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1.
Goswami S Mukherjee R Mukherjee R Jana S Maity AC Adak AK 《Molecules (Basel, Switzerland)》2005,10(8):929-936
The syntheses in good yields of some new difunctionalized 1,8-naphthyridines 4, 6, 8 and 9 and a novel triethylene glycol ether-linked dinaphthyridine, 10a, along with the mononaphthyridine-linked ether alcohol 10b are described. An improved and milder method for the synthesis of 2,7-diamino-1,8-naphthyridine (14) is also reported. 相似文献
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[reactions: see text] The catalytic amidation between 2-chloro- and 2,7-dichloro-1,8-naphthyridines and primary amides bearing functional groups is reported. When Pd(OAc)2, xantphos, and K2CO3 are used, it is possible to obtain symmetric as well as nonsymmetric 2,7-diamido-1,8-naphthyridines in 50-90% yield with good functional-group tolerance. Monoamidation of 2,7-dichloro-1,8-naphthyridine using 0.9 equiv of the amide proceeded with good selectivity compared to the formation of the diamide, but as a result of the difficult isolation of the product, isolated yields were poor to moderate (22-42%). 相似文献
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Shuntaro Mataka Kazufumi Takahashi Masashi Tashiro 《Journal of heterocyclic chemistry》1983,20(4):971-974
Di- and triphenyldibenzoylpyridines ( 1 ) were prepared by the condensation reaction of 3, 4-dibenzoyl-2, 5-diphenylthiophene ( 2 ) with methylamine derivatives 3 and by the subsequent oxidative ring cleavage of the resultant thieno[3, 4-c]pyridines 4 . The reaction of 1 with 3 afforded polyphenyl-2, 6- ( 5 ) and -2, 7-naphthyridines ( 6 ). 相似文献
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G. P. Sagitullina L. V. Glidzinskaya R. S. Sagitullin 《Russian Journal of Organic Chemistry》2006,42(8):1203-1207
A two-component Hantzsch synthesis was applied to preparation of nitropyridines and their quaternary salts from various enamines and chalcones based on nitroacetophenone. The recyclization of nitropyridinium quaternary salts under the treatment with an aqueous-alcoholic alkali led to preparation of 5′-methylamino-2′-nitro-m-terphenyl derivatives. 相似文献
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Raymond N. Castle William D. Guither Peter Hilbert Fritz E. Kempter Natu R. Patel 《Journal of heterocyclic chemistry》1969,6(4):533-538
2,7-Dimethyl-4,5,9,10-tetraazapyrene (VI) was synthesized by the catalytic hydrogenation of 4,4′-dimethyl-2,2′,6,6′-tetranitrobiphenyl (IIa) with W-2 Raney nickel in the presence of alkali. 4,4′-Dicarbomethoxy-2,2′,6,6′-tetranitrobiphenyl (IIc) under similar conditions in neutral medium gave 4,4′-dicarbomethoxy-2,2′,6,6′-tetraaminobiphenyl (IV) which on oxidation gave 2,7-dicarbomethoxy-4,5,9,10-tetraazapyrene (V). 2,7-Dimethyl-, 2,7-dimethoxy-, and 2,7-diacetamido-4,5,9,10-tetraazapyrene di-N-oxides (III a,b,c) were obtained by catalytic reduction of the corresponding 4,4′-disubstituted-2,2′,6,6′-tetranitrobiphenyls with W-7 Raney nickel in the presence of alkali. Compound VI on oxidation with hydrogen peroxide gave the di-N-oxide (IIIa). 相似文献
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《Tetrahedron letters》1988,29(45):5725-5728
N-(tert-butoxycarbonyl)anilines (7), are easily converted in a one pot reaction sequence into the N- (tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinolines (8), by directed ortho lithiation followed by reaction with 1- chloro-3-iodopropane, hence providing a new versatile quinoline ring nucleus synthesis. In an analogous reaction 2-N-(tert-butoxycarbonyl)- and an 2-N-(pivaloylamino) pyridine are converted to 1,2,3,4-tetrahydro-1,6- naphthyridines. 相似文献
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Condensation of -chloro-o-hydroxyacetophenones in the presence of perchloric acid yields 4-chloromethylflavylium perchlorates. 4-Chloromethylbenzothiapyrilium perchlorates were obtained by intramolecular cyclization of 2-arylmercapto-5-chloropentanones-4. In the reaction of 4-chloromethylflavylium salts with aqueous alkali, chloromethyleneflavenes (the anhydro bases of the starting salts) and 3-phenacylbenzo[b]furanes were separated.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 766–769, June, 1987. 相似文献
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The structure of the product obtained from the reaction of potassium amide in liquid ammonia on 1,5-naphthyridine has been identified as 4-amino-1,5-naphthyridine by comparison with a known sample. The 2-amino isomer was not detected in the mixture. The NMR spectra for 2-and 4-amino-1,5-naphthyridine along with the corresponding chloroisomers are described. 相似文献
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R. M. Titkova A. S. Elina E. A. Trifonova I. V. Persianova N. P. Solov'eva E. M. Peresleni T. A. Gus'kova Yu. N. Sheinker 《Chemistry of Heterocyclic Compounds》1981,17(6):583-590
4-Substituted 1,5-naphthyridines and their N-oxides were synthesized, and their structures and properties were studied. The IR and UV spectra of 4-hydroxy- and 4-methoxy-1,5-naphthyridines and their 1-oxides and 1-ethyl-4-oxo-1,4-dihydro-1,5-naphthyridine were examined. It is shown that 4-hydroxy-1,5-naphthyridine and its 1-oxide exist in the crystalline state in the lactam form. A quantitative estimate of the position of the tautomeric equilibrium of 4-hydroxy-1,5-naphthyridine as a function of the polarity of the solvent is given, and the tautomeric equilibrium constants and the percentages of the lactim form are calculated. The basicity constants of 4-chloro-, 4-methoxy-, 4-hydrazino-, 4-methylthio-, 4-acetamido-, and 4-amino-1,5-naphthyridines were measured. A comparison of the calculated and experimental pKa data provides evidence in favor of the fact that the compounds are protonated at the N1 atom. A correlation of the basicity constants with the substituent constants is examined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 792–799, June, 1981. 相似文献
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以4,6-二甲基-2-甲氧基-1,3-苯二甲酸二乙酯为原料,经Micheal加成、环化、溴化、消除等5步反应,合成新型的多取代2,7-萘二甲酸二乙酯.该合成路线步骤少,收率高,反应条件温和.产物中的4个新化合物的结构均经元素分析、核磁共振、红外光谱和质谱确证. 相似文献
15.
Summary Some homogeneous and mixed polyarylates were synthesized from 2,7-dihydroxyxanthene-9,9-spirofluorene and some of their properties were studied.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimisheskaya, No. 7, pp. 1286–1288, July, 1965 相似文献
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M. A. KirpichËok S. K. Gorozhankin D. S. Yufit Yu. T. Struchkov P. B. Kurapov I. I. Grandberg 《Chemistry of Heterocyclic Compounds》1989,25(6):621-631
Stable 2,7-diaminobenzopyrylium tetrafluoroborates were obtained by the successive treatment of 7-diethylaminocoumarin, 4-methyl-7-diethylaminocoumarin, and 9-methyl-1H,5H-quinolizino[9,9a,1-gh]coumarin with triethyloxonium tetrafluoroborate and amines, viz., diethylamine, piperidine, morpholine, benzylamine, and aniline. The spectral-luminescence characteristics of the synthesized compounds were investigated. The data from the 13C NMR spectra and x-ray diffraction analysis confirm the greater participation of the 2-amino group as compared with the 7-amino group in stabilization of the positive charge of the pyrylium system.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 755–766, June, 1989. 相似文献
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The Suzuki-Miyaura reaction of methyl-5-bromo-8-(tosyloxy)-1,6-naphthyridine-7-carboxylate(5),with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate(7), whereas 1 equiv. of arylboronic acid resulted in site-selective formation of 5-aryl-8-(tosyloxy)-1,6-naphthyridine-7-carboxylate(8). The reactions proceeded with excellent chemo-selectivity in favor of the bromide group. Likewise, one-pot reaction with completely different boronic acids by sequential addition produced 1,6-naphthyridine-7-carboxylates,(10) containing two different aryl groups at 5 and 8 positions. 相似文献