共查询到20条相似文献,搜索用时 15 毫秒
1.
A. I. Vorob’eva M. S. Babaev L. V. Spirikhin N. M. Shishlov S. V. Kolesov 《Russian Journal of Applied Chemistry》2016,89(1):160-164
A copolymer of N,N-diallyl-N,N-dimethylammonium chloride with maleic acid of constant composition was prepared under the conditions of radical initiation. The possibility of the functionalization of the copolymer with drugs containing amino groups by polymer-analogous transformations was examined. Conditions were found for preparing conjugates of the copolymer with isoniazid. The structures and the quantitative compositions of the conjugates were determined by 13С NMR spectroscopy, and the possibility of preparing conjugates with controlled drug content was demonstrated. 相似文献
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A. V. Lezov G. E. Polushina A. A. Lezov P. S. Vlasov N. S. Domnina 《Polymer Science Series A》2011,53(2):93-101
The hydrodynamic and conformational properties of molecules of poly(N,N-diallyl-N,N-dimethylammonium chloride) and N,N-diallyl-N,N-dimethylammonium chloride-maleic acid copolymers of different compositions in solutions with various ionic-strength and pH
values, as well as of the polyelectrolyte complex based on the copolymer with dodecyl sulfate anions in chloroform, are studied.
For poly(N,N-diallyl-N,N-dimethylammonium chloride) molecules in a 1 M NaCl solution, the Kuhn segment length and the hydrodynamic diameter of the
chain are estimated as A = 3.9 nm and d = 0.48 nm, respectively. In acidic solutions with pH 3.5, the copolymers demonstrate behavior typical for polyelectrolytes.
In an alkaline solution with pH 13, when 1 M NaCl is added to the solution of the copolymer containing 29 mol % maleic acid
units, there is an antipolyelectrolyte effect that manifests itself as an increase in the intrinsic viscosity of the copolymer
and in the hydrodynamic radius of its molecules. It is found that an increase in the fraction of maleic acid units in the
copolymer from 12 to 42 mol % brings about a reduction in the equilibrium rigidity of its macromolecules from 4.1 to 2.2 nm.
The equilibrium rigidity of polyelectrolyte-complex molecules is higher than that of initial copolymer molecules owing to
steric interactions arising between the aliphatic chains of dodecyl sulfate anions. In an electric field, the molecules of
the complex are oriented owing to the induced dipole moment resulting from the displacement of dodecyl sulfate anions along
the chain contour. 相似文献
4.
Zhongyuan Bai Zengjun Wei Yunchun Wang Shengzhen Xu Xuegang Li Changshui Chen Xiufang Cao 《Research on Chemical Intermediates》2011,37(8):859-868
A series of N-nitrourea derivatives bearing various cycloalkyl were conveniently obtained via three steps including nitration, carbamic
chlorination, and aminolysis reactions. The structures of all newly synthesized compounds were elucidated and confirmed by
IR, 1H NMR, 13C NMR, and elemental analysis. The preliminary bioassay indicated that the target compounds exhibited moderate herbicidal
activity against Amaranthus albus and Sorghum sudanense. However, some of the title compounds presented high plant growth regulating activity against rice. 相似文献
5.
A. P. Avdeenko V. V. Pirozhenko S. A. Konovalov D. A. Roman’kov G. V. Palamarchuk O. V. Shishkinc 《Russian Journal of Organic Chemistry》2009,45(3):408-416
Reactions of thiocyanate ion with N-aroyl-, N-arylsulfonyl-, and N-(N-arylsulfonylbenzimidoyl)-1,4-benzoquinone imines follow the 1,4-addition pattern, and the adducts undergo intramolecular cyclization to give the corresponding N-substituted 5-amino-1,3-benzoxathiol-2-ones as final products. 相似文献
6.
T. F. Ibragimov M. G. Levkovich V. A. Saprykina Kh. M. Shakhidoyatov 《Chemistry of Natural Compounds》2010,46(5):767-770
N-Chloroacetylcytisine was synthesized by acylation of (–)-cytisine. Stable Z- and E-conformers with respect to rotational isomerism around the N-12–CO bond were found in PMR spectra at room temperature. The
point at which PMR resonances of the Z- and E-conformers coalesced upon heating was measured. The transition barrier between the conformers was estimated. 相似文献
7.
V. I. Rakhlin R. G. Mirskov T. A. Podgorbunskaya M. G. Voronkov 《Russian Journal of General Chemistry》2007,77(9):1512-1518
The review is devoted to N-halohexamethyldisilazanes, perspective but scantily studied halogenating agents. Methods of preparation, physiochemical characteristics, and synthetic potential are considered. Mechanisms of a number of reactions are presented. 相似文献
8.
L. A. Baltina A. I. Fairushina L. A. Baltina 《Russian Journal of General Chemistry》2015,85(12):2735-2738
Synthesis of amino acid conjugates of glycyrrhizic acid with the use of N-hydroxyphthalimide, N,N'-dicyclohexylcarbodiimide, and tert-butyl esters of L-amino acids (valine, isoleucine, phenylalanine, and methionine) was performed followed by deprotection with trifluoroacetic acid. The target amino acid conjugates were isolated by column chromatography on silica gel in 40–45% yield. The structure of the prepared compounds was confirmed by IR and 13C NMR spectroscopy. 相似文献
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I. E. Efremova M. I. Vakulenko K. A. Lysenko I. S. Bushmarinov L. V. Lapshina G. A. Berkova V. M. Berestovitskaya 《Russian Journal of General Chemistry》2010,80(11):2298-2305
A modification of 1-nitrocyclohexene synthesis is proposed; its reaction with phenylhydrazine and benzoic acid hydrazide is
shown to afford monoadducts, and with hydrazine hydrate, bisaduct. With diphenylguanidine occurs heterocyclization to 1-phenyl-2-N-phenylamino-4,5,6,7-tetrahydrobenzimidazole, whose structure is confirmed by the X-ray diffraction data. The analysis performed
for this compound of the electron density distribution function in the crystal made it possible to estimate the charge distribution,
π-electrons delocalization nature, and the role of N-H…N, C-H…H-C and C-H…C interactions in the formation of the crystal packing. 相似文献
11.
Reactions of acetamide and benzamide with N-allyltrifluoromethanesulfonamide in the presence of t-BuOCl–NaI afforded exclusively 2,5-bis(chloromethyl)-1,4-bis(trifluoromethanesulfonyl)piperazine. Analogous reaction with N,N-diallyltrifluoromethanesulfonamide gave mixed halogenation product at only one C=C double bond of the substrate. 相似文献
12.
D. F. Grishin L. B. Vaganova A. V. Piskunov O. S. Lizyakina M. G. Chegerev 《Doklady Chemistry》2017,475(1):149-154
The effect of a number of quinoid compounds on methyl methacrylate polymerization initiated by azo-bis(isobutyronitrile) has been studied. It has been revealed that N-aryl-o-iminobenzoquinones, in contrast to o-benzoquinones, can provide radical polymerization of methyl methacrylate in controllable mode. The efficiency of the compounds as chain growth regulators has been found to depend on their composition and reaction conditions. It has been established that 4,6-di-tert-butyl-N-(2,6-diethylphenyl)-o-iminobenzoquinone and 4,6-di-tert-butyl-N-(2,6-diisopropylphenyl)-o-iminobenzoquinone under radical initiation conditions provide the synthesis of poly(methyl methacrylate) with wide-range molecular weight, retaining polydispersity indices about ~1.4–1.8 up to deep conversions. 相似文献
13.
Tautomers of N-allyl- and N-propargyl-substituted trifluoromethanesulfonimides (CF3SO2)2NR (R = CH2CH=CH2, Z/E-CH=CHMe, CH2C≡CH, CH=CH=CH2, C≡CCH2) were calculated by the DFT (B3LYP, wB97XD, PBE1PBE), MP2, and CBS-QB3 methods. The results were compared with the theoretical data for the corresponding amines and amides NHRR1 (R1 = H, CF3SO2). It was shown that there is no conjugation between the nitrogen atom and C=C bond and that conjugation exists with the C≡C bond with electron density displacement toward the nitrogen atom. The calculations of anions derived from N-allyl- and N-propargyl-trifluoromethanesulfonimides revealed the possibility of their rearrangement with elimination of trifluoromethanesulfinate anion and formation of its H-complex with N-(prop-2-en-1-ylidene)trifluoromethanesulfonamide or N-(prop-2-yn-1-ylidene)trifluoromethanesulfonamide. 相似文献
14.
K. G. Myakishev E. A. Il’inchik V. V. Volkov 《Russian Journal of Inorganic Chemistry》2009,54(2):219-222
Reactions of ethylamine hydrochloride C2H5NH2HCl with MBH4 (M = Li, Na, K) under mechanical activation of mixtures of crystalline substances in a vacuum vibratory ball mill are studied. The step-by-step pyrolysis of the reaction products at 90 and 240°C is found to yield N-triethylborazine. The maximum yields of N-triethylborazine are 78.9, 60.3, and 73.8% for LiBH4, NaBH4, and KBH4, respectively. The target product is characterized by various physicochemical methods. The melting point, density, refractive index, and other properties correspond to the literature data for N-triethylborazine. 相似文献
15.
Dibenzobarrelene (I) was used as a starting compound for the synthesis of some new 3a,4,9,9a-tetrahydro-4,9-[1,2]benzeno-1H-benzo[f]isoindole-1,3(2H)-diones, N-substituted with: 4-toluenesulfonyloxy, III; butoxy, IV; 3-bromopropoxy, V; 3-(4-phenylpiperazin-1-yl)propoxy, VI; 3-chloro-3-oxopropyl, VIII; 3-(4-phenylpiperazin-1-yl)-3-oxopropyl, IXa; 3-(4-methylpiperazin-1-yl)-3-oxopropyl, IXb; 3-oxo-3-(piperidin-1-yl)propyl, X; 3-morpholino-3-oxopropyl, XI; 3-phenylamino-3-oxopropyl, XII; 2-acetylaminoethyl, XIV; 2-aminoethyl, XV, and 2-acetoxyethyl, XVI. Newly synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectral data. Selected products were tested for antimicrobial activity. 相似文献
16.
Jan Zitko Barbora Servusová-Vaňásková Pavla Paterová Lucie Navrátilová František Trejtnar Jiří Kuneš Martin Doležal 《Chemical Papers》2016,70(5):649-657
N-Phenylpyrazine-2-carboxamides (anilides of pyrazinoic acids with simple substituents in various positions) were previously shown to possess significant biological activities in vitro, markedly anti-mycobacterial and photosynthesis-inhibiting activity. Based on structure-activity relationships (SAR) extracted from previously published series, 25 new anilides of non-substituted pyrazinoic acid (POA), 5-CH3-POA, 6-Cl-POA, 5-tert-butyl-POA and 5-tert-butyl-6-Cl-POA were designed and synthesised. The phenyl part was substituted with simple hydrophobic substituents chosen from methyl and halogens. 5-tert-Butyl-N-(5-fluoro-2-methylphenyl)pyrazine-2-carboxamide (9), N-(3-chloro-4-methylphenyl)-5-methylpyrazine-2-carboxamide (12), 6-chloro-N-(3-chloro-4-methylphenyl)pyrazine-2-carboxamide (13) and 6-chloro-N-(5-iodo-2-methylphenyl)pyrazine-2-carboxamide (18) possessed whole cell anti-mycobacterial activity in vitro against Mycobacterium tuberculosis H37Rv with minimum inhibitory concentration (MIC) of around 10 μM. Importantly, no cytotoxicity in the HepG2 model was detected in vitro at the concentrations tested and the estimated IC50 values were in hundreds of μM, indicating promising selectivity. N-(3-Chloro-4-methylphenyl)pyrazine-2-carboxamide (11) and N-(4-chloro-2-iodophenyl)pyrazine-2-carboxamide (21) exerted significant activity against Mycobacterium kansasii with MIC 12.6 μM and 8.7 μM, respectively. No activity was detected against Mycobacterium avium. SAR were in accordance with those observed for the derivatives previously published. 相似文献
17.
For HF solutions in DMF, concentration-dependent fractions of DMF molecules (α(DMF)) that remain unassociated and that enter heteroassociates (HAs) of 1 : 1, 4 : 1, and 12 : 1 molecular stoichiometries were obtained by two independent methods, namely, from an analysis of IR spectra and by calculating the material balance. The experimental way was shown to be enough exact in determining the ratio between the solvent molecules in four different states up to ~83 mol % HF. The equilibrium compositions of HF–DMF solutions were estimated over the entire range of concentrations. Starting with [HF] of ~25 mol %, more than one-half HF molecules are associated, and at [HF] of ~50–92 mol %, at least 90% of the HF molecules are associated. The equilibrium composition of HF–organic solvent (Solv) solutions in which HAs of 1 : 1, 1 : 4, and 1 : 12 molecular stoichiometries are formed, can be described by a single set of α(HF–Solv) versus concentration plots. 相似文献
18.
O. G. Strukov V. B. Kondrat’ev Z. V. Vlasova V. A. Petrunin 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2017,91(1):100-105
Conformers of the biologically active compounds CH3P(O)(OR)(SCH2CH2NR 2 ′ ), where (I) R = i-C4H9, R′ = C2H5 and (II) R = C2H5, R′ = i-C3H7, are calculated within the AM1 level of theory. The elongated and twisted forms with maximum and minimum distances between a nitrogen atom and those of a phosphorus tetrahedron, respectively, and bearing a syn and anti oriented alkoxy group relative to a phosphoryl oxygen, are studied. It is found that the differences between the energy, electronic, and geometric parameters of these forms are apparent in differences between their properties, e.g., the ability to participate in complexation and protonation, reactions that to some extent simulate the interaction between a substance and a biological object. 相似文献
19.
V. E. Romanov E. E. Shul’ts M. M. Shakirov G. A. Tolstikov 《Chemistry of Natural Compounds》2008,44(3):346-351
New N-acylates of the norditerpenoid alkaloid N-deacetyllappaconitine that were modified in the aromatic ring and are interesting as potential pharmacologically valuable
compounds were prepared.
__________
Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 275–279, May–June, 2008. 相似文献
20.
Decomposition of a series of N-cyclopropyl-N-nitrosoureas (CNU) in CD3OD was studied. These decompose much more rapidly than N-methyl-N-nitrosourea, one of the decomposition pathways being denitrosation, which is atypical of alkylnitrosoureas under the reaction conditions used. The nature of substituents in the cyclopropane ring has a great effect on the stability of CNU and the product ratio. In the presence of H2 SO4, decomposition occurs much more rapidly. Possible pathways of the formation of the major decomposition products of CNU are proposed based on the experimental data.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 359–370, February, 2005. 相似文献