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1.
Jun Biao CHANG* Juan HE Rong Feng CHEN Jing Xi XIE Henan Institute of Chemistry Henan Academy of Science Zhengzhou Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 《中国化学快报》2001,(1)
The reductive coupling of carbonyl compounds is an important method of carbon-carbon bond formation. The reaction can be used in both an inter-and intramolecular manner. It is important for the formation of olefins. Mukaiyama T., et al1 reported that the reductive coupling of ketones with TiCl4/Zn in tetrahydrofuran (THF) afforded the corresponding pinacols or olefins in high yields. The pinacols were obtained at 0℃. After heating, the deoxygenation reaction of pinacols afforded olefins2.… 相似文献
2.
JieHAN LiangFuZHANG WenWAN 《中国化学快报》2004,15(2):155-158
The synthesis and mesomorphic properties of two series of novel γ-substituted β-diketonates have been reported. All of the compounds 2,4-dioxo-3-pentyl 4-[[4-(n-alkoxyl) cinnamoyl]oxy]cinnamatetes Ia-If (n=7-12) exhibit two monotropic phases(N and Sc) and have a wider mesophase range than the compounds 2,4-dioxo-3-pentyl 4-[[4-(n-alkoxyl) benzoyl]oxy] cinnamatetes Ⅱa-Ⅱf (n=7-12), which display one monotropic nematic phase (n=7-10) or an enantiotropic nematic phase for n=11 or two enantiotropic phases (N and Sc)for n=12. 相似文献
3.
In the present study, we have synthesized a series of novel glucosyl triazoles for the first time. The glucosyl triazoles 4a–e were synthesized by reaction of some azidoglycosides with various terminal alkynes via a copper-catalyzed [3+2] cycloaddition (“click chemistry”) and were deprotected to afford the corresponding glucosyl triazoles 5a–e in good yields. The structures of the new compounds were determined by IR, NMR spectroscopy, and mass spectrometry. The antitumor (human cervical cancer cell) activity was evaluated for the target compounds. 相似文献
4.
ASHNAGAR Alamdar GHARIB NASERI Nahid SHEERI Behrang 《中国化学》2007,25(3):382-384
Knovenagel reaction of barbituric acid with different aldehydes were used to synthesize new barbiturates. This is a novel method which can be used to synthsis various types of new generation of barbiturates which are different from the previously reported. 相似文献
5.
V. A. Tartakovskii I. A. Savost'yanova B. G. Gribov S. S. Novikov 《Russian Chemical Bulletin》1963,12(7):1204-1205
Summary The denitration of -mercurinitro compounds has been studied and the corresponding organomercury dinitro derivatives have been obtained. 相似文献
6.
《合成通讯》2013,43(23):4359-4367
Abstract Reaction of 5‐amino‐3‐substituted pyrazoles (1a–c) and 5‐amino‐1,3‐disubstituted pyrazoles (1d–i) with fluorinated‐β‐diketones (2) results in the formation of the single isomer of pyrazolo[3,4‐b]pyridines (4a–h). A one‐pot procedure for the synthesis of title compounds starting from α‐cyanoacetophenones along with a possible mechanistic pathway for the formation of the title compounds is described. 相似文献
7.
《中国化学快报》1997,(7)
IntroductionProject59333072supportedbyNSFC.TheaPPearAnceoftheruthenium(II)POlyPyridinecomplexeshasproducedanex1ensivegrowthinphotochendopandphotophysicsinlasttWentyyears,largelybecauseoftheirhighlyverboleltalnescentandphotoredoxproperties.Thesecomplexeshaveplayedandarestillplaytngven-imPOrtanroleinthedevelopmentofphotocherniStry,photophysics,photOCatalysis,eleetrchendap',photoelectrochendsto'chem-andelectrochend-lthenescence,andelectronandenergr'tr~fer1'3.ESPeCially,inarecentbreaktIir… 相似文献
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Jian Wu WANG* Jiong JIA Hong Mei LI Cong WANG School of Chemistry Environmental Science Shandong University Jinan 《中国化学快报》2000,11(11)
Losartan 1 (Dup-753) is a nonpeptide angiotensin II receptor (type AT1) antagonist discovered by Duncia, J.V. et al. 1 in 1990 and its potassium salt (cozaar) has been marketed as an antihypertensive since 1995 2. 1 2 Starting from Dup-753, a great number of structural related compounds have been prepared by several laboratories and several antihypertensive drugs have been developed3. In order to find new and more active compounds, a novel type of Losartan analogues 2 was designed and syn… 相似文献
11.
Li Yan DAI* Ying Qi CHEN College of Material & Chemical Engineering Zhejiang University Hangzhou 《中国化学快报》2001,(10)
Difloxacin, the third generation of new quinolone antibiotics, has broad-spectrum in vitro activity and excellent potency in vivo and has been found to be against gram-positive cocci, gram-negative bacteria, anaerobe, mycoplasm, chlamydia1,2. As described previously, high reaction temperature and hazardous reagents are the defects of the methods for preparation of difloxacin3,4. We have developed a new synthetic method as shown in the Scheme. 2,4-Dichloro-5-fluoro-acetophenone 1 was used as … 相似文献
12.
Ling SHAO Yah HU Xin ZHOU Zhong JIN Jian Bing LIU Jian Xin FANG 《中国化学快报》2006,17(8):1002-1004
Ferrocenes and their derivatives have been used in material chemistry, electrochemistry and in nonlinear optics. Recently, increasing interests have been focused on their biological activity1. Ferrocifen is a ferrocene derivative of tamoxifen, will be sub… 相似文献
13.
Lignans have attracted much interest over the years on account of their widespread ocurrence in nature1, and on account of their broad range of biological activity2. Thus, several lignans are known to exhibit anti-tumor activity3-7, while others function as growth inhibitors and antifungal agents8,9. The importance is the isolation of lignans from animals, including human beings10-12, which has led to the suggestion that such compounds may be an example of a novel class of hormone controlling … 相似文献
14.
YongCHU MingXiaXU DingLU 《中国化学快报》2004,15(9):1011-1014
Based on our previous studies of 3D-QSAR, 38 novel objective compounds belonging to 4 series were designed and successfully synthesized directed by the idea of reconstructing the structure of non-pharmacophores while reserving essential ones in triazoles. In vitro pilot studies on their antifungal activities showed that most compounds have inhibitory effects on C.albicans and some inhibit S.cerevisiae also. The effects on C.albicans of 5 compounds are more potent than or equal to that of fluconazole or itraconazole. 相似文献
16.
Thenitronesareveryimportantinorganicsynthesis.TheyhavebeenwidelyutilizedasintermediatesfromwhichcomPlexheterocyclicornaturalcompoundsanddrugs"'weresynthesisedsuchasisoxazoline3andoxazine4.However,theconversionofnitronetoisoxazolebythermaldecompositionhasnotbeenreported.Inthispaper,wedevelopanewsyntheticmethodofisoxazolesfromheterocyclicnitronesasfollows:wi.-"'rtXfa.H;b.3,4-O-CH2-o-;c.4-CH3O,d.4-Cl;e.2-Brf.2-Cl,g.3,4-coCH3;h.3-ro2;i.4-so2;j.4-CH3Experiment8lAdriedroundbottomflaskundernit… 相似文献
17.
The expeditious route for the synthesis of γ-butyrolactone fused cyclooctene starting from the γ-butyrolactone fused cyclopentane through bicyclo[4.2.1]nonan-9-one is reported. Retro-Dieckmann’s condensation of bicyclo[4.2.1]nonan-9-one in presence of sodium methoxide and methanol furnished γ-butyrolactone fused cyclooctene in good yield. Surprisingly, the stereochemistry of ring-junction of γ-butyrolactone fused cyclooctene is different from the γ-butyrolactone fused cyclopentane, and the position of new ester group, which were confirmed unambiguously by X-ray analysis. 相似文献
18.
A simple and efficient synthesis for γ-cyclohomocitral (10), a key and versatile intermediate for the synthesis of some furanosesquiterpenes, is described. The formal total synthesis of (±) Pallenscensone (2) was accomplished. 相似文献
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2, 6 - D imethoxyhydroquinon e - 3 -mere aptoac et ic ac id (D M Q -MA) I -3 is a syntheti cderivative of 2, 6 - d imethoxyp -b enzoqu inone (D M Q )#, whi oh is a n atUral fermentedproduct of wheat germ and was found to have a wide spectrUm of cytotoxicity againstvarious tUmor cell lines under the synergistic activation of L-ascorbic acid as reported byG.A.Szents. Owing to the very low aqueous solubility of DMQ, which is an apparentdisadvantage for the development as a vaccine, we prep… 相似文献