment. It was found that, the double spin asymmetry T ^e ₁₀ is much smaller than the T ^e ₁₁-asymmetry. Therefore, in addition to the single tensor-deuteron asymmetry T₂₀, the doubly beam-vector-deuteron asymmetry T ^e ₁₁ can be used as an another tool for extracting the deuteron electromagnetic form factors.     

Isospin breaking in <Emphasis Type="BoldItalic">K</Emphasis><Subscript><Emphasis Type="BoldItalic">l4</Emphasis></Subscript> decays

Data on K _e4 decays allow one to extract experimental information on the elastic π π scattering amplitude near threshold, and to confront the outcome of the analysis with predictions made in the framework of QCD. These predictions concern an isospin symmetric world, while experiments are carried out in the real world, where isospin-breaking effects—generated by electromagnetic interactions and by the mass difference of the up and down quarks—are always present. We discuss the corrections required to account for these, so that a meaningful comparison with the predictions becomes possible. In particular, we note that there is a spectacular isospin-breaking effect in K _e4 decays. Once it is taken into account, the previous discrepancy between NA48/2 data on K _e4 decays and the prediction of π π scattering lengths disappears.     

Antioxidative and antiproliferative activities of novel pyrido[1,2-<Emphasis Type="Italic">a</Emphasis>]benzimidazoles

A series of pyrido[1,2-a]benzimidazoles has been designed, and novel examples are synthesized and evaluated for their potential antiproliferative activity against four human tumour cell lines—cervical (HeLa), colorectal (SW620), breast (MCF-7) and hepatocellular carcinoma (HepG2). In addition, their antioxidative potency has been evaluated by in vitro spectrophotometric assays. Preliminary structure–activity relationships among the synthesized compounds are discussed. Evaluation of their antioxidative capacity has shown that two compounds (25 and 26) possess promising reducing characteristics and free radical scavenging activity. Selective antiproliferative effect in the single-digit micromolar range was observed for compound 25 on MCF-7 \((\hbox {IC}_{50} = 6\,{\upmu }\hbox {M})\) and HeLa \((\hbox {IC}_{50} = 8\,{\upmu }\hbox {M})\) cell lines, comparable to the standards 5-fluorouracil and cisplatin. The combination of the radical scavenging activity and antiproliferative activity of compound 25 positions this compound as a potential lead candidate for further optimization.     

Prospects for the measurement of the Higgs boson masswith a linear <Emphasis Type="Italic">e</Emphasis><Superscript> + </Superscript><Emphasis Type="Italic">e</Emphasis><Superscript>-</Superscript> collider

The potential of a linear e ⁺ e^- collider operated at a centre-of-mass energy of 350 GeV is studied for the measurement of the Higgs boson mass. An integrated luminosity of 500 fb^-1 is assumed. For Higgs boson masses of 120, 150 and 180 GeV the uncertainty on the Higgs boson mass measurement is estimated to be 40, 65 and 70 MeV, respectively. The effects of beam related systematics, namely a bias in the beam energy measurement, the beam energy spread and the luminosity spectrum due to beamstrahlung, on the precision of the Higgs boson mass measurement are investigated. In order to keep the systematic uncertainty on the Higgs boson mass well below the level of the statistical error, the beam energy measurement must be controlled with a relative precision better than 10^-4. Received: 30 May 2005, Revised: 6 July 2005, Published online: 6 October 2005     

Updated estimate of the muon magnetic momentusing revised results from <Emphasis Type="Italic">e</Emphasis><Superscript> + </Superscript><Emphasis Type="Italic">e</Emphasis><Superscript>-</Superscript>annihilation

A new evaluation of the hadronic vacuum polarization contribution to the muon magnetic moment is presented. We take into account the reanalysis of the low-energy e ⁺ e ^-annihilation cross section into hadrons by the CMD-2 Collaboration. The agreement between e ⁺ e ^-and spectral functions in the channel is found to be much improved. Nevertheless, significant discrepancies remain in the center-of-mass energy range between 0.85 and , so that we refrain from averaging the two data sets. The values found for the lowest-order hadronic vacuum polarization contributions are where the errors have been separated according to their sources: experimental, missing radiative corrections in e ⁺ e ^-data, and isospin breaking. The corresponding Standard Model predictions for the muon magnetic anomaly read where the errors account for the hadronic, light-by-light (LBL) scattering and electroweak contributions. The deviations from the measurement at BNL are found to be (1.9 ) and (0.7 ) for the e ⁺ e ^-- and -based estimates, respectively, where the second error is from the LBL contribution and the third one from the BNL measurement.Received: 7 September 2003, Published online: 30 October 2003     

An efficient one-pot synthesis of functionalized chromeno[4,3-<Emphasis Type="Italic">b</Emphasis>]pyridine derivatives under catalyst-free conditions

A concise, efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives via a three-component reaction of 4-oxo-4H-chromene-3-carbaldehydes, malononitrile or cyanoacetates, and aromatic amines under catalyst-free conditions in an environmentally friendly medium (ethanol–water, 3:1 v/v) is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.     

Arylbenzo[<Emphasis Type="Italic">h</Emphasis>][1, 6]naphthyridine Derivatives: Synthesis and Photophysical Properties

Suzuki-Miyaura cross coupling was successfully used for C5-arylation in 4-amino-2-chloroquinoline-3-carbaldehyde using arylbornic acid and tetrakistriphenylphosphine palladium catalyst in water. Friedländer condensation reaction on 4-amino-2-chloro/2-arylquinoline-3-carbaldehyde and aromatic ketones gave novel aryl and diarylbenzo[h] [1, 6]naphthyridines in good yields. Fluorescence quantum yields were increased by introducing C2 and C5 π donor aryl benzo[h][1, 6]naphthyridines derivatives.

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Figure Synthesis of Fluorescent Arylbenzo[h][1, 6]naphthyridine

     

Radiative <Emphasis Type="Italic">K</Emphasis><Subscript><Emphasis Type="Italic">e</Emphasis>3</Subscript> decays revisited

Motivated by recent experimental results and ongoing measurements, we review the chiral perturbation theory prediction for decays. Special emphasis is given to the stability of the inner bremsstrahlung-dominated relative branching ratio versus the K _e3 form factors, and on the separation of the structure-dependent amplitude in differential distributions over the phase space. For the structure-dependent terms, an assessment of the order p ⁶ corrections is given, in particular, a full next-to-leading order calculation of the axial component is performed. The experimental analysis of the photon energy spectrum is discussed, and other potentially useful distributions are introduced.Received: 9 December 2004, Published online: 21 February 2005PACS: 13.20.Eb, 11.30.Rd, 12.39.Fe     

<Emphasis Type="Italic">K</Emphasis><Subscript><Emphasis Type="Italic">e</Emphasis>3</Subscript> decays and CKM unitarity

We present a detailed numerical study of the K_e3 decays to in chiral perturbation theory with virtual photons and leptons. We describe the extraction of the CKM matrix element |V_us| from the experimental K_e3 decay parameters. We propose a consistency check of the K ⁺ _e3 and K⁰_e3 data that is largely insensitive to the dominating theoretical uncertainties, in particular the contributions of . Our analysis is highly relevant in view of the recent high statistics measurement of the K ⁺ _e3 branching ratio by E865 at Brookhaven which does not indicate any significant deviation from CKM unitarity but rather a discrepancy with the present K⁰_e3 data.Received: 22 January 2004, Published online: 30 April 2004Work supported in part by IHP-RTN, Contract No. HPRN-CT2002-00311 (EURIDICE) and by Acciones Integradas, Project No. 19/2003 (Austria), HU2002-0044 (MCYT, Spain)     

Parallel and automated library synthesis of 2-long alkyl chain benzoazoles and azole[4,5-<Emphasis Type="BoldItalic">b</Emphasis>]pyridines under microwave irradiation

Summary A versatile route to 40-membered library of 2-long alkyl chain substituted benzoazoles (1 and 2) and azole[4,5-b]pyridines (3 and 4) via microwave-assisted combinatorial synthesis was developed. The reactions were carried out in both monomode and multimode microwave oven. With the latter, all reactions were performed in high-throughput experimental settings consisting of an 8×5 combinatorial library designed to synthesize 40 compounds. Each step, from the addition of reagents to the recovery of final products, was automated. The microwave-assisted N-long chain alkylation reactions of 2-alkyl-1H-benzimidazole (1) and 2-alkyl-1H-benzimidazole[4,5-b] pyridines (3) were also studied.