农林院校有机化学教学改革研究——评《有机化学——结构和性质相关分析与功能》

有机化学是农林院校生命、食品、农学、植保等多个学科和专业都涉及的基础性课程,在有机化学的课程教学中,学生既能够有针对性地掌握有机化学的理论知识与实验技巧,为农林方面的专业学习打下良好的基础,同时学生也能够在有机化学的教学中锻炼实验动手能力、观察能力和科学思维能力,全方位促进学生的能力提升。     

有机化学知识在高分子化学教学中的应用

<高分子化学>是研究聚合反应机理和聚合方法的一门科学,是高分子材料专业的一门重要专业基础课,它与前期所学课程<有机化学>课程有着非常紧密的联系.有机化学知识在高分子化学中的应用有利于调动学生的学习积极性,加深对教学难点的理解,以便提高教学质量,达到更好的教学效果.本文结合高分子化学和有机化学的课堂教学实践,就有机化学知识在辅助高分子化学教学过程中的应用提出了一些实例和自己的体会.     

关于农业高等学校有机化学的教学意见

与有机化学有关的科学是多方面的,因此它的范围是复杂广泛的。但是,一般的有机化学讨论范围尤其在结合实践时,常常在工业应用上兜圈子,因此说东说西罗列了很多的工业例子,这点在化工学院讲起来,当然很适当而且是必要的,作为培养专业专家来讲,应该使他们掌握有关本专业范围内的一切基本科学。     

介绍一本应用化学专业用的《有机化学教程》

应用化学专业属于应用理科类专业,是理工结合的新型专业,培养化学类高层次的应用型人才。为此,教育计划要求学生既具有一定的化学工程知识,也应具备深厚的化学理论基础。有机化学作为该专业的一门基础课,其重要性是不言而喻的。可是长期以来没有一本适用于应用化学专业用的有机化学教材,1990年高等教育出版社出版了北京化工学院张黯教授主编的《有机化学教程》,填补了国内高教教材中的一项空白。     

诺贝尔化学奖与生物专业有机化学教材内容相关性分析

结合有机化学教材内容总结了有机化学领域的诺贝尔化学奖情况,分析了诺贝尔化学奖与有机化学及生物科学的关系,并介绍了在生物专业有机化学教学中引入诺贝尔化学奖的方法。将诺贝尔化学奖引入生物专业有机化学的教学实践有利于学生认识课程重要性,激发学习动力,提高综合素质和创新能力。     

双一流背景下有机化学精准教学的探究实践*

有机化学课程是本校化学师范和高分子材料与工程2个国家级一流本科专业以及应用化学、制药工程等专业基础必修课程。由于化学师范和非师范专业的培养目标不同,有机化学的精准教学方面也有所差异。主要从理论教学、实验教学和多媒体教学等3个方面对化学师范专业和非师范专业有机化学差异化精准教学进行了探究实践,化学师范专业有机化学的精准教学侧重于培养学生的教学能力,非师范专业有机化学的精准教学侧重于培养学生的应用能力。     

关于21世纪医学专业有机化学课程体系的认识与实践

从近代视角扫视了有机化学与生命科学的融合和互动 ,阐述了 2 1世纪医学和生物学专业基础有机化学教材的新概念 ,介绍了医学七年制专业用有机化学课程体系的建立。     

从奎宁到白三烯——-试论有机化学在医学科学中的重要作用

有机化学,特别是天然有机化学,是和医学科学密切相关的,有机化学的成就在许多方面促进了医学科学的进步,反过来医学科学中提出的课题也推动了有机化学的发展。本文以抗疟药等天然药物和廿碳酸类等生理活性物质为例讨论了这两门学科间的一些关系。     

课程思政背景下促进科学探究意识的“糖类化合物”混合式教学实践

介绍了医学及相关专业的有机化学课程中“糖类化合物”章节线上线下混合式教学实践。在教育信息技术全面渗透进高校课堂的背景下,在“课程思政”课程观指导下,将课程思政元素与教学内容有机融合,运用多元化的教学方法,在知识学习过程中注重促进学生科学探究意识的提升。探索促进学生深入领会知识内涵,体会知识所演绎的科学思维和精神价值,促进科学素养和社会责任意识养成的教学实践。     

《有机化学》教材及其《自学指导书》的简介

一、《有机化学》教材简介中央卫星电视中学教师进修化学专业专科用的《有机化学》教材即将出版,这本书是根据1984年原教育部组织制订的中学教师进修高等师范专科化学专业的有机化学教学大纲编写的,全书共19章,最后附习题解答。在编写过程中始终坚持高师专科的标准,即通过本教材的学习能够掌握高师专科有机化学的基本理论、基础知识;了解与本门学科有关的科学成就和新发展;能够提高分析和解决中学教学实际问题的能力;为胜任中学化学教学打下比较坚实的基础。这本教材的主要特点是:1.联系中学教学实际在编写过程中注意到在职进修教师的特点。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Selective syntheses of 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones via temperature-dependent Rh(II)-carbenoid-mediated 2H-azirine-ring expansion

The Rh(II)-catalyzed reaction of 2-carbonyl-substituted 2H-azirines with ethyl 2-cyano-2-diazoacetate or 2-diazo-3,3,3-trifluoropropionate provides an easy access to 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones. These compounds can be selectively prepared from the same starting material using temperature as the only varied parameter. The 2-azabuta-1,3-diene intermediate, a common precursor for both heterocyclic products, isomerizes into 2H-1,3-oxazine under kinetic control, while 1H-pyrrol-3(2H)-one is the sole product of the reaction at elevated temperatures. According to DFT-calculations a one-atom oxazine ring contraction involving ring-opening to a 2-azabuta-1,3-diene intermediate, followed by a 1,5- and 1,2-prototropic shift leads to the consecutive formation of imidoylketene and azomethine ylide, which then further undergo cyclization to the pyrrole derivative.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.