One-pot synthesis of 2-trifluoromethylchromones

We report a simple and suitable method for the preparation of useful 2-trifluoromethylchromones in one step, in high yields and avoiding the use of solvents. We were able to detect the intermediate of this reaction. Furthermore a mechanism for the formation of the 7-methoxy-3-trifluoroacetyl-2-trifluoromethylchromone through the unexpected double trifluoroacetylation of 4-methoxy-2-hydroxyacetophenone followed by dehydration is also proposed. All compounds are fully identified and characterized by spectroscopic techniques.     

One-pot synthesis of isomeric 2-hydroxyphenyl-substituted cycloalkatetrazolopyrimidines

Russian Journal of Organic Chemistry - Three-component condensation of salicylaldehyde with tetrazol-5-amine and cycloheptanone (cyclooctanone) gave isomeric 2-hydroxyphenyl-substituted...     

One-pot synthesis of some 2H-Pyran-2-one derivatives

A one-pot synthesis of various 2H-pyran-2-one derivatives 5–19 starting from methyl ketones 1 , N,N-dimethylformamide dimethyl acetal and N-acylglycines 3 in acetic anhydride is described.     

Rational synthesis of alpha-MnO2 single-crystal nanorods

alpha-MnO2 single-crystal nanorods with diameters 20-80 nm and lengths up to 6 microns have been prepared through a low-temperature liquid-phase comproportionation method, which involves no catalysts or templates and may be adjusted to prepare alpha-MnO2 single-crystal nanorods in large scale.     

One-pot synthesis of 2-aminothiazoles in PEG-400

<正>A facile one-pot synthesis of 2-aminothiazoles has been carried in PEG-400 as a greener medium at room temperature.This method avoids the use of lachrymatric a-bromoketones as well as the volatile,toxic organic solvents.     

One-pot synthesis of 2-aminoquinoline-based alkaloids from acetonitrile

α-Diaminoboryl carbanions, readily prepared from acetonitrile, stereoselectively convert 2-nitrobenzaldehydes into nitrophenyl (Z)-acrylonitriles. Subsequent reductive cyclization leads to a series of 2-aminoquinoline derivatives. The entire procedure is practically operated in a single flask.     

One-pot synthesis of stable phosphonium ylides using 2-aminothiophenol

Protonation of reactive 1:1 intermediates produced in the reaction between triphenylphosphine and dialkyl acetylenedicarboxylate by 2-aminothiophenol leads to vinylphosphonium salts, which undergo Michael addition with thiophenolate anion to produce highly functionalized phosphonium ylides in excellent yields.     

One-pot synthesis of monodisperse CeO2 nanocrystals and superlattices

Monodisperse CeO(2) nanocrystals and superlattice-like colloidal particles have been successfully synthesized in ethanol-water mixed solvent by adopting a one-pot approach using icosahedral (NH(4))(2)Ce(NO(3))(6) as precursor.     

One-pot synthesis of arene-fused 2-acylcyclohexenones from propargylic carboxylates

From readily available propargylic carboxylates, two sequential transformations―gold-catalyzed tandem reactions and Sc(OTf)3-catalyzed cyclization―in a one-pot process led to the formation of 2-acylcyclohexenones with an electron-rich arene ring fused at the 4,5-positions.     

One-pot synthesis of functionalized indenols from 2-bromoalkenyl trifluoromethyl ketones

An elegant one-pot synthesis of indenols was successfully realized starting from 3-aryl-2-bromopropenyl trifluoromethyl ketones and secondary amines. The synthesis proceeds through domino reactions including captodative aminoenones as a key intermediate. When bromoenones having a donor substituent in meta-position of the aromatic ring were subjected to this reaction, the mixture of two isomeric indenols was formed.     

One-pot synthesis of substituted 3-amino-2-nitrothiophenes and selenophenes

In this work, we described an easy preparation of substituted 3-amino-2-nitrothiophenes and selenophenes. Substituted β-chloroacrylonitriles were reacted with sodium sulfide or sodium selenide and bromonitromethane to yield the expected compounds in a one-pot three-step procedure in good yields.     

One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles

Substituted 2-aminothiazoles have been synthesized from α-nitro-epoxides, cyanamide, and sodium sulfide through a facile, three-component, and ecofriendly protocol with good to excellent yields. This reaction was achieved at room temperature without any additives. A possible mechanism has also been proposed.     

One-pot synthesis of dendritic polyamide

Dendritic polyamides with polydispersity of 1.1–1.4 have been successfully prepared from trimesic acid, 5-aminoisophthalic acid, and 4-aminophenylpropionic acid as a core molecule, a dendron, and a spacer unit, respectively, with a one-pot procedure. This procedure involves successive activation of end carboxyl groups with the condensing agent diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate (DBOP), followed by condensation of active amide with 5-aminoisopthalic acid or 4-aminophenylpropionic acid and, finally, capping of the end carboxyl groups with p-anisidine. The structure of dendritic polyamides was investigated by ¹H-NMR spectroscopy, and it was found that the polymers obtained contained approximately 10% defects. Furthermore, the model reaction was studied to demonstrate the feasibility of dendritic polyamides. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 3638–3645, 1999     

One-pot synthesis of triazole-linked glycoconjugates

Highly efficient one-pot synthesis of 1,2,3-triazole-linked glycoconjugates was presented involving a Cu(I) catalyzed 1,3-dipolar cycloaddition as the key step. It offers a convenient route to prepare neoglycoconjugates derived from unprotected saccharides or peracetylated saccharides.     

One-pot synthesis of multifunctionalized cyclopropanes

A facile one-step synthetic protocol toward multifunctionalized cyclopropanes 4 is developed from substituted chalcones 1 and sulfones 2 in good yields via a [2C+1C] annulation.     

One-pot synthesis of polysubstituted pyrimidines

A series of polysubstituted pyrimidines were synthesized from in situ generated α,β-unsaturated imines and the corresponding amidine or guanidine derivatives in a convenient one-pot procedure.     

螺羟吲哚类杂环衍生物的一锅法合成

在室温和水作溶剂条件下,阴离子交换树脂IRA-900有效催化含不同取代基的靛红、丙二腈和1,3-环己二酮,一锅法合成了12个相应的螺羟吲哚类杂环衍生物,其产率高达92%~99%.同时讨论了催化剂的种类、溶剂用量和催化剂的重复使用次数对反应的影响,并对IRA-900催化剂的反应机理进行了初步探讨.该方法具有条件温和,实验操作简单,以及催化剂能重复使用等优点,为螺羟吲哚类杂环衍生物提供了一条绿色合成方法.