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本文合成了二十个混合甲基二环己基锡取代苯氧乙酸酯。研究了这些化合物的IR, NMR (^1H, ^1^3C, ^1^1^9Sn), 结果表明, 除邻甲氧基苯氧乙酸酯外, 这些化合物都可能是以羰基氧为桥连的五配位聚合有机锡化合物。^1^1^9Sn NMR的研究结果表明, ^1^1^9Sn化学位移与苯环上取代基有一线性关系: δ^1^1^9Sn=6.23σ+94.67, r=0.943。农药的初筛表明, 这些化合物除有很好的杀螨活性外, 还有一定的杀菌, 除草和植物激素作用。 相似文献
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本文合成了二十个混合甲基二环己基锡取代苯氧乙酸酯。研究了这些化合物的IR, NMR (^1H, ^1^3C, ^1^1^9Sn), 结果表明, 除邻甲氧基苯氧乙酸酯外, 这些化合物都可能是以羰基氧为桥连的五配位聚合有机锡化合物。^1^1^9Sn NMR的研究结果表明, ^1^1^9Sn化学位移与苯环上取代基有一线性关系: δ^1^1^9Sn=6.23σ+94.67, r=0.943。农药的初筛表明, 这些化合物除有很好的杀螨活性外, 还有一定的杀菌, 除草和植物激素作用。 相似文献
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三丁基锡羧酸酯的结构表征及其生物活性研究 总被引:18,自引:0,他引:18
合成了三十个三丁基锡羧酸酯Bu3SnO2CR(R=烷基、芳基、芳氧甲基和呋喃基)。通过对它们的红外光谱、核磁共振谱(^1^3C, ^1^1^9Sn)的研究, 表明羰基红外吸收频率与锡原子的配位数有密切关系, 同样分子上的微小变化明显地表现在δ119Sn上, 对位取代基苯甲酸酯的δ119Sn与苯环上取代基的Hammett常数(σ)之间存在良好的线性关系:δ119Sn=19.11σ+110.612 n=7, γ=0.9955着重研究了部分化合物在经济作物上的抗病原菌能力, 结果表明, 这是一类具有广谱性的有机锡化合物, 抗菌活性优于对比药剂朴海因, 接近或相当于多菌灵, 它们同时具有较强的除草活性。 相似文献
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三苄基锡羧酸酯的合成及其结构表征 总被引:16,自引:0,他引:16
本文以(三苄基锡)氧化物和相应的羧酸反应, 合成了20个三苄基锡羧酸酯, 由波谱对结构的研究表明, 红外光谱的酰基振动频率与羧基上取代基的空间和电子效应密切相关, 三苄基锡羧酸酯的结构微小变化, 明显地反映了^1^1^9Sn和^1^3CNMR化学位移的差异, ^1^1^9Sn化学位移与三苄基锡取代的苯甲酸酯的对位取代基Hammett常数(σ)之间存在着良好的线性关系: δ~1~1~9~S~n=15.48σ+14.23, n=7, r=0.995, 去烃基化是这一类化合物质谱裂解的特点。 相似文献
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Uchida R Nasu A Tokutake S Kasai K Tobe K Yamaji N 《Chemical & pharmaceutical bulletin》1999,47(2):187-193
Fifteen new N-containing maltooligosaccharides were obtained using the chemoenzymatic method. Among these compounds, maltooligosaccharides having 6-amino-6-deoxy-D-sorbitol residue, (3R,4R,5R,6S)-hexahydro-3,4,5,6-tetrahydroxy-1H-azepine residue, and (3R,5R)-3,4,5-trihydroxypiperidine residue at the reducing end showed strong inhibitory activities for human pancreatic alpha-amylase (HPA) (EC 3.2.1.1) and human salivary alpha-amylase (HSA). The administration of (3R,4R,5R,6S)-hexahydro-3,5,6-trihydroxy-1H-azepine-4-yl O-alpha-D-glucopyranosyl-(1-->4)-alpha-D-glucopyranoside (13, IC50 = 4.3 x 10(-5) M for HPA, IC50 = 8.2 x 10(-5) M for HSA) and (3R,5R)-3,5-dihydroxypiperidine-4-yl O-alpha-D-glucopyranosyl-(1-->4)-alpha-D-glucopyranoside (18, IC50 = 3.4 x 10(-5) M for HPA, IC50 = 4.6 x 10(-5) M for HSA) to ICR mice suppressed postprandial hyperglycemia. 相似文献
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用三丁基氯化锡与戊二羧酸二钠以2:1摩尔比反应,合成了双(三丁基锡)戊二羧酸酯,并用元素分析、红外光谱、核磁共振氢谱及X-射线单晶衍射进行了表征和结构测定。X-射线单晶衍射法测定表明,化合物属单斜晶系,空间群为Cc,晶胞参数:a=13.984(3),b=16.164(3),c=16.894(3)A,β=107.457(3)°,V=3642.9(11)A3,Z=4,C29H60O4Sn2,Dc=1.251g/cm3,μ=1.394 mm-1,R=0.0500,wR=0.0874,F(000)=1416。晶体结构中存在2种化学环境不同的三角双锥构型的锡原子,由于配体中2个羧基在不同方向的交联作用,使化合物呈现三维立体骨架结构,并且在骨架结构中存在沿a、b、c轴3个方向伸展的规则的大环直孔道。 相似文献
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Synthesis and characterization of tributyltin derivatives from 4‐oxo‐4‐(arylamino)butanoic acids and their in vitro biological activity against cervical cancer cell lines 下载免费PDF全文
Irma Rojas‐Oviedo Carlos Camacho‐Camacho Luis Sánchez‐Sánchez Jorge Cárdenas Hugo López‐Muñoz Hugo Eugenio‐Robledo Israel Velázquez Rubén Alfredo Toscano 《应用有机金属化学》2014,28(12):884-891
Uterine (cervix and corpus) cancer is one of the major causes of mortality in women in Mexico. Organotin carboxylated derivatives have shown high cytotoxic activity against various cell lines of human origin. We describe the synthesis of three new tri‐n‐butyltin derivatives from 4‐oxo‐4‐(arylamino)butanoic acids; their structures were confirmed using spectral data (1H NMR, 13C NMR, 119Sn NMR and infrared), elemental analyses, mass spectrometry and X‐ray diffraction. All the tri‐n‐butyltin carboxylates exhibit 1 J (119/117Sn–13C) coupling satellites in solution and lie in the range 357 to 339 Hz, suggesting a tetrahedral geometry around the tin atom. The polymeric structures of two of the derivatives and the monomeric structure of another were confirmed using X‐ray crystallography. Using succinic anhydride as raw material, five N‐substituted succinamic acid compounds were synthesized by the acylation reaction with aniline, 4‐nitroaniline, 4‐nitro‐3‐(trifluoromethyl)aniline, 2‐amino‐5‐nitrothiazole and 4‐aminoantipyrine. From these compounds, five tin derivatives were prepared and their in vitro anti‐proliferative effect on HeLa, CaSki and ViBo cell lines was screened. All of the compounds showed potency against all three strains and null or low cytotoxic activity (necrotic) as well. The most potent of our derivatives as an anti‐proliferative agent against the three cell lines was tributylstannyl 4‐oxo‐4‐[(3‐trifluoromethyl‐4‐nitrophen‐1‐yl)amino]butanoate, exhibiting an IC50 value of 0.43 μM against the HeLa cell line. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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《Tetrahedron letters》2014,55(52):7226-7228
A new series of febrifuginol analogues was prepared from l-glutamic acid. An antimalarial activity evaluation against chloroquine-sensitive (T96) and chloroquine-resistant (K1) Plasmodium falciparum indicated that all the tested compounds had very strong inhibitory activity. Compounds 4 and 17b′ were inactive against KB, MCF7, HepG2 and LU1 cell lines even at a concentration of 100 μM, while they exhibited significant inhibition towards P. falciparum. Comparison of the antimalarial activity and the cytotoxic properties revealed that the 2′S isomers were more active than the corresponding 2′R isomers for this series of febrifuginol analogues, indicating that the C-2′ position is critical for the biological activity of this class of compounds. 相似文献
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In order to search for novel fungicides with high activity, a series of heteroaryl pyrazoles were synthesized from 5-pyra-zole formhydrazide. The structures of all new compounds were confirmed by spectroscopic methods and microanalyses. Preliminary bioassays indicated that some compounds showed fungicidal activity against Puccinia tritinia and PGR activity as well. 相似文献
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P. D'Agati C. Mansueto V. Mansueto C. Pellerito M. V. Cangialosi T. Fiore M. Scopelliti L. Pellerito 《应用有机金属化学》2006,20(6):357-367
The histopathological effects of 10?7 and 10?9 M tributyltin(IV)chloride,TBTCl, solutions on different Liza saliens organs have been studied by light microscope. The fish were sacrificed after 3–4 h incubation in 10?7 M TBTCl solution or after 15 days incubation in 10?9 M solution. The observed histopathological changes were dose‐ and time‐dependent. The 10?7 M TBTCl concentration resulted in major damage to the gill epithelium, indicating that TBTCl primarily interfered with the respiration, osmoregulation, acid balance and nitrogenous waste excretion processes. After incubation in 10?9 M TBTCl solution the fish lived 20 or more days, but many of the organs were altered. Thymus atrophy, reduced spleen and altered head kidney were observed. These histological results indicated that TBTCl interfered with organ immunodefense and altered main metabolic pathways in Liza saliens. The presence of melano‐macrophage centers, only in TBT‐treated liver and spleen, can be considered a tool to facilitate, with other biomarkers, the detection of alterations by toxicants. Regarding the pancreas activity in 10?7 M solutions, it has been noted that, in the exocrine cells, very few zymogen granules were still present and the Langerhans islets were more altered. In 10?9M solution the exocrine pancreatic cells had no granules and the islet cells presented degenerative alterations. In addition, TBTCl, which altered the pancreas and gonad morphology, could again be considered an endocrine disrupter even if biochemical data are still necessary. Finally, the Liza saliens juveniles could be considered an interesting biological model for experiments with contaminants, due to their ease of adaptation to experimental conditions and food chain position. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
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E. Puccia C. Mansueto M. V. Cangialosi T. Fiore R. Di Stefano C. Pellerito F. Triolo L. Pellerito 《应用有机金属化学》2001,15(3):213-220
Considerable attention has been given in recent years to the possibility that xenobiotics in the environment may affect reproduction in animals. In this study, the relative impact of tributyltin(IV) (TBT) chloride, one of the most toxic environmental pollutants, was investigated using Ciona intestinalis ovary as a model system. The pleiotropic effects of TBT exposure are concentration dependent and include a decrease of ATP levels, lipid content and nucleic acid content and synthesis. In contrast, a marked increase in calcium (Ca2+) and glucose content is observed. Furthermore, TBT alters enzymatic activity, inhibiting creatine kinase and stimulating alkaline phosphatase and cholinesterase (at concentrations higher than 10?5M in sterile sea water solution). The implications of these effects on reproduction and embryonal development are discussed, along with the possibility that they reflect an extreme cellular defence mechanism triggered to avoid deleterious consequences for the survival of the species.Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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H. P. S. Chauhan Nitin Carpenter Sumit Bhatiya Sapana Joshi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):1116-1125
AbstractSeven complexes of type [(C4H9i-O)2PS2]2SbR have been synthesized by the reaction of chlorobis(diisobutyldithiophosphato)antimony(III) with mixed thio and/or oxo donor ligands in 1:1?M stoichiometry, where R?=?SC6H5, OOCC6H5, SCH2COOH, SOCCH3, OOCCH3, SC6H4COOH and OOC(OH)C6H4. These newly synthesized derivatives have been characterized by different physicochemical (elemental analysis (C, H, S, Sb), melting point, molecular weight determination), spectral (UV, IR, NMR (1H, 13C and 31P)) studies, as well as ESI mass, thermal, powder XRD and biological studies. In the final step of weight loss in thermogravimetric analysis, occurring in the range of 245–505?°C, the degradation of the C6H3CO moieties takes place and antimony sulfide (1/2?Sb2S3) is obtained as remaining material, which is useful in various aspects. Bonded to antimony the diisobutyldithiophosphato substituent behaves as an anisobidentate ligand, which is confirmed through spectral analysis. Powder XRD studies indicate that these compounds crystallize in a monoclinic crystal system with an unit cell volume of ~7074–7162 Å3 forming nano ranged (9.69–15.69?nm) crystallites. From the antimicrobial screening tests, bis(diisobutyldithiophosphato)antimony(III) thioglycolate (compound 3) has shown a maximum zone of inhibition (19?mm) against E. coli at 200?μg mL?1 concentration. 相似文献
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The growth response of the alga Chlorella kessleri and the euglenoid Euglena gracilis has been studied as a model system to determine the effects of a tin salt (SnCl4·5H2O) and of some organotin (OT) derivatives, namely tetrabutyltin (TeBT), tributyltin (TBT) and tributyltin oxide (TBTO). Abiotic degradation was studied as well. Cells were exposed to a toxicity series (0–50 μg/mL−1) for the four chemicals in seven-day bioassays. Both microorganisms are tolerant of the inorganic salt, but growth inhibition was significant for all OT compounds, and especially large for TBT and TBTO. Although C. kessleri and E. gracilis are known to be tolerant towards metals and organic chemicals, the present results show that both are sensitive to organotin compounds: the inhibition of the growth was greater for C. kessleri. © 1998 John Wiley & Sons, Ltd. 相似文献