功率超声在结晶过程中应用的进展

功率超声在结晶过程中的应用研究促进了结晶技术的发展,丰富了功率超声学和相关学科相互交叉的学术内容。以实例陈述了超声强化溶液结晶过程在化工、食品和制药行业中的应用,从熔融结晶和电结晶两方面阐述了超声改善金属结晶,综述了高分子材料和生物大分子等聚合物结晶过程中超声波的应用,总结了超声波对纳米晶型材料制备和性能的影响,着重说明了功率超声在食品冷冻中冰结晶过程的研究现状和发展方向。最后,总结了超声对结晶的强化机理。     

Effect of power ultrasound on crystallization characteristics of magnesium ammonium phosphate

Magnesium ammonium phosphate (MAP) crystallization could be utilized for the recovery of phosphorus from wastewater. However, the effectiveness of the recovery is largely determined by the crystallization process, which is very hard to be directly observed. As a result, a specific ultrasonic device was designed to investigate the crystallization characteristics of MAP under various ultrasonic conditions. The results demonstrated that the metastable zone width (MZW) narrowed along with the rising of the ultrasonic power. Similarly, for the 6 mM MAP solution, with the ultrasonic power gradually enhanced from 0 W to 400 W, the induction time was shortened from 340 s to 38 s. Meanwhile, the crystallization rate was accelerated till the power reached 350 W, and then remained a constant value. It can be observed from the scanning electron microscopy (SEM), the MAP crystal became bigger in size as well as the crystal size distribution (CSD) became broad and uneven, with the increase of ultrasonic power. The results indicate that the crystallization process enhanced by power ultrasound could be used as an effective method to eliminate and recover the phosphorus from wastewater.     

功率超声强化溶液冻结机理的研究进展

功率超声波强化溶液结晶是一种新型的结晶技术,由于其具有促进溶液冻结、控制晶体粒径分布和提高冻结产品质量的作用,近年来受到越来越多的关注。从过冷溶液的一次冰晶成核、二次冰晶成核以及树枝状冰晶体的生长速度等方面对超声波强化溶液结晶的机理进行了综述,并对超声结晶机理研究的发展方向提出了建议。     

The application of power ultrasound to the surface cleaning of silica and heavy mineral sands

Power ultrasound may be used in the processing of minerals to clean their surfaces of oxidation products and fine coatings, mainly through the large, but very localised, forces produced by cavitation. Results of the application of power ultrasound to remove iron-rich coatings from the surfaces of silica sand used in glass making and to improve the electrostatic separation of mineral sand concentrates through lowering the resistivity of the conducting minerals (ilmenite and rutile) are presented. Parameters affecting ultrasonic cleaning, such as input power and levels of reagent addition, are discussed. In particular, we present data showing the relationship between power input and the particle size of surface coatings removed. This can be explained by the Derjaguin approximation for the energy of interaction between a sphere and a flat surface.     

Enhancement of lysozyme crystallization under ultrasound field

With the increasing demand for biopharmaceuticals, a method to crystallize biomolecule products with high quality, high yield and uniform size distribution as well as regular crystal habit is needed. In this work, ultrasound was used as a nucleation accelerator to decrease the energy barrier for lysozyme crystal formation. Crystallization experiments on egg-white lysozyme were carried out with and without ultrasound. The effect of ultrasound on induction time, metastable zone width, crystal size and morphology and process yield was investigated in detail. The nucleation-promoting effect produced by ultrasound is illustrated by the reduction of metastable zone width and induction time. By inducing faster nucleation, ultrasound leads to protein crystals grow at lower supersaturation levels with shorter induction time. It was found that ultrasound could result in uniform size distribution of the product due to the preventing of aggregation. However, long time continuous application of ultrasound could result in smaller particle size. Hence, ultrasonic-stop method was found to be a more appropriate strategy to enhance the crystallization process of proteins such as lysozyme.     

The Suzuki homocoupling reaction under high-intensity ultrasound

The Pd-catalysed Suzuki homocoupling of boronic acids was successfully carried out in water under high-intensity ultrasound (HIU). Heterogeneous catalysis with Pd/C, facilitating work up and purification, could be used without adding phosphine ligands. Reaction rates and yields were strongly influenced by the oxidant employed; excellent results were obtained using either molecular oxygen or 3-bromo-4-hydroxycoumarin. 3-Arylation of the latter with the Suzuki procedure had failed, exclusively affording the homocoupling products, symmetric biaryls. Besides offering a number of operational advantages, the use of HIU broadens the field of application for the Suzuki reaction.     

Characterisation of mixing rate due to high power ultrasound

For meaningful assessment of results from laboratory and pilot plant trials, it is often necessary to know the mixing characteristics within the ultrasonic reactors. Previous workers have used conductivity measurements in an attempt to characterize the residence time distribution in ultrasonic reactors, but these results do not provide direct data on the mixing within the high power region adjacent to the ultrasonic probe tip. We overcome this difficulty through direct visualization of the mixing process within the high energy region close to the tip of the ultrasonic probe. Our analysis proceeds by determining an approximate turbulent diffusivity in a batch reactor arrangement for different values of ultrasonic energy input. For input electrical power levels between 70 and 120 W and a processing volume of 30 ml, the effective turbulent diffusivity varied from about 0.2 x 10(-3) to 0.7 x 10(-3)m(2)/s. We demonstrate that such results can be coupled to a suitable dispersion model to estimate the actual residence time distribution in flow-though arrangements when the through-put adds little additional mixing energy. Therefore, coupling the effective turbulent diffusivity identified in a batch reactor with a suitable dispersion model for the reactor offers an alternative approach to the deduction of RTD when determining the actual RTD in the high intensity zone of steady flow sonochemical reactors is problematic.     

Lysozyme crystallization in hydrogel media under ultrasound irradiation

Sonocrystallization implies the application of ultrasound radiation to control the nucleation and crystal growth depending on the actuation time and intensity. Its application allows to induce nucleation at lower supersaturations than required under standard conditions. Although extended in inorganic and organic crystallization, it has been scarcely explored in protein crystallization. Now, that industrial protein crystallization is gaining momentum, the interest on new ways to control protein nucleation and crystal growth is advancing. In this work we present the development of a novel ultrasound bioreactor to study its influence on protein crystallization in agarose gel. Gel media minimize convention currents and sedimentation, favoring a more homogeneous and stable conditions to study the effect of an externally generated low energy ultrasonic irradiation on protein crystallization avoiding other undesired effects such as temperature increase, introduction of surfaces which induce nucleation, destructive cavitation phenomena, etc. In-depth statistical analysis of the results has shown that the impact of ultrasound in gel media on crystal size populations are statistically significant and reproducible.     

High power ultrasound standard

A sensitive radiation force balance for laboratory measurement of ultrasonic power is presented. The principle of the system is based on measuring the ultrasonic radiation force exerted on a conical float suspended in water. Technical details of the implementation of the economically attractive system are described. The operation of the system is automated with the aid of the IEEE-488 bus and a desktop computer. Design aspects that affect measurement uncertainty are investigated. A theoretical model for the measurement of ultrasonic power with a conical reflector target is discussed. The expanded uncertainty (95% confidence level) of the above radiation force conical float system is estimated to be between 5% to 10%.     

The pion optical potential and its application to reaction processes

The gross features of the pion-nucleus interaction are studied within the framework of an optical potential approach. The optical potential is determined by a systematic analysis of the data on pionic atoms and elastic scattering. It is then decomposed into quasi-free and absorption terms through theoretical consideration of the reactive content. A method of calculating the absorption cross section using the optical potential with the above decomposition is proposed. It takes into account not only direct absorption from the elastic channel but also the absorption after the quasi-free processes. The calculated absorption cross sections are in reasonable agreement with the observed ones. The cross sections for inelastic, single-charge-exchange and double-charge-exchange processes are calculated as an extended application of the method. The results are consistent with the available data. Inclusive spectra of pions and protons are also considered in this approach. An application to the (γ, π) reaction is briefly discussed.     

Effect of ultrasound on sodium arsenate induction time and crystallization property during solution crystallization processes

The effect of ultrasound vibrations on the cooling crystallization of sodium arsenate in supersaturated solutions was investigated. In particular, the effects of ultrasound vibrations on induction time and crystal size distribution were studied using a laser-based apparatus with relative supersaturation ranging from 1.3 to 1.8. The results show that ultrasound vibrations have a significant effect on reducing induction time and crystal size distribution. The application of ultrasound vibrations to the system resulted in a small change in surface tension; however, the induction time and crystal size significantly decreased. The mean size of sodium arsenate crystals decreased from 398.87 ± 3.27 to 168.68 ± 2.07 μm, as the ultrasound power increases from 26 to 130 W. Ultrasound vibrations significantly reduced the induction time in a highly supersaturated solution compared to that in a low supersaturated solution.     

超声对细胞膜通透性的影响及应用

适当参数的超声，使细胞膜发生可以修复的损伤，使细胞膜的通透性提高，从而使细胞内的物流释放到细胞外，细胞外的物质进入细胞内，这一现象可以用于释放代谢产物或中间产物，基因转导，强化化学方法治疗肿瘤等方面。     

功率超声在生物工程中的应用

本文对于不同工作条件下超声在生物过程中的作用、功率超声对活细胞和酶的影响、功率超声在基因工程中的应用等方面,综述了这些领域的研究进展。     

The state-of-the-art research of the application of ultrasound to winemaking: A critical review

As a promising non-thermal physical technology, ultrasound has attracted extensive attention in recent years, and has been applied to many food processing operation units, such as involving filtration, freezing, thawing, sterilization, cutting, extraction, aging, etc. It is also widely used in the processing of meat products, fruits and vegetables, and dairy products. With regard to its application in winemaking, most of the studies available in the literature are focused on the impact of ultrasound on a certain characteristic of wine, lacking of systematic sorting of these literatures. This review systematically summarizes and explores the current achievements and problems of the application of ultrasound to the different stages of winemaking, including extraction, fermentation, aging and sterilization. Summarizing the advantages and disadvantages of ultrasound application in winemaking and its development in future development.     

The application of a fractal model to the scattering of ultrasound in biological media

The implications of a fractal model of medium structure for the angular dependence of the ultrasonic differential scattering cross section and for the frequency dependence of the total ultrasonic scattering cross section are explored. The results for the differential scattering cross section agree well with published experimental values for liver and those for the total scattering cross section are not inconsistent with the literature data.     

Effect of ultrasound on the kinetics of anti-solvent crystallization of sucrose

The effect of ultrasound on the kinetics of anti-solvent crystallization of sucrose was studied. The influence of temperature, stirring rate, supersaturation and ultrasonic power on the anti-solvent crystallization of sucrose was investigated. The relationship between infrared spectral characteristic band of sucrose and supersaturation was determined with an online reaction analyzer. The crystal size distribution of sucrose was detected by a laser particle-size analyzer. Ultrasound accelerated the crystallization process, and had no impact on the crystal shape. Abegg, Stevens and Larson model was fitted to the experimental data, and the results were the following: At 298.15 K, the average size of crystals was 133.8 μm and nucleation rate was 4.87 × 10⁹ m⁻³·s⁻¹ without ultrasound. In an ultrasonic field, the average size was 80.5 μm, and nucleation rate was 1.18 × 10¹¹ m⁻³·s⁻¹. Ultrasound significantly reduced the average size of crystals and improved the nucleation rate. It was observed that the crystal size decreased with the increase of stirring rate in silent environment. When the stirring rate increased from 250 to 400 rpm, the average size decreased from 173.0 to 132.9 μm. However, the stirring rate had no significant impact on the crystal size in the ultrasonic field. In addition, the activation energy of anti-solvent crystallization of sucrose was decreased, and the kinetic constant of nucleation rate was increased due to the effect of ultrasound. In the ultrasonic field, the activation energy was reduced from 20422.5 to 790.5 J·mol⁻¹, and the kinetic constant was increased from 9.76 × 10² to 8.38 × 10⁸.     

The application of high frequency ultrasound waves to remove ammonia from simulated industrial wastewater

This article aims at applying the ultrasound technique in the field of clean technology to protect environment. The principle of ultrasound was conducted here to remove and recover ammonia from industrial wastewater. Three different concentrations of ammonia namely 5%, 15% and 25% (vol.%) were used to study the efficiency of removing ammonia from water. These concentrations are exactly similar to what may be found in wastewater resulting from strippers at petroleum refinery. High ultrasound frequency device with 2.4 and 1.7 MHz was conducted to study the effect of waves on the removal of ammonia. It was found that the ultrasound has the ability to remove ammonia with 5% concentration to meet the local standard of treated wastewater within less than 2 h for 0.080 L solution. It was also found that as the concentration of the ammonia increases the removing of ammonia within 2 h decreases, still the concentration of the ammonia meets the standard of the treated wastewater. The ability of the ultrasound to remove the ammonia failed to produce any mist when the height of the liquid solution increased, namely when the height reached (0.0337 m). This is equivalent to liquid volume of 0.150 L. It means that the device capacity to remove ammonia has certain limitations based on liquid heights. The best condition for ammonia removal was obtained at 5% concentration and 0.080 L liquid volume (equivalent to 0.0165 m).     

The effect of blood acceleration on the ultrasound power Doppler spectrum

The purpose of the present work was to study the influence of blood acceleration and time window length on the power Doppler spectrum for Gaussian ultrasound beams. The work has been carried out on the basis of continuum model of the ultrasound scattering from inhomogeneities in fluid flow. Correlation function of fluctuations has been considered for uniformly accelerated scatterers, and the resulting power Doppler spectra have been calculated. It is shown that within the initial phase of systole uniformly accelerated slow blood flow in pulmonary artery and aorta tends to make the correlation function about 4.89 and 7.83 times wider, respectively, than the sensitivity function of typical probing system. Given peak flow velocities, the sensitivity function becomes, vice versa, about 4.34 and 3.84 times wider, respectively, then the correlation function. In these limiting cases, the resulting spectra can be considered as Gaussian. The optimal time window duration decreases with increasing acceleration of blood flow and equals to 11.62 and 7.54 ms for pulmonary artery and aorta, respectively. The width of the resulting power Doppler spectrum is shown to be defined mostly by the wave vector of the incident field, the duration of signal and the acceleration of scatterers in the case of low flow velocities. In the opposite case geometrical properties of probing field and the average velocity itself are more essential. In the sense of signal–noise ratio, the optimal duration of time window can be found. Abovementioned results may contribute to the improved techniques of Doppler ultrasound diagnostics of cardiovascular system.     

大功率超声功率计的研制及高强度聚焦超声肿瘤治疗头功率检测

研制一种将机械天平、辐射压力法和智能控制结合在一起的大功率超声功率计,该功率计可以安装不同种类的反射靶面或吸收靶面对多种超声换能器进行功率测量;用砝码对该功率计进行校准和误差分析,结果显示该功率计具有稳定性好、精度高、测量范围大的特点。用锥面反射靶和吸收靶对高强度聚焦超声肿瘤治疗头的输出功率进行测量,实验结果表明:一方面该功率计可以满足大功率、高精度测量要求,另一方面被测量的临床治疗用高强度聚焦超声肿瘤治疗头的驱动电压在600-2200 V之间,其功率输出稳定、可靠,在此范围之外功率输出误差变大,超过5%。     

Simulation of laser generated ultrasound with application to defect detection

Laser generated ultrasound holds substantial promise for use as a tool for defect detection in remote inspection thanks to its ability to produce frequencies in the MHz range, enabling fine spatial resolution of defects. Despite the potential impact of laser generated ultrasound in many areas of science and industry, robust tools for studying the phenomenon are lacking and thus limit the design and optimization of non-destructive testing and evaluation techniques. The laser generated ultrasound propagation in complex structures is an intricate phenomenon and is extremely hard to analyze. Only simple geometries can be studied analytically. Numerical techniques found in the literature have proved to be limited in their applicability, by the frequencies in the MHz range and very short wavelengths. The objective of this research is to prove that by using an explicit integration rule together with diagonal element mass matrices, instead of the almost universally adopted implicit integration rule to integrate the equations of motion in a dynamic analysis, it is possible to efficiently and accurately solve ultrasound wave propagation problems with frequencies in the MHz range travelling in relatively large bodies. Presented results on NDE testing of rails demonstrate that the proposed FE technique can provide a valuable tool for studying the laser generated ultrasound propagation. PACS 02.70.Dh; 43.35.+d; 42.62.-b