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1.
V. L. Gein O. V. Bobrovskaya M. V. Dmitriev 《Russian Journal of Organic Chemistry》2017,53(6):898-903
The reaction of methyl 4-aryl-2,4-dioxobut-2-enoates with 4-aminobenzenesulfonamide in acetic acid–ethanol (1: 1) afforded methyl (2Z)-4-aryl-4-oxo-2-(4-sulfamoylanilino)but-2-enoates which reacted with ninhydrin in glacial acetic acid to give 3-aroyl-4-(4-sulfamoylanilino]-5H-spiro[furan-2,2′-indene]-1′,3′,5-triones. 相似文献
2.
Gary M. Coppola Goetz E. Hardtmann Bruno S. Huegi 《Journal of heterocyclic chemistry》1974,11(1):51-56
The preparation of a number of novel 2-aryl-3-(dimethylamino)acroleins and their hydrolyses to 2-arylmalondialdehydes is described. Reactions of the acroleins with amines are discussed as well as the conversion of the 2-arylmalondialdehydes into 3-chloro and 3-alkoxyacroleins. 相似文献
3.
L. A. Shemchuk V. P. Chernykh D. V. Levashov K. M. Sytnik L. M. Shemchuk 《Russian Journal of Organic Chemistry》2010,46(11):1687-1690
By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates
were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines. 相似文献
4.
A novel boronated aminocyclobutanecarboxylic acid (1) was synthesized for potential use in boron neutron capture therapy. Starting from the readily available 3-(bromomethyl)cyclobutanone ketal (4), several synthetic routes to 1 were evaluated. After several unsuccessful attempts with traditional synthetic methods, a novel synthetic strategy to generate the new boronated cyclic amino acid was developed. The tolerance of the hydantoin group to the selenoxide elimination reaction conditions in the preparation of alkenyl compound 7 proved to be the key step in the new strategy. 相似文献
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Masayoshi Onishi Katsuma Hiraki Atsushi Iwamoto 《Journal of organometallic chemistry》1984,262(2):c11-c13
A 1,2-disubstituted ferrocene derivative, 2-[(dimethylamino)methyl]-1-hydroxyferrocene (I), was prepared from 2-[(dimethylamino)methyl]-1-iodoferrocene via 2-[(dimethylamino)methyl]-1-acetoxyferrocene. On complexation, compound I served as a stable monovalent chelate ligand of a 1,2-disubstituted ferrocene derivative. In addition, a dihydroxy derivative, 2-(hydroxymethyl)-1-hydroxyferrocene, was obtained from hydrolysis of the methiodide formed from I. 相似文献
6.
The oxidative polycondensation of 4-[(pyridin-3-ylimino)methyl]phenol (4-PIMP) with O2, H2O2, and NaOCl was studied in an aqueous alkaline medium between 50°C and 90°C. Oligo-4-[(pyridin-3-ylimino)methyl]phenol (O-4-PIMP)
prepared was characterized by 1H-NMR, 13C-NMR, FT-IR, UV-VIS, size-exclusion chromatography, and elemental and thermal analyses techniques. At the optimum reaction
conditions, the yield of O-4-PIMP was 18.9%, 39.4%, and 46.8% using H2O2, O2, and NaOCl oxidant, respectively. According to the TG analysis, the initial degradation temperature of O-4-PIMP was 218°C,
which was by 50°C higher than that of 4-PIMP. Thermal analyses of 4-PIMP and O-4-PIMP were carried out in N2 atmosphere at 15–1000°C. The highest occupied molecular orbital, the lowest unoccupied molecular orbital, and electrochemical
energy gaps of 4-PIMP and O-4-PIMP were determined from the onset potentials for n-doping and p-doping, respectively. Also, optical band gaps of 4-PIMP and O-4-PIMP were determined according to UV-VIS measurements. 相似文献
7.
WANG Feng-Wu ② WEI Yi-Jun ZHU Qi-Yong 《结构化学》2006,25(10):1179-1182
1 INTRODUCTION Schiff base ligands have played an important role in the development of coordination chemistry as they readily form stable complexes with most metal ions[1~4]. These complexes are very interesting in many fields, such as catalysis and enzymatic reac- tions[5, 6], magnetism and molecular architectures[7~9]. The complexes derived from the similar tridentate Schiff base ligand 2-[(2-dimethylaminoethylimino)- methyl]phenol[10, 11] and its derivatives[12~14] have been widely … 相似文献
8.
Sylvie PaillouxCornel Edicome Shirima Eileen N. DueslerKaren Ann Smith Robert T. Paine 《Polyhedron》2011,30(16):2746-2757
Syntheses for [(diphenylphosphinoyl)methyl]-4,5-dihydrooxazole (2) and [(diarylphosphinoyl)methyl]benzoxazoles [aryl = phenyl (3), tolyl (4), 2-trifluoromethylphenyl (5) and 3,5-bis(trifluoromethyl)phenyl (6)] have been developed. Each ligand has been characterized by spectroscopic methods and single crystal X-ray diffraction analyses have been completed for 2, 3, 4 and 5. The coordination chemistry of the ligands with Nd(NO3)3 and Yb(NO3)3 has been examined and structure determinations for [Nd(2)2(NO3)3(CH3OH)], [Nd(2)2(NO3)3], [Yb(3)2(NO3)3(H2O)]·0.5(CH3OH), [Nd(3)2(NO3)3]·3(CHCl3), [Nd(4)2(NO3)3(H2O)], [Yb(4)2(NO3)3(H2O)] and [Yb(5)2(NO3)3(H2O)]·0.5(CH3CN) are reported. Depending upon conditions, the ligands act as monodentate PO or bidentate, chelating PO,N donors. 相似文献
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A series of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes were synthesized using the Vilsmeier-Haack reagent. The structures of all the title compounds have been confirmed by elemental analysis, 1H-NMR and 13C-NMR and in addition, the structure of intermediate 5b was investigated by X-ray crystallography. 相似文献
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12.
Grace A. Bennett Patricia A. Swift George B. Mullen Stanley D. Allen Jeffrey T. Mitchell Wendy E. Jones Vassil St. Georgiev 《Journal of heterocyclic chemistry》1989,26(6):1729-1734
The synthesis and antifungal activity of a novel series of 3-aryl-5-[(aryloxy)methyl]-3-[(1H-1,2,4-triazol-1-yl)-methyl]-2-methylisoxazolidines are described. The in vitro activity was evaluated in solid agar cultures against a variety of dermatophytes and yeast fungi, while in vivo activity was measured in an immune-compromised mouse model of systemic candidiasis. The activity of the title series was compared to that of ketoconazole and one derivative, the cis-3-(4-chlorophenyl)-5-(4-chlorophenyloxy)methyl analogue 5f was found to possess a similar potency in the in vivo assay. Structure-activity relationship correlations are also discussed. 相似文献
13.
Methyl aroylpyruvates reacted with 4-amino-N-carbamimidoylbenzene-1-sulfonamide in acetic acid–ethanol (1: 1) to give methyl 4-aryl-2-{[4-(carbamimidoylsulfamoyl)phenyl]amino}-4-oxobut-2-enoates which were found to exist in solution as mixtures of Z and E isomers. 相似文献
14.
Wolff-Kishner reduction of 3-amino-4-(o-chlorobenzoyl)pyridine ( 3 ) afforded 3-amino-4-(o-chlorobenzyl)pyridine ( 5 ), which on subsequent reaction with triethyl orthoformate and then acetyl hydrazide yielded 1-acetyl-2-[N-[4-(o-chlorobenzyl)pyridin-3-yl]formimidoyl]hydrazone ( 7 ). Cyclization of hydrazone 7 gave 3-(3-methyl-4H-1,2,4-triazol-4-yl)-4-(o-chlorobenzyl)pyridine ( 8 ), which on Jones oxidation yielded 3-(3-methyl-4H-1,2,4-triazol-4-yl)-4-(o-chlorobenzyl)pyridine ( 9 ). The Mannick reaction of 3-(3-methyl-4H-l,2,4-triazol-4-yl)-4-(o-chlorobenzyl)pyridine ( 9 ) with aqueous formalin and dimethylamine hydrochloride afforded 3-[3-[(dimethylamino)methyl]-5-methyl-4H-1,2,4-triazol-4-yl]-4-(o-chlorobenzoyl)-pyridine ( 10 ). 3-[3-[(Dimethylamino)methyl]-5-methyl-4H-1,2,4-triazol-4-yl]-4-(o-chlorobenzoyl)pyridine ( 10 ) exhibited good anticonvulsant activity in the subcutaneous pentylenetetrazole anticonvulsant screen indi cating that an appropriately substituted-pyridine ring moiety can serve as a bioisostere of a chlorobenzene ring with respect to anticonvulsant activity. 相似文献
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4-(Hydroxymethyl)piperidine was selectively protected with tetrahydropyranyl group in several steps to give the title compound. Use of 1H and 19F nmr spectra in structure determination is discussed. 相似文献
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