高师无机化学实验双语教学实践与思考

介绍了师范院校无机化学实验课中开展双语教学的实践过程,在口语汇报、实验讲解、实验操作、实验报告和实验考试各个教学环节中,传统实验教学和双语教学进行了有效结合,着重提高学生的综合能力。根据调查、访谈和教师的教学反思,还对高师化学专业开展双语教学进行了深入思考。     

高中化学应用“范例教学“模式的实验报告

面对高考和课程的改革,笔者在高中化学教学中使用了“范例教学“模式进行教学的实验.该报告对模式的引入背景、实验的可行性分析以及实验的实施过程、实验的调查分析进行了如实报告.     

高中化学应用“范例教学”模式的实验报告

面对高考和课程的改革 ,笔者在高中化学教学中使用了“范例教学”模式进行教学的实验。该报告对模式的引入背景、实验的可行性分析以及实验的实施过程、实验的调查分析进行了如实报告。     

化学对比实验器的制作与使用

针对对比实验,制作了一种新的化学实验仪器,解决了化学教学中对比实验不能同时等量添加试剂、观察现象不明显的问题,使对比实验效果直观、明显,在化学教学和科研中有一定的推广应用价值。     

基于信息技术的高师化学教学论实验教学改革与实践*

在高师化学教学论实验教学过程中,为及时、充分指导学生的实验操作,加强学生间的反思交流,课题组在现有化学仿真实验平台辅助教学论实验的基础上,利用手机微信平台和化学仿真实验平台,针对实验操作和实验教学等2方面设计并制作了教学微视频,构建了信息化教学新模式。实践效果表明:该模式满足了学生的个性化学习和分层教学需求,提高了高师化学教学论实验的教学效果,具有实践价值。     

分析化学综合实验中的软件实验教学设计——以Excel为例

以Excel为例, 从实验设计原则、实验内容、教学手段等方面系统介绍了分析化学综合实验中软件实验的教学设计, 对提高学生实验数据分析能力及处理效率具有重要作用, 是分析化学实验教学的有益探索。     

基于SPOC的“大学化学实验”混合式教学模式研究

针对"大学化学实验"传统教学中存在的问题,结合化学实验的特点,利用SPOC的优势,将线上线下结合,从教学资源、教学设计、教学评价等3个方面对"大学化学实验"进行了混合式教学模式设计。     

高师化学师范生实验教学能力及其生成路径

实验教学能力是化学教师专业发展的重要标志,实验讲解能力是师范生实验教学能力的重要表征,实验思维能力是实验教学能力的重要品质,化学实验探究教学能力则是师范生实验教学能力的核心。实验教学能力的生成是在观察、实践和反思的过程中得以实现的。实验课程教学、教学说课、教学比赛、教学见习和教学实习则是师范生实验教学能力生成的有效路径。     

微型电解实验探究案例

尽管实验探究被应用于中学化学教学中,但考虑到课堂时间和教学组织等一系列现实问题,一些老师还是会选择通过演示实验来完成相应的教学任务。比如在“电解”教学中,经常是教师先进行演示实验,然后师生共同总结电解的规律,课堂教学表面看起来“效率”很高,但学生从演示实验中获得的信息并不完整,一些实验现象根本就看不清楚,     

蓝瓶子实验与碘时钟实验比较研究

蓝瓶子实验和碘时钟实验的相同点是历史悠久、趣味性强,实验现象在无色和蓝色之间变换,可用于化学动力学问题的探究教学。但是,这2个实验在发展历史、反应机理、实验现象等方面又有不同。建议化学教学中增加碘时钟实验。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.