精品课程教材《高分子物理实验》建设的体会——三个及时融入

中国科学技术大学"高分子物理实验"课程是2006年安徽省精品课程,作者结合教学研究和精品课程建设经验,总结出了"三个及时融入"的教材建设理念,本文结合实例对该理念的具体含义进行了阐述.     

“药物化学”与“药理学”课程整合教学的探索

分析了"药物化学"与"药理学"2门课程整合教学的基础,从师资队伍、教学大纲、理论教学内容、实验教学内容和试题库建设等方面具体阐述了课程整合教学改革的实施方案,并对药学本科课程整合进行了总结思考与展望,为药学人才培养探索了新的模式和方向。     

化学分析实验课程全英文教学方法研究

化学分析实验是分析化学教学的重要组成内容,是实践分析化学"量"的概念的重要途径。本文探讨了国际化合作办学背景下化学分析实验课程的全英文教学模式与方法,总结了化学分析实验(全英)课程建设过程的经验与不足,展望了化学分析实验全英文教学的前景。     

“三三制”人才培养模式下化学实验教学改革的探索与实践

南京大学国家级化学实验教学示范中心基于"三三制"本科人才培养理念,对化学实验教学进行了改革,完善了"专业学术类"人才培养的实验课程,加强了"交叉复合类"实验课程建设,探索了"就业创业类"人才培养的实验课程及平台建设,取得了显著的建设成效。     

基于"产学研用"背景下的仪器分析课程教学机制研究

"产学研用"是高等教育实现人才培养目标的重要途径。本文在"产学研用"教学一体化背景下,为提高仪器分析课程教学效果,强化课程对学生专业能力、科研能力和解决企业实际问题的能力培养,在分析目前课程教学存在问题的基础上,对仪器分析"产学研用"教学机制、教学方法、资源共享平台建设、教学团队建设、教学考核等问题进行一体化建设探索,以期通过"产学研用"教学建设促进人才培养质量进一步提升,并对高校培养人才与企业实际需求人才的有效衔接问题提供一定的解决思路。     

“化学与社会”课程体系建设

主要介绍通识课"化学与社会"的课程体系建设,其特点在于突出课程的"通识"性。课程通过帮助学生消除对化学的误解和向学生介绍社会中的化学常识,来加强对学生科学思辨能力的培养。     

有机化学课程虚拟教研室的建设与实践

提出有机化学课程虚拟教研室的建设目标和建设内容，通过36校联动，分组分层次推进有机化学课程虚拟教研室建设，并开展相关教研活动。系统阐明有机化学课程虚拟教研室的组织形式和机制建设。总结有机化学课程虚拟教研室建设以来的一系列跨校教研活动。重点论述有机化学课程虚拟教研室在教学资源建设方面的进展。通过发挥各成员学校教师在教学、科研上的特色和优势，推动互联互通、共建共享型有机化学课程虚拟教研室建设，实现协同教研新形态。     

化学综合设计实验精品课程建设的研究与实践

从教学内容、教材建设、师资队伍建设、教学方法与课程网站建设、实验室建设与开放等方面总结了化学综合设计实验课程建设取得的经验,提出了今后课程建设与改革的设想。     

化学类专业一流课程建设的思路与重点——以山东大学物理化学一流课程建设为例

一流课程建设是一流本科建设的基础。本文首先基于对一流课程"两性一度"标准的认识,指出定位准确、目标清晰、基础良好、理念先进、建设一流、效果显著、示范引领是一流课程建设的关键特征,而后以山东大学物理化学一流课程建设为例,介绍了课程定位和教学目标的确定和设计落实,介绍了课程在一流基础、一流师资、一流资源、一流理念、一流成效等5个方面开展建设的做法和经验。对未来各高校开展一流课程建设具有一定的借鉴意义。     

能源与环境系统工程专业工程化学课程的教学改革与实践

工程化学课程是本校非化学化工专业(能源与环境系统工程专业)的一门学科基础课程。该课程的目的是锻炼学生的化学思维能力,通过学习工程应用中的化学理论,提高学生运用化学知识解决实际问题的能力。本文阐述了本校工程化学课程的教学理念和授课情况,对教学内容和方法进行了深入的改革与实践,详细介绍了课程建设、课堂教学、课下反馈与评价、科研相辅、教学工作的反思与总结,进一步阐述了教学环节的教育探索与实践总结,使工程化学课程的教学质量得到了提高。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.