磁共振成像的正交线圈数字合成方法研究

当采用正交线圈来提高接收通道的性能时,合成方法对整体效果有很大的影响. 由于在一般情况下正交线圈的2个线圈的信噪比存在不平衡,故需要采用加权合成的方法来优化合成图像的信噪比. 在现有的模拟合成方法中,加权系数是固定的,不能根据每次扫描的实际情况来确定最优的参数,因此无法得到最佳的合成效果. 该文提出一种简单的磁共振正交线圈成像的数字合成方法,它采用2个完全独立的接收通道来采集磁共振信号,根据两通道信号的特性来动态地确定I/Q线圈的加权因子,最后进行加权合成.     

Visualization of 50 MHz Surface Acoustic Wave Propagation Using Stroboscopic Phase-Shift Interferometry

A Stroboscopic phase-shift interferometry has been developed to visualize surface acoustic wave (SAW) propagation on SAW devices quantitatively. The developed interferometry is a Fizeau-type one with a multi-mode semiconductor laser diode and an optical isolator. With the laser light illuminating stroboscopically, observed interference intensity gives information about average displacements of the vibrations. Fifty MHz SAW propagation on the surface of the SAW device has been measured with the interferometry. Distribution of the SAW along the propagation path has been observed, whose amplitude is 3 nm (p-p). Repetition accuracy evaluated with the root mean square method is 1/2500 of the laser wavelength. The system is useful for estimating and improving performances of micro-devices.Presented at 1996 International Workshop on Interferometry (IWI ‘96), August 27-29, Saitama, Japan.     

Small Quantum Structures with Small State Spaces

We summarize and extend results about “small” quantum structures with small dimensions of state spaces. These constructions have contributed to the theory of orthomodular lattices. More general quantum structures (orthomodular posets, orthoalgebras, and effect algebras) admit sometimes simplifications, but there are problems where no progress has been achieved.     

Visualization of Digestion Process Using <Superscript>19</Superscript>F MRI

Tracing parameters of digestion process could help in setting more accurate diagnosis for patients with gastrointestinal diseases. For this purpose, we suggest a new type of food tracer. By soaking liquid perfluorocarbon in dry rodent food, each step of digestion process can be visualized on ¹⁹F-magnetic resonance (MR) images. Compared with liquid contrast agents, food is able to fill organs of gastrointestinal tract more tightly and yield properties of digestion process. However, rats, participating in such study, should be set on a water diet before experiment. ¹⁹F-MR images are obtained with volume scanning (3D) pulse sequence based on multiple spin echo methodic with minimal time intervals between echoes. Gastrointestinal ¹⁹F-magnetic resonance imaging (MRI) visualization is a harmless real-time tracking method which could be easily transferred into clinical practice. Moreover, it does not apply ionizing radiation, so in the combination with reference ¹H-MRI this method could become very useful in treatment process assessment.     

Shockwave Visualization Using Holographic Interferometer

High-speed holographic interferometry was employed to visualize and record Shockwave phenomena. We performed three kinds of holographic interferometry for visualization and recording of the propagation of a Shockwave: a real-time holographic interferometer with a high-speed framing camera, a real-time holographic interferometer with a high-speed streak camera and a double-pulse laser holographic interferometer with a dual-reference-beam module. The experimental results were compared and their advantages and disadvantages are discussed. The experimental results clearly show the high-speed Shockwave propagation and give the feasibility of quantitative interpretation of high-speed gas-dynamics.     

MRI评价药物投递性能方法研究

采用MRI评价自制肝组织特异性非离子型高分子磁共振造影剂在小鼠体内药物投递效果. 分别在注射造影剂后0.1 h、6 h、12 h、24 h及7天采集磁共振T₁加权图像. 所有扫描均在1.5T临床磁共振成像仪上完成, 以固定体线圈为射频发射线圈, 三英寸圆形表面线圈为信号接收线圈. 数据分析前采用线圈非均匀性校正和信号非稳定性校正进行预处理. 实验结果显示,线圈空间敏感性校正使得小鼠组织图像信号强度空间更加均匀,稳定性校正后使得图像数据更加准确可靠,MRI是一种在体评价顺磁性标记高分子化合物药物投递效果的有效方法.     

Surface and Gradiometer Coils near a Conducting Body: The Lift-off Effect

The use of surface coils in magnetic resonance is widespread. Examples include MRI, detection of subsurface aquifers by NMR, and, more recently, landmine detection by nuclear quadrupole resonance. In many of these cases a finite-sized sample to be examined is contained within a larger medium that is a poor electrical conductor, and eddy currents induced by the RF fields provide a loss mechanism that reduces the effective quality factorQof the transmitter and receiver coils. Here the losses induced in a circular surface coil (a horizontal loop antenna) separated a distance from a dissipative medium are calculated and compared to measurements. It is shown that often the overall efficiency of the coil for magnetic resonance can be improved by displacing the coil away from the conducting medium a prescribed “lift-off” distance. The use of a gradiometer as a surface coil is also examined, and it is shown by theory and experiment that in certain circumstances such a gradiometer can be more efficient than a conventional surface coil for inspection of conducting media.     

周期栅格结构表面的零反射现象

为研究周期微栅格对材料法向反射特性的影响规律,利用时域有限差分(FDTD)方法计算周期在6~14μm之间的一维硅栅格结构的光谱法向反射率,通过选择合适的栅格轮廓和参数,在不同波长位置实现零反射现象.在此基础上分析三角形栅格的深度H和刻蚀宽度L对其光谱法向反射率的影响,发现在3.23μm和8.7μm附近实现零反射现象的最佳栅格参数.     

Polarization-Phase Visualization and Processing of Coherent Images of Fractal Structures of Biotissues

A polarization-phase method of visualization of optically anisotropic inhomogeneities of biotissues, which is based on multifractal modeling of biotissue properties, is proposed. An algorithm for obtaining topograms of orientations of the fractal domains of a visualized architectonic net of a biotissue is developed and realized experimentally.     

Surface Plasmon Polaritons of Two-Dimensional Three-Order Dendritic Structures

We study surface plasmon polaritons excited on two-dimensional three-order dendritic structures. Previous studies show that split ring resonators (SRRs)
can be used to obtain magnetic resonance, thus sustaining surface waves behaving like surface plasmon polaritons (SPPs). In this paper, we obtain detailed results on surface plasmon polaritons of several different grating structures and theoretically prove that this kind of structures can sustain SPPs. Besides, since dendritic structures can be fabricated by double template-assisted electrochemical deposition, it is worth noting that fabrication of SPP-based materials might be much easier.     

超极化气体肺部磁共振成像

磁共振成像(MRI)技术具有非侵入、无放射性的特点,在临床疾病诊断中具有独特的优势,但是肺部空腔的特殊结构使传统质子MRI无法对其直接成像.自旋交换光抽运(SEOP)方法可以使惰性气体原子的极化度增强4个量级以上,从而使肺部的气体MRI成为可能.该文介绍了超极化惰性气体肺部MRI的最新研究进展,包括超极化气体磁共振相关参数的测量方法、肺部通气结构成像、肺部气体交换功能成像,同时比较了常用于肺部MRI气体的优点和缺点.     

Visualization of Isofrequency Contours of Strongly Localized Waveguide Modes in Planar Dielectric Structures

An experimental method has been proposed to study the dispersion properties of optical surface and waveguide modes in planar structures. An experimental setup involves a microscope with a high numerical aperture objective and a hemispherical solid immersion lens made of zinc selenide in contact with the sample surface. The reflection from the sample is detected in the back focal plane of the system. Such a configuration makes it possible to study strongly localized states with an effective refractive index up to 2.25 in the visible and near infrared spectral ranges. For a thin silicon layer deposited on a glass substrate, the possibility of visualization of isofrequency contrours with polarization resolution and the reconstruction of dispersion of waveguide modes depending on the direction of their propagation has been demonstrated.     

Investigation of Neurovascular Structures Using Phase-Modulation Spectrophotometry

Optics and Spectroscopy - We investigated the possibility of using phase-modulation spectrophotometry for the detection and recognition of large blood vessels and nerves in the volume of biological...     

Improved paramagnetic chelate for molecular imaging with MRI

The relaxivity and transmetallation of two lipophilic paramagnetic chelates incorporated onto perfluorocarbon nanoparticles, i.e., gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid phosphatidylethanolamine (Gd-MeO-DOTA-PE) and gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid triglycine phosphatidylethanolamine (Gd-MeO-DOTA-triglycine-PE (Gd-MeO-DOTA-triglycine-PE)), were compared to a prototypic gadolinium-diethylene-triamine-pentaacetic acid bis-oleate (Gd-DTPA-BOA) paramagnetic formulation. Nanoparticles with MeO-DOTA-based chelates demonstrated higher relaxivity (40% higher for Gd-MeO-DOTA-PE and 55% higher for Gd-MeO-DOTA-triglycine-PE) and less transmetallation than the original Gd-DTPA-BOA-based agent.     

Improved matrix inversion in image plane parallel MRI

A new 3D parallel magnetic resonance imaging (MRI) method named Generalized Unaliasing Incorporating Support constraint and sensitivity Encoding (GUISE) is presented. GUISE allows direct image recovery from arbitrary Cartesian k-space trajectories. However, periodic k-space sampling patterns are considered for reconstruction efficiency. Image recovery methods such as 2D SENSE (SENSitivity Encoding) and 2D CAIPIRINHA (Controlled Aliasing In Parallel Imaging Results IN Higher Acceleration) are special instances of GUISE where specific restrictions are placed on the k-space sampling patterns used. It is shown that the sampling pattern has large impacts on the image reconstruction error due to noise. An efficient sampling pattern design method that incorporates prior knowledge of object support and coil sensitivity profile is proposed. It requires no experimental trials and could be used in clinical imaging. Comparison of the proposed sampling pattern design method with 2D SENSE and 2D CAIPIRINHA are made based on both simulation and experiment results. It is seen that this new adaptive sampling pattern design method results in a lower noise level in reconstructions due to better exploitation of the coil sensitivity variation and object support constraint. In addition, elimination of the non-object region from reconstruction potentially allows an acceleration factor higher than the number of receiver coils used.     

五层对称人工超常材料结构的表面等离子体激元

研究了由左手材料、负介电材料、常规介电材料所构成的几种五层对称结构表面等离子体激元的特性.讨论了表面等离子体激元的存在区域、色散关系、以及p和s偏振的表面色散曲线枝,发现表面模的性质强烈依赖于系统的组成材料及其组合方式|层数越多,表面色散曲线枝也越多,处在频率通带的表面极化模态也越多|在五层结构中有p和s两种偏振的表面等离子体激元,在共振时,可导致p波和s波强透射.此外,通过使用衰减全反射方法,探讨了激发并观察表面等离子体激元的可能性.     

Formation of Ordered Silicon Structures on a Graphite Surface

Physics of the Solid State - The possibility of formation of ordered silicon structures, including silicene, on the graphite substrate surface has been studied. The effect of various conditions of...     

五层对称人工超常材料结构的表面等离子体激元

研究了由左手材料、负介电材料、常规介电材料所构成的几种五层对称结构表面等离子体激元的特性.讨论了表面等离子体激元的存在区域、色散关系、以及p和s偏振的表面色散曲线枝,发现表面模的性质强烈依赖于系统的组成材料及其组合方式;层数越多,表面色散曲线枝也越多,处在频率通带的表面极化模态也越多;在五层结构中有p和s两种偏振的表面等离子体激元,在共振时,可导致p波和s波强透射.此外,通过使用衰减全反射方法,探讨了激发并观察表面等离子体激元的可能性.