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1.
The highly reactive alkylaminofurochromenone intermediate, produced from the reaction between 3-formylchromones and alkyl isocyanides, was trapped by monocyclic unsaturated acyl compounds such as maleic anhydride or maleimide derivatives to yield new types of organic fluorophores 4-(alkylamino)-1H-furo[3,4-b]xanthene-1,3,10-triones or 4-(alkylamino)chromeno[2,3-f]isoindole-1,3,10(2H)-triones, which exhibited strong sky blue emission in solution. The reaction is very simple from an experimental point-of-view and allows the creation of a fused benzene ring with concomitant formation of three new C–C bonds in a single operation. 相似文献
2.
Dialkylaminodimethylchlorosilanes react with sodium amide mainly to dialkylamino-dimethylsilyl-amines, besides to the free dialkylamine and cyclo- and polysilazanes. Bis(alkylamino)-dimethylsilanes can be isolated from the reaction of alkylaminodimethylchlorosilanes with NaNH2. Dialkylaminodimethylsilanes are formed likewise in the reaction of alkylaminophenoxydimethylsilanes with NaNH2. The analogous reaction of alkylaminophenoxydimethylsilanes leads on the other hand to 1,3-bis(alkylamino)-tetramethyldisilazanes. 相似文献
3.
Ghasem Marandi Lotfali Saghatforoush Rafael Mendoza-Meroño Santiago García-Granda 《Tetrahedron letters》2014
The synthesis of a number of 3-(alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids via a facile route involving the reaction between 2-amino-3-pyridinecarboxylic acid, benzaldehyde derivatives, and isonitriles is reported. The structures of the synthesized compounds are proved by X-ray crystallography. 相似文献
4.
A rapid, efficient and benign protocol has been developed for the construction of potentially biologically active furo[2′,3′:4,5]pyrimido[2,1-b][1,3]benzothiazole derivatives as major products along with (3E)-3-[(alkylamino)methylene]-2H-pyrimido[2,1-b][1,3]benzothiazole-2,4(3H)-dione derivatives as minor products using a one-pot, multi-component reaction of isocyanides, aromatic aldehydes and 2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one. The significant features of this protocol are the readily available and low-cost starting materials, short reaction time, mild reaction conditions, high yield of products and avoidance of toxic solvents and catalysts. Structures of compounds 4b and 5a were confirmed from single crystal X-ray studies. 相似文献
5.
Issa Yavari Jamil Sheykhahmadi Hamed Saffarian Nooshin Zahedi Samira Bahemmat Mohammad Reza Halvagar 《合成通讯》2013,43(19):2608-2614
AbstractThe four-component reaction among arylhydrazine, alkyl acetoacetate derivatives, alkyl isocyanides, and dialkyl acetylenedicarboxylates, leading to the formation of dialkyl 2-[(Z)-(alkylamino)(3-alkyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl] fumarates is described. The structure of target compounds was confirmed using X-ray diffraction study. These pyrazolone derivatives contain a highly twisted exocyclic 1,3-butadiene moiety with skew (??=?87°) geometry. 相似文献
6.
Benjamin E. Blass Keith Coburn Neil Fairweather Mark Sabat Laura West 《Tetrahedron letters》2006,47(18):3177-3180
A series of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones were prepared by a KF/Al2O3 mediated condensation of 4-(alkylamino)-2-(methylthio)pyrimidine-5-carbaldehydes and phenyl acetic acid ester derivatives. 相似文献
7.
An effective route to functionalized 4,5-dihydro-1H-pyrrol-3-carboxamide derivatives is described. This involves reaction of N-alkyl-3-oxobutanamides, which result from the addition of an amine to the diketene, and a primary amine in the presence of dibenzoylacetylene. The 1,3-dicarbonyl compounds obtained from the addition of an amine to diketene were trapped with a primary amine to produce (Z)-3-(alkylamino)-N1-alkyl-2-butenamide, which reacts with dibenzoylacetylene to produce 4,5-dihydro-1H-pyrrol-3-carboxamide derivatives. 相似文献
8.
9-Chloro-1,10-anthraquinone 1-dichlorophosphorylimine formed in the reaction of 1-amino-9,10-anthraquinone with PCl5 followed by dehydrochlorination reacts with primary amines with substitution of chlorine atoms. In the case of aliphatic
amines, the reaction occurs further concurrently in two directions: the addition of the amine molecule with the formation
of 9,9-di(alkylamino) derivatives of the anthrone and the substitution of hydrogen atom at position 4 with the formation of
4,9-di(alkylamino) derivatives of 1,10-anthraquinone 1-imine. In the case of aromatic amines, 1-amino-9,10-anthraquinone 9-arylimines
are the end products. Reactions with the anions of CH-acids containing an alkoxycarbonyl or cyano group occur with substitution
in position 9 followed by intramolecular cyclization with the formation of 2-alkoxy- or 2-amino-7H-dibenzo[f,ij]isoquinolin-7-one derivatives, respectively.
For preliminary communication, see Ref. 1.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1179–1184, June, 1998. 相似文献
9.
A facile synthesis of S-(2-thioxo-1,3-dithiolan-4-yl)methyl dialkylcarbamothioates (3) and S-thiiran-2-ylmethyl dialkylcarbamothioate (5) has been reported by the reaction of 5-(chloromethyl)-1,3-oxathiolane-2-thione (1) with sodium dialkylcarbamodithioate (2) and dialkylamine (4), respectively, through intermolecular O-S rearrangement in water. A plausible mechanism of formation of the title compounds has also been proposed. 相似文献
10.
L. M. Gornostaev I. S. Kryukovskaya T. I. Lavrikova M. V. Vigant Yu. V. Gatilov 《Russian Journal of Organic Chemistry》2014,50(2):205-210
The reaction of 2-amino(alkylamino)-1,4-naphthoquinones with nitrating mixture in concentrated sulfuric acid leads to the formation of 2-amino(alkylamino)-3-nitro-1,4-naphthoquinones. 相似文献
11.
The highly reactive 1:1 adduct, produced from the reaction between dialkyl acetylenedicarboxylates and alkyl isocyanides, was trapped by strong cyclic CH-acids such as 4-hydroxy-6-methyl-2H-pyran-2-one or 4-hydroxycoumarin to yield dialkyl 2-(alkylamino)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3,4-dicarboxylates or dialkyl 7-methyl-2-(alkylamino)-5-oxo-4H,5H-pyrano[4,3-b]pyran-3,4-dicarboxylates in good yields at room temperature. 相似文献
12.
Tetsuya Ishida Makoto Sakakibara Yoshio Ueno Kan-Ichi Hasegawa 《Journal of heterocyclic chemistry》1989,26(3):785-788
The condensation of 2-bromo- or 2, 6-dibromo-4, 8-bis(alkylamino)-1, 5-naphthoquinones with zinc 2-amino-benzeneselenolates gave 1, 5-bis(alkylamino)-4H-benzo[a]phenoselenazin-4-one and the 3- and/or 10-substituted compounds. These phenoselenazone derivatives absorb nearly infrared light and can be used as optical recording media for a laser beam. 相似文献
13.
Mario Di Braccio Giorgio Roma Gian Carlo Grossi Giovanni Ciarallo 《Journal of heterocyclic chemistry》1992,29(1):25-31
The reaction of 2-[(N-acyl, N-alkyl or phenyl)amino]-4H-pyrido[1,2-a]pyrimidin-4-ones 8a-g with the N,N-dimethylformamide/phosphorus oxychloride Vilsmeier reagent 1 (95°, 90 minutes) afforded 1-alkyl or phenyl-2H-dipyrido[1,2-a:2′,3′-d]pyrimidine-2,5(1H)?diones, 3-alkyl substituted or not, 10a-g . The starting compounds 8 were prepared by treating 2-amino-4H-pyrido[1,2-a]pyrimidin-4-ones N-alkyl substituted 7a,b or N-phenyl substituted 4 with excess anhydrides (130°, 7 hours) when the 2-(alkylamino) derivatives 7 were used in the reaction, compounds 8 were obtained along with very small amounts of 3-acyl-2-(alkylamino)-4H-pyrido[1,2-a]pyrimidin-4-ones 9 . 相似文献
14.
A. A. Yarofeeva O. A. Tsutsura T. A. Frolenko E. S. Semichenko A. A. Kondrasenko G. A. Suboch 《Russian Journal of Organic Chemistry》2017,53(1):1-5
The condensation of 2-(hydroxyimino)-3-oxobutanal with primary aliphatic amines, cyclohexanamine, and amines containing an adamantane fragment afforded 4-(alkylamino)- and 4-(cyclohexylamino)-3- nitrosobut-3-en-2-ones. Analogous reaction with substituted anilines RC6H4NH2 (R = H, 4-Me, 4-OMe, 4-NH2, 4-Br, 4-I, 3-NO2) led to the formation of 4-aryl-3-hydroxyiminobutan-2-ones. 相似文献
15.
Alkyl (E)-2-(3-Alkyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)-5-(alkylamino)-1,3-dithiole-4-carboxylates have been obtained by condensation of 2-pyrazolin-5-ones with carbon disulfide followed by ring formation with phosphorylated hydroxyketenimines [generated in situ from Nef-isocyanide-Perkow reaction] in the presence of Et3N. The structure of target compounds was confirmed by X-ray diffraction study. The good yields of the products, diastereoselectivity, and lack of activators or metal promoters are the main advantages of this method. 相似文献
16.
M. V. Dmitriev P. S. Silaichev A. N. Maslivets 《Russian Journal of Organic Chemistry》2011,47(1):92-94
Reactions of isopropyl 2-(1-aryl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)-2-oxoacetates with alkylamines involve pyrroledione-pyrroledione recyclization with formation of isopropyl 1-aryl-2-hydroxy-4,5-dioxo-3-[phenyl(alkylamino)methylidene]pyrrolidine-2-carboxylates. 相似文献
17.
Sourav MaitiSuman Kalyan Panja Chandrakanta Bandyopadhyay 《Tetrahedron letters》2011,52(16):1946-1948
2-(Arylamino)-4-oxo-4H-1-benzopyran-3-carbaldehyde rearranges to 4-oxo-4H-1-benzopyran-3-carbanilide when treated with glycine in the presence of formalin, but under similar conditions 2-(alkylamino)-4-oxo-4H-1-benzopyran-3-carbaldehyde rearranges to 3-alkylaminomethylenechroman-2,4-dione. 相似文献
18.
Acid-catalyzed reaction of benzotriazole, 5,6-dimethylbenzotriazole and 5,6-dichlorobenzotriazole with di-O-acetyl-d-xylal in ethyl acetate afforded 1-(4′-O-acetyl-2′,3′-dideoxy-d-glycero-pent-2′-enopyranosyl)benzotriazole derivatives and small amounts of 1,2,3-trideoxy-4-O-acetyl-3-(benzotriazolyl)-d-threo-pent-1-enopyranose derivatives. The reactions using di-O-acetyl-l-arabinal led to the formation of the corresponding 1- and 2-(3′,4′-di-O-acetyl-2′-deoxy-l-erythro-pentopyranosyl)benzotriazole derivatives. In addition the enantiomers of the above 2′, 3′-unsaturated N-glycosyl compounds were also obtained. The configurations and conformations of the products obtained were determined by NMR spectroscopy. 相似文献
19.
The synthesis of novel 1,6‐naphthyridines 6 with potential activity against tuberculosis is described using the reaction sequence 2←4←6. Depending on the ring N‐substitution of the 4‐alkylamino‐6‐methyl‐2(1H)‐pyridones 1 and 2 the electrophilic attack of the Vilsmeier reagent gives rise to the formation of the exocyclic N‐formyl derivatives 3 from 1 and the corresponding 3‐carbaldehydes 4 from 2. 1,2‐Dihydro‐2‐imino‐7‐methyl‐1,6(6H)‐naphthyridin‐5‐ones 6a‐j are prepared by the Knoevenagel reaction of 4 with CH‐acidic nitriles 5. These reactions are carried out using a comparative study of conventional conditions (room temperature or reflux) versus microwave irradiation. 相似文献
20.
Mehdi Asadi Mostafa Ebrahimi Mohammad Mahdavi Mina Saeedi Parviz Rashidi Ranjbar Farshad Yazdani 《合成通讯》2013,43(17):2385-2392
Heating a mixture of isatoic anhydride, amines, and N,N′-dialkyl carbodiimides under solvent-free conditions provided novel 3-alkyl-2-(alkylamino)quinazolin-4(3H)-one derivatives for the first time. The products were obtained in moderate to good yields without formation of any by-products. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. 相似文献