共查询到16条相似文献,搜索用时 109 毫秒
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4-氨基-5-烃基-2,4-二氢-3H-1,2,4-三唑-3-硫酮席夫碱的简便合成 总被引:9,自引:1,他引:9
近年来,人们发现标题类杂环席夫碱能发生很多新颖的反应,且其中许多具有强的生物活性[1~7].但其制备多以乙醇为反应介质,以酸或碱为催化剂,反应需经数小时,后处理也比较麻烦.本文报道了题示席夫碱的一种极为简便的合成方法,反应介质选用低级的脂肪酸(如冰醋... 相似文献
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以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为原料,经醚化、肼解、成盐、关环和席夫碱反应合成了20个新型的含1,2,4-三唑-5-硫酮席夫碱的1,2,4-三唑并[1,5-a]嘧啶类化合物,通过IR,1H NMR,MS和元素分析对所合成的化合物进行了结构表征.初步生物活性测试结果表明,部分化合物表现出一定的抑菌或较好的抗烟草花叶病毒(TMV)活性.在500μg/mL浓度下,化合物6b,6f和6p对TMV的抑制率分别为41%,43%和40%. 相似文献
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设计并合成了16个酰胺基硫脲类化合物的14个1、2、4-三唑-5-硫醇类化合物。生物活性初筛试验表明,两类化合物对水稻和黄瓜幼苗有一定的生长调节活性。 相似文献
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Six novel Schiff bases have been synthesized by the condensation reaction of 4-amino-5-(4-pyridyl)-2,4-dihydro-1,2,4-triazole-3-thione with various benzaldehydes. The sfructures of the compounds have been confirmed by ^1H NMR, IR and elemental analysis. The preliminary bioassay indicated that the title compounds possessed good fungicidal activities to several vegetable pathogens. 相似文献
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Baolei Wang Yanxia Shi Yizhou Zhan Liyuan Zhang Yan Zhang Lizhong Wang Xiao Zhang Yonghong Li Zhengming Li Baoju Li 《中国化学》2015,33(10):1124-1134
Series of novel furan/thiophene and piperazine‐containing 1,2,4‐triazole Mannich bases and bis(1,2,4‐triazole) Mannich bases have been conveniently synthesized via Mannich reaction with triazole Schiff bases, various piperazine derivatives, and formaldehyde as intermediates in good yields. Their structures were characterized by melting points, 1H NMR, 13C NMR, IR and elemental analysis. The preliminary bioassay showed that most compounds exhibited significant in vitro and in vivo fungicidal activity against several test plant fungi. Among 32 new compounds, the trifluoromethyl‐containing compounds showed superior activity than the methyl‐containing ones. Several compounds, such as F8 , F9 , F10 , G5 , H7 , H8 , I3 and I4 , were comparable with some commercial fungicides against different fungi during the present study and could be further structurally optimized. Meanwhile, several compounds showed good herbicidal activity against Brassica campestris at 100 µg/mL and KARI inhibitory activity at 200 µg/mL. However, compounds exhibited poor insecticidal activity against oriental armyworm at 200 µg/mL in the preliminary studies. The research results will provide useful information for the design and discovery of new agrochemicals with novel heterocyclic structures. 相似文献
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含吡唑环的1,2,4-三唑希夫碱类衍生物的合成及生物活性 总被引:1,自引:0,他引:1
以自制的4-氨基-4,5-二氢-3-[(3,5-二甲基吡唑-1-基)甲基]-1,2,4-三唑-5-硫酮衍生物为中间体, 与取代苯甲醛反应合成了一系列新型含吡唑环的1,2,4-三唑希夫碱衍生物. 通过红外光谱、 核磁共振波谱、 高分辨质谱、 元素分析及X射线单晶衍射对目标化合物进行了结构表征, 并初步测试了其生物活性. 结果表明, 大部分化合物表现出较好的抑菌活性, 其中化合物G9, G10和G15的抑菌效果优于对照药三唑酮. 相似文献
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根据活性亚结构拼接原理,以取代苯甲醛、盐酸羟胺、N-氯代丁二酰亚胺和2-苯并咪唑基乙腈等为原料,经肟化、氯代、环化及缩合反应,合成了一系列新型的含苯并咪唑和异噁唑结构的席夫碱化合物(5a~5h),收率60%~75%,其结构经~1H NMR,~(13)C NMR,IR和HR-MS表征。采用菌丝生长速率法测试了化合物对番茄灰霉菌和生菜菌核菌的抑菌活性。结果表明:在用药量为100μg·m ~(-1)时,苯环上含有氟原子或甲氧基的席夫碱(5c,5d和5e)对生菜菌核菌显示出较好的活性,抑制率为71.3%~76.1%。 相似文献