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1.
Magda A. Abdallah 《Monatshefte für Chemie / Chemical Monthly》2001,132(8):959-965
Summary. The reaction of 3-amino-2-thioxo-4(1H)-quinazolinone or its 2-methylthio derivative with hydrazonoyl halides in the presence of ethanol and triethylamine affords
6H-[1,2,4,5]tetrazino[3, 2-b]quinazolin-6-ones.
Received January 2, 2001. Accepted (revised) April 11, 2001 相似文献
2.
Dong Han Kim 《Journal of heterocyclic chemistry》1981,18(4):801-802
5H-Benzothiazolo[3,2-a]quinazolin-5-ones (Va-d) were synthesized by thermal cyclization of N-(2-benzothiazolyl)-2-fluorobenzamides (IVa-d) which were obtained by allowing 2-fluorobenzoyl chloride to react with 2-aminobenzothiazoles. 相似文献
3.
Dong Han Kim 《Journal of heterocyclic chemistry》1981,18(2):287-291
5H-Benzoxazolo[3,2-a]quinazolin-5-ones (Xa-d) were synthesized in excellent yields from N-(2-hydroxyphenyl)anthranilic acids (Ia-d) and cyanogen bromide. The synthesis was based on the mechanistic consideration of the reactions of salicylic acid with cyanogen bromide previously reported in the literature. A versatile alternative route to these novel heterocyclic compounds was through thermal cyclization of N-(2-benzoxazolyl)-2-fluorobenzamides (XIII) obtained by reacting 2-fluorobenzoyl chloride with 2-aminobenzoxazoles. The reaction of Xb with ethanol in the presence of potassium hydroxide gave an ethoxyquinazolinone (XVII). Similarly, the alkaline hydrolysis of Xb afforded an quinazolindione (XVIII). 相似文献
4.
Hari K. Gakhar Sushma Kiran Sashi Bhushan Gupta 《Monatshefte für Chemie / Chemical Monthly》1982,113(10):1145-1150
4H,6H-[1,3,4]Thiadiazino[2,3-b]quinazolin-6-one with a methyl group in position 3 (6a) has been synthesised by the condensation of 3-amino-2-mercapto-3H-quinazolin-4-one (1) with allyl bromide (2) followed by treatment with bromine and subsequent dehydrohalogenation of the brominated product (4) with ethanolic sodium hydroxide. Its isomeric 3-methyl-2H,6H-[1,3,4]thiadiazino[2,3-b]quinazolin-6-one (6b) has also been obtained by condensation of1 and bromoacetone (7) followed by cyclisation of the intermediates (8 or9) with hydrobromic acid or with concentrated sulphuric acid. The structures have been established on the basis of IR and PMR data.
3-Methyl[1,3,4]thiadiazino[2,3-b]chinazolin-6-one
Zusammenfassung Zur Synthese von 4H,6H-[1,3,4]thiadiazino[2,3-b]chinazolin-6-on (6a) wurde die Kondensation von 3-Amino-2-mercapto-3H-chinazolin-4-on (1) mit Allylbromid mit nachfolgender Behandlung mit Brom und Dehydrohalogenierung des bromierten Produktes4 mit ethanolischer Natronlauge herangezogen. Das zu6a isomere 2H,6H-Produkt6b wurde ebenfalls durch Kondensation von1 mit Bromaceton und nachfolgender Cyclisierung der Zwischenprodukte8 bzw.9 mit HBr oder H2SO4 erhalten. Die Strukturen wurden mittels IR und NMR abgesichert.相似文献
5.
A method was worked out for the preparation of isatin -semicarbazone, the starting material for the synthesis of 3-hydroxy-l,2,4-triazacarbazoles, and the structure of the latter was refined. Nucleophilic exchange of 3-chloro-l,2,4-triazacarbazole (which was obtained for the first time) with amines, hydrazines, and arylhydrazines was studied.See [1] for communication I.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 855–857, June, 1972. 相似文献
6.
N. D. Abramova B. V. Trzhtsinskaya Yu. M. Skvortsov A. G. Mal'kina A. I. Albanov G. G. Skvortsova 《Chemistry of Heterocyclic Compounds》1982,18(8):800-802
1,2,4-Triazolo[3,2-b]-1,3-thiazines were obtained by the reaction of 1,2,4,-triazole-3-thiones with an equimolar amount of 1-phenyl-2-cyanoacetylene in the presence of triethylamine or potassium hydroxide. It is shown that triazolethiones form N,S diadducts upon reaction with a twofold excess of cyanoacetylene. The nature of the heteroatom in the exo position of the heteroring affects the direction of addition to phenylcyanoacetylene. 2,4-Bis(1-phenyl-2-cyanovinylene)-1,2,4-triazol-3-one was synthesized.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1051–1053, August, 1982. 相似文献
7.
I. M. Bazavova V. N. Britsun A. N. Esipenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2003,39(6):809-812
A study was carried out on the reaction of 4-amino-6-R-2,3,4,5-tetrahydro-3-thioxo-1,2,4-triazin-5-ones with halo ketones in alkaline media to yield 4-amino-6-R-4,5-dihydro-3-phenacylthio-1,2,4-triazin-5-ones, which then convert to 8H-3-R-7-aryl-1,2,4-triazino[3,4-b][1,3,4]thiadiazin-4-ones. 相似文献
8.
Jean-Pierre Hnichart Raymond Houssin Jean-Luc Bernier 《Journal of heterocyclic chemistry》1986,23(5):1531-1533
Thiazole rings have been often encountered in the structure of antibiotic or antitumor drugs. An easy synthesis of them has revealed itself necessary in order to elucidate the mechanism of action of these naturally occurring substances. A method of preparation of conjugated b-ethylenic thiazole[3,2-b] [1,2,4]triazoles by heating a 3-thio substituted [1,2,4]triazole in the presence of polyphosphoric acid is reported here, giving the expected product in a 60% yield. 相似文献
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11.
V. N. Britsun A. N. Esipenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2006,42(5):693-697
3-Amino-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-ones were converted into 2-aryl-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-ones
on treatment with carboxylic acids and POCl3. 3-Arylmethylidenamino-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-ones also cyclized to 2-aryl-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-ones
when oxidized with potassium chlorate in acetic acid, but on heating they were deaminated to give 2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one
and aryl nitriles.
__________
Translated from Khimiya Geteotsiklicheskikh Soedinenii, No. 5, 787–791, May, 2006. 相似文献
12.
Russian Journal of Organic Chemistry - An efficient synthetic approach to new fluorine-containing [1,3,4]thiadiazolo[3,2-a]quinazolin-5-ones has been developed on the basis of intramolecular... 相似文献
13.
Barbara Milczarska Henryk Foks Urszula Dobrzycka Zofia Zwolska Ewa Augustynowicz-Kopeć 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2793-2799
The 4-hydroxyalkyl-1,2,4-triazole-3-thiones cyclization allowed us to work out the effective method of 1,3-thiazacycloalkyl[3,2-b]-1,2,4-triazoles synthesis. Some of the compounds that were obtained were tested for their tuberculostatic activity. 相似文献
14.
Katherine Buggle Úna Ní Ghógáin Patrick MacManus 《Monatshefte für Chemie / Chemical Monthly》1988,119(8-9):945-951
The conversion of 2H-[1]benzothieno[3,2-b]pyran-2-ones into mono- and dithio-derivatives and the preparation of some dibenzothiophenes, sulphines and pyridones are described.
Einige Reaktionen von 2H-[1]Benzothieno[3,2-b]pyran-2-onen und verwandten Verbindungen
Zusammenfassung Es wird die Umsetzung von 2H-[1]benzothieno[3,2-b]pyran-2-onen zu Monound Dithio-Derivaten und die Darstellung einiger Dibenzothiophene, Sulfine, und Pyridone beschrieben.相似文献
15.
Alain Rabaron Jean-Charles Lancelot Daniel Maurne Max Robba 《Journal of heterocyclic chemistry》1979,16(1):53-55
The main nmr parameters of 1,2,4-triazino[4,5-b]indazole derivatives were measured on the basis of their 13C nmr spectral analysis compared to indazole models. 1J C-H coupling constants were studied and the correct structure of 1,2,4-triazino[4,5-b]indazoles was elucidated. 相似文献
16.
A. Monge Vega I. Aldana M. M. Rabbani E. Fernandez-Alvarez 《Journal of heterocyclic chemistry》1980,17(1):77-80
This paper describes the synthesis of the previously unknown 11H-1,2,4-triazolo[4,3-b]pyridazino[4,5-b]indoles (2) and 11H-tetrazolo[4,5-b]pyridazino[4,5-b]indoles (3) from 4-hydrazino-5H-pyridazino[4,5-b]indoles (1) , as well as the synthesis of 1,2,4-triazolo[3,4-f]-1,2,4-triazino-[4,5-a]indoles (10) from 2-indolecarbohydrazide (4) . Compounds 2 were obtained by acylation of compounds 1 , followed of thermal cyclization and compounds 3 by treating compounds 1 with nitrous acid. The reactions of compound 4 with formic acid or ethyl orthoformiate gave 1,2-dihydro-1-oxo-1,2,4-triazino[4,5-a]indole (6) . Treating this last compound with phosphorus oxychloride or phosphorus pentasulfide, followed by hydrazine, gave 1-hydrazino-1,2,4-triazino-[4,5-a]indole (9) . Acylation of this last compound, followed of cyclization gave compounds 10 . All the compounds were characterized by elemental analysis and ir and 1H-nmr spectra. 相似文献
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19.
Krishna C. Majumdar Brindaban Roy Paritosh Biswas 《Monatshefte für Chemie / Chemical Monthly》2001,132(6):739-746
Summary. A number of hitherto unreported furo[3,2-b]thiochromenone derivatives were regioselectively synthesized in good yields starting from 3-allyloxy-thiochromenones.
Received September 18, 2000. Accepted (revised) November 15, 2000 相似文献