Hard collisions of spinning protons: Past,present and future

There will be a review of the history of polarized proton beams, and a discussion of the unexpected and still unexplained large transverse spin effects found in several high-energy proton-proton spin experiments at the ZGS, AGS and Fermilab. Next, there will be a discussion of present and possible future experiments on the violent elastic collisions of polarized protons at IHEP-Protvino's 70GeV U-70 accelerator in Russia and the new high-intensity 50GeV J-PARC facility being built at Tokai in Japan.     

The search for Higgs particles at high-energy colliders: Past,present and future

I briefly review the Higgs sector in the standard model (SM) and its minimal aupersymmetric extension, the MSSM. After summarizing the properties of the Higgs bosons and the present experimental constraints, I will discuss the prospects for discovering these particle at the upgraded Tevatron, the large hadron collider (LHC) and a high-energye ⁺ e ⁻ linear collider. The possibility of studying the properties of the Higgs particles will be then summarized.     

Metastable antiprotonic helium atoms: Past,present and future

This review briefly summarises the experimental studies carried out on metastable antiprotonic helium over the last few years, and points out a possible way ahead, assuming that very low-energy antiprotons continue to be available. Very recently, an abundance of new results has been found by the Japanese-European collaboration working in these exotic atoms at LEAR, the Low Energy Antiproton Ring at CERN. Together with tremendous progress in several of the techniques needed for antihydrogen synthesis, this has provided new hope that some way will be found to continue this fruitful line of research after the closure of this excellent machine.     

The ISIS pulsed muon facility: Past,present and future

The pulsed muon facility at ISIS of the Rutherford Appleton Laboratory has been operational since March 1987. It is now fully scheduled for condensed matter research using polarised surface muons, atomic physics with sub-surface muons, and μCF experiments requiring negative cloud muons. The design and performance of the present beam are briefly discussed and recent improvements to the facility are described. Essential future upgrades have recently received international support and funding, which will lead to a complete facility comparable in extent to those of the continuous meson factories at PSI and TRIUMF, but with the unique advantages of the pulsed nature of the source. Such an upgraded facility will provide unprecedented opportunities for muon science at ISIS, unmatched by any other facility until the end of the decade.     

Stochastic radiative transfer in Markovian mixtures: Past, present, and future

The Markovian approach, originally suggested in the early 1900s, has widespread practical use in many of our present-day studies and allows one to build bridges between diverse research areas such as statistical physics, astronomy, and computational science. This overview takes a broad sweep of several important examples with the emphasis on the stochastic radiative transfer in a cloudy atmosphere. In particular, the overview (i) highlights important contributions made by Pomraning and Titov to the neutron and radiation transport theory in a stochastic medium with homogeneous statistics and (ii) illustrates that ideas and tools introduced by these two distinguished scientists are gaining increasing impact and recognition in the atmospheric science.     

基于光纤光栅传感器的体外血管模型应力测量北大核心CSCD

血管中的血液流动会对血管壁产生周向应力,周向应力与血管的结构及功能变化密切相关,测量体外血管模型的周向应力是生物力学研究中较重要的问题。提出了利用光纤光栅测量血管周向应力的方法,基于微流控技术利用钢针模具建立了集成光纤光栅的三维圆形血管模型,通过仿真研究了不同流动速度与应力的关系。仿真结果得到流速在8 mm/s~75 mm/s范围内,应力随速度的改变呈线性变化。利用光纤光栅传感器测量了流体流动时产生的周向应力,根据实验得到了光栅波长改变量与速度的关系,流速范围在8 mm/s~75 mm/s之间变化时,速度引起波长的变化为0.173 nm。结合仿真实验得到了应力与光栅波长改变量的关系,为血液流动时产生周向应力的体外测量提供了新思路。     

Optical gap solitons: Past,present, and future; theory and experiments

Optical gap solitons refer to nonlinear waves propagating in optical fibers whose linear refractive index has a periodic variation. Stationary gap solitons came to light first in 1987 [Chen and Mills, Phys. Rev. Lett. 58, 160 (1987)]; two years later, they re-emerge in Christodoulides and Joseph [Phys. Rev. Lett. 62, 1746 (1989)] and are first extended to a more general traveling wave form in Aceves and Wabnitz [Phys. Lett. A 141, 37 (1989)]. But it was not until seven years later, that the first experimental demonstration [Eggleton et al., Phys. Rev. Lett. 76, 1627 (1996); J. Opt. Soc. Am. B 14, 2980 (1997)] was reported. Since then, there has been an increase in the study of the dynamics and applications of such solitons. This paper is a brief survey of some of the ongoing and future research on optical gap solitons. (c) 2000 American Institute of Physics.     

Editorial: Past,present and future of the combinatorial chemistry in Spain

Molecular Diversity -     

Real time imaging of catalytic reactions on surfaces: Past,present and future

Simple surface reactions like the CO-oxidation on single crystal platinum surfaces show a rich scenario of non-linear behavior under specific reaction parameters. Gerhard Ertl started in the late 1980s a new research group focusing on imaging of surface reactions to discover possible spatio-temporal pattern formation. Necessarily we conceived several unique imaging methods, which are discussed in the first part of the paper. An unexpected wealth of adsorbate patterns during the CO-oxidation on Pt was soon discovered and can be modeled by a reconstruction model. But the interaction of a multitude of micrometer scale concentration waves and fronts on the surface complicate our understanding of the underlying mechanisms for such patterns. We tackled those complications by constraining pattern formation within inactive or active boundaries formed by different metals evaporated onto the Pt single crystal, thereby isolating individual features of reaction diffusion systems (for example single pulses). Since 2001 we have been able to dynamically change the surface catalytic activity in real time and space by focusing an addressable laser beam to differentially heat a single crystal surface. Combining fixed microstructures made with different catalytic activities and the local heating of the surface opens new avenues of controlling pattern formation. In contrast to these approaches, varying one of the control parameters in time creates a globally coupled system, with the choice between direct forcing or a feedback experiment. In the last part temperature effects arising from the reaction heat are discussed, which become dominant at higher partial pressures for the reactants or on ultra thin samples where the reaction heat cannot be effectively dissipated into the bulk.     

The impact of infrared synchrotron radiation in biology: Past,present and future

The Synchrotron Radiation Center (SRC) at the University of Wisconsin-Madison was shut down permanently in March 2014. It began operation in 1968 as the world's first dedicated synchrotron radiation user facility. This revolutionary idea of using synchrotron radiation for broad support of science and technology proved a resounding success, and it subsequently led to worldwide development of ever more powerful light sources for R&;D in many major scientific and technical areas. With upgrades and groundbreaking initiatives, SRC remained a cutting-edge and cost-effective facility to the end. SRC filled an important niche for tough experiments that were not possible at the newer facilities, given their beam time constraints. The world of IR, VUV, and soft X-ray research has been diminished by its loss, but its closing was necessitated by higher priorities at the US NSF.     

脑磁图仪的前世今生与未来

脑磁图仪通过记录大脑神经活动在头皮外产生的磁场来进行脑活动的成像,它具备超高的时间分辨率和较高的空间分辨率,是一种重要的无创脑功能成像技术。文章介绍了脑磁信号的神经生理起源、生物物理特征及其与脑电信号的联系和区别,回顾了当前基于超导量子干涉仪的脑磁图设备与相关技术,并针对制约当前超导脑磁图发展的技术瓶颈,介绍了基于原子磁强计的新型脑磁探测技术及国内相关研究的最新进展,指出了脑磁图在脑科学研究及临床应用中不可或缺的地位和其硬件技术未来发展的方向。     

Surface passivation of III-V semiconductors for future CMOS devices—Past research, present status and key issues for future

Currently, III-V metal-insulator-semiconductor field effect transistors (MISFETs) are considered to be promising device candidates for the so-called “More Moore Approach” to continue scaling CMOS transistors on the silicon platform. Strong interest also exists in III-V nanowire MISFETs as a possible candidate for a “Beyond CMOS”-type device. III-V sensors using insulator-semiconductor interfaces are good candidates for “More Moore”-type of devices on the Si platform. The success of these new approaches for future electronics depends on the availability of a surface passivation technology which can realize pinning-free, high-quality interfaces between insulator and III-V semiconductors.This paper reviews the past history, present status and key issues of the research on the surface passivation technology for III-V semiconductors. First, a brief survey of previous research on surface passivation and MISFETs is made, and Fermi level pinning at insulator-semiconductor interface is discussed. Then, a brief review is made on recent approaches of interface control for high-k III-V MIS structures. Subsequently, as an actual example of interface control, latest results on the authors’ surface passivation approach using a silicon interface control layer (Si ICL) are discussed. Finally, a photoluminescence (PL) method to characterize the interface quality is presented as an efficient contactless and non-destructive method which can be applied at each step of interface formation process without fabrication of MIS capacitors and MISFETs.     

Theoretical studies at the Institute of Theoretical and Experimental Physics (ITEP, Moscow): Past, present, and future

Basic results obtained by theorical physicists at the Institute of Theoretical and Experimental Physics (ITEP, Moscow) over the 60 years of its existence are reviewed.     

Rapid biochemical profiling of endothelial dysfunction in diabetes,hypertension and cancer metastasis by hierarchical cluster analysis of Raman spectra

Raman spectroscopy is a label free, versatile, simple and fast method that is increasingly used to detect pathological changes in the cells and tissues that could be useful in medical diagnostics. In this work, we tested the hypothesis that Raman spectroscopy may serve to detect endothelial dysfunction in murine models of lifestyle diseases associated with endothelial dysfunction. For that purpose, we analysed spectra from ex vivo vessels taken from mice with diabetes, hypertension and cancer metastasis. We extracted 50–70 random, single spectra, recorded in 0.2 s, from endothelium of mice with diseases and respective control animals and subjected them to hierarchical cluster analysis. Independently on the sample preparation protocol, very good discrimination was obtained for three‐tested murine models, i.e. diabetes, hypertension and cancer metastasis. Obtained sensitivity and specificity parameters were between 93% and 96% (with the exception of sensitivity in the diabetes model equalled to 88%). Our results show that single, random spectra of endothelium, recorded in less than a second, contains enough information on biochemical content of the endothelium to detect endothelial dysfunction. Furthermore, we demonstrated that biochemical profile of the endothelial dysfunction in diabetes, hypertension or cancer metastasis differs with a very high specificity and sensitivity. This conclusion can be a good starting point for the development of in vivo fast diagnostic methodology of endothelium in the future. Copyright © 2016 John Wiley & Sons, Ltd.     

三维微纳米制造技术在癌症生物物理研究中的应用

癌症致命的主要原因是癌细胞在临床上的转移性. 癌细胞的侵袭和转移是一个非常复杂的三维过程, 但现有的癌症研究在活体上有诸多观测和操作上的困难. 而体外实验又通常在培养皿中进行, 其二维的生长环境已完全不能满足对癌细胞空间转移性的深入研究, 故在活体外构建出癌细胞侵袭和转移的三维物理模型具有十分重要的意义. 然而如何在体外尽可能真实地模拟体内癌细胞的生长微环境一直是困扰科学家的难题. 本文系统介绍了三维微纳米制造的几种主流技术, 探讨了它们在癌症生物物理研究中的应用和发展. 在此基础上为了在未来实现对体外三维模型的制造、观测和精确操作, 文章还创新性地提出了一种结合紫外线固化生物型水凝胶的三维成型技术、光片三维成像技术以及微纳米探针控制技术的一体化研究平台. 这些先进的技术和理念, 势必会逐步升级现有传统的癌症研究手段, 为未来理解和治疗癌症揭开全新的篇章.     

Development and validation of a three-dimensional,wave-current coupled model on unstructured meshes

Using unstructured meshes provides great flexibility for modeling the flow in complex geomorphology of tidal creeks,barriers and islands,with refined grid resolution in regions of interest and not elsewhere.In this paper,an unstructured three-dimensional fully coupled wave-current model is developed.Firstly,a parallel,unstructured wave module is developed.Variations in wave properties are governed by a wave energy equation that includes wave-current interactions and dissipation representative of wave breaki...     

Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development,cancer metastasis and antibody therapy against cancer

N-Acetylglucosaminyltransferase V (GnT-V), N-acetylglucosaminyltransferase III (GnT-III) and α1-6 fucosyltransferase (Fut8) catalyze reactions that form biologically important branching N-linked sugar chains in glycoproteins. The above three branching N-glycan sugar chains, β1-6 GlcNAc branching, bisecting GlcNAc and core fucose (α1-6 fucose), play major roles in cancer invasion and metastasis, the inhibition of cancer metastasis, and antibody-dependent cellular cytotoxicity (ADCC), growth and development, respectively. A functional glycomic approach identified the gain- and loss-of-functions of glycoproteins as the result of the aberrant glycosylation. A membrane-type metal dependent serine proteinase designated matriptase which contains β1-6 GlcNAc branching became resistant to auto-digestion and proteolysis by trypsin, and resulted in a constitutively active form which might be implicated in cancer invasion and metastasis. GnT-V also acts as an angiogenic factor without the mediation of functions as a glycosyltransferase. Recently, a GnT-V homologue, GnT-IX has been identified. This gene is expressed at relatively high levels in the brain and acts on N-glycans to form a unique branched structure, as well as O-mannosyl glycans. The addition of bisecting GlcNAc to various signaling molecules or adhesion molecules suppresses cancer metastasis. Fut8 knock-out mice, due to the lack of a core fucose (α1-6 fucose) in target glycoproteins, show disorders in growth and development. The presence of a bisecting GlcNAc or the absence of a core fucose in IgG molecules enhances ADCC activity for killing tumor cells by up to 10 to 100 fold and therefore is thought to have considerable use in antibody therapy against cancer. These data clearly indicate that gain- and loss-of-functions of target proteins for these glycosyltransferases are biologically important.