共查询到20条相似文献,搜索用时 31 毫秒
1.
Vera L. M. Silva Artur M. S. Silva Diana C. G. A. Pinto José A. S. Cavaleiro José Elguero 《Monatshefte für Chemie / Chemical Monthly》2009,45(2):87-95
Abstract
An efficient synthesis method for the preparation of a series of new (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles was developed. The reaction of (Z)- and (E)-3-styrylchromones with hydrazine hydrate afforded the corresponding (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles, except for nitro derivatives, where both (Z)- and (E)-4′-nitro-3-styrylchromones afforded (E)-3(5)-(2-hydroxyphenyl)-4-(4-nitrostyryl)pyrazoles. The reaction mechanism for these transformations is discussed and the stereochemistries of all products were established by NMR experiments. 相似文献2.
Mohammad Bayat Hossein Imanieh Nader Zabarjad Shiraz Mohammad Shah Qavidel 《Monatshefte für Chemie / Chemical Monthly》2010,15(2):333-338
Abstract
Isocyanides, dialkyl acetylenedicarboxylates, and non-cyclic anhydrides, for example acetic anhydride or benzoic anhydride, react in one-pot to afford 2,5-diaminofuran derivatives and dialkyl (E)-2-[(N-acyl-N-alkylamino)carbonyl]-2-butenedioates in fairly good yields at room temperature. 相似文献3.
N. B. Patel A. I. Gandhi R. D. Sharma 《Monatshefte für Chemie / Chemical Monthly》2010,46(2):1123-1133
Abstract
6-(Substituted amino)-4-(4-ethoxyphenyl)-1-phenyl-2(1H)-pyridinones were prepared from β-aryl glutaconic acid, which, on fusion with aniline, results in 4-(4-ethoxyphenyl)-1-phenylpyridine-2,6(1H,5H)-dione. This, on further treatment with phosphorus oxychloride gave 6-chloro-4-(4-ethoxyphenyl)-1-phenyl-2(1H)-pyridinone, and further treatment with secondary amines yielded 6-(substituted amino)-4-(4-ethoxyphenyl)-1-phenyl-2(1H)-pyridinones. These were subjected to azo coupling with different aryldiazonium chlorides furnishing two isomers, which were separated by column chromatography. All compounds were characterized by elemental analysis, and use of IR and NMR spectral data, and were evaluated for antimicrobial activity. 相似文献4.
Madhukar N. Jachak Maruti G. Ghagare Dilip R. Birari Ramhari V. Rote Muddassar A. Kazi Sanjay M. Jachak Raghunath B. Toche 《Monatshefte für Chemie / Chemical Monthly》2010,46(3):569-576
Abstract
A novel synthesis of pyrazole-4-carboxamides is reported. The reaction of N-(3-(dimethylamino)-2-formylacryloyl)formamide, an intermediate obtained by Vilsmeier–Haack formylation of acetonitrile, with hydrazine hydrate or monosubstituted hydrazines provides such compounds in good yields. This method has advantages over other methods for construction of such ring systems previously described in the literature. 相似文献5.
Tomá? Gucky Eva ?ezní?ková Petr D?ubák Marián Hajdúch Vladimír Kry?tof 《Monatshefte für Chemie / Chemical Monthly》2010,55(7):709-714
Abstract
The deregulation of cell cycle components in cancer cells has provided a rationale for the development of small molecule inhibitors of cyclin-dependent kinases as novel anticancer drugs. A series of 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines was synthesized and their kinase inhibitory activity and cytotoxicity against several cancer cell lines has been evaluated. Some of the compounds of the series exhibited induction of caspase-dependent cell death and inhibition of cyclin-dependent kinase 2 (CDK2). 相似文献6.
Shahrukh T. Asundaria Hemant S. Patel Keshav C. Patel 《Monatshefte für Chemie / Chemical Monthly》2010,66(8):917-927
Abstract
Ten homopolyamides have been synthesized by polycondensation of the monomer 2,4-bis(6-chlorocarbonyl-2-naphthyloxy)-6-(4-methyl-1-piperazinyl)-s-triazine and different diamines such as 4,4′-biphenyldiamine, 4,4′-diaminobenzanilide, 4,4′-diaminodiphenylmethane, 4,4′-diaminodiphenyl sulfone, 4,4′-diaminodiphenyl sulfonamide, 2,4-diaminotoluene, o-phenylenediamine, m-phenylenediamine, p-phenylenediamine, and ethylenediamine. All polyamides were characterized by solubility, density, viscosity measurements, IR, NMR spectroscopy, and thermogravimetric analysis. The products were found to possess high thermal stability. 相似文献7.
Abstract
An effective diastereoselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butanamide and (S)-2-formyl-2-(methoxymethoxy)butanoic acid ethyl ester, which are two key chiral building blocks for the synthesis of 20(S)-camptothecins, has been developed by employing an asymmetric bromolactonization using (R)-proline. The (R) compounds were also synthesized to obtain 20(R)-camptothecin. 相似文献8.
A. M. Khalil M. A. Berghot M. A. Gouda S. A. El Bialy 《Monatshefte für Chemie / Chemical Monthly》2010,46(2):1353-1360
Abstract
A dibenzobarrelene derivative was used as key intermediate for the synthesis of 2-(4-(methyl/phenylthiaz-ol-2-yl)-2,3,4a,5,10,10a-hexahydro-5,10-benzenobenzo[g]phthalazine-1,4-diones. These compounds were coupled with the appropriate diazonium chlorides to give the corresponding 5-(arylazo)thiazole derivatives. The synthesized dyes were applied to polyester as disperse dyes, and their antibacterial, color measurement, and fastness properties were evaluated. 相似文献9.
Monika M. Karpińska Joanna Matysiak Andrzej Niewiadomy Joanna Wietrzyk Dagmara K?opotowska 《Monatshefte für Chemie / Chemical Monthly》2012,34(10):269-276
Abstract
A one-pot synthesis of new biologically active 4- and 6-(1-alkyl/aryl-1H-benzimidazol-2-yl)benzene-1,3-diols has been developed. The compounds were obtained by the reaction of aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethione] with N-substituted benzene-1,2-diamines. Elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data were used to elucidate their structures. The developed method offers short reaction times, easy and quick isolation of the products, and good yields. The antiproliferative properties of the synthesized compounds were investigated against a panel of human cancer cell lines. Some of the tested compounds showed significant cytotoxic activity. 相似文献10.
Au?ra Voskien? Birut? Sapijanskait? Vytautas Mickevi?ius Kristina Kantminien? Maryna Stasevych Olena Komarovska-Porokhnyavets Rostyslav Musyanovych Volodymyr Novikov 《Monatshefte für Chemie / Chemical Monthly》2011,17(1):529-537
Abstract
Mono- and disubstituted [(tetrahydro-2,4-dioxopyrimidin-1(2H)-yl)phenoxy]naphthalene-1,4-diones were synthesized by the reaction of dihydro-1-(3-hydroxy- and 4-hydroxyphenyl)pyrimidine-2,4(1H,3H)-diones and their 5- and 6-methyl derivatives with 2,3-dichloro-1,4-naphthoquinone. Their stability in alkaline and acidic media was investigated. Four of the compounds exhibited good antimicrobial activity against Staphylococcus aureus, Mycobacterium luteum, Candida tenuis, and Aspergillus niger. 相似文献11.
Abstract
Stereoselective reaction of various substituted phenols with alkyl propiolates in the presence of a catalytic amount of sodium azide in tert-butyl alcohol at reflux temperature leads to alkyl (Z)-3-phenoxy-2-propenoates in good yields. 相似文献12.
Habibe Tezcan Hülya ?en?z Nesrin Tokay 《Monatshefte für Chemie / Chemical Monthly》2012,287(11):579-588
Abstract
1-[(NO2, COOH)-substituted phenyl]-3,5-diphenylformazans were synthesized. The compounds were characterized by infrared (IR), ultraviolet–visible (UV–vis), 1H nuclear magnetic resonance (NMR), 13C NMR spectra, elemental analysis, and cyclic voltammetry. From the UV–vis spectra of substituted formazans it was seen that λ max values were shorter than the λ max value of unsubstituted formazan. It was observed that the shift values were dependent on the type and position of the substituents. A correlation between Hammett substituent coefficients and λ max values was obtained. The oxidation peak potentials of substituted formazans were found more anodic than that of unsubstituted formazan. The oxidation mechanism was a single step for the NO2-substituted formazans, and two steps for COOH-substituted formazans. 相似文献13.
A new anti-inflammatory active phenylpropenoid, (R,E)-1-[4-(3-hydroxyprop-1-enyl) phenoxyl]-3-methylbutane-2,3-diol (1), isolated from the stem wood of Zanthoxylum integrifoliolum, has been synthesized for the first time using commercially available 4-hydroxy benzaldehyde (2). The key step involves the Sharpless asymmetric dihydroxylation of olefin (3).
14.
A. M. Khalil M. A. Berghot Mostafa A. Gouda 《Monatshefte für Chemie / Chemical Monthly》2009,46(2):1371-1379
Abstract
3-(1,4-Dioxo-3,4,4a,5,10,10a-hexahydro-1H-5,10-benzenobenzo[g]phthalazin-2-yl)-3-oxopropionitrile and 3-(1,4-dioxo-3,4,4a,5,10,10a-hexahydro-1H-5,10-benzenobenzo[g]phthalazin-2-yl)-3-oxo-2-(5-oxo-3-phenylthiazolidin-2-ylidene)propionitrile were coupled with various diazotized aryl amines in pyridine to give the corresponding aryl hydrazonopropionitriles. Some of the dyes produced were applied to polyester as disperse dyes, and their antibacterial, color, and fastness properties were evaluated. 相似文献15.
Krzysztof Kolodziejczyk Gheorghe D. Roiban Michael Schnürch Marko D. Mihovilovic Peter Stanetty 《Monatshefte für Chemie / Chemical Monthly》2009,51(3):1349-1359
Abstract
An efficient synthesis of novel N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides is presented starting from furan-3-carboxylic acid. Two complementary strategies to 2-aryl-3-furanamines with directed ortho lithiation, functionalization of the 2-position, and subsequent cross-coupling reaction as key steps were developed. Acylation of these intermediates with appropriate acid chlorides led finally to the target compounds. 相似文献16.
Beata Orlińska Zbigniew Stec Jan Zawadiak 《Monatshefte für Chemie / Chemical Monthly》2012,9(4):295-301
Abstract
Aerobic oxidation of 2-methoxy-6-(1-methylethyl)naphthalene to hydroperoxide, alcohol, and ketone, is reported. These compounds, particularly 2-acetyl-6-methoxynaphthalene, are important intermediates in naproxen synthesis. N-Hydroxyphthalimide is shown here to be an efficient catalyst for oxidation to the hydroperoxide, 2-methoxy-6-(1-hydroperoxy-1-methylethyl)naphthalene, with a yield of 87%. However, the ketone and alcohol were obtained with lower yields, with a maximum yield of 13% for the ketone and 27% for the alcohol, using N-hydroxyphthalimide and Cu(II) acetylacetonate as a catalyst. The synthesis of the products 2-acetyl-6-methoxynaphthalene and 2-methoxy-6-(1-hydroxy-1-methylethyl)naphthalene via an initial oxidation step to the hydroperoxide followed by a hydroperoxide decomposition step is shown to be more efficient; the ketone and alcohol were obtained from 2-methoxy-6-(1-methylethyl)naphthalene with yields of 40 and 56%, respectively. 相似文献17.
Vera L. M. Silva Artur M. S. Silva Diana C. G. A. Pinto José A. S. Cavaleiro José Elguero 《Monatshefte für Chemie / Chemical Monthly》2009,140(1):87-95
Abstract An efficient synthesis method for the preparation of a series of new (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles was developed. The reaction of (Z)- and (E)-3-styrylchromones with hydrazine hydrate afforded the corresponding (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles, except for nitro derivatives, where both (Z)- and (E)-4′-nitro-3-styrylchromones afforded (E)-3(5)-(2-hydroxyphenyl)-4-(4-nitrostyryl)pyrazoles. The reaction mechanism for these transformations is discussed and the
stereochemistries of all products were established by NMR experiments.
Graphical abstract
相似文献
18.
Kasthuri Balasubramani Packianathan Thomas Muthiah Daniel E Lynch 《Chemistry Central journal》2007,1(1):28
Background
Pyrimethamine [2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine] is an antifolate drug used in anti-malarial chemotherapy. Pyrimidine and aminopyrimidine derivatives are biologically important compounds owing to their natural occurrence as components of nucleic acids. 相似文献19.
Raquel S. G. R. Seixas Artur M. S. Silva Ibon Alkorta José Elguero 《Monatshefte für Chemie / Chemical Monthly》2011,18(5):731-742
Abstract
We report the synthesis and structural study of eight compounds, either quinolin-4(1H)-ones or quinolines. Tautomerism as well as (E) → (Z) and rotational isomerism were studied both experimentally (1H and 13C NMR) and theoretically [B3LYP/6-311++G(d,p)]. 相似文献20.
Sobhi M. Gomha 《Monatshefte für Chemie / Chemical Monthly》2009,32(7):213-220