Addition of protic molecules to coordinated 2-pyridinecarboxaldehyde in gold(III), palladium(II), and platinum(II) complexes

The reactions of Au^III, Pt^II and Pd^II complexes with 2-pyridinecarboxaldehyde (2CHO-py) have been examined in protic (H₂O, MeOH, EtOH) and aprotic (DMF, CH₂Cl₂) solvents. Compounds in which the pyridine ligand is N-coordinated, either in the original aldehydic form or in a new form derived from addition of one or two protic molecules, have been isolated, namely: [Au(2CHO-py · H₂O)Cl₃], [Au(2CHO-py · MeOH)Cl₃], [Au(2CHO-py · 2EtOH)Cl₃], cis-[Pt(2CHO-py)₂Cl₂], trans-[Pd(2CHO-py)₂Cl₂], trans-[Pt(dmso)(2CHO-py)Cl₂], [Pt{C₅H₄N-(CH₂SMe)}Cl(2CHO-py)](ClO₄), [Pt(terpy)(2CHOpy)](ClO₄)₂, [Pt(terpy)(2CHO-py · H₂O)](ClO₄)₂ (terpy = 2,2′:6′,2′′-terpyridine). ¹H-n.m.r. experiments show that the addition of the protic molecule(s) to the Pt^II and Pd^II complexes is reversible. The effects of the nature of the metal ion and the ancillary ligands as well as of the total charge of the complexes on the relative stability of the addition products are discussed. This revised version was published online in June 2006 with corrections to the Cover Date.     

Coordination compounds of 2-mercapto-1-methylimidazole with platinum(II), palladium(II), rhodium(III) and ruthenium(III)

Summary Complexes of 2-mercapto-1-methylimidazole (TMZ) with Pt^II, Pd^II, Rh^III and Ru^III of the general formulae Pt(TMZ)₂Cl₂, Pd(TMZ)₄Cl₂. Rh(TMZ)Cl₃ and Ru(TMZ)Cl₃ have been obtained. The thermal stabilities of the compounds were estimated by derivatographic measurements and the electron-donating atom of the measurements and the electron-donating atom of the ligand was identified from the i.r. absorbtion spectra. Lattice constants for the Pt^II and Pd^II complexes were estimated from their x-ray powder diffraction patterns.     

Synthesis, characterization and crystal structure determination of platinum(IV) complexes containing, bipyridine derivatives and chloride, [Pt(5,5′-dmbipy)Cl4] and [Pt(6-mbipy)Cl4]

The complex [Pt(5,5′-dmbipy)Cl₄] (1) (5,5′-dmbipy is 5,5′-dimethyl-2,2′-bipyridine) was prepared from the reaction of H₂PtCl₆·6H₂O with 5,5′-dimethyl-2,2′-bipyridine in methanol. The same method was employed to make [Pt(6-mbipy)Cl₄] (2) (6-mbipy is 6-methyl-2,2′-bipyridine). Both complexes were characterized by elemental analysis, IR, UV–Vis, ¹H NMR, ¹³C NMR and ¹⁹⁵Pt NMR spectroscopy. Their solid state structures were determined by the X-ray diffraction method.     

Outer-sphere electron-transfer reactions with the participation of platinum(IV) haloammines

The kinetics of some outer-sphere electron-transfer reactions with the participation of the complexes [Pt(NH₃)_nX_6–n]² (n=6–0, X=Cl^–, Br^–) and dipyridyl complexes of Os(II), Ru(II), Ir(III), and Cr(II) have been investigated by means of luminescence-quenching measurements and flash photolysis. Estimates of the values of the Pt(IV)/Pt(III) one-electron potential and the change in the free energy of activation of electron self-exchange processes of the type Pt(IV) Pt(III) have been obtained on the basis of an analysis of the dependence of the rate constant on the change in the free energy accompanying the electrontransfer process.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 26, No. 4, pp. 455–462, July–August, 1990.     

Rh(III), Pd(II), Pt(IV) and Au(III) complexes of 2-thiopyrimidine derivatives

Some news thiopyrimidine derivatives and complexes [4-amino-5-nitroso-6-oxo-1,2,3,6-tetrahydro-2-thio-pyrimidine (TANH), its 2-methylthio derivative (MTH), the ammonium salt ofTANH (sTANH) and six new complexes of formulas: Rh(MT)₂Cl · 2H₂O, Pd(MTH)₂Cl₂, Pt(MTH)₂Cl₄, Au(MTH)Cl₃ Pd(TANH)₂Cl₂ and Au(TAN ^–)Cl] have been synthesized and characterized by elemental analysis, IR and¹H-NMR spectroscopy techniques. The thermal behaviour of all compounds has also been studied.

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Rh(III), Pd(II), Pt(IV) und Au(III) Komplexe von 2-Thiopyrimidin Derivaten

Zusammenfassung Es wurden einige neue Thiopyrimidinderivate und deren Komplexe synthetisiert und mittels Elementaranalyse, IR und¹H-NMR charakterisiert: 4-Amino-5-nitroso-6-oxo-1,2,3,6-tetrahydro-2-thio-pyrimidin (TANH), dessen 2-Methylthio-Derivat (MTH), das Ammoniumsalz vonTANH (sTANH) und sechs neue Komplexe der Formeln Rh(MT)₂Cl · 2H₂O, Pd(MTH)₂Cl₂, Pt(MTH)₂Cl₄, Au(MTH)Cl₃, Pd(TANH)₂Cl₂ und Au(TAN ^–)Cl. Das thermische Verhalten der Verbindungen wurde ebenfalls untersucht.

     

Influence of the chloride counterion on the redox reactivity of tetraammineplatinum(II) cation with octacyanotungstate(V) anion: Crystal structure of [Pt(NH3)4]2[W(CN)8]

The redox reaction between [Pt(NH₃)₄]²⁺ and [W(CN)₈]³⁻ in the presence of Cl⁻ anions in aqueous solution affords single crystals of [Pt^II(NH₃)₄]₂[W^IV(CN)₈] and [Pt^IV(NH₃)₄Cl₂]Cl₂. Trapped cyano ligands of [W(CN)₈]⁴⁻ rectangular antiprisms of D₂ point symmetry between parallel Pt(II) square planes show that the inner-sphere redox pathway is prohibited. The presence of Cl⁻ counterions enables the formation of [Pt(NH₃)₄Cl₂]Cl₂ as the product of the rare outer-sphere pathway of the oxidation of Pt(II) by [W(CN)₈]³⁻.     

Darstellung,Kristallstrukturen und Schwingungsspektren von [Pt(N3)6]2– und [Pt(N3)Cl5]2–, 195Pt‐ und 15N‐NMR‐Spektren von [Pt(N3)nCl6–n]2– und [Pt(15NN2)n(N215N)6–n]2–, n = 0–6

Synthesis, Crystal Structures, and Vibrational Spectra of [Pt(N₃)₆]^2– and [Pt(N₃)Cl₅]^2–, ¹⁹⁵Pt and ¹⁵N NMR Spectra of [Pt(N₃)_nCl_6–n]^2– and [Pt(¹⁵NN₂)_n(N₂¹⁵N)_6–n]^2–, n = 0–6 By ligand exchange of [PtCl₆]^2– with sodium azide mixed complexes of the series [Pt(N₃)_nCl_6–n]^2– and with ¹⁵N‐labelled sodium azide (Na¹⁵NN₂) mixtures of the isotopomeres [Pt(¹⁵NN₂)_n(N₂¹⁵N)_6–n]^2–, n = 0–6 and the pair [Pt(¹⁵NN₂)Cl₅]^2–/[Pt(N₂¹⁵N)Cl₅]^2– are formed. X‐ray structure determinations on single crystals of (Ph₄P)₂[Pt(N₃)₆] ( 1 ) (triclinic, space group P1, a = 10.175(1), b = 10.516(1), c = 12.380(2) Å, α = 87.822(9), β = 73.822(9), γ = 67.987(8)°, Z = 1) and (Ph₄As)₂[Pt(N₃)Cl₅] · HCON(CH₃)₂ ( 2 ) (triclinic, space group P1, a = 10.068(2), b = 11.001(2), c = 23.658(5) Å, α = 101.196(14), β = 93.977(15), γ = 101.484(13)°, Z = 2) have been performed. The bond lengths are Pt–N = 2.088 ( 1 ), 2.105 ( 2 ) and Pt–Cl = 2.318 Å ( 2 ). The approximate linear azido ligands with N^α–N^β–N^γ‐angles = 173.5–174.6° are bonded with Pt–N^α–N^β‐angles = 116.4–121.0°. In the vibrational spectra the PtCl stretching vibrations of (n‐Bu₄N)₂[Pt(N₃)Cl₅] are observed at 318–345, the PtN stretching modes of (n‐Bu₄N)₂[Pt(N₃)₆] at 401–428 and of (n‐Bu₄N)₂[Pt(N₃)Cl₅] at 408–413 cm^–1. The mixtures (n‐Bu₄N)₂[Pt(¹⁵NN₂)_n(N₂¹⁵N)_6–n], n = 0–6 and (n‐Bu₄N)₂[Pt(¹⁵NN₂)Cl₅]/(n‐Bu₄N)₂[Pt(N₂¹⁵N)Cl₅] exhibit ¹⁵N‐isotopic shifts up to 20 cm^–1. Based on the molecular parameters of the X‐ray determinations the vibrational spectra are assigned by normal coordinate analysis. The average valence force constants are f_d(PtCl) = 1.93, f_d(PtN^α) = 2.38 and f_d(N^αN^β, N^βN^γ) = 12.39 mdyn/Å. In the ¹⁹⁵Pt NMR spectrum of [Pt(N₃)_nCl_6–n]^2–, n = 0–6 downfield shifts with the increasing number of azido ligands are observed in the range 4766–5067 ppm. The ¹⁵N NMR spectrum of (n‐Bu₄N)₂[Pt(¹⁵NN₂)_n(N₂¹⁵N)_6–n], n = 0–6 exhibits by ¹⁵N–¹⁹⁵Pt coupling a pseudotriplett at –307.5 ppm. Due to the isotopomeres n = 0–5 for terminal ¹⁵N six well‐resolved signals with distances of 0.03 ppm are observed in the low field region at –201 to –199 ppm.     

Mononuclear and heterobimetallic palladium(II) and platinum(II) complexes containing the mixed ligands <Emphasis Type="Italic">N</Emphasis>-(2-pyridyl or 2-pyrimidyl) acetamide and tertiary diphosphine

Palladium(II) and platinum(II) complexes containing mixed ligands N-(2-pyridyl)acetamide (AH) or N-(2-pyrimidyl)acetamide (BH) and the diphosphines Ph₂P(CH₂) _n PPh₂, (n = 1, 2 or 3) have been prepared. The prepared complexes [Pd(A)₂(diphos)] or [Pd(B)₂(diphos)] have been used effectively to prepare bimetallic complexes of the type [(diphos)Pd(μ-L)₂M′Cl₂] where M′ = Co, Cu, Mn, Ni, Pd, Pt or SnCl₂; L = A or B. The prepared complexes were characterized by elemental analysis magnetic susceptibility, i.r. and UV–Vis spectral data. ³¹P–{¹H}-n.m.r. data have been applied to characterize the produced linkage isomers.     

Synthesis,Characterization, Covalent Binding,and Degree of Unwinding of Platinum(II) Bipyridine Complexes

The complexes [Pt(3′′‐clpbpy)Cl₂] ( 1 ) [3′′‐clpbpy = 4‐(3′′‐chlorophenyl)‐6‐phenyl‐2, 2′‐bipyridine], [Pt(4′′‐clpbpy)Cl₂] ( 2 ) [4′′‐clpbpy = 4‐(4′′‐chlorophenyl)‐6‐phenyl‐2, 2′‐bipyridine], [Pt(3′′‐brpbpy)Cl₂] ( 3 ) [3′′‐brpbpy = 4‐(3′′‐bromophenyl)‐6‐phenyl‐2, 2′‐bipyridine], and [Pt(4′′‐brpbpy)Cl₂] ( 4 ) [4′′‐brpbpy = 4‐(4′′‐bromophenyl)‐6‐phenyl‐2, 2′‐bipyridine] were synthesized and characterized. The binding of the complexes with herring sperm DNA (HS DNA) was investigated by absorption titration and viscosity measurements. It was found that the complexes have ability of interaction with DNA by covalent mode. The intrinsic binding constant K_b of the complexes with HS DNA is 8.76 × 10⁴ ( 1 ), 9.89 ×10⁴ ( 2 ), 1.52 × 10⁵ ( 3 ), and 2.31 × 10⁵ ( 4 ) M^–1. The slight depression in relative specific viscosity was observed, which also attributes to covalent binding of complexes with DNA bases. Gel electrophoresis assay demonstrated the ability of the complexes to unwind negatively supercoiled pUC19 plasmid by 14° ( 1 ), 13° ( 2 ), 13° ( 3 ), and 11° ( 4 ). The in vitro cytotoxic property of the synthesized metal complexes was also carried out against brine shrimp bioassay.     

Kinetic characterization of the interactions of trans-dichloro-platinum(IV) anticancer prodrugs and a model compound with thiosulfate

Sodium thiosulfate has been utilized as a rescuing agent for relief of the toxic effects of cisplatin and carboplatin. In this work, we characterized the kinetics of reactions of the trans-dichloro-platinum(IV) complexes cis-[Pt(NH₃)₂Cl₄], ormaplatin [Pt(dach)Cl₄] and trans-[PtCl₂(CN)₄]^2? (anticancer prodrugs and a model compound) with thiosulfate at biologically important pH. An overall second-order rate law was established for the reduction of trans-[PtCl₂(CN)₄]^2? by thiosulfate, and varying the pH from 4.45 to 7.90 had virtually no influence on the reaction rate. In the reactions of thiosulfate with cis-[Pt(NH₃)₂Cl₄] and with [Pt(dach)Cl₄], the kinetic traces displayed a fast reduction step followed by a slow substitution involving the intermediate Pt(II) complexes. The reduction step also followed second-order kinetics. Reductions of cis-[Pt(NH₃)₂Cl₄] and [Pt(dach)Cl₄] by thiosulfate proceeded with similar rates, presumably due to their similar configurations, whereas the reduction of trans-[PtCl₂(CN)₄]^2? was about 1,000 times faster. A common reduction mechanism is suggested, and the transition state for the rate-determining step has been delineated. The activation parameters are consistent with transfer of Cl⁺ from the platinum(IV) center to the attacking thiosulfate in the rate-determining step.     

Novel platinum(II) and (IV) complexes of naphthaldimine schiff bases

Naphthaldimines containing N₂O₂ donor centers react with platinum(II) and (IV) chlorides to give two types of complexes depending on the valence of the platinum ion. For [Pt(II)], the ligand is neutral, [(H₂L¹)PtCl₂]·3H₂O (1) and [(H₂L³)₂Pt₂Cl₄]·5H₂O (3), or monobasic [(HL²)₂Pt₂Cl₂]·2H₂O (2) and [(HL⁴)₂Pt]·2H₂O (4). These complexes are all diamagnetic having square-planar geometry. For [Pt(IV)], the ligand is dibasic, [(L¹)Pt₂Cl₄(OH)₂]·2H₂O (5), [(L²)Pt₃Cl₁₀]·3H₂O (6), [(L³)Pt₂Cl₄(OH)₂]·C₂H₅OH (7) and [(L⁴)Pt₂Cl₆]·H₂O (8). The Pt(IV) complexes are diamagnetic and exhibit octahedral configuration around the platinum ion. The complexes were characterized by elemental analysis, UV-Vis and IR spectra, electrical conductivity and thermal analyses (DTA and TGA). The molar conductances in DMF solutions indicate that the complexes are non-ionic. The complexes were tested for their catalytic activities towards cathodic reduction of oxygen.     

Stereoisomeric Pt(IV) complexes with threonine

Stereoisomeric Pt(IV) complexes with threonine (ThrH = HOCH(CH₃)CH(NH₂)COOH, ??-amino-??-hydroxybutyric acid) were obtained. In the complexes trans-[Pt(S-ThrH)₂Cl₄] and trans-[Pt(R-ThrH)(S-ThrH)Cl₄], the ThrH molecules act as monodentate ligands coordinated through the NH₂ group. In the complexes cis- and trans-[Pt(S-Thr)₂Cl₂] and trans-[Pt(R-Thr)(S-Thr)Cl₂], the deprotonated ligands are coordinated in a bidentate fashion through the NH₂ and COO^?-groups (R,S is the absolute configuration of the asymmetric carbon atom). All the complexes were identified using elemental analysis, IR spectroscopy, and ¹⁹⁵Pt, ¹³C, and ¹H NMR spectroscopy. The complexes trans-[Pt(S-ThrH)₂Cl₄] · 3H₂O and cis-[Pt(S-Thr)₂Cl₂] · 2H₂O were additionally characterized by X-ray diffraction.     

Experimental and quantum‐chemical studies of 1H, 13C and 15N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with picolines

¹H, ¹³C and ¹⁵N NMR studies of gold(III), palladium(II) and platinum(II) chloride complexes with picolines, [Au(PIC)Cl₃], trans‐[Pd(PIC)₂Cl₂], trans/cis‐[Pt(PIC)₂Cl₂] and [Pt(PIC)₄]Cl₂, were performed. After complexation, the ¹H and ¹³C signals were shifted to higher frequency, whereas the ¹⁵N ones to lower (by ca 80–110 ppm), with respect to the free ligands. The ¹⁵N shielding phenomenon was enhanced in the series [Au(PIC)Cl₃] < trans‐[Pd(PIC)₂Cl₂] < cis‐[Pt(PIC)₂Cl₂] < trans‐[Pt(PIC)₂Cl₂]; it increased following the Pd(II) → Pt(II) replacement, but decreased upon the trans → cis‐transition. Experimental ¹H, ¹³C and ¹⁵N NMR chemical shifts were compared to those quantum‐chemically calculated by B3LYP/LanL2DZ + 6‐31G**//B3LYP/LanL2DZ + 6‐31G*. Copyright © 2008 John Wiley & Sons, Ltd.     

Tetrakis(thione)platinum(II) complexes: synthesis,spectroscopic characterization,crystal structures,and in vitro cytotoxicity

A new series of platinum(II) complexes based on thione ligands with general formula [Pt(thione)₄]X₂ (X^??=?Cl^?, NO₃^?) has been synthesized and characterized using CHNS elemental analysis, infrared, ¹H and ¹³C solution-state NMR as well as ¹³C and ¹⁵N solid-state NMR spectroscopy, and X-ray crystallography. The spectroscopic methods confirm the coordination of Pt(II) with thiocarbonyl groups via sulfur of the thione ligands. The X-ray structures showed a distorted square planar geometry for 1, [Pt(MeImt)₄]Cl₂ (MeImt = N-Methylimidazolidine-2-thione) while the hydrogen bonding interactions in 7, [Pt(iPrImt)₄](NO₃)₂·0.6(H₂O) induce a bent see-saw distortion relative to the ideal square planar geometry. The in vitro cytotoxicity studies showed that 2, [Pt(EtImt)₄]Cl₂ is generally the most effective, a two-fold better cytotoxic agent than cisplatin and carboplatin against MCF7 (human breast cancer).     

Hydrogen bonding between a water molecule and electronegative additives (O or Cl) on a Pt(111) surface

Water adsorption on Pt(111) surfaces treated with oxygen or hydrogen chloride at 20 K has been studied by Fourier transform infrared spectroscopy and scanning tunneling microscopy. Water molecules chemisorb predominantly on the sites of the electronegative additives (O or Cl^-), forming hydrogen bonds of O-HO or O-HCl^-. On a Pt(111)-2×2-O surface, water adsorption produces species (O(D₂O)), monomeric water (D₂O), (O(D₂O)₂) and ring tetramer-like cluster (O(D₂O)₃) on a Pt(111) surface. On a Pt(111)-3×3-Cl^- (θ=0.44) surface, water adsorption gives rise to a Pt(111)-(4×2)-(H₃O⁺+Cl^-) co-adsorption structure to form a hydrogen-bonding network between Cl^- and H₃O⁺ ions.     

Demercuriation reactions of the complexes [(PPh3)2RPtHgR′] containing platinum-mercury bonds

The compounds [(PPh₃)₂,RPtHgR′] (R = CH₃, R′= 2,5-C₆H₃Cl₂, 2,3,4- and 2,4,6-C₆H₂Cl₃, 2,3,4,5-, 2,3,4,6- and 2,3,5,6-C₆HCl₄, C₆Cl₅; R = Et, R′ = 2,5-C₆H₃Cl₂, 2,4,6-C₆H₂Cl₃; R = 2-C₆H₄Cl, R′=2-C₆H₄(CH₃)) have been prepared by the reactions of RHgR′ with Pt(PPh₃)₃, in order to study their possible use as intermediates in the preparation of diorganoplatinum complexes with different organic ligands. The dependence of J(³¹P-¹⁹⁵Pt) on slight differences in the electronic character of the ligand R′ in the series of compounds [(PPh₃)₂(CH₃)Pt-HgR′] has been studied.     

Synthesis and Photocatalytic Activity of Poly(triazine imide)

Poly(triazine imide) was synthesized with incorporation of Li⁺ and Cl^? ions (PTI/Li⁺Cl^?) to form a carbon nitride derivative. The synthesis of this material by the temperature‐induced condensation of dicyandiamide was examined both in a eutectic mixture of LiCl–KCl and without KCl. On the basis of X‐ray diffraction measurements of the synthesized materials, we suggest that a stoichiometric amount of LiCl is necessary to obtain the PTI/Li⁺Cl^? phase without requiring the presence of KCl at 873 K. PTI/Li⁺Cl^? with modification by either Pt or CoO_x as cocatalyst photocatalytically produced H₂ or O₂, respectively, from water. The production of H₂ or O₂ from water indicates that the valence and conduction bands of PTI/Li⁺Cl^? were properly located to achieve overall water splitting. The treatment of PTI/Li⁺Cl^? with [Pt(NH₃)₄]²⁺ cations enabled the deposition of Pt through ion exchange, demonstrating photocatalytic activity for H₂ evolution, while treatment with [PtCl₆]^2? anions resulted in no Pt deposition. This was most likely because of the preferential exchange between Li⁺ ions and [Pt(NH₃)₄]²⁺ cations.     

HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity

K[Pt(NH₃)Cl₃], a valuable precursor for the preparation of platinum complexes with cytostatic activity, e.g. satraplatin, picoplatin, LA-12 and cycloplatam, is currently prepared from cis-[Pt(NH₃)₂Cl₂] or K₂[PtCl₄] and these are the usual impurities in the final product. A simple, selective and sensitive HPLC-UV analytical method for the determination of the purity of K[Pt(NH₃)Cl₃] and the quantification of the impurities has been developed and validated. The platinum complexes present in the final product were separated on a strong base ion exchange column by the gradient elution with detection at 213 nm. Intra-assay precisions for the platinum complexes respective to their ions ([PtCl₄]^2?, [Pt(NH₃)Cl₃]^? and cis-[Pt(NH₃)₂Cl₂]) were between 0.1 and 2.0% (relative standard deviation); intermediate precisions were between 1.4 and 2.0% and accuracies were between 98.6 and 101.4%. Limits of detection of [PtCl₄]^2?, [Pt(NH₃)Cl₃]^? and cis-[Pt(NH₃)₂Cl₂] were 6 µg · ml^?1, 13 mg · ml^?1 and 5 µg · ml^?1 respectively, limits of quantification of [PtCl₄]^2?, [Pt(NH₃)Cl₃]^? and cis-[Pt(NH₃)₂Cl₂] were 51 µg · ml^?1, 55 mg · ml^?1 and 20 µg · ml^?1 respectively.     

Synthesis and spectroscopic studies of nickel(II) chalcogenolates derived from 1,2-diarylchalcogenolato-o-xylene

Nickel(II) chalcogenolate complexes [Ni(L-L)₂(dppe) Cl₂] (1, 2) have been prepared in high yields by reacting 1,2-diarylchalcogenolato-o-xylene, o-C₆H₄(CH₂EAr)₂ (E = Se or Te; Ar = Ph, C₆H₄OMe-4 and C₆H₄OEt-4), generated in situ, with Ni(dppe)Cl₂ [dppe = 1,2-bis(diphenylphosphino)ethane] in benzene. The structures were established by elemental analyses, molar conductance, i.r. and Raman, electronic ¹H- and ³¹P-n.m.r. and mass spectral data. The analytical and spectroscopic data are consistent with an octahedral geometry around nickel in (1) and (2). The ³¹P-n.m.r. spectra indicate their cis configuration in solution. This revised version was published online in June 2006 with corrections to the Cover Date.     

Platinum(II) and palladium(II) chlorides complexes with purine,pyrimidine,N-ethylimidazole andN-propylimidazole

Summary Platinum(II) and palladium(II) chloride complexes with purine, pyrimidine (pyrimid),N-ethylimidazole(N-EtIm) andN-propylimidazole(N-PropIm) ligands have been prepared and characterized by analysis and spectroscopic methods. The compounds have general formula M(L₁)(L₂)Cl₂ where M=Pt^II, Pd^II; L₁=purine or pyrimid, L₂=N-EtIm orN-PropIm, except the complexes Pt(purine)(pyrimid)Cl₂ and [Pd(purine)(pyrimid)₂Cl]Cl and [Pt(purine)₂ (N-propIm)Cl]Cl·2H₂O.