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1.
吲哚取代10H—吡啶并[1,2—a]吲哚盐的合成 总被引:2,自引:0,他引:2
通过2,3,3-三甲基-3H-吲哚高氯酸盐与吲哚取代查耳酮或芳基乙烯基酮在异戊醇介质中反应,合成了15种新的10H-吡啶并[1,2-a]吲哚高氯酸盐,其结构用各种波谱确定,从结构上进一步推理提出了反应历程,并讨论了~1H NMR谱中取代基对吡啶环质子化学位移的影响。 相似文献
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本文合成了6,7-(1',4'-亚丁基)-8-(4"-取代苯基)-10,10-二甲基-10H-吡啶并[1,2-α]吲哚盐,通过元素分析、IR 、^1HNMR、MS确定了化合物的结构,并对波谱性质及其它不同取代基常数之间的线性关系进行了讨论。 相似文献
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利用Thorpe-Ziegler反应,通过2-氯甲基-4H-吡啶并[1,2-a]嘧啶-4-酮与2-巯基苯甲腈的环化制得2-(3-氨基苯并噻吩-2-基)-4H-吡啶并[1,2-a]嘧啶酮,继而在氨基磺酸作用下,通过Pictet-Spengler反应,设计合成了新型苯并噻吩并[3',2':2,3]吡啶并[4,5-d]吡啶并[1,2-a]嘧啶衍生物.初步抑菌活性试验表明,当浓度为50 mg/L时,化合物5b对黄瓜灰霉病菌和小麦赤霉病菌的抑制率达96%以上,5f对油菜菌核病菌的抑制率为98%,5g和5i对烟草赤星病菌的抑制率达93%以上. 相似文献
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为了合成咪唑[1,2-a]并吡啶-肼类衍生物,发展了一种以简单易得的甲酰甲基溴化物、2-氨基吡啶衍生物和偶氮二甲酸酯为原料的三分子串联反应的方法.该串联反应先生成咪唑[1,2-a]并吡啶,然后紧接着连续发生C(3)—H键肼基化反应,而不像传统的一步接一步反应的方法.该方法具有操作简单、反应条件温和(无需过渡金属且反应温度低等)以及底物适用性广的特点.实验结果表明,带有给电子取代基的甲酰甲基溴化物和2-氨基吡啶衍生物有利于反应的进行,并以优秀的产率获得目标产物. 相似文献
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L. M. Potikha A. R. Turelyk V. A. Kovtunenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2010,46(1):82-95
The interaction of (Z)-1,3-diaryl-4-bromo-2-buten-1-ones with 1-substituted (benz)imidazoles in benzene gave (Z)-1-R-3-(2,4-diaryl-4-oxo-2-butenyl)-1H-imidazolium
bromides and (Z)-1-R-3-(2,4-diaryl-4-oxo-2-butenyl)-1H-benzimidazolium bromides which readily cyclize in the presence of base
to form derivatives of 7,9-diarylpyrido[1,2-a]benzimidazole and 6,8-diarylpyrimidazo[1,2-a]pyridine. The effects of the nature of substituents in the benzene ring of the diarylbutenones and the substituent at N(1)
in the (benz)imidazoles on the alkylation and cyclization reactions has been studied. The optimum conditions for the synthesis
of the 5-R-4-hydroxy-2,4-diphenyl-4,5-dihydro-1H-pyrido[1,2-a]benz-imidazol-10-ium, 5-R-2,4-diaryl-4-hydroxy-4,5-dihydro-3H-pyrido[1,2-a]benzimidazol-10-ium, and 5-R-2,4-diaryl-5H-pyrido[1,2-a]benzimidazol-10-ium
have been found. 相似文献
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本文简要叙述了取代10 H-吡啶并[1.2-a]吲哚盐的合成、结构分析以及应用研究. 相似文献
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Reaction of 2,3,3-trimethyl-3H-indolium salts with crotonaldehyde leads to 8-methyl-10H-pyrido[1,2-a]indolium salts. Condensation of the latter with aromatic aldehydes gave 8-styryl-10H-pyrido[1,2-a]indolium derivatives.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1055–1057, August, 1990. 相似文献
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V. V. Dotsenko S. G. Krivokolysko E. B. Rusanov A. V. Gutov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2007,43(7):906-912
The interaction of N-methylmorpholinium 1-amino-2,4-dicyano-4-ethoxycarbonyl-1,3-butadienethiolate with primary amines and
formaldehyde leads to the formation of ethyl esters of 7-cyano-6-thioxo-1,3,4,6-2H-pyrido[1,2-a][1,3,5]triazine-9-carboxylic
acid in place of the expected derivatives of pyrido[2,1-b][1,3,5]thiadiazine. The structure of the ethyl ester of 7-cyano-3-phenyl-6-thioxo-1,3,4,6-2H-pyrido[1,2-a][1,3,5]triazine-9-carboxylic
acid was demonstrated by X-ray structural analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1075–1081, July, 2007. 相似文献
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Crescenzi O Correale G Bolognese A Piscopo V Parrilli M Barone V 《Organic & biomolecular chemistry》2004,2(11):1577-1581
Carbon and proton NMR spectra of several substituted 5H-pyrido[3,2-a]-, 5H-pyrido[2,3-a]phenoxazin-5-ones and 3H-phenoxazin-3-one derivatives have been assigned, and the experimental chemical shifts have been compared with the results of density functional calculations employing large basis sets. Solvent effects were explored by means of the polarizable continuum method (PCM), while the (limited) side-chain flexibility of the compounds has been addressed by Boltzmann averaging of the computed spectral parameters over different conformational minima. Overall, the calculated shifts reproduce well the experiment results; thus, the computational procedure represents a feasible and useful complement to multidimensional NMR experiments in the assignment process. 相似文献
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By the reactions of ketimines bearing a pyridyl or a picolyl group on a nitrogen atom of the imine moiety with tosylisocyanate, 4H-pyrido[1,2-a]pyrimidin-4-one derivatives could be obtained in quantitative yields. In these reactions, tosylisocyanate acts as a carbonyl precursor. The pyridyl or picolyl group is a key functional group because it is not only the constituent structure of the 4H-pyrido[1,2-a]pyrimidin-4-one framework but also the promoter of the formation of a ketene intermediate. 相似文献
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Molnár A Kapros A Párkányi L Mucsi Z Vlád G Hermecz I 《Organic & biomolecular chemistry》2011,9(19):6559-6565
The palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-one with (het)arylboronic acids allow easy access to (het)aryl and vinyl derivatives of this bicycle in good to excellent yields, even from chloro derivatives. The sequence of reactivity of the halogen in the different positions of the ring system was also investigated. 6-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one could be prepared by thermal cyclization of isopropylidene (6-phenylpyrid-2-ylamino)methylenemalonate, together with a small amount of 7-phenyl-1,4-dihydro-1,8-naphthyridin-4-one. 相似文献
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Quantitation of mutagenic/carcinogenic heterocyclic aromatic amines in food products. 总被引:1,自引:0,他引:1
A method for screening genotoxic heterocyclic aromatic amines in cooked foods using solid-phase extraction and high-performance liquid chromatography with ultraviolet and fluorescence detection is described. Solid-phase extraction includes basic extraction on diatomaceous earth (Extrelut) and subsequent purification on propylsulphonic acid silica gel. This convenient procedure separates the analytes into a polar group and an apolar group. We have identified the following components in the two groups. The polar group contains aminoimidazoazaarenes i.e. 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, and glutamic acid pyrolysates, i.e. 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-aminodipyrido[1,2-a:3',2'-d]-imidazole. The apolar group consists of five carbolines: 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, 3-amino-1-methyl-5H-pyrido[4,3-b]indole, 2-amino-9H-pyrido[2,3-b]indole, 9H-pyrido[3,4-b]indole and 1-methyl-9H-pyrido[3,4-b]indole. The extraction efficiencies range from 45 to 90%, and the detection limits are in the low nanogram per gram range. The method was applied to the analysis of heterocyclic aromatic amines in pan-fried, oven-cooked and barbecued salmon. 相似文献