共查询到20条相似文献,搜索用时 78 毫秒
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合成了5种氨基酸席夫碱Sal-Gly(甘氨酸席夫碱)、Sal-Glu(谷氨酸席夫碱)、Sal-Met(甲硫氨酸席夫碱)、Sal-Tyr(酪氨酸席夫碱)、Sal-Arg(精氨酸席夫碱)及其金属锌离子配合物共10种化合物.用元素分析、核磁共振、红外光谱、紫外-可见光谱等手段对其组成的结构进行表征.以Sal-Tyr-Zn为主体,咪唑(1),1-甲基-咪唑(2),2-乙基-4-甲基咪唑(3),吡唑(4),4-碘苯胺(5),DABCO(1,4-重氮双环[2,2,2]辛烷)(6),邻苯二胺(7)和1,2-环己二胺(8)为客体,进行配位相互作用研究.选取大肠杆菌作为抑菌菌种,研究了氨基酸席夫碱的抑菌能力.结果表明,氨基酸席夫碱配体及金属锌配合物对大肠杆菌均有抑菌活性,配体的抗菌活性随氨基酸残基的增大而减小.金属锌配合物的抑菌活性大于其所对应的氨基酸席夫碱配体的抑菌活性,活性最大的则为Sal-Arg-Zn. 相似文献
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在微波辐射无溶剂条件下快速、高产率地合成了2,4,6-三芳基吡啶四氟硼酸盐化合物, 并对其进行核磁共振、红外光谱、元素分析表征. 同时得到了化合物4f的晶体, 对其进行了X单晶射线衍射表征. 结果表明, 该晶体属正交晶系, 空间群Pbca, a=2.1050(2) nm, b=1.64360(17) nm, c=2.9209(3) nm, α=β=90.00°, γ=90.00°, Dc=1.276 g•cm-3, V=10.1057(17) nm-3, Z=16. 相似文献
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微波辐射和加热条件下的无催化剂无溶剂Knoevenagel缩合反应 总被引:12,自引:0,他引:12
芳香醛和丙二腈在无催化剂无溶剂存在下在微波辐射或加热条件下可以发生Knoevenagel缩合反应,反应产率良好. 相似文献
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氨基酸席夫碱配合物的制备及性能研究进展 总被引:15,自引:0,他引:15
研究表明,某些含有-N=CH-基团的有机化合物具有一定的抗癌作用,它与某些金属生成配合物后效果更加显著。氨基酸是组成酶和蛋白质的基本单元,与含活泼羰基的化合物形成含有多个强电负性配位原子的席夫碱,此类席夫碱具有较强的配位能力和多样的配位模式的优点,研究其与金属离子配位所形成配合物可以为研究抗肿瘤、抗癌药物提供信息。80年代以来,有不少关于研究过渡金属离子与氨基酸席夫碱配合物的合成和性质的报道,并进行了大量生物生理活性的研究旧剖。本文综述了近年来国内外有关氨基酸席夫碱配合物的制备及其性能应用。 相似文献
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Juan I. Sarmiento-Sánchez Adrián Ochoa-Terán Lorenzo A. Picos-Corrales Lorenzo U. Osuna-Martínez Julio Montes-Ávila Pedro Bastidas-Bastidas 《Green Chemistry Letters and Reviews》2016,9(4):196-202
Benzoxazinediones exhibit potential as versatile synthons in the synthesis of wide variety of heterocyclic compounds with biological activity. In this work, an efficient and eco-friendly one-step synthesis of benzoxazine-2,4-diones from phthalic anhydrides derivatives and trimethylsilyl azide using the microwave technique was developed and compared with conventional heating. Microwave irradiation plays a critical role in driving the reaction and providing access to products and/or regioisomers not available from conventional heating. Thus, the regioselectivity of the reaction may be modulated by the irradiation time. Depending on the method employed the benzoxazinediones were isolated with yields in the range of 30–90%. 相似文献
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以水飞蓟宾和氨基酸为原料,通过常规方法合成了一系列具有靶向性的水飞蓟宾-氨基酸席夫碱,并对其抗肿瘤作用进行研究.采用核磁共振碳谱、质谱和红外光谱对已合成的水飞蓟宾-氨基酸席夫碱(氨基酸=甘氨酸(1)、丙氨酸(2)、赖氨酸(3)、苯丙氨酸(4)、谷氨酸(5)、半胱氨酸(6))进行结构表征.采用MTT法对化合物1-6及水飞蓟宾进行抗肝癌细胞SMMC-7721的活性研究,抑制率分别为70.2%,53.7%,47.8%,55.6%,49.2%,51.8%,33.3%.体外抗肿瘤活性实验表明,水飞蓟宾-氨基酸席夫碱系列化合物对人肝癌细胞株SMMC-7721均有抑制作用,且明显高于水飞蓟宾母核.实现了以氨基酸为载体,将具有抗肿瘤活性的天然药物靶向运输至癌细胞内,极具肝靶向药物开发潜力. 相似文献
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An efficient method for ring-closing metathesis under solvent-free conditions and by microwave activation was established. Non-thermal microwave specific effects were evident. 相似文献
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The one-pot, three-component condensation of benzil, benzonitrile derivatives and primary amines on the surface of silica gel under solvent-free conditions and microwave irradiation provided tetrasubstituted imidazoles in high yields. 相似文献
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The recently developed Gross's method for the synthesis of corroles has been modified and successfully applied to the preparation of new free base tris-aryl- and tris-pyrimidyl-corroles using solvent-free conditions and microwave irradiation. Compared to conventional heating, the microwave technique afforded an increase in corrole yields of ca. 30% and led to noticeably cleaner reaction mixtures. It is demonstrated that short reaction times and high temperatures are required to afford optimum yields. 相似文献
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沙利度胺(Thalidomide)又名反应停,化学名称为N-2-(2,6-二氧-3-哌啶基)-邻苯二甲酰亚胺[N-2-(2,6-dioxo-3-piperidinyl)-phthalidomide],是一种合成类谷氨酸衍生物,曾因致畸副作用而一度停止对其的研究[1].但上个世纪末期,Sampaio[2]等曾报道,沙利度胺可抑制体外LPS刺激原代人体单核细胞生成TNF-α,Kenyon[3]等的研究表明(S)-沙利度胺有着很强的抑制血管生成作用,再度引发了科学界对沙利度胺及其相关衍生物的研究兴趣. 相似文献
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Javad Safari Sayed Hossein Banitaba Shiva Dehghan Khalili 《Arabian Journal of Chemistry》2011,4(1):11-15
Silica sulfuric acid was found to be an efficient, reusable and environment-friendly catalyst for fast hydrolysis of various isobenzofuranone to corresponding 2-ketomethylquinoline derivatives in a high yield under solvent-free using microwave irradiation. As the activator of silica sulfuric acid the wet SiO2 was chosen. The reactions in conventional conditions were compared with the microwave assisted reactions. This approach can prove beneficial since the recovery of solvents from conventional reaction systems always results in some losses. 相似文献