共查询到20条相似文献，搜索用时 46 毫秒
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微型化学实验技术近年来愈来愈引起我国化学教育工作者的兴趣.我们从1991年开始把微型仪器应用到物理化学实验中,取得了较好效果.现简单介绍如下: 相似文献
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介绍了相对活度的概念和化学势表达式的通式在物理化学课程中的一些应用,有助于学生深刻理解和系统掌握相关知识,对提高教师的授课效率和学生的学习效率均有一定的帮助。 相似文献
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SigmaPlot软件功能强大,使用方便、快捷,普遍用于数据分析和科研绘图。将其应用到物理化学实验数据处理、计算以及对所作的图形进行线性拟合、非线性曲线拟合,不仅简化了数据处理的过程,而且还提高了分析结果的准确度,同时也可以培养学生运用现代技术手段学习物理化学实验科学规律的能力。该文以物理化学实验教学中相关实验数据处理为例,探讨了SigmaPlot在物理化学实验教学中运用的基本原理和方法。 相似文献
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为解决学生难以理解物理化学中原理和概念的问题,让概念和原理变得形象生动、通俗易懂,在授课时引入了一种颇有特色的比拟教学法。介绍了这一拟人拟物教学法的要点,并通过列举的8个典型实例,对此方法的运用进行了详细的解读。 相似文献
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在物理化学教学中通过引入和分析案例引出知识点,并将案例与知识点互相印证,最终使难懂的理论和知识点变得容易接受。 相似文献
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《Analytical letters》2012,45(14):2625-2632
Abstract A simple, sensitive, reliable, and rapid HPTLC method has been developed for the determination of pitavastatin calcium in tablet dosage form. Identification and determination were performed on aluminum backed silica gel 60F254 washed with methanol. The mobile phase of ethyl acetate‐methanol‐ammonia‐1 drop formic acid (7:2:0.8) calibration plots were established showing the dependence of response (peak area) on the amount chromatographed. The spot were scanned at 245 nm. The method has a linear range of 50–250 ng/spot. The method was validated for selectivity, repeatability, and accuracy. The method was used for determination of the compound in commercial pharmaceutical dosage forms. It is a more effective option than other chromatographic techniques in routine quality control. 相似文献
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无机物的ADME/Tox研究 总被引：1，自引：0，他引：1
无机物的吸收、分配、代谢和排除以及毒性（ADME/Tox)研究在药物和毒物研究中非常重要,近年来发展在细胞层次上应用高通量和计算机等技术系统探索药物先导化合物的ADME/Tox发展迅速。金属和其它无机化合物的ADME/Tox研究在国内外都还是一个新兴的、具有广阔发展前途的跨学科研究领域。本文综述了国内外对于铁和铜以及稀土等金属的化合物的ADME/Tox研究结果,提出了一些应该开展的工作和有待解决的问题。 相似文献
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Snezana Savic Slobodanka Tamburic Andjelka Kovacevic Rolf Daniels Christel Müller-Goymann 《Journal of Dispersion Science and Technology》2013,34(9):1276-1287
There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-crystalline (Lα) and complex lamellar gel (Lβ) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles. 相似文献
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《液相色谱法及相关技术杂志》2012,35(18):2118-2129
A simple, rapid, and sensitive high performance liquid chromatographic method with UV detection has been developed for the quantification of clopidogrel in human plasma and pharmaceutical dosage form using diclofenac sodium as an internal standard and validated according to standard guidelines. The separation of clopidogrel and diclofenac sodium was achieved using Hypersil BDS RP18 (250 × 4.6 mm, 5 µm) at a column oven temperature of 35°C. The methanol and phosphoric acid 25 mM (80:20, v/v) (pH 3.0), used as a mobile phase in the isocratic mode was pumped at a flow rate of 1.2 mL min−1 and eluents were monitored at a wavelength of 220 nm. The retention times for diclofenac sodium and clopidogrel were 4.15 and 4.62 min, respectively. Extraction of drug from plasma was carried out with diethyl ether. The limit of detection (LOD) was 2.0 ng mL−1, while limit of quantification (LOQ) was 5.0 ng mL−1. The calibration curves were linear (r2 = 0.999) over the concentration range of 0.005 to 5.0 µg mL−1 for both standard solutions and spiked plasma. The intra-day and inter-days precision (RSDs) was less than 4.08 and 6.38%, respectively, and the accuracy was more than 99%. The method could be applied for the pharmacokinetic study of clopidogrel in healthy human volunteers as well as to pharmaceutical dosage forms. 相似文献
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Prof. Dr. Erika Bustos Bustos Prof. Dr. Antonia Sandoval-González Prof. Dr. Carolina Martínez-Sánchez 《ChemElectroChem》2022,9(12):e202200188
Environmental problems of great complexity arise from the enormous number of toxic substances that are generated by anthropogenic activities. Seemingly, society encounters new issues every day thus these problems seem to be endless. Now in the face of the COVID-19 pandemic and the SARS-CoV-2 crisis, a large number of emerging treatment compounds generated by pharmaceutical companies worldwide makes future issues even more treacherous. For this reason, there is an increasing need to detect and treat emerging compounds to prevent them from becoming persistent pollutants. This review describes the advances in the use of electrochemical sensors with modified carbon-based electrodes among other issues, to determine antibiotics, anti-inflammatories and antidepressants levels in the environment. It further explores technologies suggested for cleaning wastewater polluted by pharmaceutical products using biological or advanced oxidation processes including photolysis, photocatalysis, microwave heating, ultrasound, Fenton, electro-Fenton, photoelectro-Fenton and various combined treatments. 相似文献
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《Analytical letters》2012,45(11):2409-2420
Abstract A method for the spectrofluorimetric determination of nafcillin is proposed (λex = 226 nm, λem = 366 nm), for concentrations between 0.10 and 1.0 μg mL?1. The method was performed in ethanol/water medium (30% V/V), at apparent pH 6.0 provided by adding of phosphate buffer solution with pH = 6.20. The obtained values of detection and determination limits are 0.016 and 0.054 μg mL?1, respectively. The method was successfully applied to assay a commercial injection containing nafcillin sodium monohydrate. 相似文献
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Chenyang Wu Tingting Zheng Huan Chen Peizhi Zou Mengxue Zhang Jinrui Wang Nan Li Yun Zhang Ying Li Zhengqi Dong 《Molecules (Basel, Switzerland)》2022,27(18)
Background: Various potential effect of drugs on alleviating diseases by regulating intestinal microbiome as well as the pharmaceutical excipients on gut microbiota has been revealed. However, the interaction between them is rarely investigated. Methods: Histological analysis, immunohistochemistry analysis, enzyme-linked immunosorbent assay (ELISA) analysis, RT-qPCR, and 16S rRNA analysis were utilized to explore the effect mechanism of the five excipients including hydroxypropyl methylcellulose (HPMC) F4M, Eudragit (EU) S100, chitosan (CT), pectin (PT), and rheum officinale polysaccharide (DHP) on berberine (BBR) to cure UC. Results: The combined BBR with PT and DHP group exhibited better therapeutic efficacy of UC with significantly increased colon length, and decreased hematoxylin-eosin (H&E) scores than other groups. Furthermore, the expression of tight junction ZO-1 and occludin in colon tissue were upregulated, and claudin-2 was downregulated. Ultimately, the serum content of tumor necrosis (TNF)-α, interleukin (IL)-1β, and IL-6 was decreased. Moreover, the combined BBR with PT significantly promoted the restoration of gut microbiota. The relative abundance of Firmicutes and Lactobacillus was significantly increased by the supplement of PT and DHP, and the relative abundance of Proteobacteria was downregulated. Conclusions: Our study may provide a new perspective that the selection of pharmaceutical excipients could be a crucial factor affecting the drugs’ therapeutic efficiency outcome. 相似文献
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Fathalla Belal 《Mikrochimica acta》1992,108(3-6):329-334
Azintamide was found to be reduced at the dropping mercury electrode over the pH range 1.8–9.4 in Britton Robinson buffers containing 20% methanol. At pH 7.42 a well defined diffusion-controlled cathodic wave was produced. The limiting current versus concentration plot was linear over the range 0.025–1.0 mM and 0.005–1.0 mM in the DCt and DPP modes, respectively, with a lower detection limit of 1 × 10–7
M by the latter technique. A mechanism for the electrode reaction has been proposed. The method has been applied to the determination of azintamide in tablets, and the results obtained were in agreement with those obtained by a reference method.AvH Scholar 1989–1991. 相似文献
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为了提高药物制剂工程课程的教学质量,可以将物理化学知识融入到该课程的教学中。以“喷雾干燥工艺技术”为例,介绍了采用阶梯设疑法,将物理化学中的“弯曲液面上的饱和蒸气压”这一知识点融合到该技术中的教学情况,并根据期末考核结果对多元知识融合的教学效果进行评价。 相似文献